CA2333901A1 - Low adenosine anti-sense oligonucleotide agent, composition, kit and treatments - Google Patents
Low adenosine anti-sense oligonucleotide agent, composition, kit and treatments Download PDFInfo
- Publication number
- CA2333901A1 CA2333901A1 CA002333901A CA2333901A CA2333901A1 CA 2333901 A1 CA2333901 A1 CA 2333901A1 CA 002333901 A CA002333901 A CA 002333901A CA 2333901 A CA2333901 A CA 2333901A CA 2333901 A1 CA2333901 A1 CA 2333901A1
- Authority
- CA
- Canada
- Prior art keywords
- group
- composition
- formulation
- receptor
- receptors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/334—Modified C
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9521298P | 1998-08-03 | 1998-08-03 | |
US60/095,212 | 1998-08-03 | ||
PCT/US1999/017712 WO2000009525A2 (en) | 1998-08-03 | 1999-08-03 | Low adenosine anti-sense oligonucleotide agent, composition, kit and treatments |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2333901A1 true CA2333901A1 (en) | 2000-02-24 |
Family
ID=22250687
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002333901A Abandoned CA2333901A1 (en) | 1998-08-03 | 1999-08-03 | Low adenosine anti-sense oligonucleotide agent, composition, kit and treatments |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP1102786A4 (de) |
CN (1) | CN1317009A (de) |
AU (1) | AU5337499A (de) |
CA (1) | CA2333901A1 (de) |
HK (1) | HK1042706A1 (de) |
WO (1) | WO2000009525A2 (de) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6825174B2 (en) | 1995-06-07 | 2004-11-30 | East Carolina University | Composition, formulations & method for prevention & treatment of diseases and conditions associated with bronchoconstriction, allergy(ies) & inflammation |
US7034007B1 (en) | 1995-06-07 | 2006-04-25 | East Carolina University | Low adenosine anti-sense oligonucleotide, compositions, kit & method for treatment of airway disorders associated with bronchoconstriction, lung inflammation, allergy(ies) & surfactant depletion |
EP1165783A4 (de) * | 1999-03-26 | 2002-09-11 | Human Genome Sciences Inc | 47 menschliche, sekretierte proteine |
CA2368442A1 (en) * | 1999-03-26 | 2000-10-05 | Craig A. Rosen | 48 human secreted proteins |
WO2000062736A2 (en) * | 1999-04-06 | 2000-10-26 | East Carolina University | Low adenosine anti-sense oligonucleotide, compositions, kit and method for treatment of airway disorders associated with bronchoconstriction, lung inflammation, allergy(ies) and surfactant depletion |
US6489151B1 (en) * | 2000-03-27 | 2002-12-03 | The Research Foundation Of State University Of New York | Biologically active alternative form of the IKKα IκB kinase |
DE10019252A1 (de) * | 2000-04-18 | 2001-10-31 | Klaus Karl Degitz | Polydesoxyribonukleotide zur Hemmung der ICAM-1-Genexpression |
DE10049549A1 (de) | 2000-10-06 | 2002-05-02 | Markus Hecker | Modulation der Transkription pro-inflammatorischer Genprodukte |
ES2301659T3 (es) * | 2001-07-06 | 2008-07-01 | Topigen Pharmaceuticals Inc. | Metodos para aumentar la eficacia in vivo de oligonucleotidos e inhibir la inflamacion en mamiferos. |
JP2005522519A (ja) * | 2002-04-05 | 2005-07-28 | ユニヴァーシティ コート オブ ザ ユニヴァーシティ オブ エディンバラ | 精神分裂病関連遺伝子 |
AR040996A1 (es) | 2002-08-19 | 2005-04-27 | Coley Pharm Group Inc | Acidos nucleicos inmunoestimuladores |
CN1322899C (zh) * | 2004-02-11 | 2007-06-27 | 中国科学院上海生命科学研究院 | 抗肝癌基因药物组合物、小分子干扰rna及其筛选方法 |
RU2416412C2 (ru) | 2004-10-29 | 2011-04-20 | Топиджен Фармасьютикалз Инк. | Антисмысловые олигонуклеотиды для лечения аллергии и пролиферации неопластических клеток |
MX2008002101A (es) | 2005-08-12 | 2008-04-19 | Schering Corp | Fusiones de la proteina-1 quimiotactica de monocito. |
US8524217B2 (en) | 2010-05-11 | 2013-09-03 | Merck Sharp & Dohme Corp. | MCP1-Ig fusion variants |
US10017762B2 (en) * | 2010-11-24 | 2018-07-10 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Compositions and methods for treating or preventing lupus |
CN103635575B (zh) * | 2011-06-15 | 2019-03-01 | 盖立复治疗公司 | 用于测定人免疫缺陷病毒(hiv)的方法、组合物和试剂盒 |
CN102866153B (zh) * | 2012-09-29 | 2014-08-13 | 郑州安图生物工程股份有限公司 | 前列腺炎联合检测试剂盒 |
RU2015138544A (ru) * | 2013-03-11 | 2017-04-18 | Юниверсити Оф Норс Керолайна Эт Чапел Хилл | Композиции и способы целенаправленного воздействия на О-связанную N-ацетилглюкозаминтрансферазу и стимулирования заживления ран |
EP4237436A2 (de) * | 2020-10-29 | 2023-09-06 | Mariano A. Garcia-Blanco | Lösliche interleukin-7-rezeptor (sil7r)-modulierende therapie zur behandlung von krebs |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU3222793A (en) * | 1991-11-26 | 1993-06-28 | Gilead Sciences, Inc. | Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines |
US5858784A (en) * | 1991-12-17 | 1999-01-12 | The Regents Of The University Of California | Expression of cloned genes in the lung by aerosol- and liposome-based delivery |
US6498147B2 (en) * | 1992-05-22 | 2002-12-24 | The Scripps Research Institute | Suppression of nuclear factor-κb dependent processes using oligonucleotides |
US5994315A (en) * | 1995-06-07 | 1999-11-30 | East Carolina University | Low adenosine agent, composition, kit and method for treatment of airway disease |
US5856462A (en) * | 1996-09-10 | 1999-01-05 | Hybridon Incorporated | Oligonucleotides having modified CpG dinucleosides |
US5932557A (en) * | 1997-08-12 | 1999-08-03 | Mustafa; S. Jamal | Adenosine A1 receptor antisense oligonucleotide treatment of alcohol and marijuana-induced psychomotor impairments |
EP1080225A4 (de) * | 1998-05-21 | 2004-02-04 | Isis Pharmaceuticals Inc | Zusammensetzungen und methoden zur pulmonalen verabreichung von nukleinsäuren |
-
1999
- 1999-08-03 EP EP99939006A patent/EP1102786A4/de not_active Withdrawn
- 1999-08-03 AU AU53374/99A patent/AU5337499A/en not_active Abandoned
- 1999-08-03 CA CA002333901A patent/CA2333901A1/en not_active Abandoned
- 1999-08-03 CN CN99809303A patent/CN1317009A/zh active Pending
- 1999-08-03 WO PCT/US1999/017712 patent/WO2000009525A2/en active Search and Examination
-
2002
- 2002-04-08 HK HK02102614.0A patent/HK1042706A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
EP1102786A4 (de) | 2002-03-06 |
AU5337499A (en) | 2000-03-06 |
WO2000009525A3 (en) | 2000-05-18 |
HK1042706A1 (zh) | 2002-08-23 |
CN1317009A (zh) | 2001-10-10 |
WO2000009525A2 (en) | 2000-02-24 |
EP1102786A2 (de) | 2001-05-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Dead |