CA2335837A1 - Compositions antalgiques transdermiques et leurs methodes d'administration - Google Patents

Compositions antalgiques transdermiques et leurs methodes d'administration Download PDF

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Publication number
CA2335837A1
CA2335837A1 CA002335837A CA2335837A CA2335837A1 CA 2335837 A1 CA2335837 A1 CA 2335837A1 CA 002335837 A CA002335837 A CA 002335837A CA 2335837 A CA2335837 A CA 2335837A CA 2335837 A1 CA2335837 A1 CA 2335837A1
Authority
CA
Canada
Prior art keywords
compound
transdermal composition
amine containing
transdermal
subject
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002335837A
Other languages
English (en)
Inventor
C. Donald Williams
Robert W. Murdock
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PHARMACEUTICALS APPLICATIONS ASSOCIATES LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/106,684 external-priority patent/US6290986B1/en
Application filed by Individual filed Critical Individual
Publication of CA2335837A1 publication Critical patent/CA2335837A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne des compositions antalgiques transdermiques et leurs méthodes d'administration. Selon un mode de réalisation, l'invention concerne des compositions à administration transdermique qui renferment un composé avec amine à solubilité biphasique et/ou un agent qui favorise l'activité antalgique dudit composé en tant que décontractant musculaire.
CA002335837A 1998-06-29 1999-06-29 Compositions antalgiques transdermiques et leurs methodes d'administration Abandoned CA2335837A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US09/106,684 US6290986B1 (en) 1996-10-24 1998-06-29 Method and composition for transdermal administration of pharmacologic agents
US12290399P 1999-03-05 1999-03-05
US60/122,903 1999-03-05
US09/106,684 1999-03-05
PCT/US1999/014653 WO2000000120A1 (fr) 1998-06-29 1999-06-29 Compositions antalgiques transdermiques et leurs methodes d'administration

Publications (1)

Publication Number Publication Date
CA2335837A1 true CA2335837A1 (fr) 2000-01-06

Family

ID=26803907

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002335837A Abandoned CA2335837A1 (fr) 1998-06-29 1999-06-29 Compositions antalgiques transdermiques et leurs methodes d'administration

Country Status (18)

