CA2333688A1 - Methods and devices for providing prolonged drug therapy - Google Patents
Methods and devices for providing prolonged drug therapy Download PDFInfo
- Publication number
- CA2333688A1 CA2333688A1 CA002333688A CA2333688A CA2333688A1 CA 2333688 A1 CA2333688 A1 CA 2333688A1 CA 002333688 A CA002333688 A CA 002333688A CA 2333688 A CA2333688 A CA 2333688A CA 2333688 A1 CA2333688 A1 CA 2333688A1
- Authority
- CA
- Canada
- Prior art keywords
- drug
- dosage form
- layer
- release
- methylphenidate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 238000012552 review Methods 0.000 description 1
- 229940125723 sedative agent Drugs 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 235000011008 sodium phosphates Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000009747 swallowing Effects 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000001975 sympathomimetic effect Effects 0.000 description 1
- 229940064707 sympathomimetics Drugs 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 239000003204 tranquilizing agent Substances 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 230000007723 transport mechanism Effects 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 229940124549 vasodilator Drugs 0.000 description 1
- 239000003071 vasodilator agent Substances 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4458—Non condensed piperidines, e.g. piperocaine only substituted in position 2, e.g. methylphenidate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
- G01N21/88—Investigating the presence of flaws or contamination
- G01N21/95—Investigating the presence of flaws or contamination characterised by the material or shape of the object to be examined
- G01N21/9508—Capsules; Tablets
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Psychology (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8778798P | 1998-06-03 | 1998-06-03 | |
| US60/087,787 | 1998-06-03 | ||
| US09/253,317 US6919373B1 (en) | 1996-11-12 | 1999-02-19 | Methods and devices for providing prolonged drug therapy |
| US09/253,317 | 1999-02-19 | ||
| PCT/US1999/011920 WO1999062496A1 (en) | 1998-06-03 | 1999-05-27 | Methods and devices for providing prolonged drug therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2333688A1 true CA2333688A1 (en) | 1999-12-09 |
Family
ID=26777397
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002333688A Abandoned CA2333688A1 (en) | 1998-06-03 | 1999-05-27 | Methods and devices for providing prolonged drug therapy |
Country Status (16)
| Country | Link |
|---|---|
| EP (2) | EP1449524A1 (enExample) |
| JP (1) | JP2002516848A (enExample) |
| KR (1) | KR20080083074A (enExample) |
| CN (1) | CN1209098C (enExample) |
| AT (1) | ATE277594T1 (enExample) |
| AU (1) | AU4319799A (enExample) |
| CA (1) | CA2333688A1 (enExample) |
| DE (1) | DE69920689T2 (enExample) |
| DK (1) | DK1083879T3 (enExample) |
| ES (1) | ES2229783T3 (enExample) |
| HK (1) | HK1046638B (enExample) |
| IL (1) | IL140020A0 (enExample) |
| NO (1) | NO330235B1 (enExample) |
| NZ (1) | NZ508567A (enExample) |
| PT (1) | PT1083879E (enExample) |
| WO (1) | WO1999062496A1 (enExample) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5837284A (en) | 1995-12-04 | 1998-11-17 | Mehta; Atul M. | Delivery of multiple doses of medications |
| US6919373B1 (en) | 1996-11-12 | 2005-07-19 | Alza Corporation | Methods and devices for providing prolonged drug therapy |
| US6962997B1 (en) | 1997-05-22 | 2005-11-08 | Celgene Corporation | Process and intermediates for resolving piperidyl acetamide steroisomers |
| KR20070051953A (ko) | 1998-11-02 | 2007-05-18 | 엘란 코포레이션, 피엘씨 | 다입자 변형 방출 조성물 |
| US6419960B1 (en) | 1998-12-17 | 2002-07-16 | Euro-Celtique S.A. | Controlled release formulations having rapid onset and rapid decline of effective plasma drug concentrations |
