EP1082111A4 - Assay for identification of compounds that promote melanin production and retinoid-like compounds identified by said assay - Google Patents

Assay for identification of compounds that promote melanin production and retinoid-like compounds identified by said assay

Info

Publication number
EP1082111A4
EP1082111A4 EP99921689A EP99921689A EP1082111A4 EP 1082111 A4 EP1082111 A4 EP 1082111A4 EP 99921689 A EP99921689 A EP 99921689A EP 99921689 A EP99921689 A EP 99921689A EP 1082111 A4 EP1082111 A4 EP 1082111A4
Authority
EP
European Patent Office
Prior art keywords
assay
compounds
retinoid
identification
melanin production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99921689A
Other languages
German (de)
French (fr)
Other versions
EP1082111A1 (en
Inventor
Deepa Rungta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Galderma Research and Development SNC
Original Assignee
Galderma Research and Development SNC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galderma Research and Development SNC filed Critical Galderma Research and Development SNC
Publication of EP1082111A1 publication Critical patent/EP1082111A1/en
Publication of EP1082111A4 publication Critical patent/EP1082111A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/04—Preparations for care of the skin for chemically tanning the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/14—Liposomes; Vesicles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4933—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having sulfur as an exocyclic substituent, e.g. pyridinethione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/673—Vitamin B group
    • A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/08—Preparations for bleaching the hair

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EP99921689A 1998-05-06 1999-05-06 Assay for identification of compounds that promote melanin production and retinoid-like compounds identified by said assay Withdrawn EP1082111A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8447898P 1998-05-06 1998-05-06
US84478P 1998-05-06
PCT/US1999/009845 WO1999056740A1 (en) 1998-05-06 1999-05-06 Assay for identification of compounds that promote melanin production and retinoid-like compounds identified by said assay

Publications (2)

Publication Number Publication Date
EP1082111A1 EP1082111A1 (en) 2001-03-14
EP1082111A4 true EP1082111A4 (en) 2004-03-10

Family

ID=22185213

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99921689A Withdrawn EP1082111A4 (en) 1998-05-06 1999-05-06 Assay for identification of compounds that promote melanin production and retinoid-like compounds identified by said assay

Country Status (13)

Country Link
EP (1) EP1082111A4 (en)
JP (1) JP3669925B2 (en)
KR (1) KR100538417B1 (en)
CN (1) CN1247192C (en)
AR (1) AR018340A1 (en)
AU (1) AU762364B2 (en)
BR (1) BR9909599A (en)
CA (1) CA2324001C (en)
ID (1) ID26632A (en)
IL (1) IL138772A0 (en)
NO (1) NO20004723L (en)
WO (1) WO1999056740A1 (en)
ZA (1) ZA200005026B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19926779A1 (en) * 1999-06-11 2000-12-14 Basf Ag Use of substituted vinyl tetrahydronaphthalenes and vinyl benzotetrahydropyrans as light stabilizers
US20020034772A1 (en) 1999-06-29 2002-03-21 Orlow Seth J. Methods and compositions that affect melanogenesis
FR2831439A1 (en) * 2002-02-14 2003-05-02 Oreal Cosmetic composition used for coloring or repigmenting skin or hair contains self tanning agent and melanogenesis activator
JP4303616B2 (en) * 2004-03-01 2009-07-29 花王株式会社 Detection method of melanosome transfer
KR100798853B1 (en) * 2005-02-15 2008-01-28 (주)한국스티펠 A pharmaceutical composition comprising retinoid for prevention and treatment of vitiligo
EP2130908A3 (en) 2006-08-29 2010-01-06 Reinnervate Limited Retinoid compounds and their use
WO2008121850A2 (en) * 2007-03-30 2008-10-09 University Of Rochester Small-molecule modulators of melanin expression
EP2910549A1 (en) 2011-09-15 2015-08-26 Arizona Board of Regents, a Body Corporate of the State of Arizona acting for and on behalf of Arizona State University 1,2,3,4-tetrahydro-1,1,4,4-tetramethylnaphthalene derivatives useful as rxr modulators for treating alzheimer's disease and cancer
US10328040B2 (en) 2014-01-17 2019-06-25 Arizona Board Of Regents On Behalf Of Arizona State University Therapeutic methods
WO2018048358A1 (en) * 2016-09-08 2018-03-15 Agency For Science, Technology And Research Use of polyamines in compositions and methods for inducing or promoting skin darkening and regulating melanogenesis
US10231947B2 (en) 2017-01-23 2019-03-19 Arizona Board Of Regents On Behalf Of Arizona State University Isochroman compounds and methods of use thereof
US10238655B2 (en) 2017-01-23 2019-03-26 Arizona Board Of Regents On Behalf Of Arizona State University Dihydroindene and tetrahydronaphthalene compounds
US10238626B2 (en) 2017-01-23 2019-03-26 Arizona Board Of Regents On Behalf Of Arizona State University Therapeutic compounds
EP3709963A1 (en) 2017-11-14 2020-09-23 Unilever N.V. Peptides for increasing melanin in melanocytes
CA3084853A1 (en) 2017-12-06 2019-06-13 Unilever Plc A skin darkening composition

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993021146A1 (en) * 1992-04-22 1993-10-28 Ligand Pharmaceuticals Incorporated Compounds having selectivity for retinoid x receptors
WO1994017796A1 (en) * 1993-02-11 1994-08-18 Allergan, Inc. Therapeutic use of compounds having selective agonist-like activity on rxr retinoid receptors
EP0749752A1 (en) * 1995-06-19 1996-12-27 Centre International De Recherches Dermatologiques Galderma (C.I.R.D. Galderma) Use of specific RXR receptor ligands
WO1997000892A2 (en) * 1995-06-23 1997-01-09 The Government Of The United States Of America, Represented By The Secretary Department Of Health And Human Services Depigmenting activity of agouti signal protein and peptides thereof
WO1997033881A1 (en) * 1996-03-14 1997-09-18 Centre International De Recherches Dermatologiques Galderma (C.I.R.D. Galderma) Bicyclic-aromatic compounds
WO1997035998A1 (en) * 1996-03-28 1997-10-02 Trustees Of Boston University Methods of modulating melanin synthesis
WO1998022423A1 (en) * 1996-11-19 1998-05-28 Centre International De Recherches Dermatologiques Galderma (C.I.R.D. Galderma) Bi-aromatic compounds, pharmaceutical and cosmetic compositions containing same and uses

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5470577A (en) * 1993-07-07 1995-11-28 Trustees Of Boston University Stimulation of tanning by DNA fragments or single-stranded DNA
US5824685A (en) * 1995-02-01 1998-10-20 The Johns Hopkins University School Of Medicine Method of preventing proliferation of retinal pigment epithelium by retinoic acid receptor agonists
FR2735370B1 (en) * 1995-06-19 1997-07-18 Cird Galderma METHOD FOR IDENTIFYING AGONIST COMPOUNDS OF RXRS RECEPTORS

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993021146A1 (en) * 1992-04-22 1993-10-28 Ligand Pharmaceuticals Incorporated Compounds having selectivity for retinoid x receptors
WO1994017796A1 (en) * 1993-02-11 1994-08-18 Allergan, Inc. Therapeutic use of compounds having selective agonist-like activity on rxr retinoid receptors
EP0749752A1 (en) * 1995-06-19 1996-12-27 Centre International De Recherches Dermatologiques Galderma (C.I.R.D. Galderma) Use of specific RXR receptor ligands
WO1997000892A2 (en) * 1995-06-23 1997-01-09 The Government Of The United States Of America, Represented By The Secretary Department Of Health And Human Services Depigmenting activity of agouti signal protein and peptides thereof
WO1997033881A1 (en) * 1996-03-14 1997-09-18 Centre International De Recherches Dermatologiques Galderma (C.I.R.D. Galderma) Bicyclic-aromatic compounds
WO1997035998A1 (en) * 1996-03-28 1997-10-02 Trustees Of Boston University Methods of modulating melanin synthesis
WO1998022423A1 (en) * 1996-11-19 1998-05-28 Centre International De Recherches Dermatologiques Galderma (C.I.R.D. Galderma) Bi-aromatic compounds, pharmaceutical and cosmetic compositions containing same and uses

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BEARD R L ET AL: "SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS OF STILBENE RETINOIDANALOGS SUBSTITUTED WITH HETEROAROMATIC CARBOXYLIC ACIDS", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 38, no. 15, 21 July 1995 (1995-07-21), pages 2820 - 2829, XP000575926, ISSN: 0022-2623 *
BOEHM M F ET AL: "SYNTHESIS AND STRUCTURE - ACTIVITY RELATIONSHIPS OF NOVEL RETINOID X RECEPTOR-SELECTIVE RETINOIDS", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 37, no. 18, 2 September 1994 (1994-09-02), pages 2930 - 2941, XP000615432, ISSN: 0022-2623 *
See also references of WO9956740A1 *

Also Published As

Publication number Publication date
IL138772A0 (en) 2001-10-31
EP1082111A1 (en) 2001-03-14
AR018340A1 (en) 2001-11-14
AU762364B2 (en) 2003-06-26
CA2324001C (en) 2007-08-07
AU3882999A (en) 1999-11-23
WO1999056740A1 (en) 1999-11-11
NO20004723D0 (en) 2000-09-21
ZA200005026B (en) 2001-05-22
ID26632A (en) 2001-01-25
CN1299274A (en) 2001-06-13
NO20004723L (en) 2000-11-06
CA2324001A1 (en) 1999-11-11
CN1247192C (en) 2006-03-29
KR100538417B1 (en) 2005-12-22
JP3669925B2 (en) 2005-07-13
JP2002513756A (en) 2002-05-14
KR20010043147A (en) 2001-05-25
BR9909599A (en) 2001-09-25

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