CA2313684A1 - Resolution of chiral amines - Google Patents

Resolution of chiral amines Download PDF

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Publication number
CA2313684A1
CA2313684A1 CA002313684A CA2313684A CA2313684A1 CA 2313684 A1 CA2313684 A1 CA 2313684A1 CA 002313684 A CA002313684 A CA 002313684A CA 2313684 A CA2313684 A CA 2313684A CA 2313684 A1 CA2313684 A1 CA 2313684A1
Authority
CA
Canada
Prior art keywords
group
amine
enantiomer
groups
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002313684A
Other languages
English (en)
French (fr)
Inventor
Christopher David Reeve
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Avecia Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2313684A1 publication Critical patent/CA2313684A1/en
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
    • C12P41/007—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures by reactions involving acyl derivatives of racemic amines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Optical Integrated Circuits (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA002313684A 1997-12-12 1998-12-09 Resolution of chiral amines Abandoned CA2313684A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9726229.9A GB9726229D0 (en) 1997-12-12 1997-12-12 Resolution of chiral amines
GB9726229.9 1997-12-12
PCT/GB1998/003679 WO1999031264A1 (en) 1997-12-12 1998-12-09 Resolution of chiral amines

Publications (1)

Publication Number Publication Date
CA2313684A1 true CA2313684A1 (en) 1999-06-24

Family

ID=10823474

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002313684A Abandoned CA2313684A1 (en) 1997-12-12 1998-12-09 Resolution of chiral amines

Country Status (9)

Country Link
US (1) US6335187B1 (https=)
EP (1) EP1036189B1 (https=)
JP (1) JP2002508189A (https=)
AT (1) ATE233324T1 (https=)
AU (1) AU1495999A (https=)
CA (1) CA2313684A1 (https=)
DE (1) DE69811723T2 (https=)
GB (1) GB9726229D0 (https=)
WO (1) WO1999031264A1 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6624311B2 (en) 2000-10-27 2003-09-23 Bristol-Myers Squibb Pharma Company Enantioselective enzymatic aminolysis of a racemic 2-isoxazolylacetate alkyl ester
WO2003022785A2 (en) 2001-09-12 2003-03-20 Anormed Inc. Synthesis of enantiomerically pure amino-substituted fused bicyclic rings
US7067291B2 (en) 2002-12-20 2006-06-27 Pfizer Inc. Biocatalytic preparation of enantiomerically enriched aminopentanenitrile
KR100929437B1 (ko) 2007-08-02 2009-12-03 포항공과대학교 산학협력단 광학 활성을 갖는 아민의 제조방법
GB201020026D0 (en) 2010-11-25 2011-01-12 Cambrex Karlskoga Ab New process
WO2017106332A1 (en) 2015-12-14 2017-06-22 X4 Pharmaceuticals, Inc. Methods for treating cancer
CN109069426B (zh) 2015-12-14 2021-10-29 X4 制药有限公司 治疗癌症的方法
PL3393468T3 (pl) 2015-12-22 2023-01-23 X4 Pharmaceuticals, Inc. Metody leczenia niedoboru odporności
US11337969B2 (en) 2016-04-08 2022-05-24 X4 Pharmaceuticals, Inc. Methods for treating cancer
WO2017223243A1 (en) 2016-06-21 2017-12-28 X4 Pharmaceuticals, Inc. Cxcr4 inhibitors and uses thereof
CN109640988A (zh) 2016-06-21 2019-04-16 X4 制药有限公司 Cxcr4抑制剂及其用途
ES2870920T3 (es) 2016-06-21 2021-10-28 X4 Pharmaceuticals Inc Inhibidores de CXCR4 y usos de los mismos
US10548889B1 (en) 2018-08-31 2020-02-04 X4 Pharmaceuticals, Inc. Compositions of CXCR4 inhibitors and methods of preparation and use
CN109234352A (zh) * 2018-10-30 2019-01-18 江苏理工学院 一种酶法拆分制备(r)-1-(1-萘基)乙胺的方法
CA3171250A1 (en) 2020-03-10 2021-09-16 E. Lynne KELLEY Methods for treating neutropenia

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991019002A1 (en) 1990-06-01 1991-12-12 Carlbiotech Ltd. A/S A process for chiral enrichment of asymmetric primary amines
DE4332738A1 (de) 1993-09-25 1995-03-30 Basf Ag Racematspaltung primärer und sekundärer Amine durch Enzym-katalysierte Acylierung
DE19523151A1 (de) 1995-02-03 1996-08-14 Basf Ag Racematspaltung primärer und sekundärer heteroatomsubstituierter Amine durch Enzym-katalysierte Acylierung

Also Published As

Publication number Publication date
DE69811723D1 (de) 2003-04-03
DE69811723T2 (de) 2003-12-18
EP1036189A1 (en) 2000-09-20
US6335187B1 (en) 2002-01-01
WO1999031264A1 (en) 1999-06-24
JP2002508189A (ja) 2002-03-19
GB9726229D0 (en) 1998-02-11
ATE233324T1 (de) 2003-03-15
EP1036189B1 (en) 2003-02-26
AU1495999A (en) 1999-07-05

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued