ATE233324T1 - Trennung von chiralen aminen - Google Patents

Trennung von chiralen aminen

Info

Publication number
ATE233324T1
ATE233324T1 AT98959022T AT98959022T ATE233324T1 AT E233324 T1 ATE233324 T1 AT E233324T1 AT 98959022 T AT98959022 T AT 98959022T AT 98959022 T AT98959022 T AT 98959022T AT E233324 T1 ATE233324 T1 AT E233324T1
Authority
AT
Austria
Prior art keywords
enantiomer
chiral amines
separation
ester
group
Prior art date
Application number
AT98959022T
Other languages
English (en)
Inventor
Christopher David Reeve
Original Assignee
Avecia Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avecia Ltd filed Critical Avecia Ltd
Application granted granted Critical
Publication of ATE233324T1 publication Critical patent/ATE233324T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
    • C12P41/007—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures by reactions involving acyl derivatives of racemic amines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Optical Integrated Circuits (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT98959022T 1997-12-12 1998-12-09 Trennung von chiralen aminen ATE233324T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9726229.9A GB9726229D0 (en) 1997-12-12 1997-12-12 Resolution of chiral amines
PCT/GB1998/003679 WO1999031264A1 (en) 1997-12-12 1998-12-09 Resolution of chiral amines

Publications (1)

Publication Number Publication Date
ATE233324T1 true ATE233324T1 (de) 2003-03-15

Family

ID=10823474

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98959022T ATE233324T1 (de) 1997-12-12 1998-12-09 Trennung von chiralen aminen

Country Status (9)

Country Link
US (1) US6335187B1 (de)
EP (1) EP1036189B1 (de)
JP (1) JP2002508189A (de)
AT (1) ATE233324T1 (de)
AU (1) AU1495999A (de)
CA (1) CA2313684A1 (de)
DE (1) DE69811723T2 (de)
GB (1) GB9726229D0 (de)
WO (1) WO1999031264A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6624311B2 (en) 2000-10-27 2003-09-23 Bristol-Myers Squibb Pharma Company Enantioselective enzymatic aminolysis of a racemic 2-isoxazolylacetate alkyl ester
CN100412062C (zh) 2001-09-12 2008-08-20 阿诺麦德股份有限公司 对映体纯的氨基取代稠合双环的合成
US7067291B2 (en) 2002-12-20 2006-06-27 Pfizer Inc. Biocatalytic preparation of enantiomerically enriched aminopentanenitrile
KR100929437B1 (ko) 2007-08-02 2009-12-03 포항공과대학교 산학협력단 광학 활성을 갖는 아민의 제조방법
GB201020026D0 (en) 2010-11-25 2011-01-12 Cambrex Karlskoga Ab New process
CN109069486A (zh) 2015-12-14 2018-12-21 X4 制药有限公司 治疗癌症的方法
WO2017106328A1 (en) 2015-12-14 2017-06-22 X4 Pharmaceuticals, Inc. Methods for treating cancer
EP3393468B1 (de) 2015-12-22 2022-09-14 X4 Pharmaceuticals, Inc. Verfahren zur behandlung einer immunschwächekrankheit
WO2017177230A1 (en) 2016-04-08 2017-10-12 X4 Pharmaceuticals, Inc. Methods for treating cancer
ES2870920T3 (es) 2016-06-21 2021-10-28 X4 Pharmaceuticals Inc Inhibidores de CXCR4 y usos de los mismos
JP6994767B2 (ja) 2016-06-21 2022-01-14 エックス４ ファーマシューティカルズ， インコーポレイテッド Ｃｘｃｒ４阻害剤およびその使用
WO2017223229A1 (en) 2016-06-21 2017-12-28 X4 Pharmaceuticals, Inc. Cxcr4 inhibitors and uses thereof
US10548889B1 (en) 2018-08-31 2020-02-04 X4 Pharmaceuticals, Inc. Compositions of CXCR4 inhibitors and methods of preparation and use
CN109234352A (zh) * 2018-10-30 2019-01-18 江苏理工学院 一种酶法拆分制备(r)-1-(1-萘基)乙胺的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991019002A1 (en) * 1990-06-01 1991-12-12 Carlbiotech Ltd. A/S A process for chiral enrichment of asymmetric primary amines
DE4332738A1 (de) * 1993-09-25 1995-03-30 Basf Ag Racematspaltung primärer und sekundärer Amine durch Enzym-katalysierte Acylierung
DE19523151A1 (de) * 1995-02-03 1996-08-14 Basf Ag Racematspaltung primärer und sekundärer heteroatomsubstituierter Amine durch Enzym-katalysierte Acylierung

Also Published As

Publication number Publication date
EP1036189A1 (de) 2000-09-20
EP1036189B1 (de) 2003-02-26
US6335187B1 (en) 2002-01-01
WO1999031264A1 (en) 1999-06-24
DE69811723D1 (de) 2003-04-03
GB9726229D0 (en) 1998-02-11
AU1495999A (en) 1999-07-05
DE69811723T2 (de) 2003-12-18
JP2002508189A (ja) 2002-03-19
CA2313684A1 (en) 1999-06-24

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Legal Events

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