CA2317674A1 - Methodes et compositions permettant de traiter et de diagnostiquer les troubles lies a l'insuline - Google Patents

Methodes et compositions permettant de traiter et de diagnostiquer les troubles lies a l'insuline Download PDF

Info

Publication number
CA2317674A1
CA2317674A1 CA002317674A CA2317674A CA2317674A1 CA 2317674 A1 CA2317674 A1 CA 2317674A1 CA 002317674 A CA002317674 A CA 002317674A CA 2317674 A CA2317674 A CA 2317674A CA 2317674 A1 CA2317674 A1 CA 2317674A1
Authority
CA
Canada
Prior art keywords
insulin
polypeptide
degrading enzyme
complex
activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002317674A
Other languages
English (en)
Inventor
William Clifford Duckworth
Frederick G. Hamel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2317674A1 publication Critical patent/CA2317674A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente invention concerne des méthodes et des compositions permettant de traiter ou de diminuer les symptômes d'une carence insulinique absolue ou relative, d'une grave résistance insulinique, d'une accumulation lipidique ou d'une synthèse lipidique excessive, ou d'un catabolisme ou d'une dégradation protéiques. L'invention concerne également des méthodes permettant de détecter et d'évaluer les traitements de ces troubles.
CA002317674A 1998-01-08 1999-01-08 Methodes et compositions permettant de traiter et de diagnostiquer les troubles lies a l'insuline Abandoned CA2317674A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7082198P 1998-01-08 1998-01-08
US60/070,821 1998-01-08
PCT/US1999/000471 WO1999035169A2 (fr) 1998-01-08 1999-01-08 Methodes et compositions permettant de traiter et de diagnostiquer les troubles lies a l'insuline

Publications (1)

Publication Number Publication Date
CA2317674A1 true CA2317674A1 (fr) 1999-07-15

Family

ID=22097585

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002317674A Abandoned CA2317674A1 (fr) 1998-01-08 1999-01-08 Methodes et compositions permettant de traiter et de diagnostiquer les troubles lies a l'insuline

Country Status (7)

Country Link
EP (1) EP1045860A2 (fr)
JP (1) JP2002500234A (fr)
CN (1) CN1292798A (fr)
AU (1) AU2313899A (fr)
BR (1) BR9906833A (fr)
CA (1) CA2317674A1 (fr)
WO (1) WO1999035169A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6465714B2 (en) * 1999-11-05 2002-10-15 Arexis Ab Congenic animal models of non-insulin dependent diabetes mellitus
EP1846438A2 (fr) * 2005-01-31 2007-10-24 Leiden University Medical Center Méthodes et moyens pour l'usage dans le diagnostic et le traitement du diabète
EP2356452B1 (fr) * 2008-10-31 2019-04-24 B.R.A.H.M.S GmbH Procédés et analyses pour classifier aliments et/ou boissons et/ou régimes et/ou régimes nutritionnels et/ou médicaments susceptibles d'avoir un effet sur le système cardiovasculaire
CN102369015A (zh) * 2009-02-02 2012-03-07 雷蒙特亚特特拉维夫大学有限公司 肽、包含该肽的药物组合物及其用途
EP2600885A2 (fr) 2010-08-04 2013-06-12 Ramot at Tel Aviv University, Ltd. Procédés de traitement de maladies auto-immunes du système nerveux central (snc) et de maladies neurodégénératives
CN104961706B (zh) * 2015-07-06 2017-03-01 成都知普莱生物医药科技有限公司 一种合成胰岛素降解酶抑制剂ml345的方法
CN115477686B (zh) * 2022-09-22 2024-01-30 北海黑珍珠海洋生物科技有限公司 一种具有美白功效的珍珠贝活性肽及其应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5891435A (en) * 1993-04-16 1999-04-06 Research Corporation Technologies, Inc. Methods and compositions for delaying or preventing the onset of autoimmune disease
AUPM411994A0 (en) * 1994-02-25 1994-03-24 Deakin Research Limited Epitopes
US5594100A (en) * 1995-02-22 1997-01-14 Regents Of The University Of Colorado Epitope for prevention of type I diabetes

Also Published As

Publication number Publication date
WO1999035169A9 (fr) 1999-11-11
CN1292798A (zh) 2001-04-25
AU2313899A (en) 1999-07-26
EP1045860A2 (fr) 2000-10-25
BR9906833A (pt) 2001-11-27
WO1999035169A2 (fr) 1999-07-15
WO1999035169A3 (fr) 1999-10-07
JP2002500234A (ja) 2002-01-08

Similar Documents

Publication Publication Date Title
Duckworth et al. Insulin degradation: progress and potential
Scrocchi et al. Design of peptide-based inhibitors of human islet amyloid polypeptide fibrillogenesis
JP2828250B2 (ja) 真性糖尿病の治療
Owens Human insulin: clinical pharmacological studies in normal man
JP2961708B2 (ja) 成長ホルモンとインスリン様成長因子―１の組み合わせが成長を増進する
US5811395A (en) Relaxin analogs and derivatives methods and uses thereof
Clemmons Structural and functional analysis of insulin-like growth factors
Kumar Tumor-induced osteomalacia and the regulation of phosphate homeostasis
Westermark et al. Islet amyloid polypeptide, islet amyloid, and diabetes mellitus
JP5240586B2 (ja) 糖尿病性合併症治療用薬学的組成物
DE69736129T2 (de) Verfahren und Zusammensetzungen für die Behandlung von neoplastichen Krankheiten
JP2004520345A (ja) 糖尿病を有する被験者にガストリン／ｃｃｋ受容体リガンド及びｅｇｆ受容体リガンド組成物を用いた島細胞新生治療方法の効果持続
Swope et al. Bombesin stimulates insulin secretion by a pancreatic islet cell line.
MX2008015657A (es) Polipeptidos de factor de crecimiento similares a insulina estabilizados.
JP2003535106A (ja) グルコース検知性インスリン誘導体からの、インスリンのグルコース依存性放出
EP2229952A1 (fr) Peptide plasmatique anti-diabétique NUCB2 (pladin et nesfatin-1) et ses utilisations
Goodyer et al. Renal tubular cells are potential targets for epidermal growth factor
Cheung et al. Glucocorticoid regulation of an insulin-like growth factor-binding protein-4 protease produced by a rat neuronal cell line
KR20040040482A (ko) 글루카곤-유사 펩타이드 (ｇｌｐ-1) 및 호흡 곤란의 치료
Duckworth et al. Insulin acts intracellularly on proteasomes through insulin-degrading enzyme
Myers et al. Insulin-like growth factor-I (IGF-I) enhanced proteolysis of IGF-binding protein-4 in conditioned medium from primary cultures of human decidua: independence from IGF receptor binding
Zucker et al. Effects of the CCK receptor antagonist L364, 718 on pancreatic growth in adult and developing animals
Griffiths et al. Enzymic inactivation of hypothalamic regulatory hormones
CA2317674A1 (fr) Methodes et compositions permettant de traiter et de diagnostiquer les troubles lies a l'insuline
Lazarus et al. Studies on the biological activity of porcine proinsulin

Legal Events

Date Code Title Description
FZDE Discontinued