CA2354672C - Desaturases et leurs methodes d'utilisation pour la synthese d'acides gras polyinsatures - Google Patents
Desaturases et leurs methodes d'utilisation pour la synthese d'acides gras polyinsatures Download PDFInfo
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- CA2354672C CA2354672C CA2354672A CA2354672A CA2354672C CA 2354672 C CA2354672 C CA 2354672C CA 2354672 A CA2354672 A CA 2354672A CA 2354672 A CA2354672 A CA 2354672A CA 2354672 C CA2354672 C CA 2354672C
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- 238000012546 transfer Methods 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 108010058119 tryptophyl-glycyl-glycine Proteins 0.000 description 1
- 108010044292 tryptophyltyrosine Proteins 0.000 description 1
- 108010079202 tyrosyl-alanyl-cysteine Proteins 0.000 description 1
- 108010077037 tyrosyl-tyrosyl-phenylalanine Proteins 0.000 description 1
- 108010003137 tyrosyltyrosine Proteins 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 241000701447 unidentified baculovirus Species 0.000 description 1
- 241001430294 unidentified retrovirus Species 0.000 description 1
- 125000002987 valine group Chemical group [H]N([H])C([H])(C(*)=O)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 108010073969 valyllysine Proteins 0.000 description 1
- 239000013603 viral vector Substances 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 108010027345 wheylin-1 peptide Proteins 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
- C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
- C12P7/6432—Eicosapentaenoic acids [EPA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
- C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
- C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6436—Fatty acid esters
- C12P7/6445—Glycerides
- C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
Abstract
L'invention concerne les séquences d'acides aminés et d'acides nucléiques d'une enzyme .DELTA.?5¿-désaturase et d'une enzyme .DELTA.?8¿-désaturase. Les séquences d'acides nucléiques peuvent s'utiliser pour mettre au point des produits de recombinaison et des vecteurs d'ADN recombiné. Ces vecteurs peuvent ensuite s'utiliser pour transformer plusieurs organismes, y compris par exemple, des végétaux et de la levure. Les organismes transformés produisent ensuite des acides gras polyinsaturés. Les séquences d'acides aminés s'utilisent pour générer des anticorps spécifiques aux enzymes permettant d'identifier les désaturases.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2791961A CA2791961A1 (fr) | 1998-12-07 | 1999-12-06 | Desaturases et leurs methodes d'utilisation pour la synthese d'acides gras polyinsatures |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11130198P | 1998-12-07 | 1998-12-07 | |
US60/111,301 | 1998-12-07 | ||
PCT/US1999/028655 WO2000034439A1 (fr) | 1998-12-07 | 1999-12-06 | Desaturases et leurs methodes d'utilisation pour la synthese d'acides gras polyinsatures |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2791961A Division CA2791961A1 (fr) | 1998-12-07 | 1999-12-06 | Desaturases et leurs methodes d'utilisation pour la synthese d'acides gras polyinsatures |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2354672A1 CA2354672A1 (fr) | 2000-06-15 |
CA2354672C true CA2354672C (fr) | 2012-10-02 |
Family
ID=22337705
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2354672A Expired - Lifetime CA2354672C (fr) | 1998-12-07 | 1999-12-06 | Desaturases et leurs methodes d'utilisation pour la synthese d'acides gras polyinsatures |
CA2791961A Abandoned CA2791961A1 (fr) | 1998-12-07 | 1999-12-06 | Desaturases et leurs methodes d'utilisation pour la synthese d'acides gras polyinsatures |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2791961A Abandoned CA2791961A1 (fr) | 1998-12-07 | 1999-12-06 | Desaturases et leurs methodes d'utilisation pour la synthese d'acides gras polyinsatures |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP1147174B1 (fr) |
JP (1) | JP4383671B2 (fr) |
