CA2322629A1 - Procede de production de corps moules spheriques solides contenant des principes actifs pharmaceutiques dans une matrice constituee d'un liant - Google Patents

Procede de production de corps moules spheriques solides contenant des principes actifs pharmaceutiques dans une matrice constituee d'un liant Download PDF

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Publication number
CA2322629A1
CA2322629A1 CA002322629A CA2322629A CA2322629A1 CA 2322629 A1 CA2322629 A1 CA 2322629A1 CA 002322629 A CA002322629 A CA 002322629A CA 2322629 A CA2322629 A CA 2322629A CA 2322629 A1 CA2322629 A1 CA 2322629A1
Authority
CA
Canada
Prior art keywords
melt
matrix
pharmaceutical active
producing solid
ancillary
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002322629A
Other languages
English (en)
Inventor
Andreas Kleinke
Thomas Kessler
Jorg Rosenberg
Harald Krull
Gunther Berndl
Werner Maier
Jorg Breitenbach
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2322629A1 publication Critical patent/CA2322629A1/fr
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention concerne un procédé de production de corps moulés sphériques solides contenant au moins un principe actif pharmaceutique homogène en dispersion dans une matrice constituée d'un produit auxiliaire. Selon ce procédé, on mélange les composants pour obtenir une masse en fusion puis on façonne cette masse. Ce procédé est caractérisé en ce que l'on transforme au moins un principe actif pharmaceutique comprenant au moins un produit auxiliaire-matrice thermoplastiquement transformable en une masse en fusion homogène d'une viscosité inférieure à 5000 mPas et en ce que l'on transforme cette masse en fusion en gouttes à l'aide d'un cylindre perceur rotatif. Ces gouttes sont ensuite solidifiées par refroidissement.
CA002322629A 1998-03-05 1999-02-26 Procede de production de corps moules spheriques solides contenant des principes actifs pharmaceutiques dans une matrice constituee d'un liant Abandoned CA2322629A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE1998109242 DE19809242A1 (de) 1998-03-05 1998-03-05 Verfahren zur Herstellung von festen, sphärischen Formkörpern, enthaltend pharmazeutische Wirkstoffe in einer Bindemittelmatrix
DE19809242.3 1998-03-05
PCT/EP1999/001271 WO1999044588A2 (fr) 1998-03-05 1999-02-26 Procede de production de corps moules spheriques solides contenant des principes actifs pharmaceutiques dans une matrice constituee d'un liant

Publications (1)

Publication Number Publication Date
CA2322629A1 true CA2322629A1 (fr) 1999-09-10

Family

ID=7859688

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002322629A Abandoned CA2322629A1 (fr) 1998-03-05 1999-02-26 Procede de production de corps moules spheriques solides contenant des principes actifs pharmaceutiques dans une matrice constituee d'un liant

Country Status (4)

Country Link
EP (1) EP1059914A2 (fr)
CA (1) CA2322629A1 (fr)
DE (1) DE19809242A1 (fr)
WO (1) WO1999044588A2 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102631325A (zh) * 2004-08-12 2012-08-15 利洁时保健（英国）有限公司 通过熔体挤出制备的包含非类固醇类抗炎药和糖醇的颗粒剂
US8349229B2 (en) 2007-12-11 2013-01-08 Sandvik Materials Technology Deutschland Gmbh Method and drop former for producing tablets and method for producing a sulfurous fertilizer
US8486447B2 (en) 2003-02-03 2013-07-16 Novartis Ag Pharmaceutical formulation

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19943501A1 (de) * 1999-09-10 2001-03-15 Basf Ag Unterwassergranulation wirkstoffhaltiger Schmelzen
US20010036959A1 (en) * 2000-04-03 2001-11-01 Gabel Rolf Dieter Carvedilol-hydrophilic solutions
GB0113841D0 (en) * 2001-06-07 2001-08-01 Boots Co Plc Therapeutic agents

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3139920A1 (de) * 1981-10-08 1983-04-28 Nittner, Erich, Dr., 8280 Kreuzlingen "mittel in granulatform auf basis von polysaccharid-gummen, verfahren zu seiner herstellung und verwendung"
DE3813756C1 (fr) * 1988-04-23 1989-03-02 Santrade Ltd., Luzern, Ch
TW230742B (fr) * 1992-06-16 1994-09-21 Du Pont
DE4225730C2 (de) * 1992-08-04 2003-04-30 Merz Pharma Gmbh & Co Kgaa Verfahren zur Herstellung von festen Arzneiformkörpern mit protrahierter 2-Stufen-Freisetzung
DE19536394A1 (de) * 1995-09-29 1997-04-03 Basf Ag Feste Arzneiformen, erhältlich durch Extrusion einer Isomalt enthaltenden Polymer-Wirkstoff-Schmelze
DE19753300A1 (de) * 1997-12-01 1999-06-02 Basf Ag Verfahren zur Herstellung von festen Dosierungsformen

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8486447B2 (en) 2003-02-03 2013-07-16 Novartis Ag Pharmaceutical formulation
CN102631325A (zh) * 2004-08-12 2012-08-15 利洁时保健（英国）有限公司 通过熔体挤出制备的包含非类固醇类抗炎药和糖醇的颗粒剂
CN102784113A (zh) * 2004-08-12 2012-11-21 利洁时保健（英国）有限公司 用熔融挤出法制备并含有对乙酰氨基酚、非甾体抗炎药物和糖醇的颗粒剂
US8349229B2 (en) 2007-12-11 2013-01-08 Sandvik Materials Technology Deutschland Gmbh Method and drop former for producing tablets and method for producing a sulfurous fertilizer

Also Published As

Publication number Publication date
WO1999044588A3 (fr) 1999-10-28
EP1059914A2 (fr) 2000-12-20
WO1999044588A2 (fr) 1999-09-10
DE19809242A1 (de) 1999-09-09

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Legal Events

Date Code Title Description
FZDE Discontinued