CA2340920C - A method for preventing the onset of asthma - Google Patents
A method for preventing the onset of asthma Download PDFInfo
- Publication number
- CA2340920C CA2340920C CA002340920A CA2340920A CA2340920C CA 2340920 C CA2340920 C CA 2340920C CA 002340920 A CA002340920 A CA 002340920A CA 2340920 A CA2340920 A CA 2340920A CA 2340920 C CA2340920 C CA 2340920C
- Authority
- CA
- Canada
- Prior art keywords
- asthma
- cetirizine
- onset
- ige
- infants
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 208000006673 asthma Diseases 0.000 title claims abstract description 81
- 238000000034 method Methods 0.000 title abstract description 13
- ZKLPARSLTMPFCP-UHFFFAOYSA-N Cetirizine Chemical compound C1CN(CCOCC(=O)O)CCN1C(C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 ZKLPARSLTMPFCP-UHFFFAOYSA-N 0.000 claims abstract description 44
- 229960001803 cetirizine Drugs 0.000 claims abstract description 43
- 150000003839 salts Chemical class 0.000 claims abstract description 19
- 230000003287 optical effect Effects 0.000 claims abstract description 18
- 239000003814 drug Substances 0.000 claims description 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 8
- 238000002360 preparation method Methods 0.000 claims description 8
- 230000000979 retarding effect Effects 0.000 claims description 3
- 239000008194 pharmaceutical composition Substances 0.000 description 18
- 206010012438 Dermatitis atopic Diseases 0.000 description 16
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- 229940046528 grass pollen Drugs 0.000 description 16
- 239000000203 mixture Substances 0.000 description 15
- 238000011282 treatment Methods 0.000 description 15
- 239000000428 dust Substances 0.000 description 13
- 239000000902 placebo Substances 0.000 description 11
- 229940068196 placebo Drugs 0.000 description 11
- 208000026935 allergic disease Diseases 0.000 description 9
- 206010011224 Cough Diseases 0.000 description 8
- 208000037656 Respiratory Sounds Diseases 0.000 description 8
- 206010047924 Wheezing Diseases 0.000 description 8
- 206010020751 Hypersensitivity Diseases 0.000 description 7
- 230000007815 allergy Effects 0.000 description 7
- 208000024891 symptom Diseases 0.000 description 7
- 206010070834 Sensitisation Diseases 0.000 description 6
- 230000002265 prevention Effects 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
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- -1 acetic Chemical class 0.000 description 4
- 239000013566 allergen Substances 0.000 description 4
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
- 230000008313 sensitization Effects 0.000 description 4
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 206010003645 Atopy Diseases 0.000 description 3
- 241000282326 Felis catus Species 0.000 description 3
- 201000009961 allergic asthma Diseases 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
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- XNWFRZJHXBZDAG-UHFFFAOYSA-N 2-METHOXYETHANOL Chemical compound COCCO XNWFRZJHXBZDAG-UHFFFAOYSA-N 0.000 description 2
- 208000035285 Allergic Seasonal Rhinitis Diseases 0.000 description 2
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- ZCVMWBYGMWKGHF-UHFFFAOYSA-N Ketotifene Chemical compound C1CN(C)CCC1=C1C2=CC=CC=C2CC(=O)C2=C1C=CS2 ZCVMWBYGMWKGHF-UHFFFAOYSA-N 0.000 description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
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- 235000019359 magnesium stearate Nutrition 0.000 description 2
- 238000002483 medication Methods 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N p-hydroxybenzoic acid methyl ester Natural products COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 230000009862 primary prevention Effects 0.000 description 2
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
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- 239000007921 spray Substances 0.000 description 2
- 239000003381 stabilizer Substances 0.000 description 2
- 239000000829 suppository Substances 0.000 description 2
- 239000003826 tablet Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 230000000699 topical effect Effects 0.000 description 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 208000012657 Atopic disease Diseases 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 241000238711 Pyroglyphidae Species 0.000 description 1
- 206010039085 Rhinitis allergic Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 206010041349 Somnolence Diseases 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 208000024780 Urticaria Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 201000010105 allergic rhinitis Diseases 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 229940125715 antihistaminic agent Drugs 0.000 description 1
- 239000000739 antihistaminic agent Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000011914 asymmetric synthesis Methods 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 239000000090 biomarker Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
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- 239000000872 buffer Substances 0.000 description 1
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- 239000001913 cellulose Substances 0.000 description 1
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- 239000003795 chemical substances by application Substances 0.000 description 1
- 208000029771 childhood onset asthma Diseases 0.000 description 1
- 230000007012 clinical effect Effects 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000003246 corticosteroid Substances 0.000 description 1
- 229960001334 corticosteroids Drugs 0.000 description 1
