CA2325282C - Use of apo b secretion/mtp inhibitors - Google Patents
Use of apo b secretion/mtp inhibitors Download PDFInfo
- Publication number
- CA2325282C CA2325282C CA002325282A CA2325282A CA2325282C CA 2325282 C CA2325282 C CA 2325282C CA 002325282 A CA002325282 A CA 002325282A CA 2325282 A CA2325282 A CA 2325282A CA 2325282 C CA2325282 C CA 2325282C
- Authority
- CA
- Canada
- Prior art keywords
- pharmaceutically acceptable
- compound
- alkylamino
- acceptable salts
- alkylaminocarbonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 230000028327 secretion Effects 0.000 title claims abstract description 35
- 239000003112 inhibitor Substances 0.000 title abstract description 35
- 241001465754 Metazoa Species 0.000 claims abstract description 57
- 230000037406 food intake Effects 0.000 claims abstract description 41
- 235000012631 food intake Nutrition 0.000 claims abstract description 41
- 102100031545 Microsomal triglyceride transfer protein large subunit Human genes 0.000 claims abstract description 40
- 239000000883 anti-obesity agent Substances 0.000 claims abstract description 40
- 229940125710 antiobesity agent Drugs 0.000 claims abstract description 40
- 108010038232 microsomal triglyceride transfer protein Proteins 0.000 claims abstract description 32
- 102000018616 Apolipoproteins B Human genes 0.000 claims abstract description 31
- 108010027006 Apolipoproteins B Proteins 0.000 claims abstract description 31
- 229940121649 protein inhibitor Drugs 0.000 claims abstract description 30
- 239000012268 protein inhibitor Substances 0.000 claims abstract description 30
- 101710095342 Apolipoprotein B Proteins 0.000 claims abstract description 28
- 102100040202 Apolipoprotein B-100 Human genes 0.000 claims abstract description 28
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 17
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- 239000003085 diluting agent Substances 0.000 claims abstract description 14
- 241000124008 Mammalia Species 0.000 claims abstract description 12
- 239000002552 dosage form Substances 0.000 claims abstract description 12
- 239000003937 drug carrier Substances 0.000 claims abstract description 10
- 150000001875 compounds Chemical class 0.000 claims description 107
- -1 cyano, nitro, oxo, thioxo, aminosulfonyl Chemical group 0.000 claims description 100
- 150000003839 salts Chemical class 0.000 claims description 79
- 125000003282 alkyl amino group Chemical group 0.000 claims description 58
- 239000000203 mixture Substances 0.000 claims description 54
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 claims description 48
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 46
- 125000001424 substituent group Chemical group 0.000 claims description 39
- 125000005010 perfluoroalkyl group Chemical group 0.000 claims description 38
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- 125000002252 acyl group Chemical group 0.000 claims description 33
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 32
- 150000004677 hydrates Chemical class 0.000 claims description 32
- 229920006395 saturated elastomer Polymers 0.000 claims description 32
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 29
- 125000000623 heterocyclic group Chemical group 0.000 claims description 29
- 125000004423 acyloxy group Chemical group 0.000 claims description 28
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- 229910052736 halogen Inorganic materials 0.000 claims description 28
- 150000002367 halogens Chemical class 0.000 claims description 28
- 229910052760 oxygen Inorganic materials 0.000 claims description 25
- 125000003118 aryl group Chemical group 0.000 claims description 23
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims description 23
- 229910052757 nitrogen Inorganic materials 0.000 claims description 23
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims description 22
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- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 17
- 125000004442 acylamino group Chemical group 0.000 claims description 17
- 125000006413 ring segment Chemical group 0.000 claims description 17
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- 125000000217 alkyl group Chemical group 0.000 claims description 16
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- DBGIVFWFUFKIQN-UHFFFAOYSA-N (+-)-Fenfluramine Chemical compound CCNC(C)CC1=CC=CC(C(F)(F)F)=C1 DBGIVFWFUFKIQN-UHFFFAOYSA-N 0.000 claims description 5
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- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims description 5
- LNIVDAPIGFBRFB-UHFFFAOYSA-N n-(2-butyl-3,4-dihydro-1h-isoquinolin-6-yl)-2-[4-(trifluoromethyl)phenyl]benzamide Chemical compound C=1C=C2CN(CCCC)CCC2=CC=1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 LNIVDAPIGFBRFB-UHFFFAOYSA-N 0.000 claims description 5
