CA2378324A1 - Adenovirus recombinant - Google Patents
Adenovirus recombinant Download PDFInfo
- Publication number
- CA2378324A1 CA2378324A1 CA002378324A CA2378324A CA2378324A1 CA 2378324 A1 CA2378324 A1 CA 2378324A1 CA 002378324 A CA002378324 A CA 002378324A CA 2378324 A CA2378324 A CA 2378324A CA 2378324 A1 CA2378324 A1 CA 2378324A1
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- Prior art keywords
- fiber
- adenovirus
- seq
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- leu
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- C—CHEMISTRY; METALLURGY
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10345—Special targeting system for viral vectors
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/40—Vectors comprising a peptide as targeting moiety, e.g. a synthetic peptide, from undefined source
- C12N2810/405—Vectors comprising RGD peptide
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
- C12N2810/80—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates
- C12N2810/85—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates mammalian
- C12N2810/851—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates mammalian from growth factors; from growth regulators
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
- C12N2810/80—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates
- C12N2810/85—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates mammalian
- C12N2810/854—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates mammalian from hormones
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
- C12N2810/80—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates
- C12N2810/85—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates mammalian
- C12N2810/855—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates mammalian from receptors; from cell surface antigens; from cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
- C12N2810/80—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates
- C12N2810/85—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates mammalian
- C12N2810/859—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates mammalian from immunoglobulins
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
L'invention concerne un adénovirus recombinant de tropisme modifié. Dans un adénovirus, la fibre pentone native composée d'une queue, d'une tige et d'un spicule incluant un motif de trimérisation, a été changée en ce sens que le spicule natif contenant la structure liaison de cellule et le motif de trimérisation natif ont été enlevés et un nouveau ligand liaison de cellule et un motif de trimérisation externe ont été introduits dans la fibre virus. L'invention concerne également l'adénovirus recombinant destiné au traitement de maladies de l'être humain, in vivo ou par des procédés in vitro, ainsi qu'un procédé de sauvetage de fibres adénovirus recombinant dans le génome adénovirus.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9902601A SE9902601D0 (sv) | 1999-07-06 | 1999-07-06 | Recombinant adenovirus |
SE9902601-5 | 1999-07-06 | ||
US14363299P | 1999-07-14 | 1999-07-14 | |
US60/143,632 | 1999-07-14 | ||
PCT/SE2000/001390 WO2001002431A1 (fr) | 1999-07-06 | 2000-06-30 | Adenovirus recombinant |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2378324A1 true CA2378324A1 (fr) | 2001-01-11 |
Family
ID=26663617
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002378324A Abandoned CA2378324A1 (fr) | 1999-07-06 | 2000-06-30 | Adenovirus recombinant |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP1196435A1 (fr) |
JP (1) | JP2003531568A (fr) |
KR (1) | KR20020092886A (fr) |
CN (1) | CN1359391A (fr) |
AU (1) | AU763733B2 (fr) |
CA (1) | CA2378324A1 (fr) |
WO (1) | WO2001002431A1 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104634978A (zh) * | 2013-11-13 | 2015-05-20 | 长春百克生物科技股份公司 | 一种分型检测腺病毒中和抗体的方法以及用于分型检测腺病毒中和抗体的试剂盒 |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1276888A2 (fr) * | 2000-04-26 | 2003-01-22 | Crucell Holland B.V. | Vecteurs d'adenovirus a fibres sans spicule, et leurs utilisations |
AU6368901A (en) | 2000-05-31 | 2001-12-11 | Univ Saskatchewan | Modified bovine adenovirus having altered tropism |
GB0017720D0 (en) | 2000-07-19 | 2000-09-06 | Got A Gene Ab | Modified virus |
AU2002238537B8 (en) * | 2001-02-07 | 2006-08-24 | Wilex Ag | Hybridoma cell line G250 and its use for producing monoclonal antibodies |
US20040077081A1 (en) | 2001-02-07 | 2004-04-22 | Egbert Oosterwijk | Hybridoma cell line g250 and its use for producing monoclonal antibodies |
EP1524995B1 (fr) | 2002-07-01 | 2011-12-21 | Wilex AG | Coadministration de cg250 et d'il-2 ou d'ifn-alpha, destinee au traitement de cancers tels que les hypernephromes |
CA2601629A1 (fr) * | 2004-11-30 | 2006-06-08 | Kiim Pharm Lab. Inc. | Medicament anti-vih, polypeptide constituant ledit medicament, gene codant le polypeptide et procede de production du medicament anti-vih |
WO2007094653A1 (fr) * | 2006-02-13 | 2007-08-23 | Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patientenzorg | Particules adénovirales ayant une protéine s adénovirale chimérique, et utilisation et procédés de production de ces particules |
EP2248903A1 (fr) | 2009-04-29 | 2010-11-10 | Universitat Autònoma De Barcelona | Procédés et réactifs pour le transfert génétique efficace et ciblé vers des monocytes et macrophages |
CN102775500A (zh) * | 2012-08-03 | 2012-11-14 | 郑骏年 | 嵌合抗原受体iRGD-scFv(G250)-CD8-CD28-CD137-CD3ζ及其用途 |
SG11201507393TA (en) | 2013-03-14 | 2015-10-29 | Salk Inst For Biological Studi | Oncolytic adenovirus compositions |
EP3250609A4 (fr) * | 2015-01-26 | 2018-07-11 | The University of Chicago | Agents de liaison à l'il13ra alpha 2 et leur utilisation dans le traitement du cancer |
KR102471633B1 (ko) | 2016-02-23 | 2022-11-25 | 솔크 인스티튜트 포 바이올로지칼 스터디즈 | 바이러스 동역학에 미치는 영향 최소화를 위한 치료용 아데노바이러스의 외인성 유전자 발현 |
EP3390428B1 (fr) | 2016-02-23 | 2019-09-25 | Salk Institute for Biological Studies | Dosage à haut débit pour mesurer la cinétique de réplication d'un adénovirus |
JP2019536468A (ja) | 2016-12-12 | 2019-12-19 | ソーク インスティテュート フォー バイオロジカル スタディーズ | 腫瘍を標的にする合成アデノウイルスおよびその使用 |
CN107602672B (zh) * | 2017-08-30 | 2021-06-18 | 广州医科大学附属第一医院 | 重组表达的腺病毒纤毛蛋白肽、腺病毒亚单位疫苗及其制备方法 |
CN107365365B (zh) * | 2017-08-30 | 2021-01-01 | 广州医科大学附属第一医院 | 重组表达的腺病毒纤毛蛋白肽、腺病毒亚单位疫苗及其制备方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5770442A (en) * | 1995-02-21 | 1998-06-23 | Cornell Research Foundation, Inc. | Chimeric adenoviral fiber protein and methods of using same |
NZ323834A (en) * | 1995-11-28 | 2000-01-28 | Genvec Inc | Chimeric adenovirus coat protein vectors and methods for gene transfer to cells |
JP2001520511A (ja) * | 1995-12-08 | 2001-10-30 | ザ ユーナヴァーサティ オブ アラバマ アト バーミングハム リサーチ ファンデーション | 向標的性アデノウイルス・ベクター |
BR9908018A (pt) * | 1998-02-17 | 2000-10-24 | Uab Research Foundation | Adenovìrus modificado contendo uma proteìna de substituição de fibra |
-
2000
- 2000-06-30 AU AU60401/00A patent/AU763733B2/en not_active Ceased
- 2000-06-30 CA CA002378324A patent/CA2378324A1/fr not_active Abandoned
- 2000-06-30 CN CN00809885A patent/CN1359391A/zh active Pending
- 2000-06-30 KR KR1020027000132A patent/KR20020092886A/ko not_active Application Discontinuation
- 2000-06-30 EP EP00946680A patent/EP1196435A1/fr not_active Withdrawn
- 2000-06-30 WO PCT/SE2000/001390 patent/WO2001002431A1/fr not_active Application Discontinuation
- 2000-06-30 JP JP2001508218A patent/JP2003531568A/ja active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104634978A (zh) * | 2013-11-13 | 2015-05-20 | 长春百克生物科技股份公司 | 一种分型检测腺病毒中和抗体的方法以及用于分型检测腺病毒中和抗体的试剂盒 |
Also Published As
Publication number | Publication date |
---|---|
AU763733B2 (en) | 2003-07-31 |
WO2001002431A1 (fr) | 2001-01-11 |
AU6040100A (en) | 2001-01-22 |
KR20020092886A (ko) | 2002-12-12 |
JP2003531568A (ja) | 2003-10-28 |
EP1196435A1 (fr) | 2002-04-17 |
CN1359391A (zh) | 2002-07-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Dead |