BR9909599A - Método cosmético, dermatológico e/ou terapêutico para alterar (promover ou inibir) a pigmentação da pele e/ou dos cabelos de um ser humano, composição farmacêutica/cosmética/dermatológica que altera a pigmentação da pele e/ou dos cabelos humanos com aplicação tópica e método in vitro para selecionar composto ou combinação de composto que alteram (aumentam ou diminuem) a pigmentação da pele e/ou dos cabelos humanos - Google Patents

Método cosmético, dermatológico e/ou terapêutico para alterar (promover ou inibir) a pigmentação da pele e/ou dos cabelos de um ser humano, composição farmacêutica/cosmética/dermatológica que altera a pigmentação da pele e/ou dos cabelos humanos com aplicação tópica e método in vitro para selecionar composto ou combinação de composto que alteram (aumentam ou diminuem) a pigmentação da pele e/ou dos cabelos humanos

Info

Publication number
BR9909599A
BR9909599A BR9909599-8A BR9909599A BR9909599A BR 9909599 A BR9909599 A BR 9909599A BR 9909599 A BR9909599 A BR 9909599A BR 9909599 A BR9909599 A BR 9909599A
Authority
BR
Brazil
Prior art keywords
pigmentation
hair
skin
human
alter
Prior art date
Application number
BR9909599-8A
Other languages
English (en)
Inventor
Deepa Rungta
Original Assignee
Galderma Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galderma Res & Dev filed Critical Galderma Res & Dev
Publication of BR9909599A publication Critical patent/BR9909599A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/04—Preparations for care of the skin for chemically tanning the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/14—Liposomes; Vesicles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4933—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having sulfur as an exocyclic substituent, e.g. pyridinethione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/673—Vitamin B group
    • A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/08—Preparations for bleaching the hair

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"MéTODO COSMéTICO, DERMATOLóGICO E/OU TERAPêUTICO PARA ALTERAR (PROMOVER OU INIBIR) A PIGMENTAçãO DA PELE E/OU DOS CABELOS DE UM SER HUMANO, COMPOSIçãO FARMACêUTICA/COSMéTICA/DERMATOLóGICA QUE ALTERA A PIGMENTAçãO DA PELE E/OU DOS CABELOS HUMANOS COM APLICAçãO TóPICA E MéTODO IN VITRO PARA SELECIONAR COMPOSTO OU COMBINAçãO DE COMPOSTOS QUE ALTERAM (AUMENTAM OU DIMINUEM) A PIGMENTAçãO DA PELE E/OU DOS CABELOS HUMANOS" A presente invenção apresenta um ensaio in vitro para selecionar compostos que alteram a pigmentação da pela. Além disso, apresenta uma nova classe de compostos pró-pimentadores que compreendem ácidos carboxílicos aromáticos ou heterocíclicos substituídos, ou seus sais farmaceuticamente aceitáveis, que não apresentam um fenol, naftol, tiofenol ou tionaftol na forma livre ou protegida. Em uma modalidade preferida, esses compostos irão apresentar atividade para RXRs. Esses compostos podem ser utilizados para alterar a pigmentação da pele e/ou cabelos humanos em composições cosméticas ou dermatológicas, e para o tratamento de distúrbios e condições doentias que afetam a pigmentação da pele ou dos cabelos.
BR9909599-8A 1998-05-06 1999-05-06 Método cosmético, dermatológico e/ou terapêutico para alterar (promover ou inibir) a pigmentação da pele e/ou dos cabelos de um ser humano, composição farmacêutica/cosmética/dermatológica que altera a pigmentação da pele e/ou dos cabelos humanos com aplicação tópica e método in vitro para selecionar composto ou combinação de composto que alteram (aumentam ou diminuem) a pigmentação da pele e/ou dos cabelos humanos BR9909599A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8447898P 1998-05-06 1998-05-06
PCT/US1999/009845 WO1999056740A1 (en) 1998-05-06 1999-05-06 Assay for identification of compounds that promote melanin production and retinoid-like compounds identified by said assay

Publications (1)

Publication Number Publication Date
BR9909599A true BR9909599A (pt) 2001-09-25

Family

ID=22185213

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9909599-8A BR9909599A (pt) 1998-05-06 1999-05-06 Método cosmético, dermatológico e/ou terapêutico para alterar (promover ou inibir) a pigmentação da pele e/ou dos cabelos de um ser humano, composição farmacêutica/cosmética/dermatológica que altera a pigmentação da pele e/ou dos cabelos humanos com aplicação tópica e método in vitro para selecionar composto ou combinação de composto que alteram (aumentam ou diminuem) a pigmentação da pele e/ou dos cabelos humanos

Country Status (13)

Country Link
EP (1) EP1082111A4 (pt)
JP (1) JP3669925B2 (pt)
KR (1) KR100538417B1 (pt)
CN (1) CN1247192C (pt)
AR (1) AR018340A1 (pt)
AU (1) AU762364B2 (pt)
BR (1) BR9909599A (pt)
CA (1) CA2324001C (pt)
ID (1) ID26632A (pt)
IL (1) IL138772A0 (pt)
NO (1) NO20004723L (pt)
WO (1) WO1999056740A1 (pt)
ZA (1) ZA200005026B (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19926779A1 (de) * 1999-06-11 2000-12-14 Basf Ag Verwendung von substituierten Vinyl-tetrahydronaphthalinen und Vinyl-benzotetrahydropyranen als Lichtschutzmittel
US20020034772A1 (en) 1999-06-29 2002-03-21 Orlow Seth J. Methods and compositions that affect melanogenesis
FR2831439A1 (fr) * 2002-02-14 2003-05-02 Oreal Composition comprenant au moins un autobronzant et au moins un compose activteur de la melanogenese
JP4303616B2 (ja) * 2004-03-01 2009-07-29 花王株式会社 メラノソーム転送の検出法
KR100798853B1 (ko) * 2005-02-15 2008-01-28 (주)한국스티펠 레티노이드를 유효성분으로 하는 백반증 예방 및 치료용 약학적 조성물
US8293803B2 (en) 2006-08-29 2012-10-23 Reinnervate Limited Retinoid compounds and their use
US9162984B2 (en) 2007-03-30 2015-10-20 University Of Rochester Small-molecule modulators of melanin expression
EP2910549A1 (en) * 2011-09-15 2015-08-26 Arizona Board of Regents, a Body Corporate of the State of Arizona acting for and on behalf of Arizona State University 1,2,3,4-tetrahydro-1,1,4,4-tetramethylnaphthalene derivatives useful as rxr modulators for treating alzheimer's disease and cancer
US10328040B2 (en) 2014-01-17 2019-06-25 Arizona Board Of Regents On Behalf Of Arizona State University Therapeutic methods
EP3509576A4 (en) * 2016-09-08 2020-07-15 Agency for Science, Technology and Research USE OF POLYAMINES IN COMPOSITIONS AND METHODS FOR INDUCING OR PROMOTING SKIN BROWNING AND REGULATING MELANOGENESIS
US10231947B2 (en) 2017-01-23 2019-03-19 Arizona Board Of Regents On Behalf Of Arizona State University Isochroman compounds and methods of use thereof
US10238655B2 (en) 2017-01-23 2019-03-26 Arizona Board Of Regents On Behalf Of Arizona State University Dihydroindene and tetrahydronaphthalene compounds
US10238626B2 (en) 2017-01-23 2019-03-26 Arizona Board Of Regents On Behalf Of Arizona State University Therapeutic compounds
WO2019096546A1 (en) 2017-11-14 2019-05-23 Unilever N.V. Peptides for increasing melanin in melanocytes
EP3720414A1 (en) 2017-12-06 2020-10-14 Unilever N.V. A skin darkening composition

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69333371D1 (de) * 1992-04-22 2004-01-29 Ligand Pharm Inc Verbindungen mit Retinoid x receptorselektivität
US5455265A (en) * 1993-02-11 1995-10-03 Allergan, Inc. Method of treatment with compounds having selective agonist-like activity on RXR retinoid receptors
US5470577A (en) * 1993-07-07 1995-11-28 Trustees Of Boston University Stimulation of tanning by DNA fragments or single-stranded DNA
US5824685A (en) * 1995-02-01 1998-10-20 The Johns Hopkins University School Of Medicine Method of preventing proliferation of retinal pigment epithelium by retinoic acid receptor agonists
FR2735370B1 (fr) * 1995-06-19 1997-07-18 Cird Galderma Procede pour identifier des composes agonistes des recepteurs rxrs
FR2735367B1 (fr) * 1995-06-19 1997-07-18 Cird Galderma Utilisation de ligands specifiques des recepteurs rxrs
EP0833843B1 (en) * 1995-06-23 2002-01-02 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Depigmenting activity of agouti signal protein and peptides thereof
FR2746101B1 (fr) * 1996-03-14 1998-04-30 Composes bicycliques-aromatiques
EP0939829B1 (en) * 1996-03-28 2008-08-20 Trustees Of Boston University Methods of modulating melanin synthesis
FR2755965B1 (fr) * 1996-11-19 1998-12-18 Cird Galderma Composes biaromatiques, compositions pharmaceutiques et cosmetiques les contenant et utilisations

Also Published As

Publication number Publication date
CN1299274A (zh) 2001-06-13
EP1082111A1 (en) 2001-03-14
AU3882999A (en) 1999-11-23
ID26632A (id) 2001-01-25
EP1082111A4 (en) 2004-03-10
JP2002513756A (ja) 2002-05-14
WO1999056740A1 (en) 1999-11-11
AU762364B2 (en) 2003-06-26
IL138772A0 (en) 2001-10-31
KR20010043147A (ko) 2001-05-25
JP3669925B2 (ja) 2005-07-13
AR018340A1 (es) 2001-11-14
NO20004723D0 (no) 2000-09-21
ZA200005026B (en) 2001-05-22
CA2324001C (en) 2007-08-07
KR100538417B1 (ko) 2005-12-22
CN1247192C (zh) 2006-03-29
NO20004723L (no) 2000-11-06
CA2324001A1 (en) 1999-11-11

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

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