CA2323927A1 - Mutations responsible for attenuation in measles virus or human respiratory syncytial virus subgroup b - Google Patents

Mutations responsible for attenuation in measles virus or human respiratory syncytial virus subgroup b Download PDF

Info

Publication number
CA2323927A1
CA2323927A1 CA002323927A CA2323927A CA2323927A1 CA 2323927 A1 CA2323927 A1 CA 2323927A1 CA 002323927 A CA002323927 A CA 002323927A CA 2323927 A CA2323927 A CA 2323927A CA 2323927 A1 CA2323927 A1 CA 2323927A1
Authority
CA
Canada
Prior art keywords
virus
gene
vaccine
nucleotide
rsv
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002323927A
Other languages
English (en)
French (fr)
Inventor
Stephen A. Udem
Mohinderjit S. Sidhu
Valerie B. Randolph
Deborah A. Buonagurio
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2323927A1 publication Critical patent/CA2323927A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04—Inactivation or attenuation; Producing viral sub-units
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18411—Morbillivirus, e.g. Measles virus, canine distemper
    • C12N2760/18422—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18522—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA002323927A 1998-03-26 1999-03-22 Mutations responsible for attenuation in measles virus or human respiratory syncytial virus subgroup b Abandoned CA2323927A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7946698P 1998-03-26 1998-03-26
US60/079,466 1998-03-26
PCT/US1999/006225 WO1999049017A2 (en) 1998-03-26 1999-03-22 Mutations responsible for attenuation in measles virus or human respiratory syncytial virus subgroup b

Publications (1)

Publication Number Publication Date
CA2323927A1 true CA2323927A1 (en) 1999-09-30

Family

ID=22150746

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002323927A Abandoned CA2323927A1 (en) 1998-03-26 1999-03-22 Mutations responsible for attenuation in measles virus or human respiratory syncytial virus subgroup b

Country Status (9)

Country Link
EP (1) EP1064358A2 (xx)
JP (1) JP2002507408A (xx)
KR (1) KR20010080863A (xx)
CN (2) CN1600852A (xx)
AU (1) AU767193B2 (xx)
BR (1) BR9909076A (xx)
CA (1) CA2323927A1 (xx)
IL (1) IL138681A0 (xx)
WO (1) WO1999049017A2 (xx)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100885325B1 (ko) 2000-06-23 2009-02-25 와이어쓰 홀딩스 코포레이션 변형된 모빌리바이러스 ｖ 단백질
EP2110382A1 (en) * 2002-06-20 2009-10-21 Institut Pasteur Infectious cDNA of an improved vaccine strain of measles virus, use for immunogenic compositions
JP4783726B2 (ja) * 2003-03-28 2011-09-28 メディミューン，エルエルシー 呼吸器合胞体ウイルスサブグループｂ株９３２０に関連する組成物および方法
JPWO2008065752A1 (ja) * 2006-11-30 2010-03-04 国立大学法人北海道大学 ｄｉＲＮＡを有効成分とする免疫治療用薬剤
JP5016731B2 (ja) 2008-11-05 2012-09-05 メルク・シャープ・エンド・ドーム・コーポレイション 生弱毒化呼吸器合胞体ウイルス
EP2420242A1 (en) 2010-08-20 2012-02-22 Lauer, Ulrich M. Oncolytic measles virus
JP6453063B2 (ja) * 2014-12-02 2019-01-16 国立大学法人北海道大学 アジュバント組成物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3045581B2 (ja) * 1991-10-14 2000-05-29 社団法人北里研究所 麻疹ワクチンウイルス株同定方法
TW275632B (xx) * 1992-04-21 1996-05-11 American Cyanamid Co
EP0932684A2 (en) * 1996-09-27 1999-08-04 American Cyanamid Company 3' genomic promoter region and polymerase gene mutations responsible for attenuation in viruses of the order designated mononegavirales

Also Published As

Publication number Publication date
IL138681A0 (en) 2001-10-31
EP1064358A2 (en) 2001-01-03
WO1999049017A2 (en) 1999-09-30
CN1294628A (zh) 2001-05-09
CN1600852A (zh) 2005-03-30
KR20010080863A (ko) 2001-08-25
JP2002507408A (ja) 2002-03-12
AU767193B2 (en) 2003-11-06
WO1999049017A3 (en) 1999-12-16
BR9909076A (pt) 2000-12-05
CN1177927C (zh) 2004-12-01
AU3109599A (en) 1999-10-18

Similar Documents

Publication Publication Date Title
AU4427897A (en) 3' genomic promoter region and polymerase gene mutations responsible for att enuation in viruses of the order designated mononegavirales
CA2302867A1 (en) Attenuated respiratory syncytial viruses
US5993824A (en) Production of attenuated respiratory syncytial virus vaccines from cloned nucleotide sequences
US6790449B2 (en) Methods for producing self-replicating infectious RSV particles comprising recombinant RSV genomes or antigenomes and the N, P, L, and M2 proteins
CA2304932C (en) Recombinant rsv virus expression systems and vaccines
AU2020203460B2 (en) Attenuation of human respiratory syncytial virus by genome scale codon-pair deoptimization
US6689367B1 (en) Production of attenuated chimeric respiratory syncytial virus vaccines from cloned nucleotide sequences
KR20110063863A (ko) 생 약독화 호흡기 세포융합 바이러스
EP1171623A2 (en) Production of attenuated negative stranded rna virus vaccines
CA2380108C (en) Recombinant rsv virus expression systems and vaccines
CA2430115C (en) Recombinant rsv virus expression systems and vaccines
AU767193B2 (en) Mutations responsible for attenuation in measles virus or human respiratory syncytial virus subgroup B
AU2002236522A1 (en) Recombinant RSV virus expression systems and vaccines
US20120308602A1 (en) Recombinant RSV Virus Expression Systems And Vaccines
CN109310752B (zh) 提供一系列减毒表型的在m2-2 orf中具有突变的重组呼吸道合胞病毒株
MXPA00009256A (en) Mutations responsible for attenuation in measles virus or human respiratory syncytial virus subgroup b
AU8933001A (en) 3' genomic promoter region and polymerase gene mutations responsible for attenuation in viruses of the order designated mononegavirales
AU5592201A (en) Production of attenuated respiratory syncytial virus vaccines from cloned nucleotide sequences
AU5591601A (en) Production of attenuated respiratory syncytial virus vaccines from cloned nucleotide sequences

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued