CA2343336C - Procede pour la preparation d'intermediaires de la nizatidine - Google Patents

Procede pour la preparation d'intermediaires de la nizatidine Download PDF

Info

Publication number
CA2343336C
CA2343336C CA002343336A CA2343336A CA2343336C CA 2343336 C CA2343336 C CA 2343336C CA 002343336 A CA002343336 A CA 002343336A CA 2343336 A CA2343336 A CA 2343336A CA 2343336 C CA2343336 C CA 2343336C
Authority
CA
Canada
Prior art keywords
solution
thiazoline
dimethylaminomethyl
toluene
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002343336A
Other languages
English (en)
Other versions
CA2343336A1 (fr
Inventor
Kenneth Philip Moder
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of CA2343336A1 publication Critical patent/CA2343336A1/fr
Application granted granted Critical
Publication of CA2343336C publication Critical patent/CA2343336C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CA002343336A 1991-05-21 1992-05-20 Procede pour la preparation d'intermediaires de la nizatidine Expired - Lifetime CA2343336C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US70352691A 1991-05-21 1991-05-21
US703,526 1991-05-21
CA002069055A CA2069055C (fr) 1991-05-21 1992-05-20 Procede pour la preparation d'intermediaires de la nizatidine et de composes connexes

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA002069055A Division CA2069055C (fr) 1991-05-21 1992-05-20 Procede pour la preparation d'intermediaires de la nizatidine et de composes connexes

Publications (2)

Publication Number Publication Date
CA2343336A1 CA2343336A1 (fr) 1992-11-22
CA2343336C true CA2343336C (fr) 2004-10-19

Family

ID=24825733

Family Applications (3)

Application Number Title Priority Date Filing Date
CA002343023A Expired - Lifetime CA2343023C (fr) 1991-05-21 1992-05-20 Procede de preparation du nizatidine en utilisant du toluene comme solvant
CA002069055A Expired - Lifetime CA2069055C (fr) 1991-05-21 1992-05-20 Procede pour la preparation d'intermediaires de la nizatidine et de composes connexes
CA002343336A Expired - Lifetime CA2343336C (fr) 1991-05-21 1992-05-20 Procede pour la preparation d'intermediaires de la nizatidine

Family Applications Before (2)

Application Number Title Priority Date Filing Date
CA002343023A Expired - Lifetime CA2343023C (fr) 1991-05-21 1992-05-20 Procede de preparation du nizatidine en utilisant du toluene comme solvant
CA002069055A Expired - Lifetime CA2069055C (fr) 1991-05-21 1992-05-20 Procede pour la preparation d'intermediaires de la nizatidine et de composes connexes

Country Status (15)

Country Link
EP (2) EP0515121B1 (fr)
JP (2) JP3504280B2 (fr)
KR (1) KR100214184B1 (fr)
AT (1) ATE197296T1 (fr)
BR (1) BR9201895A (fr)
CA (3) CA2343023C (fr)
DE (1) DE69231541T2 (fr)
DK (1) DK0515121T3 (fr)
ES (1) ES2151480T3 (fr)
GR (1) GR3035263T3 (fr)
HU (1) HU219459B (fr)
IE (1) IE921623A1 (fr)
IL (1) IL101915A (fr)
MX (1) MX9202347A (fr)
PT (1) PT515121E (fr)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI76795C (fi) * 1979-09-04 1988-12-12 Bristol Myers Co Foerfarande foer framstaellning av nya, terapeutiskt anvaendbara 3,4-disubstituerade 1,2,5-tiadiazol-1-oxider och -1,1-dioxider samt nya mellanprodukter.
US4375547A (en) * 1980-10-02 1983-03-01 Eli Lilly And Company N-Methyl-N'-2-([(2-dimethylaminomethyl)-4-thiazolyl]methylthio)ethyl 2-nitro-1,1-ethenediamine

Also Published As

Publication number Publication date
DK0515121T3 (da) 2000-11-27
IE921623A1 (en) 1992-12-02
JP3504280B2 (ja) 2004-03-08
CA2343336A1 (fr) 1992-11-22
EP0960880A1 (fr) 1999-12-01
ES2151480T3 (es) 2001-01-01
KR100214184B1 (ko) 1999-08-02
CA2343023C (fr) 2002-02-05
EP0515121A1 (fr) 1992-11-25
HU219459B (hu) 2001-04-28
IL101915A0 (en) 1992-12-30
HU9201664D0 (en) 1992-08-28
CA2069055A1 (fr) 1992-11-22
PT515121E (pt) 2001-04-30
KR920021563A (ko) 1992-12-18
CA2069055C (fr) 2001-08-07
HUT62870A (en) 1993-06-28
JPH05155889A (ja) 1993-06-22
GR3035263T3 (en) 2001-04-30
JP2003040876A (ja) 2003-02-13
EP0515121B1 (fr) 2000-11-02
DE69231541D1 (de) 2000-12-07
IL101915A (en) 1996-12-05
MX9202347A (es) 1994-06-30
DE69231541T2 (de) 2001-06-07
BR9201895A (pt) 1993-01-05
ATE197296T1 (de) 2000-11-15

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