CA2331878A1 - Pyrazoles a substitution 1,5-diaryle comme inhibiteurs de la proteine p38 kinase - Google Patents

Pyrazoles a substitution 1,5-diaryle comme inhibiteurs de la proteine p38 kinase Download PDF

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Publication number
CA2331878A1
CA2331878A1 CA002331878A CA2331878A CA2331878A1 CA 2331878 A1 CA2331878 A1 CA 2331878A1 CA 002331878 A CA002331878 A CA 002331878A CA 2331878 A CA2331878 A CA 2331878A CA 2331878 A1 CA2331878 A1 CA 2331878A1
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Prior art keywords
hydrocarbyl
aryl
group
hydrido
hydrocarbyloxy
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Abandoned
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CA002331878A
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English (en)
Inventor
Richard M. Weier
Paul W. Collins
Xiangdong Xu
Joyce Z. Crich
Shashidhar N. Rao
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GD Searle LLC
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Individual
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61P19/00—Drugs for skeletal disorders
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Health & Medical Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
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  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • AIDS & HIV (AREA)
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Abstract

Cette invention, qui a trait à des composés de pyrazole à substitution 1,5-diaryle, représentés par la formule (I) dans laquelle A représente =N ou =CH-, concerne également un sel de ces composés, acceptable du point de vue pharmaceutique. Ces composés, entre autres effets, inhibent l'activité de la protéine-kinase associée aux membranes, en l'occurrence la protéine p38. Elle porte également sur des procédés de préparation de ces composés ainsi que sur l'utilisation qui est faite de l'un deux pour traiter un mammifère atteint d'une maladie liée à la p38 kinase ou au facteur de nécrose tumorale.
CA002331878A 1998-05-14 1999-05-12 Pyrazoles a substitution 1,5-diaryle comme inhibiteurs de la proteine p38 kinase Abandoned CA2331878A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8549498P 1998-05-14 1998-05-14
US60/085,494 1998-05-14
PCT/US1999/007036 WO1999058523A1 (fr) 1998-05-14 1999-05-12 PYRAZOLES A SUBSTITUTION 1,5-DIARYLE COMME INHIBITEURS DE LA PROTEINE p38 KINASE

Publications (1)

Publication Number Publication Date
CA2331878A1 true CA2331878A1 (fr) 1999-11-18

Family

ID=22191985

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002331878A Abandoned CA2331878A1 (fr) 1998-05-14 1999-05-12 Pyrazoles a substitution 1,5-diaryle comme inhibiteurs de la proteine p38 kinase

Country Status (5)

Country Link
EP (1) EP1077971A1 (fr)
JP (1) JP2002514640A (fr)
AU (1) AU3859999A (fr)
CA (1) CA2331878A1 (fr)
WO (1) WO1999058523A1 (fr)

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WO1998056377A1 (fr) * 1997-06-13 1998-12-17 Smithkline Beecham Corporation Nouveaux composes de pyrazole et de pyrazoline substitues
US7301021B2 (en) 1997-07-02 2007-11-27 Smithkline Beecham Corporation Substituted imidazole compounds
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US6569885B1 (en) 1999-12-23 2003-05-27 Icos Corporation Cyclic AMP-specific phosphodiesterase inhibitors
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ES2243579T3 (es) 2000-12-15 2005-12-01 Glaxo Group Ltd Derivados de pirazolopirideno.
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ATE274515T1 (de) 2001-03-08 2004-09-15 Smithkline Beecham Corp Pyrazolopyridinderivate
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EP1401836B1 (fr) 2001-06-21 2006-08-23 SmithKline Beecham Corporation Derives d'imidazo¬1,2-a|pyridine destines a la prevention et au traitement d'infections au virus de l'herpes
ATE309239T1 (de) * 2001-08-30 2005-11-15 Hoffmann La Roche Aminopyrrol verbindungen als entzündungshemmende wirkstoffe
US7057049B2 (en) 2001-09-25 2006-06-06 Pharmacia Corporation Process for making substituted pyrazoles
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WO2004004725A2 (fr) 2002-07-09 2004-01-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Nouvelles compositions pharmaceutiques a base de nouveaux anticholinergiques et d'inhibiteurs de la kinase p38
ATE323702T1 (de) 2002-08-06 2006-05-15 Astrazeneca Ab Kondensierte pyridine und pyrimidine mit tie2 (tek) aktivität
WO2004033454A1 (fr) 2002-10-03 2004-04-22 Smithkline Beecham Corporation Composes therapeutiques a base de derives de pyrazolopyridine
ATE457716T1 (de) 2002-12-30 2010-03-15 Angiotech Int Ag Wirkstofffreisetzung von schnell gelierender polymerzusammensetzung
EP1591443B1 (fr) 2003-02-07 2010-08-25 Daiichi Sankyo Company, Limited Derive de pyrazole
EP1620108B1 (fr) 2003-05-01 2012-06-06 Bristol-Myers Squibb Company Composes de pyrazole-amines utiles en tant qu'inhibiteurs de kinases
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AP2326A (en) 2004-08-12 2011-11-24 Pfizer Triazolopyridinylsulfanyl derivatives as p38 map kinase inhibitors.
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EP1992344A1 (fr) 2007-05-18 2008-11-19 Institut Curie P38 alpha comme cible therapeutique pour les maladies associées á une mutation de FGFR3
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EP3481808A4 (fr) * 2016-07-06 2020-07-15 Algomedix, Inc. Antagonistes trpa1 pour le traitement du syndrome de l' il sec, de la douleur oculaire et de l'inflammation
CA3209491A1 (fr) 2021-03-15 2022-09-22 Saul Yedgar Dipalmitoyl-phosphatidyl-ethanol-amine conjuguee a l'acide hyaluronique en combinaison avec des medicaments anti-inflammatoires non steroidiens (ains) pour traiter ou soulager des maladies inflammatoire
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WO1998056377A1 (fr) * 1997-06-13 1998-12-17 Smithkline Beecham Corporation Nouveaux composes de pyrazole et de pyrazoline substitues

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Publication number Publication date
JP2002514640A (ja) 2002-05-21
WO1999058523A1 (fr) 1999-11-18
EP1077971A1 (fr) 2001-02-28
AU3859999A (en) 1999-11-29

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