AT (1) | ATE353952T1 (fr) |
AU (1) | AU776711B2 (fr) |
CA (2) | CA2354672C (fr) |
DE (1) | DE69935162T2 (fr) |
NZ (1) | NZ512656A (fr) |
WO (1) | WO2000034439A1 (fr) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1911837T3 (da) | 2000-09-28 | 2011-08-29 | Bioriginal Food & Science Corp | FAD5-2 fedtsyredesaturasefamiliemedlem og anvendelser deraf |
DE10102338A1 (de) * | 2001-01-19 | 2002-07-25 | Basf Plant Science Gmbh | Verfahren zur Expression von Biosynthesegenen in pflanzlichen Samen unter Verwendung von neuen multiplen Expressionskonstrukten |
JP4900746B2 (ja) * | 2001-02-28 | 2012-03-21 | 月桂冠株式会社 | 香気成分高生産性酵母 |
GB0107510D0 (en) | 2001-03-26 | 2001-05-16 | Univ Bristol | New elongase gene and a process for the production of -9-polyunsaturated fatty acids |
AU2003296638B2 (en) * | 2002-12-19 | 2009-06-11 | University Of Bristol | Method for the production of polyunsaturated fatty acids |
GB0229578D0 (en) * | 2002-12-19 | 2003-01-22 | Univ Bristol | Novel method for the production of polyunsaturated fatty acids |
US11952581B2 (en) | 2003-08-01 | 2024-04-09 | Basf Plant Science Gmbh | Process for the production of polyunsaturated fatty acids in transgenic organisms |
EP2166090B1 (fr) | 2003-08-01 | 2015-07-01 | BASF Plant Science GmbH | Procédé de fabrication d'acides gras insaturés de manière multiple dans des organismes transgéniques |
WO2005083053A2 (fr) | 2004-02-27 | 2005-09-09 | Basf Plant Science Gmbh | Procede pour produire des acides gras $g(v)-3 insatures dans des organismes transgeniques |
MXPA06009572A (es) | 2004-02-27 | 2007-05-23 | Basf Plant Science Gmbh | Metodo para la produccion de acidos grasos poliinsaturados en plantas transgenicas. |
ES2529572T3 (es) | 2004-04-22 | 2015-02-23 | Commonwealth Scientific And Industrial Research Organisation | Síntesis de ácidos grasos poliinsaturados de cadena larga por células recombinantes |
EP2357244A3 (fr) | 2004-04-22 | 2011-11-23 | Commonwealth Scientific and Industrial Research Organisation | Synthèse d'acides gras polyinsaturés à longue chaîne par cellules recombinantes |
JP4955540B2 (ja) | 2004-06-04 | 2012-06-20 | フラクスオーム サイエンセズ エイ/エス | 多価不飽和脂肪酸生産のための代謝改変細胞 |
US7256033B2 (en) | 2004-06-25 | 2007-08-14 | E. I. Du Pont De Nemours And Company | Delta-8 desaturase and its use in making polyunsaturated fatty acids |
US7550286B2 (en) * | 2004-11-04 | 2009-06-23 | E. I. Du Pont De Nemours And Company | Docosahexaenoic acid producing strains of Yarrowia lipolytica |
GB2431158A (en) | 2005-10-13 | 2007-04-18 | Rothamsted Res Ltd | Process for the production of arachidonic and/or eicosapentaenoic acid |
CA2624661C (fr) | 2005-11-23 | 2015-06-30 | E.I. Du Pont De Nemours And Company | Delta-9 elongases et leur utilisation pour produire de acides gras polyinsatures |
AR059376A1 (es) | 2006-02-21 | 2008-03-26 | Basf Plant Science Gmbh | Procedimiento para la produccion de acidos grasos poliinsaturados |
US7943823B2 (en) | 2006-04-28 | 2011-05-17 | E.I. Du Pont De Nemours And Company | Delta-8 desaturase and its use in making polyunsaturated fatty acids |
US7695950B2 (en) | 2006-05-17 | 2010-04-13 | E. I. Du Pont De Nemours And Company | Δ5 desaturase and its use in making polyunsaturated fatty acids |
US7678560B2 (en) | 2006-05-17 | 2010-03-16 | E.I. Du Pont De Nemours And Company | Δ 5 desaturase and its use in making polyunsaturated fatty acids |
PL2390339T3 (pl) | 2006-10-23 | 2013-12-31 | Du Pont | Delta-8 desaturazy i ich zastosowanie w wytwarzaniu polinienasyconych kwasów tłuszczowych |
WO2008073275A2 (fr) | 2006-12-07 | 2008-06-19 | E. I. Du Pont De Nemours And Company | Gènes mutants de la désaturase delta 8 modifiés par mutagenèse ciblée et utilisation de ceux-ci dans la fabrication d'acides gras polyinsaturés |
US7709239B2 (en) | 2006-12-07 | 2010-05-04 | E.I. Du Pont De Nemours And Company | Mutant Δ8 desaturase genes engineered by targeted mutagenesis and their use in making polyunsaturated fatty acids |