| US6673367B1 (en) | 1998-12-17 | 2004-01-06 | Euro-Celtique, S.A. | Controlled/modified release oral methylphenidate formulations |
| US7083808B2 (en) | 1998-12-17 | 2006-08-01 | Euro-Celtique S.A. | Controlled/modified release oral methylphenidate formulations |
| IL150657A0 (en) * | 2000-01-20 | 2003-02-12 | Delsys Pharmaceutical Corp | Multi-step drug dosage forms |
| AR030557A1 (es) | 2000-04-14 | 2003-08-27 | Jagotec Ag | Una tableta en multicapa de liberacion controlada y metodo de tratamiento |
| US20020187192A1 (en) * | 2001-04-30 | 2002-12-12 | Yatindra Joshi | Pharmaceutical composition which reduces or eliminates drug abuse potential |
| US20030049272A1 (en) * | 2001-08-30 | 2003-03-13 | Yatindra Joshi | Pharmaceutical composition which produces irritation |
| US7838026B2 (en) | 2001-09-28 | 2010-11-23 | Mcneil-Ppc, Inc. | Burst-release polymer composition and dosage forms comprising the same |
| CA2461682A1 (en) | 2001-09-28 | 2003-04-03 | Mcneil-Ppc, Inc. | Composite dosage forms |
| US7122143B2 (en) | 2001-09-28 | 2006-10-17 | Mcneil-Ppc, Inc. | Methods for manufacturing dosage forms |
| US20050232995A1 (en) * | 2002-07-29 | 2005-10-20 | Yam Nyomi V | Methods and dosage forms for controlled delivery of paliperidone and risperidone |
| ATE373472T1 (de) * | 2002-07-29 | 2007-10-15 | Alza Corp | Verfahren und dosierformen für die kontrollierte abgabe von paliperidon |
| WO2004028504A1 (en) * | 2002-09-28 | 2004-04-08 | Mcneil-Ppc, Inc. | Modified release dosage forms |
| GR1004330B (el) * | 2002-10-14 | 2003-09-05 | Lavipharm A.E. | Φαρμακοτεχνικη μορφη για τη χορηγηση οργανικων νιτρικων ενωσεων |
| US7988993B2 (en) | 2002-12-09 | 2011-08-02 | Andrx Pharmaceuticals, Inc. | Oral controlled release dosage form |
| EP1592410B1 (en) * | 2003-02-11 | 2008-07-23 | Alza Corporation | Methods and dosage forms with modified layer geometry |
| CN1897924B (zh) | 2003-09-26 | 2011-09-21 | 阿尔扎公司 | 能提供高载药量的药物包衣和提供它的方法 |
| CN1867359B (zh) * | 2003-10-08 | 2010-12-15 | 马林克罗特公司 | 哌甲酯溶液及其制药用途和制备方法 |
| US7879354B2 (en) | 2004-01-13 | 2011-02-01 | Mcneil-Ppc, Inc. | Rapidly disintegrating gelatinous coated tablets |
| JP5395355B2 (ja) * | 2004-05-21 | 2014-01-22 | アキュ−ブレイク テクノロジーズ インコーポレーテッド | ２個またはそれ以上の単位セグメントを含む医薬錠剤 |
| ES2261006B1 (es) * | 2004-06-10 | 2007-11-01 | Laboratorios Rubio, S.A. | Pellet multicapa de liberacion controlada de metilfenidato. |
| US8541026B2 (en) | 2004-09-24 | 2013-09-24 | Abbvie Inc. | Sustained release formulations of opioid and nonopioid analgesics |
| WO2006046114A2 (en) * | 2004-10-25 | 2006-05-04 | Ranbaxy Laboratories Limited | Osmotic dosage forms providing ascending drug release, and processes for their preparation |
| US8673352B2 (en) | 2005-04-15 | 2014-03-18 | Mcneil-Ppc, Inc. | Modified release dosage form |
| WO2009023006A2 (en) * | 2006-05-08 | 2009-02-19 | Mcneil-Ppc, Inc. | Modified release dosage form |
| PL116330U1 (en) | 2005-10-31 | 2007-04-02 | Alza Corp | Method for the reduction of alcohol provoked rapid increase in the released dose of the orally administered opioide with prolonged liberation |
| FR2899476B1 (fr) * | 2006-04-11 | 2008-07-04 | Assist Publ Hopitaux De Paris | Association du mazindol dans le traitement du deficit de l'attention/hyperactivite |
| JP2011511782A (ja) | 2008-02-12 | 2011-04-14 | アボット・ラボラトリーズ | 長期放出性ヒドロコドンアセトアミノフェンならびにその関連方法および用途 |
| CN102238946B (zh) * | 2008-11-07 | 2014-11-26 | 株式会社三养生物制药 | 用于哌醋甲酯的控制释放的药物组合物 |
| AU2010328353B2 (en) | 2009-12-07 | 2015-07-16 | Mcneil-Ppc, Inc. | Partial dip coating of dosage forms for modified release |
| UY34856A (es) * | 2012-07-03 | 2013-12-31 | Bayer Pharma AG | Formas de presentación farmacéuticas que contienen 5-cloro-n-({(5s)-2-oxo-3-[4-(3-oxo-4- morfolinil)-fenil]-1,3-oxazolidin-5-il}-metil)-2-tiofencarboxamida |
