CA2318536C - Method of and compositions for immunization with the pseudomonas v antigen - Google Patents

Method of and compositions for immunization with the pseudomonas v antigen Download PDF

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Publication number
CA2318536C
CA2318536C CA002318536A CA2318536A CA2318536C CA 2318536 C CA2318536 C CA 2318536C CA 002318536 A CA002318536 A CA 002318536A CA 2318536 A CA2318536 A CA 2318536A CA 2318536 C CA2318536 C CA 2318536C
Authority
CA
Canada
Prior art keywords
pcrv
antigen
infection
pseudomonas aeruginosa
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002318536A
Other languages
English (en)
French (fr)
Other versions
CA2318536A1 (en
Inventor
Dara W. Frank
Timothy L. Yahr
Teiji Sawa
Jeanine Wiener-Kronish
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medical College of Wisconsin Research Foundation Inc
University of California San Diego UCSD
Original Assignee
Medical College of Wisconsin Research Foundation Inc
University of California San Diego UCSD
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medical College of Wisconsin Research Foundation Inc, University of California San Diego UCSD filed Critical Medical College of Wisconsin Research Foundation Inc
Publication of CA2318536A1 publication Critical patent/CA2318536A1/en
Application granted granted Critical
Publication of CA2318536C publication Critical patent/CA2318536C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/104Pseudomonadales, e.g. Pseudomonas
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/21Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911Bacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/21Assays involving biological materials from specific organisms or of a specific nature from bacteria from Pseudomonadaceae (F)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00Immunoassays for the detection of microorganisms
    • G01N2469/20Detection of antibodies in sample from host which are directed against antigens from microorganisms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Mycology (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Food Science & Technology (AREA)
CA002318536A 1998-11-25 1999-11-23 Method of and compositions for immunization with the pseudomonas v antigen Expired - Fee Related CA2318536C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US10995298P 1998-11-25 1998-11-25
US60/109,952 1998-11-25
US12679499P 1999-03-30 1999-03-30
US60/126,794 1999-03-30
PCT/US1999/027796 WO2000033872A2 (en) 1998-11-25 1999-11-23 Method of and compositions for immunization with the pseudomonas v antigen

Publications (2)

Publication Number Publication Date
CA2318536A1 CA2318536A1 (en) 2000-06-15
CA2318536C true CA2318536C (en) 2009-11-17

Family

ID=26807543

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002318536A Expired - Fee Related CA2318536C (en) 1998-11-25 1999-11-23 Method of and compositions for immunization with the pseudomonas v antigen

Country Status (10)

