CA2354019A1 - Procede de preparation d'esters de sulfoxyde d'acide penicillanique - Google Patents

Procede de preparation d'esters de sulfoxyde d'acide penicillanique Download PDF

Info

Publication number
CA2354019A1
CA2354019A1 CA002354019A CA2354019A CA2354019A1 CA 2354019 A1 CA2354019 A1 CA 2354019A1 CA 002354019 A CA002354019 A CA 002354019A CA 2354019 A CA2354019 A CA 2354019A CA 2354019 A1 CA2354019 A1 CA 2354019A1
Authority
CA
Canada
Prior art keywords
formula
compound
reaction
acid
bromide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002354019A
Other languages
English (en)
Inventor
John Paul Gardner
Tony Yantao Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2354019A1 publication Critical patent/CA2354019A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

La présente invention concerne une nouvelle synthèse d'ester de sulfoxyde d'acide pénicillanique. On commence la synthèse avec de l'acide 6-amino pénicillanique et on la continue par une conversion en bromure via la diazotation, l'estérification la réduction du bromure puis l'oxydation de l'ester d'acide pénicillanique obtenu.
CA002354019A 1998-12-08 1999-12-03 Procede de preparation d'esters de sulfoxyde d'acide penicillanique Abandoned CA2354019A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11134898P 1998-12-08 1998-12-08
US60/111,348 1998-12-08
PCT/US1999/028643 WO2000034289A1 (fr) 1998-12-08 1999-12-03 Procede de preparation d'esters de sulfoxyde d'acide penicillanique

Publications (1)

Publication Number Publication Date
CA2354019A1 true CA2354019A1 (fr) 2000-06-15

Family

ID=22338003

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002354019A Abandoned CA2354019A1 (fr) 1998-12-08 1999-12-03 Procede de preparation d'esters de sulfoxyde d'acide penicillanique

Country Status (5)

Country Link
EP (1) EP1149107A4 (fr)
JP (1) JP2002531571A (fr)
AU (1) AU2039000A (fr)
CA (1) CA2354019A1 (fr)
WO (1) WO2000034289A1 (fr)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2045236A (en) * 1979-03-26 1980-10-29 Hoechst Uk Ltd Oxapenem derivatives
ES2010485A6 (es) * 1989-04-25 1989-11-01 Asturpharma S A Procedimiento de obtencion del acido 1,1-dioxopenicilanico, sus esteres y sus sales.
ES2039299B1 (es) * 1991-10-04 1994-05-16 Asturpharma S A Procedimiento de obtencion de esteres de acido 1,1-dioxopenicilanico y sus sales.

Also Published As

Publication number Publication date
WO2000034289A1 (fr) 2000-06-15
JP2002531571A (ja) 2002-09-24
AU2039000A (en) 2000-06-26
EP1149107A4 (fr) 2002-04-17
EP1149107A1 (fr) 2001-10-31

Similar Documents

Publication Publication Date Title
EP0868423B1 (fr) Procede de synthese d'un compose benzimidazole
JPS6354717B2 (fr)
US6936711B2 (en) Process for preparation of penam derivatives from cepham derivatives
EP0094227B1 (fr) Dérivés d'ampicilline et d'amoxycilline avec des inhibiteurs de bêta-laktamase
US20080009634A1 (en) Process for synthesizing beta-lactamase inhibitor intermediates
KR100343434B1 (ko) 7-아미노-3-메톡시메틸-3-세펨-4-카복실산의 제조방법
KR20020068517A (ko) 페니실린 결정 및 그 제조 방법
CA2354019A1 (fr) Procede de preparation d'esters de sulfoxyde d'acide penicillanique
US4619785A (en) Novel synthesis route for bacampicillin
JPH04282387A (ja) セフエム誘導体の製造法
NO144170B (no) Fremgangsmaate til fremstilling av desacetoksy-cefalosporansyrederivater.
JP3747328B2 (ja) ７−アミノ−３−クロロメチル−３−セフェム誘導体の製造法
KR20020065970A (ko) 타조박탐 제조에 유용한 중간체의 제조방법
EP0597051B1 (fr) Elimination du groupe hydroxy protecteur dans les penemes
GB2125807A (en) Preparation of penicillin and cephalosporin compounds and novel intermediates useful therein
HU181761B (en) Process for preparing crystalline 3-hydroxy-cefem-carboxylic acid solvates
KR100304325B1 (ko) 세팔로스포린계항생제의합성중간체제조방법
JPH0446958B2 (fr)
IE56326B1 (en) Process and intermediates for sultamicillin and analogs
JP2005179247A (ja) エステル類の製造方法
CA1252471A (fr) Procede de preparation d'azetidinones
KR100432425B1 (ko) 세펨 유도체 또는 그 염의 신규한 제조방법
GB2123821A (en) ???-Halogeno diethyl carbonates and their use in the preparation of antibiotics
JP2005047827A (ja) ３−クロロメチル−３−セフェム誘導体結晶の製造方法
JPS63264486A (ja) ２β−Ｎ−置換トリアゾリルメチルペナム誘導体、その塩及びそのエステル並びにそれらの製造法

Legal Events

Date Code Title Description
FZDE Discontinued