CA2322629A1 - Procede de production de corps moules spheriques solides contenant des principes actifs pharmaceutiques dans une matrice constituee d'un liant - Google Patents
Procede de production de corps moules spheriques solides contenant des principes actifs pharmaceutiques dans une matrice constituee d'un liant Download PDFInfo
- Publication number
- CA2322629A1 CA2322629A1 CA002322629A CA2322629A CA2322629A1 CA 2322629 A1 CA2322629 A1 CA 2322629A1 CA 002322629 A CA002322629 A CA 002322629A CA 2322629 A CA2322629 A CA 2322629A CA 2322629 A1 CA2322629 A1 CA 2322629A1
- Authority
- CA
- Canada
- Prior art keywords
- melt
- matrix
- pharmaceutical active
- producing solid
- ancillary
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
L'invention concerne un procédé de production de corps moulés sphériques solides contenant au moins un principe actif pharmaceutique homogène en dispersion dans une matrice constituée d'un produit auxiliaire. Selon ce procédé, on mélange les composants pour obtenir une masse en fusion puis on façonne cette masse. Ce procédé est caractérisé en ce que l'on transforme au moins un principe actif pharmaceutique comprenant au moins un produit auxiliaire-matrice thermoplastiquement transformable en une masse en fusion homogène d'une viscosité inférieure à 5000 mPas et en ce que l'on transforme cette masse en fusion en gouttes à l'aide d'un cylindre perceur rotatif. Ces gouttes sont ensuite solidifiées par refroidissement.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE1998109242 DE19809242A1 (de) | 1998-03-05 | 1998-03-05 | Verfahren zur Herstellung von festen, sphärischen Formkörpern, enthaltend pharmazeutische Wirkstoffe in einer Bindemittelmatrix |
DE19809242.3 | 1998-03-05 | ||
PCT/EP1999/001271 WO1999044588A2 (fr) | 1998-03-05 | 1999-02-26 | Procede de production de corps moules spheriques solides contenant des principes actifs pharmaceutiques dans une matrice constituee d'un liant |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2322629A1 true CA2322629A1 (fr) | 1999-09-10 |
Family
ID=7859688
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002322629A Abandoned CA2322629A1 (fr) | 1998-03-05 | 1999-02-26 | Procede de production de corps moules spheriques solides contenant des principes actifs pharmaceutiques dans une matrice constituee d'un liant |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1059914A2 (fr) |
CA (1) | CA2322629A1 (fr) |
DE (1) | DE19809242A1 (fr) |
WO (1) | WO1999044588A2 (fr) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102631325A (zh) * | 2004-08-12 | 2012-08-15 | 利洁时保健(英国)有限公司 | 通过熔体挤出制备的包含非类固醇类抗炎药和糖醇的颗粒剂 |
US8349229B2 (en) | 2007-12-11 | 2013-01-08 | Sandvik Materials Technology Deutschland Gmbh | Method and drop former for producing tablets and method for producing a sulfurous fertilizer |
US8486447B2 (en) | 2003-02-03 | 2013-07-16 | Novartis Ag | Pharmaceutical formulation |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19943501A1 (de) * | 1999-09-10 | 2001-03-15 | Basf Ag | Unterwassergranulation wirkstoffhaltiger Schmelzen |
US20010036959A1 (en) * | 2000-04-03 | 2001-11-01 | Gabel Rolf Dieter | Carvedilol-hydrophilic solutions |
GB0113841D0 (en) * | 2001-06-07 | 2001-08-01 | Boots Co Plc | Therapeutic agents |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3139920A1 (de) * | 1981-10-08 | 1983-04-28 | Nittner, Erich, Dr., 8280 Kreuzlingen | "mittel in granulatform auf basis von polysaccharid-gummen, verfahren zu seiner herstellung und verwendung" |
DE3813756C1 (fr) * | 1988-04-23 | 1989-03-02 | Santrade Ltd., Luzern, Ch | |
TW230742B (fr) * | 1992-06-16 | 1994-09-21 | Du Pont | |
DE4225730C2 (de) * | 1992-08-04 | 2003-04-30 | Merz Pharma Gmbh & Co Kgaa | Verfahren zur Herstellung von festen Arzneiformkörpern mit protrahierter 2-Stufen-Freisetzung |
DE19536394A1 (de) * | 1995-09-29 | 1997-04-03 | Basf Ag | Feste Arzneiformen, erhältlich durch Extrusion einer Isomalt enthaltenden Polymer-Wirkstoff-Schmelze |
DE19753300A1 (de) * | 1997-12-01 | 1999-06-02 | Basf Ag | Verfahren zur Herstellung von festen Dosierungsformen |
-
1998
- 1998-03-05 DE DE1998109242 patent/DE19809242A1/de not_active Withdrawn
-
1999
- 1999-02-26 WO PCT/EP1999/001271 patent/WO1999044588A2/fr not_active Application Discontinuation
- 1999-02-26 CA CA002322629A patent/CA2322629A1/fr not_active Abandoned
- 1999-02-26 EP EP99911718A patent/EP1059914A2/fr not_active Withdrawn
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8486447B2 (en) | 2003-02-03 | 2013-07-16 | Novartis Ag | Pharmaceutical formulation |
CN102631325A (zh) * | 2004-08-12 | 2012-08-15 | 利洁时保健(英国)有限公司 | 通过熔体挤出制备的包含非类固醇类抗炎药和糖醇的颗粒剂 |
CN102784113A (zh) * | 2004-08-12 | 2012-11-21 | 利洁时保健(英国)有限公司 | 用熔融挤出法制备并含有对乙酰氨基酚、非甾体抗炎药物和糖醇的颗粒剂 |
US8349229B2 (en) | 2007-12-11 | 2013-01-08 | Sandvik Materials Technology Deutschland Gmbh | Method and drop former for producing tablets and method for producing a sulfurous fertilizer |
Also Published As
Publication number | Publication date |
---|---|
WO1999044588A2 (fr) | 1999-09-10 |
DE19809242A1 (de) | 1999-09-09 |
EP1059914A2 (fr) | 2000-12-20 |
WO1999044588A3 (fr) | 1999-10-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Discontinued |