Country Link
EP (1) EP1093348A4 (fr)
JP (1) JP2002519310A (fr)
KR (1) KR20010078754A (fr)
CN (1) CN1331576A (fr)
AU (1) AU4841599A (fr)
BG (1) BG105175A (fr)
BR (1) BR9912508A (fr)
CA (1) CA2335837A1 (fr)
HR (1) HRP20000905A2 (fr)
HU (1) HUP0102728A3 (fr)
ID (1) ID28213A (fr)
IL (1) IL140420A0 (fr)
MX (1) MXPA00012767A (fr)
NO (1) NO20006604L (fr)
PL (1) PL345216A1 (fr)
SK (1) SK20012000A3 (fr)
TR (1) TR200003801T2 (fr)
WO (1) WO2000000120A1 (fr)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6572880B2 (en) * 1996-10-24 2003-06-03 Pharmaceutical Applications Associates Llc Methods and transdermal compositions for pain relief
EP0986540B1 (fr) 1997-04-22 2005-02-16 Euro-Celtique S.A. L'utilisation des semicarbazones et thiosemicarbazones carbocycliques et heterocycliques substitues comme agents bloquants du canal sodique
PL196996B1 (pl) 1999-07-01 2008-02-29 Upjohn Co Zastosowanie optycznie czystej (S,S)-reboksetyny lub jej dopuszczalnej farmaceutycznie soli do wytwarzania leku
DK1500395T3 (da) * 1999-07-01 2006-06-19 Pharmacia & Upjohn Co Llc Reboxetin til behandling af fibromyalgi og andre somatoforme lidelser
WO2001041732A1 (fr) * 1999-12-06 2001-06-14 Gore Stanley L Compositions et procedes d'administration intranasale d'agents actifs destines au cerveau
IN191512B (fr) * 2000-01-21 2003-12-06 Panacea Biotech
DE10032132A1 (de) * 2000-07-01 2002-01-17 Lohmann Therapie Syst Lts Dermales Therapeutisches System enthaltend nichtsteroidale Antiphlogistika mit selektiver COX-2-Hemmung
DE10042412B4 (de) * 2000-08-30 2005-12-22 Lts Lohmann Therapie-Systeme Ag Transdermales therapeutisches System zur Abgabe von Venlafaxin, und seine Verwendung
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
SI2218448T1 (sl) 2002-12-13 2016-01-29 Durect Corporation Sistem za oralno dajanje zdravila, ki obsega tekoči nosilec materialov z visoko viskoznostjo
JP2005154368A (ja) * 2003-11-27 2005-06-16 Teikoku Seiyaku Co Ltd ジソピラミド含有神経因性疼痛の鎮痛剤
JP4807721B2 (ja) * 2004-01-29 2011-11-02 株式会社 メドレックス 消炎鎮痛外用剤
ES2378671T3 (es) 2004-09-17 2012-04-16 Durect Corporation Composición anestésica local prolongada que contiene SAIB
US20070027105A1 (en) 2005-07-26 2007-02-01 Alza Corporation Peroxide removal from drug delivery vehicle
JP2007308403A (ja) * 2006-05-17 2007-11-29 Kenji Yoshida 皮膚外用剤
KR100880748B1 (ko) * 2006-08-29 2009-02-02 정헌택 디메톡시커큐민을 함유하는 혈관재협착 방지용 조성물
EP2117521B1 (fr) 2006-11-03 2012-06-27 Durect Corporation Systèmes d'administration par voie transdermique
US9511016B2 (en) * 2007-06-12 2016-12-06 Epicentrx, Inc. Topical composition for treating pain
CA2706931C (fr) 2007-12-06 2015-05-12 Durect Corporation Formes posologiques pharmaceutiques orales
US20100260844A1 (en) 2008-11-03 2010-10-14 Scicinski Jan J Oral pharmaceutical dosage forms
JP5826742B2 (ja) * 2009-05-07 2015-12-02 ドンコック ファーマシューティカル カンパニー リミテッド 神経損傷及び神経疾患の予防または治療用薬学組成物
US8491927B2 (en) 2009-12-02 2013-07-23 Nimble Epitech, Llc Pharmaceutical composition containing a hypomethylating agent and a histone deacetylase inhibitor
AU2014233453A1 (en) 2013-03-15 2015-10-01 Durect Corporation Compositions with a rheological modifier to reduce dissolution variability
RU2016136430A (ru) * 2014-02-11 2018-03-15 Др. Редди'С Лабораторис Лтд. Парентеральные композиции целекоксиба
EP3870150A1 (fr) 2018-10-26 2021-09-01 Viramal Limited Composition de gel mucoadhésif
ES2948955T3 (es) 2018-11-30 2023-09-22 Viramal Ltd Un método de preparación de un agente gelificante, el agente gelificante obtenido de este modo y el uso de dicho agente gelificante
CA3167217A1 (fr) 2020-01-13 2021-07-22 Durect Corporation Systemes d'administration de medicament a liberation prolongee avec impuretes reduites et procedes associes
FR3108841B1 (fr) * 2020-04-06 2023-11-03 Algotherapeutix Composition pharmaceutique topique sous forme de gel aqueux comprenant au moins de l’amitriptyline

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4395420A (en) * 1981-12-09 1983-07-26 Bernstein Joel E Method and composition for treating pruritis
SI9300468A (en) * 1992-10-14 1994-06-30 Hoffmann La Roche Injectable composition for the sustained release of biologically active compounds
GB9315856D0 (en) * 1993-07-30 1993-09-15 Wellcome Found Stabilized pharmaceutical
US5654337A (en) * 1995-03-24 1997-08-05 II William Scott Snyder Topical formulation for local delivery of a pharmaceutically active agent
US5837289A (en) * 1996-07-23 1998-11-17 Grasela; John C. Transdermal delivery of medications using a combination of penetration enhancers
US5885597A (en) * 1997-10-01 1999-03-23 Medical Research Industries,Inc. Topical composition for the relief of pain

Also Published As

Publication number Publication date
SK20012000A3 (sk) 2001-08-06
CN1331576A (zh) 2002-01-16
KR20010078754A (ko) 2001-08-21
HUP0102728A2 (hu) 2002-03-28
WO2000000120A1 (fr) 2000-01-06
PL345216A1 (en) 2001-12-03
AU4841599A (en) 2000-01-17
EP1093348A1 (fr) 2001-04-25
BR9912508A (pt) 2001-05-02
NO20006604D0 (no) 2000-12-22
HUP0102728A3 (en) 2002-12-28
IL140420A0 (en) 2002-02-10
WO2000000120A9 (fr) 2000-03-30
EP1093348A4 (fr) 2003-07-16
MXPA00012767A (es) 2002-08-09
TR200003801T2 (tr) 2001-06-21
HRP20000905A2 (en) 2001-08-31
NO20006604L (no) 2001-02-28
BG105175A (bg) 2001-11-30
ID28213A (id) 2001-05-10
JP2002519310A (ja) 2002-07-02

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Legal Events

Date Code Title Description
FZDE Discontinued