CA2361013A1 - Rapid and sensitive detection of aberrant protein aggregation in neurodegenerative diseases - Google Patents

Rapid and sensitive detection of aberrant protein aggregation in neurodegenerative diseases Download PDF

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Publication number
CA2361013A1
CA2361013A1 CA002361013A CA2361013A CA2361013A1 CA 2361013 A1 CA2361013 A1 CA 2361013A1 CA 002361013 A CA002361013 A CA 002361013A CA 2361013 A CA2361013 A CA 2361013A CA 2361013 A1 CA2361013 A1 CA 2361013A1
Authority
CA
Canada
Prior art keywords
species
forming
fibril
binding
aggregate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002361013A
Other languages
English (en)
French (fr)
Inventor
R. Shoshana Bamdad
Cynthia Carol Bamdad
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Minerva Biotechnologies Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2361013A1 publication Critical patent/CA2361013A1/en
Abandoned legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders

Landscapes

  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nanotechnology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Neurosurgery (AREA)
  • Food Science & Technology (AREA)
  • Neurology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Composite Materials (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Materials Engineering (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CA002361013A 1999-01-25 2000-01-25 Rapid and sensitive detection of aberrant protein aggregation in neurodegenerative diseases Abandoned CA2361013A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US11712699P 1999-01-25 1999-01-25
US60/117,126 1999-01-25
US13228899P 1999-05-03 1999-05-03
US60/132,288 1999-05-03
US15593799P 1999-09-24 1999-09-24
US60/155,937 1999-09-24
PCT/US2000/001997 WO2000043791A2 (en) 1999-01-25 2000-01-25 Rapid and sensitive detection of aberrant protein aggregation in neurodegenerative diseases

Publications (1)

Publication Number Publication Date
CA2361013A1 true CA2361013A1 (en) 2000-07-27

Family

ID=27381935

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002361013A Abandoned CA2361013A1 (en) 1999-01-25 2000-01-25 Rapid and sensitive detection of aberrant protein aggregation in neurodegenerative diseases

Country Status (5)

Country Link
EP (1) EP1169646A2 (enExample)
JP (2) JP5122705B2 (enExample)
AU (1) AU3474100A (enExample)
CA (1) CA2361013A1 (enExample)
WO (1) WO2000043791A2 (enExample)

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AU2003300371A1 (en) 2002-12-20 2004-07-22 Minerva Biotechnologies Corporation Optical devices and methods involving nanoparticles
ES2398394T3 (es) 2003-08-13 2013-03-15 Novartis Vaccines And Diagnostics, Inc. Reactivos peptídicos específicos de prión
DE602005016537D1 (de) 2004-03-31 2009-10-22 Anges Mg Inc Testverfahren zur identifizierung eines kandidatenarzneistoffs
DE102004040119A1 (de) * 2004-08-18 2006-04-27 Heinrich-Heine-Universität Düsseldorf Mittel zur Therapie und Prävention von Prionenerkrankungen
US20090130774A1 (en) * 2005-01-13 2009-05-21 David Peretz Elisa assays using prion-specific peptide reagents
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JP5097206B2 (ja) 2006-07-28 2012-12-12 エイディーライフ インコーポレイティッド 診断および治療のためのペプチドプローブ
AU2009246397B2 (en) 2008-05-13 2013-01-17 University Of Kansas Metal abstraction peptide (MAP) tag and associated methods
KR20160017117A (ko) 2008-10-09 2016-02-15 미네르바 바이오테크놀로지 코포레이션 세포내에서 다능성을 유도하기 위한 방법
WO2012017739A1 (ja) * 2010-07-31 2012-02-09 エレコン科学株式会社 アミロイドアッセイ装置およびアミロイドアッセイ方法
EP4086338A1 (en) 2011-03-17 2022-11-09 Minerva Biotechnologies Corporation Method for making pluripotent stem cells
KR101352849B1 (ko) * 2012-01-03 2014-01-21 주식회사 나노엔텍 멀티머-형성 폴리펩타이드의 멀티머형을 분별 검출하는 방법
WO2013181461A2 (en) 2012-06-01 2013-12-05 University Of Kansas Metal abstraction peptide with superoxide dismutase activity
JP2016520846A (ja) * 2013-06-06 2016-07-14 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． 多量体の標的分子の検出に対する粒子ベースの試験において凝集を防ぐ試薬、方法及び装置
EP3256494A4 (en) 2015-02-10 2018-12-05 Minerva Biotechnologies Corporation Humanized anti-muc1* antibodies
JP6630972B2 (ja) * 2015-03-24 2020-01-15 学校法人甲南学園 アミロイドβペプチドを電気化学的に測定するためのバイオセンサ
WO2017138696A1 (ko) * 2016-02-12 2017-08-17 주식회사 캔티스 단백질 응집형의 검출 방법, 전기화학적 검출 키트 및 이를 이용한 비정상 단백질 응집 관련 질병의 진단 방법 및 전기화학적 진단 키트
US11167283B2 (en) 2018-05-04 2021-11-09 University Of South Carolina Dot blot box and use thereof
CA3183682A1 (en) 2020-06-26 2021-12-30 Minerva Biotechnologies Corporation Anti-nme antibody and method of treating cancer or cancer metastasis
CA3248038A1 (en) 2022-04-12 2023-10-19 Minerva Biotechnologies Corporation ANTI-MUC1* VARIABLE ANTIBODIES AND RELATED USES

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Also Published As

Publication number Publication date
JP2002540383A (ja) 2002-11-26
JP5122705B2 (ja) 2013-01-16
WO2000043791A3 (en) 2001-07-26
JP2012230124A (ja) 2012-11-22
WO2000043791A9 (en) 2002-03-28
WO2000043791A2 (en) 2000-07-27
EP1169646A2 (en) 2002-01-09
AU3474100A (en) 2000-08-07

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued