CA2322629A1 - Method for producing solid, spherical forms containing pharmaceutical active agents in a binder matrix - Google Patents
Method for producing solid, spherical forms containing pharmaceutical active agents in a binder matrix Download PDFInfo
- Publication number
- CA2322629A1 CA2322629A1 CA002322629A CA2322629A CA2322629A1 CA 2322629 A1 CA2322629 A1 CA 2322629A1 CA 002322629 A CA002322629 A CA 002322629A CA 2322629 A CA2322629 A CA 2322629A CA 2322629 A1 CA2322629 A1 CA 2322629A1
- Authority
- CA
- Canada
- Prior art keywords
- melt
- matrix
- pharmaceutical active
- producing solid
- ancillary
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE1998109242 DE19809242A1 (de) | 1998-03-05 | 1998-03-05 | Verfahren zur Herstellung von festen, sphärischen Formkörpern, enthaltend pharmazeutische Wirkstoffe in einer Bindemittelmatrix |
DE19809242.3 | 1998-03-05 | ||
PCT/EP1999/001271 WO1999044588A2 (de) | 1998-03-05 | 1999-02-26 | Verfahren zur herstellung von festen, sphärischen formkörpern, enthaltend pharmazeutische wirkstoffe in einer bindemittelmatrix |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2322629A1 true CA2322629A1 (en) | 1999-09-10 |
Family
ID=7859688
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002322629A Abandoned CA2322629A1 (en) | 1998-03-05 | 1999-02-26 | Method for producing solid, spherical forms containing pharmaceutical active agents in a binder matrix |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1059914A2 (de) |
CA (1) | CA2322629A1 (de) |
DE (1) | DE19809242A1 (de) |
WO (1) | WO1999044588A2 (de) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102631325A (zh) * | 2004-08-12 | 2012-08-15 | 利洁时保健(英国)有限公司 | 通过熔体挤出制备的包含非类固醇类抗炎药和糖醇的颗粒剂 |
US8349229B2 (en) | 2007-12-11 | 2013-01-08 | Sandvik Materials Technology Deutschland Gmbh | Method and drop former for producing tablets and method for producing a sulfurous fertilizer |
US8486447B2 (en) | 2003-02-03 | 2013-07-16 | Novartis Ag | Pharmaceutical formulation |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19943501A1 (de) * | 1999-09-10 | 2001-03-15 | Basf Ag | Unterwassergranulation wirkstoffhaltiger Schmelzen |
US20010036959A1 (en) * | 2000-04-03 | 2001-11-01 | Gabel Rolf Dieter | Carvedilol-hydrophilic solutions |
GB0113841D0 (en) * | 2001-06-07 | 2001-08-01 | Boots Co Plc | Therapeutic agents |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3139920A1 (de) * | 1981-10-08 | 1983-04-28 | Nittner, Erich, Dr., 8280 Kreuzlingen | "mittel in granulatform auf basis von polysaccharid-gummen, verfahren zu seiner herstellung und verwendung" |
DE3813756C1 (de) * | 1988-04-23 | 1989-03-02 | Santrade Ltd., Luzern, Ch | |
TW230742B (de) * | 1992-06-16 | 1994-09-21 | Du Pont | |
DE4225730C2 (de) * | 1992-08-04 | 2003-04-30 | Merz Pharma Gmbh & Co Kgaa | Verfahren zur Herstellung von festen Arzneiformkörpern mit protrahierter 2-Stufen-Freisetzung |
DE19536394A1 (de) * | 1995-09-29 | 1997-04-03 | Basf Ag | Feste Arzneiformen, erhältlich durch Extrusion einer Isomalt enthaltenden Polymer-Wirkstoff-Schmelze |
DE19753300A1 (de) * | 1997-12-01 | 1999-06-02 | Basf Ag | Verfahren zur Herstellung von festen Dosierungsformen |
-
1998
- 1998-03-05 DE DE1998109242 patent/DE19809242A1/de not_active Withdrawn
-
1999
- 1999-02-26 WO PCT/EP1999/001271 patent/WO1999044588A2/de not_active Application Discontinuation
- 1999-02-26 CA CA002322629A patent/CA2322629A1/en not_active Abandoned
- 1999-02-26 EP EP99911718A patent/EP1059914A2/de not_active Withdrawn
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8486447B2 (en) | 2003-02-03 | 2013-07-16 | Novartis Ag | Pharmaceutical formulation |
CN102631325A (zh) * | 2004-08-12 | 2012-08-15 | 利洁时保健(英国)有限公司 | 通过熔体挤出制备的包含非类固醇类抗炎药和糖醇的颗粒剂 |
CN102784113A (zh) * | 2004-08-12 | 2012-11-21 | 利洁时保健(英国)有限公司 | 用熔融挤出法制备并含有对乙酰氨基酚、非甾体抗炎药物和糖醇的颗粒剂 |
US8349229B2 (en) | 2007-12-11 | 2013-01-08 | Sandvik Materials Technology Deutschland Gmbh | Method and drop former for producing tablets and method for producing a sulfurous fertilizer |
Also Published As
Publication number | Publication date |
---|---|
WO1999044588A3 (de) | 1999-10-28 |
DE19809242A1 (de) | 1999-09-09 |
EP1059914A2 (de) | 2000-12-20 |
WO1999044588A2 (de) | 1999-09-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Discontinued |