| WO2014174388A1 (en) * | 2013-03-29 | 2014-10-30 | Wockhardt Limited | Modified release pharmaceutical compositions of methylphenidate or salts thereof |
| CA2902911C (en) | 2014-10-31 | 2017-06-27 | Purdue Pharma | Methods and compositions particularly for treatment of attention deficit disorder |
| US9707217B1 (en) | 2017-02-03 | 2017-07-18 | Osmotica Kereskedelmi Es Szolgaltato Kft | Dose-dumping resistant controlled release dosage form |
| US10722473B2 (en) | 2018-11-19 | 2020-07-28 | Purdue Pharma L.P. | Methods and compositions particularly for treatment of attention deficit disorder |
| CN113891713A (zh) * | 2019-01-25 | 2022-01-04 | 艾伦索尔医药发展股份有限公司 | 用于治疗注意力缺陷多动障碍的哌甲酯组合物 |
| CA3130379A1 (en) * | 2019-03-05 | 2020-09-10 | Kashiv Biosciences, Llc | Delayed release methylphenidate compositions |
| CN114681422B (zh) * | 2020-12-30 | 2023-09-05 | 深圳翰宇药业股份有限公司 | 一种硝苯地平控释片及其制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4824675A (en) * | 1987-07-13 | 1989-04-25 | Alza Corporation | Dispenser with movable matrix comprising a plurality of tiny pills |
| EP0758244B2 (en) * | 1994-05-06 | 2008-02-13 | Pfizer Inc. | Controlled-release dosage forms of azithromycin |
| US5837284A (en) * | 1995-12-04 | 1998-11-17 | Mehta; Atul M. | Delivery of multiple doses of medications |
| ES2194210T3 (es) * | 1996-08-16 | 2003-11-16 | Alza Corp | Forma de dosificacion para suministrar una dosis ascendente de farmaco. |
| DE69735581T2 (de) * | 1996-09-30 | 2007-01-25 | Alza Corp., Palo Alto | Dosierungsform für eine verzögerte und zunehmende wirkstoffsfreisetzung |
-
1999
- 1999-05-27 AT AT99955212T patent/ATE277594T1/de active
- 1999-05-27 EP EP04075594A patent/EP1449524A1/en not_active Withdrawn
- 1999-05-27 KR KR1020087021536A patent/KR20080083074A/ko not_active Ceased
- 1999-05-27 HK HK02108159.8A patent/HK1046638B/zh not_active IP Right Cessation
- 1999-05-27 PT PT99955212T patent/PT1083879E/pt unknown
- 1999-05-27 NZ NZ508567A patent/NZ508567A/xx not_active IP Right Cessation
- 1999-05-27 JP JP2000551752A patent/JP2002516848A/ja not_active Withdrawn
- 1999-05-27 CN CNB998069701A patent/CN1209098C/zh not_active Expired - Lifetime
- 1999-05-27 CA CA002333688A patent/CA2333688A1/en not_active Abandoned
- 1999-05-27 IL IL14002099A patent/IL140020A0/xx unknown
- 1999-05-27 ES ES99955212T patent/ES2229783T3/es not_active Expired - Lifetime
- 1999-05-27 DK DK99955212T patent/DK1083879T3/da active
- 1999-05-27 WO PCT/US1999/011920 patent/WO1999062496A1/en not_active Ceased
- 1999-05-27 EP EP99955212A patent/EP1083879B1/en not_active Expired - Lifetime
- 1999-05-27 DE DE69920689T patent/DE69920689T2/de not_active Expired - Lifetime
- 1999-05-27 AU AU43197/99A patent/AU4319799A/en not_active Abandoned
-
2000
- 2000-11-28 NO NO20006007A patent/NO330235B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NO330235B1 (no) | 2011-03-07 |
| JP2002516848A (ja) | 2002-06-11 |
| CN1352549A (zh) | 2002-06-05 |
| EP1083879B1 (en) | 2004-09-29 |
| CN1209098C (zh) | 2005-07-06 |
| DK1083879T3 (da) | 2005-01-31 |
| ES2229783T3 (es) | 2005-04-16 |
| NZ508567A (en) | 2004-02-27 |
| DE69920689D1 (de) | 2004-11-04 |
| HK1035492A1 (en) | 2001-11-30 |
| AU4319799A (en) | 1999-12-20 |
| NO20006007L (no) | 2001-02-05 |
| ATE277594T1 (de) | 2004-10-15 |
| KR20080083074A (ko) | 2008-09-12 |
| EP1083879A1 (en) | 2001-03-21 |
| PT1083879E (pt) | 2005-01-31 |
| DE69920689T2 (de) | 2005-02-24 |
| NO20006007D0 (no) | 2000-11-28 |
| EP1449524A1 (en) | 2004-08-25 |
| WO1999062496A1 (en) | 1999-12-09 |
| HK1046638A1 (en) | 2003-01-24 |
| HK1046638B (zh) | 2006-02-24 |
| IL140020A0 (en) | 2002-02-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |