CA2378628C - Nouveaux derives d'indenoindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent - Google Patents

Nouveaux derives d'indenoindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent Download PDF

Info

Publication number
CA2378628C
CA2378628C CA002378628A CA2378628A CA2378628C CA 2378628 C CA2378628 C CA 2378628C CA 002378628 A CA002378628 A CA 002378628A CA 2378628 A CA2378628 A CA 2378628A CA 2378628 C CA2378628 C CA 2378628C
Authority
CA
Canada
Prior art keywords
branched
group
linear
formula
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002378628A
Other languages
English (en)
French (fr)
Other versions
CA2378628A1 (fr
Inventor
Michel Wierzbicki
Marie-Francoise Boussard
Anne Rousseau
Jean-Albert Boutin
Philippe Delagrange
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Les Laboratoires Servier SAS
Original Assignee
Les Laboratoires Servier SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Les Laboratoires Servier SAS filed Critical Les Laboratoires Servier SAS
Publication of CA2378628A1 publication Critical patent/CA2378628A1/fr
Application granted granted Critical
Publication of CA2378628C publication Critical patent/CA2378628C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Psychology (AREA)
  • Emergency Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA002378628A 2001-03-19 2002-03-19 Nouveaux derives d'indenoindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent Expired - Fee Related CA2378628C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR01.03667 2001-03-19
FR0103667A FR2822153B1 (fr) 2001-03-19 2001-03-19 Nouveaux derives d'indenoindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
CA2378628A1 CA2378628A1 (fr) 2002-09-19
CA2378628C true CA2378628C (fr) 2007-07-10

Family

ID=8861264

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002378628A Expired - Fee Related CA2378628C (fr) 2001-03-19 2002-03-19 Nouveaux derives d'indenoindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Country Status (24)

Country Link
US (1) US6844445B2 (en:Method)
EP (1) EP1245565B1 (en:Method)
JP (1) JP3886829B2 (en:Method)
KR (1) KR100453979B1 (en:Method)
CN (1) CN1185214C (en:Method)
AR (1) AR034861A1 (en:Method)
AT (1) ATE250578T1 (en:Method)
AU (1) AU780027B2 (en:Method)
BR (1) BR0200871A (en:Method)
CA (1) CA2378628C (en:Method)
DE (1) DE60200041T2 (en:Method)
DK (1) DK1245565T3 (en:Method)
EA (1) EA004711B1 (en:Method)
ES (1) ES2207629T3 (en:Method)
FR (1) FR2822153B1 (en:Method)
HK (1) HK1049159B (en:Method)
HU (1) HU226674B1 (en:Method)
MX (1) MXPA02002816A (en:Method)
NO (1) NO321890B1 (en:Method)
NZ (1) NZ517855A (en:Method)
PL (1) PL352866A1 (en:Method)
PT (1) PT1245565E (en:Method)
SI (1) SI1245565T1 (en:Method)
ZA (1) ZA200202220B (en:Method)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006047231B4 (de) * 2006-10-04 2009-02-12 Hemmerling, Hans-Jörg, Dr. Substituierte Indeno[1,2-b]indolderivate als neue Hemmstoffe der Protein Kinase CK2 und ihre Verwendung als Tumor Therapeutika, Cytostatika und Diagnostika
ES2580702B1 (es) 2015-02-25 2017-06-08 Palobiofarma, S.L. Derivados de 2-aminopiridina como antagonistas del receptor A2b de adenosina y ligandos del receptor MT3 de melatonina
US11833156B2 (en) 2017-09-22 2023-12-05 Jubilant Epipad LLC Heterocyclic compounds as pad inhibitors
WO2019077631A1 (en) 2017-10-18 2019-04-25 Jubilant Biosys Limited IMIDAZO-PYRIDINE COMPOUNDS FOR USE AS PAD INHIBITORS
KR20200085836A (ko) 2017-11-06 2020-07-15 주빌런트 프로델 엘엘씨 Pd1/pd-l1 활성화 억제제로서의 피리미딘 유도체
BR112020010322A2 (pt) 2017-11-24 2020-11-17 Jubilant Episcribe Llc composto da fórmula i; composto da fórmula ia; composto da fórmula ib; processo de preparação de compostos da fórmula i; composição farmacêutica; método para o tratamento e/ou prevenção de várias doenças; uso dos compostos; método para o tratamento de câncer; e método para o tratamento e/ou prevenção de uma afecção mediada por prmt5 ou um distúrbio proliferativo ou câncer
CN112105610B (zh) 2018-03-13 2024-01-26 朱比连特普罗德尔有限责任公司 作为pd1/pd-l1相互作用/活化的抑制剂的双环化合物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL99750A0 (en) * 1990-10-16 1992-08-18 Univ Bath Indenoindole compounds

Also Published As

Publication number Publication date
NO20021330D0 (no) 2002-03-18
NO321890B1 (no) 2006-07-17
NO20021330L (no) 2002-09-20
FR2822153A1 (fr) 2002-09-20
US6844445B2 (en) 2005-01-18
EP1245565A1 (fr) 2002-10-02
KR100453979B1 (ko) 2004-10-20
EA004711B1 (ru) 2004-06-24
ES2207629T3 (es) 2004-06-01
KR20020074420A (ko) 2002-09-30
ATE250578T1 (de) 2003-10-15
EA200200263A2 (ru) 2002-10-31
NZ517855A (en) 2002-10-25
JP2002322150A (ja) 2002-11-08
CA2378628A1 (fr) 2002-09-19
SI1245565T1 (en) 2003-12-31
BR0200871A (pt) 2003-01-07
AR034861A1 (es) 2004-03-24
MXPA02002816A (es) 2004-11-12
ZA200202220B (en) 2002-10-10
CN1185214C (zh) 2005-01-19
US20020173531A1 (en) 2002-11-21
HUP0201024A3 (en) 2003-12-29
PT1245565E (pt) 2003-12-31
FR2822153B1 (fr) 2003-10-31
EA200200263A3 (ru) 2002-12-26
PL352866A1 (en) 2002-09-23
HU0201024D0 (en:Method) 2002-05-29
DE60200041D1 (de) 2003-10-30
DE60200041T2 (de) 2004-06-09
HUP0201024A2 (hu) 2002-11-28
DK1245565T3 (da) 2004-01-12
AU2746902A (en) 2002-09-26
CN1375490A (zh) 2002-10-23
HK1049159B (zh) 2005-07-29
EP1245565B1 (fr) 2003-09-24
AU780027B2 (en) 2005-02-24
JP3886829B2 (ja) 2007-02-28
HU226674B1 (en) 2009-06-29
HK1049159A1 (en) 2003-05-02

Similar Documents

Publication Publication Date Title
CA2164119A1 (en) 1-substituted isatin and oxindole derivatives as inhibitors of acetylcholinesterase
CN1450997A (zh) 含铜的胺氧化酶的抑制剂
EP0506539A1 (fr) Nouveaux amides alkyl hétérocycliques, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
FR2722190A1 (fr) Derives de 1-benzyl-1,3-dihydro-2h-benzimidazol-2-one, leur preparation, les compositions pharmaceutique en contenant
CA2503995A1 (fr) Nouveaux composes de pyridopyrimidinone, leur procede de preparation et les compositions qui les contiennent
EP0902027A1 (fr) Nouveaux dérivés de l'indole et de l'indazole, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
CA2378628C (fr) Nouveaux derives d'indenoindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2930249A1 (fr) Nouveaux derives de 3-aminoalkyl-1,3-dihydro-2h-indol-2-one, leur preparation et leur application en therapeutique.
EP1241169B1 (fr) Dérivés d'isoindoloindolone, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
CA2297279C (fr) Nouveaux composes cyano-indoles inhibiteurs de recapture de serotonine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP0591027A1 (fr) Dérivés de pipéridine, leur préparation et leur application en thérapeutique
EP0452204A1 (fr) Nouveaux dérivés du 3-aminochromane, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
EP1828125B1 (fr) Derives d'arylpiperazine et leur utilisation comme ligands selectifs du recepteur d3 de la dopamine
FR2766824A1 (fr) Nouveaux composes heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2005080333A1 (en) Process for purification of ropinirole
EP1119564B1 (fr) Derives d'aryl- 4-fluoro-4- (2-pyridin-2-yl-ethylamino)-methyl]-piperidin-1-yl -methanone comme agonistes du recepteur 5-ht1
FR2601951A1 (fr) Nouvelles tetrahydrocarbazolones, composition pharmaceutique les contenant et leur procede de preparation
EP1492792B1 (fr) Derives de 3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazino¬4,5-b|indole-1-acetamide,leur preparation et leur application en therapeutique
EP0718299A1 (fr) Nouveaux éthers d'oximes tricycliques, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
EP1794123B1 (fr) Derives de 3-spiro-indolin-2-one comme ligand des recepteurs de la vasopressine
EP1383761B1 (fr) Phenyl- et pyridyl-pipéridines avec une activité du tnf
WO2005012282A1 (fr) Nouveaux derives du benzothiofene 2-thiosubstitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
LU87047A1 (fr) Nouveaux derives de l'octahydrobenzo(g)quinoleene,leur preparation et leur utilisation comme medicaments
EP1476433A1 (fr) Nouveaux derives de tricyclo-imidazolines, leur procede de preparation et leur utilisation a titre de medicaments
FR2724170A1 (fr) Nouveaux derives de spiro(indole-pyrrolidine) agonistes de la melatonine, leur procede de preparation et leur utilisation a titre de medicament

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed