CA2373509A1 - Pyridones aryle et heteroaryle polycycliques substituees utilisees pour l'inhibition selective de la cascade de coagulation - Google Patents
Pyridones aryle et heteroaryle polycycliques substituees utilisees pour l'inhibition selective de la cascade de coagulation Download PDFInfo
- Publication number
- CA2373509A1 CA2373509A1 CA002373509A CA2373509A CA2373509A1 CA 2373509 A1 CA2373509 A1 CA 2373509A1 CA 002373509 A CA002373509 A CA 002373509A CA 2373509 A CA2373509 A CA 2373509A CA 2373509 A1 CA2373509 A1 CA 2373509A1
- Authority
- CA
- Canada
- Prior art keywords
- group
- hydrido
- amino
- carbon
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 0 *CC=***(C(*)=C(*)C(*)=C1*N*)C1=O Chemical compound *CC=***(C(*)=C(*)C(*)=C1*N*)C1=O 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/76—Nitrogen atoms to which a second hetero atom is attached
- C07D213/77—Hydrazine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Quinoline Compounds (AREA)
Abstract
L'invention concerne des composés de pyridone aryle et hétéroaryle polycycliques substitués de formule (I) ou un sel pharmaceutiquement acceptable desdits composés, a, o et ~ étant choisis dans le groupe constitué par NH et NOH, utilisés comme inhibiteurs de sérine protéases de la cascade de coagulation. L'invention concerne également des composés, des compositions et des méthodes utilisés dans la thérapie anticoagulante pour le traitement et la prévention de nombreux états thrombotiques, tels que les coronaropathies et les affections cérébrovasculaires.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13481199P | 1999-05-19 | 1999-05-19 | |
US60/134,811 | 1999-05-19 | ||
PCT/US2000/008220 WO2000069826A1 (fr) | 1999-05-19 | 2000-05-15 | Pyridones aryle et heteroaryle polycycliques substituees utilisees pour l'inhibition selective de la cascade de coagulation |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2373509A1 true CA2373509A1 (fr) | 2000-11-23 |
Family
ID=22465131
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002373509A Abandoned CA2373509A1 (fr) | 1999-05-19 | 2000-05-15 | Pyridones aryle et heteroaryle polycycliques substituees utilisees pour l'inhibition selective de la cascade de coagulation |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP1178964A1 (fr) |
JP (1) | JP2002544260A (fr) |
KR (1) | KR20010113970A (fr) |
CN (1) | CN1378534A (fr) |
AR (1) | AR029635A1 (fr) |
AU (1) | AU771928B2 (fr) |
BR (1) | BR0011272A (fr) |
CA (1) | CA2373509A1 (fr) |
CZ (1) | CZ20014117A3 (fr) |
EA (1) | EA005367B1 (fr) |
HU (1) | HUP0201996A3 (fr) |
IL (1) | IL146244A0 (fr) |
MX (1) | MXPA01011805A (fr) |
MY (1) | MY138303A (fr) |
NO (1) | NO20015606L (fr) |
NZ (1) | NZ514875A (fr) |
PL (1) | PL352403A1 (fr) |
SK (1) | SK15862001A3 (fr) |
UY (1) | UY26154A1 (fr) |
WO (1) | WO2000069826A1 (fr) |
ZA (2) | ZA200109340B (fr) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6458952B1 (en) | 1999-05-19 | 2002-10-01 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade |
US7015230B1 (en) | 1999-05-19 | 2006-03-21 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade |
US6867217B1 (en) | 1999-05-19 | 2005-03-15 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade |
US6664255B1 (en) | 1999-05-19 | 2003-12-16 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade |
US6716838B1 (en) | 1999-05-19 | 2004-04-06 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils as anticoagulative agents |
US6653316B1 (en) | 1999-05-19 | 2003-11-25 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade |
US6750342B1 (en) | 1999-05-19 | 2004-06-15 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade |
WO2001068605A1 (fr) | 2000-03-13 | 2001-09-20 | Pharmacia Corporation | Benzenes polycycliques substitues aryle et heteroaryle utiles pour l'inhibition selective de la cascade de coagulation |
JP2004505014A (ja) | 2000-04-05 | 2004-02-19 | ファルマシア・コーポレーション | 凝血カスケードの選択的阻害に有用な多環式アリールおよびヘテロアリール置換された4−ピロン類 |
JP2004505013A (ja) | 2000-04-05 | 2004-02-19 | ファルマシア・コーポレーション | 凝固カスケードを選択的に阻害するのに有用な多環式アリール及びヘテロアリール置換4−ピリドン類 |
WO2001079195A2 (fr) * | 2000-04-14 | 2001-10-25 | Corvas International, Inc. | Nouveaux inhibiteurs de thrombine de type non covalent |
US20040171616A9 (en) | 2000-04-17 | 2004-09-02 | South Michael S. | Polycyclic aryl and heteroaryl substituted 1,4-quinones useful for selective inhibition of the coagulation cascade |
AU2001217827A1 (en) * | 2000-05-18 | 2001-11-26 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade |
US6710058B2 (en) | 2000-11-06 | 2004-03-23 | Bristol-Myers Squibb Pharma Company | Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors |
JP2004517074A (ja) | 2000-11-20 | 2004-06-10 | ファルマシア・コーポレーション | 凝血カスケードを選択的に阻害するのに有用な置換された多環アリールおよびヘテロアリールピリジン類 |
US7015223B1 (en) | 2000-11-20 | 2006-03-21 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl 1,2,4-triazinones useful for selective inhibition of the coagulation cascade |
US7119094B1 (en) | 2000-11-20 | 2006-10-10 | Warner-Lambert Company | Substituted polycyclic aryl and heteroarpyl pyrazinones useful for selective inhibition of the coagulation cascade |
DK1357111T3 (da) | 2000-12-28 | 2009-11-02 | Shionogi & Co | 2-pyridonderivater med affinitet for cannabinoid type 2-receptor |
US6969715B2 (en) | 2001-10-03 | 2005-11-29 | Pharmacia Corporation | 6-membered heterocyclic compounds useful for selective inhibition of the coagulation cascade |
EP1432687A2 (fr) | 2001-10-03 | 2004-06-30 | Pharmacia Corporation | Composes polycycliques a 5 elements substitues pour l'inhibition selective de la cascade de reactions dans la coagulation sanguine |
WO2003048127A1 (fr) * | 2001-12-04 | 2003-06-12 | Corvas International, Inc. | Inhibiteurs non covalents heterocycliques aromatiques de l'urokinase et de la formation de vaisseaux sanguins |
TW200307667A (en) | 2002-05-06 | 2003-12-16 | Bristol Myers Squibb Co | Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors |
JP5864546B2 (ja) | 2010-05-07 | 2016-02-17 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーGlaxoSmithKline LLC | インダゾール |
TWI633089B (zh) * | 2013-03-28 | 2018-08-21 | 拜耳製藥股份有限公司 | 經取代的酮基吡啶衍生物 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997001338A1 (fr) * | 1995-06-27 | 1997-01-16 | Merck & Co., Inc. | Inhibiteurs de la thrombine a base de pyridinone |
AU720616B2 (en) * | 1996-02-22 | 2000-06-08 | Merck & Co., Inc. | Pyridinone thrombin inhibitors |
WO1999011267A1 (fr) * | 1997-09-05 | 1999-03-11 | Merck & Co., Inc. | Inhibiteurs de thrombine a base de pyrazinone |
AU743544B2 (en) * | 1996-10-11 | 2002-01-31 | Millennium Pharmaceuticals, Inc. | Selective factor Xa inhibitors |
US5792779A (en) * | 1997-02-19 | 1998-08-11 | Merck & Co., Inc. | Pyridinone thrombin inhibitors |
JP2001518932A (ja) * | 1997-03-24 | 2001-10-16 | メルク エンド カンパニー インコーポレーテッド | トロンビン阻害薬 |
IL123986A (en) * | 1997-04-24 | 2011-10-31 | Organon Nv | Medicinal compounds |
WO1999000126A1 (fr) * | 1997-06-26 | 1999-01-07 | Eli Lilly And Company | Agents antithrombotiques |
EP1036063B1 (fr) * | 1997-11-26 | 2006-11-02 | Ortho-McNeil Pharmaceuticals, Inc. | Aminoguanidines et alcoxyguanidines heteroaryliques et leur utilisation en tant qu'inhibiteurs de protease |
AU758237B2 (en) * | 1998-09-28 | 2003-03-20 | Merck & Co., Inc. | Thrombin inhibitors |
AU752186B2 (en) * | 1998-10-30 | 2002-09-12 | Merck & Co., Inc. | Thrombin inhibitors |
US6610692B1 (en) * | 1998-10-30 | 2003-08-26 | Merck & Co., Inc. | Thrombin inhibitors |
FR2786482B1 (fr) * | 1998-11-27 | 2002-08-09 | Synthelabo | Nouveaux derives de 2-pyridone, leur preparation et leur application en therapeutique |
-
2000
- 2000-05-15 BR BR0011272-0A patent/BR0011272A/pt not_active IP Right Cessation
- 2000-05-15 EA EA200101213A patent/EA005367B1/ru not_active IP Right Cessation
- 2000-05-15 CA CA002373509A patent/CA2373509A1/fr not_active Abandoned
- 2000-05-15 WO PCT/US2000/008220 patent/WO2000069826A1/fr not_active Application Discontinuation
- 2000-05-15 CN CN00810182A patent/CN1378534A/zh active Pending
- 2000-05-15 JP JP2000618243A patent/JP2002544260A/ja active Pending
- 2000-05-15 NZ NZ514875A patent/NZ514875A/en unknown
- 2000-05-15 MX MXPA01011805A patent/MXPA01011805A/es active IP Right Grant
- 2000-05-15 PL PL00352403A patent/PL352403A1/xx not_active Application Discontinuation
- 2000-05-15 IL IL14624400A patent/IL146244A0/xx unknown
- 2000-05-15 CZ CZ20014117A patent/CZ20014117A3/cs unknown
- 2000-05-15 EP EP00930092A patent/EP1178964A1/fr not_active Withdrawn
- 2000-05-15 HU HU0201996A patent/HUP0201996A3/hu unknown
- 2000-05-15 SK SK1586-2001A patent/SK15862001A3/sk unknown
- 2000-05-15 KR KR1020017014751A patent/KR20010113970A/ko not_active Application Discontinuation
- 2000-05-15 AU AU47973/00A patent/AU771928B2/en not_active Ceased
- 2000-05-19 MY MYPI20002212A patent/MY138303A/en unknown
- 2000-05-19 AR ARP000102448A patent/AR029635A1/es unknown
- 2000-05-19 UY UY26154A patent/UY26154A1/es not_active Application Discontinuation
-
2001
- 2001-11-13 ZA ZA200109340A patent/ZA200109340B/xx unknown
- 2001-11-16 NO NO20015606A patent/NO20015606L/no not_active Application Discontinuation
-
2004
- 2004-01-21 ZA ZA200400449A patent/ZA200400449B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
SK15862001A3 (sk) | 2002-08-06 |
KR20010113970A (ko) | 2001-12-28 |
UY26154A1 (es) | 2000-12-29 |
NZ514875A (en) | 2004-10-29 |
AR029635A1 (es) | 2003-07-10 |
EA200101213A1 (ru) | 2002-04-25 |
CZ20014117A3 (cs) | 2002-05-15 |
MXPA01011805A (es) | 2003-09-04 |
JP2002544260A (ja) | 2002-12-24 |
ZA200109340B (en) | 2004-05-26 |
IL146244A0 (en) | 2002-07-25 |
MY138303A (en) | 2009-05-29 |
CN1378534A (zh) | 2002-11-06 |
BR0011272A (pt) | 2002-05-07 |
NO20015606D0 (no) | 2001-11-16 |
ZA200400449B (en) | 2004-11-24 |
AU4797300A (en) | 2000-12-05 |
EA005367B1 (ru) | 2005-02-24 |
HUP0201996A2 (en) | 2002-09-28 |
AU771928B2 (en) | 2004-04-08 |
EP1178964A1 (fr) | 2002-02-13 |
WO2000069826A1 (fr) | 2000-11-23 |
HUP0201996A3 (en) | 2002-12-28 |
PL352403A1 (en) | 2003-08-25 |
NO20015606L (no) | 2002-01-21 |
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