CA2363123C - Solid oral dosage form containing an enhancer - Google Patents
Solid oral dosage form containing an enhancer Download PDFInfo
- Publication number
- CA2363123C CA2363123C CA2363123A CA2363123A CA2363123C CA 2363123 C CA2363123 C CA 2363123C CA 2363123 A CA2363123 A CA 2363123A CA 2363123 A CA2363123 A CA 2363123A CA 2363123 C CA2363123 C CA 2363123C
- Authority
- CA
- Canada
- Prior art keywords
- dosage form
- oral dosage
- solid oral
- drug
- enhancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000003623 enhancer Substances 0.000 title claims abstract description 113
- 239000007787 solid Substances 0.000 title claims abstract description 69
- 239000006186 oral dosage form Substances 0.000 title claims abstract description 66
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- 239000002552 dosage form Substances 0.000 claims abstract description 52
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- 125000004432 carbon atom Chemical group C* 0.000 claims abstract description 14
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12104899P | 1999-02-22 | 1999-02-22 | |
| US60/121,048 | 1999-02-22 | ||
| PCT/GB2000/000628 WO2000050012A1 (en) | 1999-02-22 | 2000-02-22 | Solid oral dosage form containing an enhancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2363123A1 CA2363123A1 (en) | 2000-08-31 |
| CA2363123C true CA2363123C (en) | 2011-09-06 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2363123A Expired - Fee Related CA2363123C (en) | 1999-02-22 | 2000-02-22 | Solid oral dosage form containing an enhancer |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1154761B1 (https=) |
| JP (2) | JP2002537321A (https=) |
| AT (1) | ATE386508T1 (https=) |
| AU (1) | AU2681300A (https=) |
| CA (1) | CA2363123C (https=) |
| DE (1) | DE60038097T2 (https=) |
| ES (1) | ES2301477T3 (https=) |
| WO (1) | WO2000050012A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8241670B2 (en) | 2004-04-15 | 2012-08-14 | Chiasma Inc. | Compositions capable of facilitating penetration across a biological barrier |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US6478771B1 (en) | 1998-11-13 | 2002-11-12 | Elan Pharma International Limited | Drug delivery systems and methods |
| US7084279B1 (en) | 1999-02-11 | 2006-08-01 | Emisphere Technologies Inc. | Oxadiazole compounds and compositions for delivering active agents |
| US7658938B2 (en) | 1999-02-22 | 2010-02-09 | Merrion Reasearch III Limited | Solid oral dosage form containing an enhancer |
| JP2007016034A (ja) * | 2000-12-26 | 2007-01-25 | Kirin Brewery Co Ltd | 吸収促進剤 |
| JP2004525110A (ja) * | 2001-02-16 | 2004-08-19 | 清水製薬株式会社 | ムコ多糖類製剤およびその製造法 |
| EP1392272B1 (en) * | 2001-05-11 | 2014-08-06 | Merrion Research III Limited | Permeation enhancers |
| AU2014200247B2 (en) * | 2004-07-19 | 2015-05-14 | Biocon Limited | Insulin-oligomer conjugates, formulations and uses thereof |
| RU2527893C2 (ru) * | 2004-07-19 | 2014-09-10 | Биокон Лимитед | Инсулин-олигомерные конъюгаты, их препараты и применения |
| EP1781257B1 (en) * | 2004-08-13 | 2018-12-19 | Emisphere Technologies, Inc. | Pharmaceutical formulations containing microparticles or nanoparticles of a delivery agent |
| JP4759289B2 (ja) * | 2005-03-02 | 2011-08-31 | 国立大学法人北海道大学 | カルシウム吸収促進組成物およびその利用 |
| BRPI0710503A2 (pt) | 2006-04-07 | 2011-08-16 | Merrion Res Iii Ltd | uso de uma composição farmacêutica, composição farmacêutica, e, forma de dosagem oral |
| JP2009539862A (ja) * | 2006-06-09 | 2009-11-19 | メリオン リサーチ Ｉｉｉ リミテッド | 強化剤を含む固体経口投与剤形 |
| EA200970267A1 (ru) * | 2006-09-12 | 2009-08-28 | Глэксо Груп Лимитед | ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ВКЛЮЧАЮЩАЯ МНОЖЕСТВО МИНИ-ТАБЛЕТОК, СОДЕРЖАЩИХ ИНГИБИТОР ФАКТОРА Xa |
| RU2453332C2 (ru) * | 2007-10-16 | 2012-06-20 | Байокон Лимитид | Твердая фармацевтическая композиция (варианты) и способ контроля концентрации глюкозы с ее помощью, способ получения твердой фармацевтической композиции (варианты), таблетка (варианты) и способ получения амфорных частиц |
| WO2009061805A1 (en) * | 2007-11-05 | 2009-05-14 | Scolr Pharma, Inc. | Formulations for enhanced bioavailability of orally administered polar agents |
| RU2517135C2 (ru) * | 2008-05-07 | 2014-05-27 | Меррион Рисерч Iii Лимитед | Композиции пептидов и способы их получения |
| KR101814186B1 (ko) | 2008-09-17 | 2018-03-14 | 키아스마 인코포레이티드 | 약제학적 조성물 및 연관된 투여방법 |
| GB0904942D0 (en) * | 2009-03-23 | 2009-05-06 | Ntnu Technology Transfer As | Composition |
| CA2769633C (en) | 2009-07-31 | 2017-06-06 | Thar Pharma, Llc | Crystallization method and bioavailability |
| US9169279B2 (en) | 2009-07-31 | 2015-10-27 | Thar Pharmaceuticals, Inc. | Crystallization method and bioavailability |
| US20160016982A1 (en) | 2009-07-31 | 2016-01-21 | Thar Pharmaceuticals, Inc. | Crystallization method and bioavailability |
| AU2010339907A1 (en) | 2009-12-16 | 2012-07-05 | Nod Pharmaceuticals, Inc. | Compositions and methods for oral drug delivery |
| US20110182985A1 (en) * | 2010-01-28 | 2011-07-28 | Coughlan David C | Solid Pharmaceutical Composition with Enhancers and Methods of Preparing thereof |
| US9089484B2 (en) * | 2010-03-26 | 2015-07-28 | Merrion Research Iii Limited | Pharmaceutical compositions of selective factor Xa inhibitors for oral administration |
| WO2012071517A2 (en) | 2010-11-24 | 2012-05-31 | Thar Pharmaceuticals, Inc. | Novel crystalline forms |
| KR20140046395A (ko) * | 2010-12-15 | 2014-04-18 | 메리온 리서치 Ⅲ 리미티드 | 경구 투여를 위한 선택적 인자 ｘａ 억제제의 제약 조성물 |
| SI2651398T1 (en) | 2010-12-16 | 2018-04-30 | Novo Nordisk A/S | SOLID COMPOSITIONS CONTAINING GLP-1 AGONIST AND SOL N- (8- (2-HYDROXYBENZOIL) AMINO) CAPRICULATE ACIDS |
| KR20140026354A (ko) * | 2011-01-07 | 2014-03-05 | 메리온 리서치 Ⅲ 리미티드 | 경구 투여용 철의 제약 조성물 |
| PL2696687T3 (pl) | 2011-04-12 | 2017-06-30 | Novo Nordisk A/S | Pochodne podwójnie acylowanej GLP-1 |
| ES2965469T3 (es) | 2012-03-22 | 2024-04-15 | Novo Nordisk As | Composiciones que comprenden un agente de suministro y preparación de estas |
