CA2326377C - Internalizing erbb2 antibodies - Google Patents

Internalizing erbb2 antibodies Download PDF

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Publication number
CA2326377C
CA2326377C CA2326377A CA2326377A CA2326377C CA 2326377 C CA2326377 C CA 2326377C CA 2326377 A CA2326377 A CA 2326377A CA 2326377 A CA2326377 A CA 2326377A CA 2326377 C CA2326377 C CA 2326377C
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Prior art keywords
antibody
antibodies
phage
cells
seq
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Expired - Fee Related
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CA2326377A
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English (en)
French (fr)
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CA2326377A1 (en
Inventor
James D. Marks
Marie Alix Poul
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University of California San Diego UCSD
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University of California San Diego UCSD
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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    • C—CHEMISTRY; METALLURGY
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    • C07K2319/00—Fusion polypeptide
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    • C12N2810/00—Vectors comprising a targeting moiety
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    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/812—Liposome comprising an antibody, antibody fragment, antigen, or other specific or nonspecific immunoeffector

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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CA2326377A 1998-04-24 1999-04-23 Internalizing erbb2 antibodies Expired - Fee Related CA2326377C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US8295398P 1998-04-24 1998-04-24
US60/082,953 1998-04-24
US09/250,056 US7244826B1 (en) 1998-04-24 1999-02-12 Internalizing ERB2 antibodies
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WO1999055367A9 (en) 2000-03-02
US8173424B2 (en) 2012-05-08
US20160279262A1 (en) 2016-09-29
ATE412432T1 (de) 2008-11-15
ES2316186T3 (es) 2009-04-01
DE69939820D1 (de) 2008-12-11
AU3742999A (en) 1999-11-16
JP2002524024A (ja) 2002-08-06
EP1071460B1 (en) 2008-10-29
EP1071460A4 (en) 2004-09-08
US20130337039A1 (en) 2013-12-19
US9388244B2 (en) 2016-07-12
US7892554B2 (en) 2011-02-22
US20080108135A1 (en) 2008-05-08
WO1999055367A1 (en) 1999-11-04
US20150239976A1 (en) 2015-08-27
AU769304B2 (en) 2004-01-22
US7244826B1 (en) 2007-07-17
US8974792B2 (en) 2015-03-10
US20110218333A1 (en) 2011-09-08
CA2326377A1 (en) 1999-11-04

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