Country Link
US (2) US6309651B1 (enExample)
EP (2) EP1666058B1 (enExample)
JP (2) JP4707234B2 (enExample)
AT (2) ATE539349T1 (enExample)
AU (1) AU3580800A (enExample)
CA (1) CA2318536C (enExample)
DE (1) DE69930166T2 (enExample)
DK (1) DK1049488T3 (enExample)
ES (2) ES2255329T3 (enExample)
WO (1) WO2000033872A2 (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007231760B2 (en) * 2001-01-26 2009-10-29 Mcw Research Foundation, Inc. Method and compositions for immunization with the pseudomonas V antigen
WO2002064161A2 (en) * 2001-01-26 2002-08-22 Mcw Research Foundation, Inc. Method and compositions for immunization with the pseudomonas v antigen
DE10294091D2 (de) * 2001-09-13 2004-08-05 Hannover Med Hochschule Phänotyp bestimmende Virulenzgene von Pseudomonas aeruginosa zur Kolonisation und Persistenz in Mensch, Tier und Pflanze, Verwendungen der Gene und zugehörigen Proteine
WO2003058205A2 (en) * 2002-01-11 2003-07-17 Cornell Research Foundation, Inc. Methods of identifying putative effector proteins
CA2495725C (en) 2002-08-13 2013-06-25 Haptogen Ltd Methods for the treatment of an infectious bacterial disease with an anti-lactone or lactone derived signal molecules antibody
JP4782700B2 (ja) * 2004-01-20 2011-09-28 カロバイオス ファーマシューティカルズ インコーポレイティッド 最低限必須な結合決定基を用いた抗体特異性の移入
GB0407008D0 (en) 2004-03-27 2004-04-28 Haptogen Ltd Methods for inducing rapid cell death (autolysis) in infectious bacteria
GB0410958D0 (en) 2004-05-15 2004-06-16 Haptogen Ltd Methods for reducing biofilm formation in infectious bacteria
EP1946768A4 (en) 2005-10-28 2009-11-11 Meiji Seika Kaisha OUTER COAT PROTEIN PA5158 OF PSEUDOMONAS AERUGINOSA
AU2007232894B2 (en) 2006-03-30 2013-01-31 Meiji Seika Kaisha, Ltd. Pseudomonas aeruginosa outer membrane protein PA0427
CN101878302A (zh) * 2007-06-29 2010-11-03 明治制果株式会社 绿脓杆菌的外膜蛋白质pa4710
EA201000903A1 (ru) * 2007-11-30 2011-02-28 Калобиос Фармасьютикалс, Инк. Антитела к pcrv-антигену pseudomonas aeruginosa
CA2709500A1 (en) 2007-12-25 2009-07-02 Meiji Seika Kaisha, Ltd. Type iii secretion system component protein pa1698 of pseudomonas aeruginosa
BRPI0906810A2 (pt) * 2008-01-10 2019-10-01 Shionogi & Co anticorpo contra pcrv
EP2393515A1 (en) 2009-02-04 2011-12-14 Kalobios Pharmaceuticals, Inc. Combination antibiotic and antibody therapy for the treatment of pseudomonas aeruginosa infection
KR101686261B1 (ko) 2009-03-11 2016-12-14 시오노기세야쿠 가부시키가이샤 항녹농균 작용을 갖는 인간화 PcrV 항체
WO2011087799A1 (en) * 2009-12-22 2011-07-21 Kalobios Pharmaceuticals, Inc. A method of treating a staphylococcus infection in a patient having a low-level pathogenic pseudomonas aeruginosa infection
EP2726103B1 (en) * 2011-07-01 2018-09-05 The Trustees Of The University Of Pennsylvania Anti-properdin antibodies and uses thereof
BR112014011028B1 (pt) 2011-11-07 2021-03-02 Medimmune, Llc anticorpo biespecífico, composição, e, uso da composição
US9926366B2 (en) 2012-10-04 2018-03-27 Novelmed Therapeutics, Inc. Methods of treating a hemolytic disorder comprising administering anti-properdin antibodies
CN110028559B (zh) * 2019-04-15 2022-06-10 中国人民解放军陆军军医大学 一种铜绿假单胞菌疫苗重组蛋白及其编码基因和它们的应用
WO2021031270A1 (zh) * 2019-08-22 2021-02-25 四川大学 细菌膜囊泡及其分离制备系统和方法
WO2021113740A1 (en) * 2019-12-04 2021-06-10 The Research Foundation For The State University Of New York Compositions and methods for reducing off-target toxicity of antibody drug conjugates

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3178014B2 (ja) * 1991-07-05 2001-06-18 東ソー株式会社 Rnaの測定方法
US5599665A (en) 1993-12-21 1997-02-04 Mcw Research Foundation Pseudomonas aeruginosa nucleic acids encoding exoenzyme S activity and use thereof in detecting pseudomonas aeruginosa infection

Also Published As

Publication number Publication date
CA2318536A1 (en) 2000-06-15
WO2000033872A2 (en) 2000-06-15
US20040208888A1 (en) 2004-10-21
DE69930166D1 (de) 2006-04-27
EP1666058B1 (en) 2011-12-28
JP2002531522A (ja) 2002-09-24
WO2000033872A3 (en) 2000-10-19
WO2000033872A9 (en) 2000-12-14
EP1666058A3 (en) 2008-03-12
ES2379801T3 (es) 2012-05-03
DE69930166T2 (de) 2006-12-14
AU3580800A (en) 2000-06-26
EP1049488B1 (en) 2006-03-01
JP4707234B2 (ja) 2011-06-22
ES2255329T3 (es) 2006-06-16
ATE539349T1 (de) 2012-01-15
DK1049488T3 (da) 2006-06-26
EP1666058A2 (en) 2006-06-07
US6827935B2 (en) 2004-12-07
US6309651B1 (en) 2001-10-30
ATE318613T1 (de) 2006-03-15
JP2011068672A (ja) 2011-04-07
EP1049488A1 (en) 2000-11-08

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Effective date: 20181123