| HRP20181447T1 (hr) | 2012-03-22 | 2018-11-02 | Novo Nordisk A/S | Pripravci glp-1 peptida i njihova priprava |
| PT2827845T (pt) | 2012-03-22 | 2019-03-29 | Novo Nordisk As | Composições compreendendo um agente de entrega e sua preparação |
| JP6517690B2 (ja) | 2012-06-20 | 2019-05-22 | ノヴォ ノルディスク アー／エス | ペプチド及び送達剤を含む錠剤製剤 |
| KR102272671B1 (ko) | 2013-05-02 | 2021-07-06 | 노보 노르디스크 에이/에스 | Glp-1 화합물의 경구 투여 |
| JP7211704B2 (ja) | 2015-01-29 | 2023-01-24 | ノヴォ ノルディスク アー／エス | Ｇｌｐ－１アゴニスト及び腸溶コーティングを含む錠剤 |
| WO2016126830A1 (en) | 2015-02-03 | 2016-08-11 | Chiasma Inc. | Method of treating diseases |
| LT3280447T (lt) * | 2015-04-08 | 2019-05-27 | Torrent Pharmaceuticals Limited | Farmacinės kompozicijos |
| GB201515387D0 (en) | 2015-08-28 | 2015-10-14 | Amazentis Sa | Compositions |
| US10946074B2 (en) | 2016-03-03 | 2021-03-16 | Novo Nordisk A/S | GLP-1 derivatives and uses thereof |
| WO2017208070A1 (en) | 2016-05-31 | 2017-12-07 | Grünenthal GmbH | Bisphosphonic acid and coformers with lysin, glycin, nicotinamide for treating psoriatic arthritis |
| MA49617A (fr) | 2017-07-19 | 2020-05-27 | Novo Nordisk As | Analogues d'egf(a), préparation, formulations et utilisations associées |
| JP6898518B2 (ja) | 2018-02-02 | 2021-07-07 | ノヴォ ノルディスク アー／エス | Ｇｌｐ−１アゴニスト、ｎ−（８−（２−ヒドロキシベンゾイル）アミノ）カプリル酸の塩及び滑沢剤を含む固形組成物 |
| US11141457B1 (en) | 2020-12-28 | 2021-10-12 | Amryt Endo, Inc. | Oral octreotide therapy and contraceptive methods |
| JPWO2024143501A1 (https=) * | 2022-12-28 | 2024-07-04 |
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-
2000
- 2000-02-22 DE DE60038097T patent/DE60038097T2/de not_active Expired - Lifetime
- 2000-02-22 WO PCT/GB2000/000628 patent/WO2000050012A1/en not_active Ceased
- 2000-02-22 AT AT00905186T patent/ATE386508T1/de not_active IP Right Cessation
- 2000-02-22 EP EP00905186A patent/EP1154761B1/en not_active Expired - Lifetime
- 2000-02-22 JP JP2000600624A patent/JP2002537321A/ja active Pending
- 2000-02-22 AU AU26813/00A patent/AU2681300A/en not_active Abandoned
- 2000-02-22 CA CA2363123A patent/CA2363123C/en not_active Expired - Fee Related
- 2000-02-22 ES ES00905186T patent/ES2301477T3/es not_active Expired - Lifetime
-
2011
- 2011-11-07 JP JP2011243450A patent/JP5412491B2/ja not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8241670B2 (en) | 2004-04-15 | 2012-08-14 | Chiasma Inc. | Compositions capable of facilitating penetration across a biological barrier |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2002537321A (ja) | 2002-11-05 |
| CA2363123A1 (en) | 2000-08-31 |
| JP5412491B2 (ja) | 2014-02-12 |
| AU2681300A (en) | 2000-09-14 |
| DE60038097D1 (de) | 2008-04-03 |
| WO2000050012A1 (en) | 2000-08-31 |
| ES2301477T3 (es) | 2008-07-01 |
| EP1154761B1 (en) | 2008-02-20 |
| EP1154761A1 (en) | 2001-11-21 |
| DE60038097T2 (de) | 2009-02-12 |
| JP2012067115A (ja) | 2012-04-05 |
| ATE386508T1 (de) | 2008-03-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20170222 |