- RKHQGWMMUURILY-UHRZLXHJSA-N cortivazol Chemical class C([C@H]1[C@@H]2C[C@H]([C@]([C@@]2(C)C[C@H](O)[C@@H]1[C@@]1(C)C2)(O)C(=O)COC(C)=O)C)=C(C)C1=CC1=C2C=NN1C1=CC=CC=C1 RKHQGWMMUURILY-UHRZLXHJSA-N 0.000 description 1
- 235000020247 cow milk Nutrition 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
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- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 210000002216 heart Anatomy 0.000 description 1
- 229940046533 house dust mites Drugs 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 208000027866 inflammatory disease Diseases 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 235000015110 jellies Nutrition 0.000 description 1
- 239000008274 jelly Substances 0.000 description 1
- 239000012669 liquid formulation Substances 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 238000011866 long-term treatment Methods 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 229960002216 methylparaben Drugs 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 239000006186 oral dosage form Substances 0.000 description 1
- 229940100688 oral solution Drugs 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 239000008180 pharmaceutical surfactant Substances 0.000 description 1
- 235000011007 phosphoric acid Nutrition 0.000 description 1
- 150000003016 phosphoric acids Chemical class 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229920001515 polyalkylene glycol Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
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- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 230000009863 secondary prevention Effects 0.000 description 1
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- 229910052708 sodium Inorganic materials 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
Landscapes
- Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9692998P | 1998-08-18 | 1998-08-18 | |
| US9745598P | 1998-08-21 | 1998-08-21 | |
| US60/096,929 | 1998-08-21 | ||
| US60/097,455 | 1998-08-21 | ||
| PCT/EP1999/005969 WO2000010544A2 (en) | 1998-08-18 | 1999-08-14 | A method for preventing the onset of asthma |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2340920A1 CA2340920A1 (en) | 2000-03-02 |
| CA2340920C true CA2340920C (en) | 2007-10-16 |
Family
ID=26792214
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002340920A Expired - Fee Related CA2340920C (en) | 1998-08-18 | 1999-08-14 | A method for preventing the onset of asthma |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP1109557B1 (enExample) |
| JP (1) | JP3878416B2 (enExample) |
| AR (1) | AR020167A1 (enExample) |
| AT (1) | ATE228366T1 (enExample) |
| AU (1) | AU749169B2 (enExample) |
| CA (1) | CA2340920C (enExample) |
| DE (1) | DE69904206T2 (enExample) |
| ES (1) | ES2188232T3 (enExample) |
| HN (1) | HN1999000140A (enExample) |
| MA (1) | MA26676A1 (enExample) |
| MY (1) | MY124089A (enExample) |
| PA (1) | PA8480401A1 (enExample) |
| SA (1) | SA99200492B1 (enExample) |
| TN (1) | TNSN99158A1 (enExample) |
| TW (1) | TW581675B (enExample) |
| WO (1) | WO2000010544A2 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002221854A1 (en) * | 2000-12-15 | 2002-06-24 | U C B, S.A. | Use of cetirizine or efletirizine for preventing urticaria |
| WO2005077371A1 (en) * | 2004-02-12 | 2005-08-25 | Ucb Farchim Sa | Use of levocetirizine for the preparation of a drug |
| US8263581B2 (en) | 2009-07-03 | 2012-09-11 | Jdp Therapeutics, Inc. | Non-sedating antihistamine injection formulations and methods of use thereof |
| US8513259B2 (en) | 2009-07-03 | 2013-08-20 | Jdp Therapeutics, Inc. | Non-sedating antihistamine injection formulations and methods of use thereof |
-
1999
- 1999-07-23 TW TW088112517A patent/TW581675B/zh not_active IP Right Cessation
- 1999-08-12 AR ARP990104039A patent/AR020167A1/es not_active Application Discontinuation
- 1999-08-13 MY MYPI99003475A patent/MY124089A/en unknown
- 1999-08-13 HN HN1999000140A patent/HN1999000140A/es unknown
- 1999-08-13 MA MA25733A patent/MA26676A1/fr unknown
- 1999-08-14 AT AT99944395T patent/ATE228366T1/de not_active IP Right Cessation
- 1999-08-14 EP EP99944395A patent/EP1109557B1/en not_active Expired - Lifetime
- 1999-08-14 DE DE69904206T patent/DE69904206T2/de not_active Expired - Lifetime
- 1999-08-14 WO PCT/EP1999/005969 patent/WO2000010544A2/en not_active Ceased
- 1999-08-14 AU AU57346/99A patent/AU749169B2/en not_active Ceased
- 1999-08-14 CA CA002340920A patent/CA2340920C/en not_active Expired - Fee Related
- 1999-08-14 ES ES99944395T patent/ES2188232T3/es not_active Expired - Lifetime
- 1999-08-14 JP JP2000565866A patent/JP3878416B2/ja not_active Expired - Fee Related
- 1999-08-16 TN TNTNSN99158A patent/TNSN99158A1/fr unknown
- 1999-08-17 PA PA19998480401A patent/PA8480401A1/es unknown
- 1999-08-18 SA SA99200492A patent/SA99200492B1/ar unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU749169B2 (en) | 2002-06-20 |
| WO2000010544A2 (en) | 2000-03-02 |
| PA8480401A1 (es) | 2000-09-29 |
| DE69904206T2 (de) | 2003-07-17 |
| EP1109557A2 (en) | 2001-06-27 |
| ATE228366T1 (de) | 2002-12-15 |
| MY124089A (en) | 2006-06-30 |
| AR020167A1 (es) | 2002-04-10 |
| ES2188232T3 (es) | 2003-06-16 |
| HN1999000140A (es) | 2001-07-31 |
| EP1109557B1 (en) | 2002-11-27 |
| TW581675B (en) | 2004-04-01 |
| WO2000010544A3 (en) | 2000-05-18 |
| CA2340920A1 (en) | 2000-03-02 |
| AU5734699A (en) | 2000-03-14 |
| MA26676A1 (fr) | 2004-12-20 |
| SA99200492B1 (ar) | 2006-06-04 |
| JP2002523362A (ja) | 2002-07-30 |
| DE69904206D1 (de) | 2003-01-09 |
| TNSN99158A1 (ar) | 2005-11-10 |
| JP3878416B2 (ja) | 2007-02-07 |
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