CA2324001C - Composes de type retinoide pour la promotion de la production de melanine - Google Patents

Composes de type retinoide pour la promotion de la production de melanine Download PDF

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Publication number
CA2324001C
CA2324001C CA002324001A CA2324001A CA2324001C CA 2324001 C CA2324001 C CA 2324001C CA 002324001 A CA002324001 A CA 002324001A CA 2324001 A CA2324001 A CA 2324001A CA 2324001 C CA2324001 C CA 2324001C
Authority
CA
Canada
Prior art keywords
tetrahydro
acid
pentamethyl
naphthalen
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002324001A
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English (en)
Other versions
CA2324001A1 (fr
Inventor
Deepa Rungta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Galderma Research and Development SNC
Original Assignee
Galderma Research and Development SNC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galderma Research and Development SNC filed Critical Galderma Research and Development SNC
Publication of CA2324001A1 publication Critical patent/CA2324001A1/fr
Application granted granted Critical
Publication of CA2324001C publication Critical patent/CA2324001C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/04—Preparations for care of the skin for chemically tanning the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/14—Liposomes; Vesicles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4933—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having sulfur as an exocyclic substituent, e.g. pyridinethione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/673—Vitamin B group
    • A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/08—Preparations for bleaching the hair

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention concerne un dosage in vitro permettant de sélectionner des composés modifiant la pigmentation de la peau. L'invention concerne également une nouvelle catégorie de composés pro-pigmentaires comprenant des acides carboxyliques hétérocycliques ou aromatiques substitués, des dérivés de ceux-ci, ou des sels pharmaceutiquement acceptables, lesquels composés ne renferment pas de fonction phénol, naphtol, thiophénol, ou thionaphtol sous forme libre ou protégée. Selon un mode de réalisation préféré, ces composés présentent une activité vis-à-vis des récepteurs RXR. Ces composés peuvent être utilisés dans des compositions cosmétiques ou dermatologiques destinées à modifier la pigmentation de la peau et/ou les cheveux de l'homme, ainsi que pour traiter des troubles et des états pathologiques ayant une incidence sur la pigmentation de la peau et des cheveux.
CA002324001A 1998-05-06 1999-05-06 Composes de type retinoide pour la promotion de la production de melanine Expired - Fee Related CA2324001C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8447898P 1998-05-06 1998-05-06
US60/084,478 1998-05-06
PCT/US1999/009845 WO1999056740A1 (fr) 1998-05-06 1999-05-06 Dosage d'identification de composes favorisant la production de melanine, et composes de type retinoide identifies par ce dosage

Publications (2)

Publication Number Publication Date
CA2324001A1 CA2324001A1 (fr) 1999-11-11
CA2324001C true CA2324001C (fr) 2007-08-07

Family

ID=22185213

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002324001A Expired - Fee Related CA2324001C (fr) 1998-05-06 1999-05-06 Composes de type retinoide pour la promotion de la production de melanine

Country Status (13)