EP2121934A2 (fr) | 2007-02-12 | 2009-11-25 | E. I. Du Pont de Nemours and Company | Production d'acide arachidonique dans des plantes à graines oléagineuses |
MX2009010574A (es) | 2007-04-03 | 2009-10-22 | Du Pont | Multienzimas y su uso en la fabricacion de acidos grasos poliinsaturados. |
US8188338B2 (en) * | 2007-04-10 | 2012-05-29 | E. I. Du Pont De Nemours And Company | Delta-8 desaturases and their use in making polyunsaturated fatty acids |
US8119860B2 (en) | 2007-04-16 | 2012-02-21 | E. I. Du Pont De Nemours And Company | Delta-9 elongases and their use in making polyunsaturated fatty acids |
US8957280B2 (en) | 2007-05-03 | 2015-02-17 | E. I. Du Pont De Nemours And Company | Delta-5 desaturases and their use in making polyunsaturated fatty acids |
WO2010130725A1 (fr) | 2009-05-13 | 2010-11-18 | Basf Plant Science Company Gmbh | Acyltransférases et leurs utilisations dans la production d'acide gras |
JP2012529277A (ja) | 2009-06-08 | 2012-11-22 | ロザムステッド リサーチ リミテッド | 新規の脂肪酸伸長成分およびその使用 |
DE112010002967T5 (de) | 2009-07-17 | 2012-10-11 | Basf Plant Science Company Gmbh | Neue Fettsäuredesaturasen und -elongasen und Anwendungen davon |
JP2013502914A (ja) | 2009-08-31 | 2013-01-31 | ビーエーエスエフ プラント サイエンス カンパニー ゲーエムベーハー | 多価不飽和脂肪酸合成の増強を促進する植物の種子特異的遺伝子発現を増強する調節核酸分子 |
WO2011064181A1 (fr) | 2009-11-24 | 2011-06-03 | Basf Plant Science Company Gmbh | Nouvelle désaturase d'acides gras et ses utilisations |
EP2504438A1 (fr) | 2009-11-24 | 2012-10-03 | BASF Plant Science Company GmbH | Nouvelle élongase d'acides gras et ses utilisations |
US9388437B2 (en) | 2010-06-25 | 2016-07-12 | Basf Plant Science Company Gmbh | Acyltransferases and uses thereof in fatty acid production |
WO2012052468A2 (fr) | 2010-10-21 | 2012-04-26 | Basf Plant Science Company Gmbh | Nouvelles désaturases d'acides gras, élongases, composants d'allongement leurs utilisations |
AU2013298113A1 (en) | 2012-08-03 | 2015-01-29 | Basf Plant Science Company Gmbh | Novel enzymes, enzyme components and uses thereof |
US20190054127A1 (en) * | 2016-03-04 | 2019-02-21 | Euglena Co., Ltd. | Antiviral agent and antiviral food |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5057419A (en) * | 1988-09-22 | 1991-10-15 | Rutgers University | Genetically engineered plasmid and organisms for the production of specialized oils |
US5614393A (en) * | 1991-10-10 | 1997-03-25 | Rhone-Poulenc Agrochimie | Production of γ-linolenic acid by a Δ6-desaturase |
FR2755638B1 (fr) * | 1996-11-14 | 1999-02-05 | Mphi Sa | Machine de soudage de feuilles ou films en matiere synthetique |
DK0996732T3 (da) * | 1997-04-11 | 2005-10-17 | Calgene Llc | Fremgangsmåder og sammensætninger til syntese af langkædede polyumættede fedtsyrer i planter |
-
1999
- 1999-12-06 WO PCT/US1999/028655 patent/WO2000034439A1/fr active IP Right Grant
- 1999-12-06 AU AU31090/00A patent/AU776711B2/en not_active Expired
- 1999-12-06 DE DE69935162T patent/DE69935162T2/de not_active Expired - Lifetime
- 1999-12-06 AT AT99965105T patent/ATE353952T1/de not_active IP Right Cessation
- 1999-12-06 NZ NZ512656A patent/NZ512656A/en not_active IP Right Cessation
- 1999-12-06 CA CA2354672A patent/CA2354672C/fr not_active Expired - Lifetime
- 1999-12-06 EP EP99965105A patent/EP1147174B1/fr not_active Revoked
- 1999-12-06 CA CA2791961A patent/CA2791961A1/fr not_active Abandoned
- 1999-12-06 JP JP2000586873A patent/JP4383671B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU3109000A (en) | 2000-06-26 |
EP1147174B1 (fr) | 2007-02-14 |
ATE353952T1 (de) | 2007-03-15 |
AU776711B2 (en) | 2004-09-16 |
JP4383671B2 (ja) | 2009-12-16 |
EP1147174A4 (fr) | 2004-10-06 |
EP1147174A1 (fr) | 2001-10-24 |
DE69935162D1 (de) | 2007-03-29 |
JP2002531116A (ja) | 2002-09-24 |
CA2791961A1 (fr) | 2000-06-15 |
WO2000034439A1 (fr) | 2000-06-15 |
NZ512656A (en) | 2003-09-26 |
DE69935162T2 (de) | 2007-11-22 |
CA2354672A1 (fr) | 2000-06-15 |
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Legal Events
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EEER | Examination request | ||
MKEX | Expiry |
Effective date: 20191206 |