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- 230000001629 suppression Effects 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 150000003526 tetrahydroisoquinolines Chemical class 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000011285 therapeutic regimen Methods 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- 125000004568 thiomorpholinyl group Chemical group 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 239000006211 transdermal dosage form Substances 0.000 description 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 description 1
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
- 238000009827 uniform distribution Methods 0.000 description 1
- 230000003827 upregulation Effects 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000004552 water soluble powder Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16451399P | 1999-11-10 | 1999-11-10 | |
| US60/164,513 | 1999-11-10 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2325282A1 CA2325282A1 (en) | 2001-05-10 |
| CA2325282C true CA2325282C (en) | 2005-12-06 |
Family
ID=22594839
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002325282A Expired - Fee Related CA2325282C (en) | 1999-11-10 | 2000-11-08 | Use of apo b secretion/mtp inhibitors |
Country Status (11)
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6825209B2 (en) | 2002-04-15 | 2004-11-30 | Research Triangle Institute | Compounds having unique CB1 receptor binding selectivity and methods for their production and use |
| JP2007520543A (ja) | 2004-02-04 | 2007-07-26 | ファイザー・プロダクツ・インク | 置換キノリン化合物 |
| CA2609783A1 (en) * | 2005-05-27 | 2006-12-07 | Pfizer Products Inc. | Combination of a cannabinoid-1- receptor-antagonist and a microsomal triglyceride transfer protein inhibitor for treating obesity or mainataining weight loss |
| WO2008090198A1 (en) * | 2007-01-25 | 2008-07-31 | Janssen Pharmaceutica Nv | Use of mtp inhibitors for increasing levels of satiety hormones |
| US10611819B2 (en) | 2014-07-15 | 2020-04-07 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Isolated polypeptides of CD44 and uses thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992018132A1 (en) * | 1991-04-17 | 1992-10-29 | Merck & Co., Inc. | Pharmaceutical combination for the treatment of benign prostatic hyperplasia comtaining a 5 alpha-reductase inhibitor |
| US5474993A (en) * | 1994-06-14 | 1995-12-12 | Sterling Winthrop, Inc. | Lactam inhibitors of cholesterol esterase |
| WO1996040640A1 (en) * | 1995-06-07 | 1996-12-19 | Pfizer Inc. | BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION |
| DK0902785T3 (da) * | 1996-04-30 | 2002-10-07 | Pfizer | Fremgangsmåder og mellemprodukter til fremstilling af 4'-trifluormethylbiphenyl-2-carboxylsyre-[2-(2H-[1,2,4]triazol-3-ylmethyl)-1,2,3,4-tetrahydroisoquinolin-2-yl]amid |
| US5883109A (en) * | 1996-07-24 | 1999-03-16 | Bristol-Myers Squibb Company | Method for lowering serum lipid levels employing an MTP inhibitor in combination with another cholesterol lowering drug |
| KR100334567B1 (ko) * | 1996-11-27 | 2002-05-03 | 디. 제이. 우드, 스피겔 알렌 제이 | 아포 비-분비/엠티피 억제성 아미드 |
| US5968950A (en) * | 1997-06-23 | 1999-10-19 | Pfizer Inc | Apo B-secretion/MTP inhibitor hydrochloride salt |
| IL133201A0 (en) * | 1998-12-04 | 2001-03-19 | Pfizer Prod Inc | Lowering blood levels of lipoproten (a) |
-
2000
- 2000-11-02 CO CO00083607A patent/CO5271688A1/es not_active Application Discontinuation
- 2000-11-02 IL IL13944900A patent/IL139449A0/xx unknown
- 2000-11-03 EP EP00309705A patent/EP1099438A3/en not_active Withdrawn
- 2000-11-07 PE PE2000001184A patent/PE20010679A1/es not_active Application Discontinuation
- 2000-11-08 CA CA002325282A patent/CA2325282C/en not_active Expired - Fee Related
- 2000-11-08 ZA ZA200006417A patent/ZA200006417B/xx unknown
- 2000-11-08 KR KR10-2000-0066044A patent/KR100439384B1/ko not_active Expired - Fee Related
- 2000-11-09 HU HU0004454A patent/HUP0004454A3/hu unknown
- 2000-11-09 NZ NZ508061A patent/NZ508061A/en unknown
- 2000-11-09 AU AU71519/00A patent/AU777542B2/en not_active Ceased
- 2000-11-10 JP JP2000344128A patent/JP2001181209A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| PE20010679A1 (es) | 2001-06-30 |
| AU7151900A (en) | 2001-05-17 |
| HUP0004454A3 (en) | 2004-04-28 |
| HUP0004454A2 (hu) | 2001-10-28 |
| AU777542B2 (en) | 2004-10-21 |
| JP2001181209A (ja) | 2001-07-03 |
| CO5271688A1 (es) | 2003-04-30 |
| IL139449A0 (en) | 2001-11-25 |
| KR100439384B1 (ko) | 2004-07-09 |
| NZ508061A (en) | 2002-04-26 |
| CA2325282A1 (en) | 2001-05-10 |
| HU0004454D0 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 2001-01-29 |
| EP1099438A2 (en) | 2001-05-16 |
| KR20010051509A (ko) | 2001-06-25 |
| EP1099438A3 (en) | 2003-03-19 |
| ZA200006417B (en) | 2002-05-08 |
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| Date | Code | Title | Description |
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| EEER | Examination request | ||
| MKLA | Lapsed |