Country Link
EP (1) EP1082111A4 (fr)
JP (1) JP3669925B2 (fr)
KR (1) KR100538417B1 (fr)
CN (1) CN1247192C (fr)
AR (1) AR018340A1 (fr)
AU (1) AU762364B2 (fr)
BR (1) BR9909599A (fr)
CA (1) CA2324001C (fr)
ID (1) ID26632A (fr)
IL (1) IL138772A0 (fr)
NO (1) NO20004723L (fr)
WO (1) WO1999056740A1 (fr)
ZA (1) ZA200005026B (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19926779A1 (de) * 1999-06-11 2000-12-14 Basf Ag Verwendung von substituierten Vinyl-tetrahydronaphthalinen und Vinyl-benzotetrahydropyranen als Lichtschutzmittel
US20020034772A1 (en) 1999-06-29 2002-03-21 Orlow Seth J. Methods and compositions that affect melanogenesis
FR2831439A1 (fr) * 2002-02-14 2003-05-02 Oreal Composition comprenant au moins un autobronzant et au moins un compose activteur de la melanogenese
JP4303616B2 (ja) * 2004-03-01 2009-07-29 花王株式会社 メラノソーム転送の検出法
KR100798853B1 (ko) * 2005-02-15 2008-01-28 (주)한국스티펠 레티노이드를 유효성분으로 하는 백반증 예방 및 치료용 약학적 조성물
EP2130908A3 (fr) 2006-08-29 2010-01-06 Reinnervate Limited Composés rétinoïdes et leur utilisation
WO2008121850A2 (fr) * 2007-03-30 2008-10-09 University Of Rochester Modulateurs de type petite molécule, de l'expression de la mélanine
EP2910549A1 (fr) 2011-09-15 2015-08-26 Arizona Board of Regents, a Body Corporate of the State of Arizona acting for and on behalf of Arizona State University Dérivés de 1,2,3,4-tétrahydro-1,1,4,4-tétraméthylnaphthalène en tant que modulateur du rxr utiles pour le traitement du cancer et de la maladie d'alzheimer
US10328040B2 (en) 2014-01-17 2019-06-25 Arizona Board Of Regents On Behalf Of Arizona State University Therapeutic methods
WO2018048358A1 (fr) * 2016-09-08 2018-03-15 Agency For Science, Technology And Research Utilisation de polyamines dans des compositions et procédés d'induction ou de promotion du brunissage de la peau et de régulation de la mélanogenèse
US10231947B2 (en) 2017-01-23 2019-03-19 Arizona Board Of Regents On Behalf Of Arizona State University Isochroman compounds and methods of use thereof
US10238655B2 (en) 2017-01-23 2019-03-26 Arizona Board Of Regents On Behalf Of Arizona State University Dihydroindene and tetrahydronaphthalene compounds
US10238626B2 (en) 2017-01-23 2019-03-26 Arizona Board Of Regents On Behalf Of Arizona State University Therapeutic compounds
EP3709963A1 (fr) 2017-11-14 2020-09-23 Unilever N.V. Peptides pour augmenter la mélanine dans les mélanocytes
CA3084853A1 (fr) 2017-12-06 2019-06-13 Unilever Plc Composition d'assombrissement de la peau

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2133587C (fr) * 1992-04-22 2008-11-18 Marcus F. Boehm Composes se liant selectivement aux recepteurs de la retinoide
US5455265A (en) * 1993-02-11 1995-10-03 Allergan, Inc. Method of treatment with compounds having selective agonist-like activity on RXR retinoid receptors
US5470577A (en) * 1993-07-07 1995-11-28 Trustees Of Boston University Stimulation of tanning by DNA fragments or single-stranded DNA
US5824685A (en) * 1995-02-01 1998-10-20 The Johns Hopkins University School Of Medicine Method of preventing proliferation of retinal pigment epithelium by retinoic acid receptor agonists
FR2735367B1 (fr) * 1995-06-19 1997-07-18 Cird Galderma Utilisation de ligands specifiques des recepteurs rxrs
FR2735370B1 (fr) * 1995-06-19 1997-07-18 Cird Galderma Procede pour identifier des composes agonistes des recepteurs rxrs
CA2224691A1 (fr) * 1995-06-23 1997-01-09 Vincent J. Hearing, Jr. Activite de depigmentation de la proteine-signal d'agouti et ses peptides
FR2746101B1 (fr) * 1996-03-14 1998-04-30 Composes bicycliques-aromatiques
WO1997035998A1 (fr) * 1996-03-28 1997-10-02 Trustees Of Boston University Techniques de modulation de la synthese de la melanine
FR2755965B1 (fr) * 1996-11-19 1998-12-18 Cird Galderma Composes biaromatiques, compositions pharmaceutiques et cosmetiques les contenant et utilisations

Also Published As

Publication number Publication date
IL138772A0 (en) 2001-10-31
EP1082111A1 (fr) 2001-03-14
AR018340A1 (es) 2001-11-14
AU762364B2 (en) 2003-06-26
AU3882999A (en) 1999-11-23
WO1999056740A1 (fr) 1999-11-11
NO20004723D0 (no) 2000-09-21
ZA200005026B (en) 2001-05-22
ID26632A (id) 2001-01-25
CN1299274A (zh) 2001-06-13
NO20004723L (no) 2000-11-06
CA2324001A1 (fr) 1999-11-11
CN1247192C (zh) 2006-03-29
EP1082111A4 (fr) 2004-03-10
KR100538417B1 (ko) 2005-12-22
JP3669925B2 (ja) 2005-07-13
JP2002513756A (ja) 2002-05-14
KR20010043147A (ko) 2001-05-25
BR9909599A (pt) 2001-09-25

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