CA2293824A1 - Agents aromatiques a six membres amidino utiles en tant qu'inhibiteurs du facteur xa - Google Patents

Agents aromatiques a six membres amidino utiles en tant qu'inhibiteurs du facteur xa Download PDF

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Publication number
CA2293824A1
CA2293824A1 CA002293824A CA2293824A CA2293824A1 CA 2293824 A1 CA2293824 A1 CA 2293824A1 CA 002293824 A CA002293824 A CA 002293824A CA 2293824 A CA2293824 A CA 2293824A CA 2293824 A1 CA2293824 A1 CA 2293824A1
Authority
CA
Canada
Prior art keywords
phenyl
methyl
pyridyl
ch2nh2
pyrimidyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002293824A
Other languages
English (en)
Inventor
Mimi Lifen Quan
James Russell Pruitt
Ruth Richmond Wexler
Donald Joseph Phillip Pinto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Pharma Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2293824A1 publication Critical patent/CA2293824A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Cette invention concerne des composés aromatiques à six éléments de formule (I) ou des formes de sel pharmaceutiquement acceptable de ces derniers. Dans la formule, D peut représenter CH¿2?NH¿2? ou C(=NH)NH¿2?. Ces composés sont utiles en tant qu'inhibiteurs du facteur Xa.
CA002293824A 1997-06-19 1998-06-18 Agents aromatiques a six membres amidino utiles en tant qu'inhibiteurs du facteur xa Abandoned CA2293824A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87856297A 1997-06-19 1997-06-19
US08/878,562 1997-06-19
PCT/US1998/012682 WO1998057934A1 (fr) 1997-06-19 1998-06-18 Agents aromatiques a six membres amidino utiles en tant qu'inhibiteurs du facteur xa

Publications (1)

Publication Number Publication Date
CA2293824A1 true CA2293824A1 (fr) 1998-12-23

Family

ID=25372285

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002293824A Abandoned CA2293824A1 (fr) 1997-06-19 1998-06-18 Agents aromatiques a six membres amidino utiles en tant qu'inhibiteurs du facteur xa

Country Status (4)

Country Link
EP (1) EP0993448A1 (fr)
AU (1) AU7976998A (fr)
CA (1) CA2293824A1 (fr)
WO (1) WO1998057934A1 (fr)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2300699A (en) 1998-02-17 1999-08-30 Ono Pharmaceutical Co. Ltd. Amidino derivatives and drugs containing the same as the active ingredient
JP2002509924A (ja) 1998-03-27 2002-04-02 デュポン ファーマシューティカルズ カンパニー 第Ｘａ因子阻害剤としてのジ置換ピラゾリン類およびトリアゾリン類
US6127376A (en) * 1998-12-04 2000-10-03 Berlex Laboratories, Inc. Aryl and heterocyclyl substituted pyrimidine derivatives as anti-coagulants
CA2320730A1 (fr) 1998-12-23 2000-07-06 Renhua Li Inhibiteurs du facteur xa ou de la thrombine
JP2003522733A (ja) * 1999-02-11 2003-07-29 コア セラピューティクス，インコーポレイティド Ｘａ因子の阻害剤としてのアルケニルおよびアルキニル化合物
CA2374793A1 (fr) 1999-05-24 2000-11-30 Penglie Zhang Inhibiteurs du facteur xa
TR200201413T2 (tr) * 1999-09-17 2003-02-21 Millennium Pharmaceuticals, Inc. Faktör Xa' nın inhibitörleri.
US6632815B2 (en) 1999-09-17 2003-10-14 Millennium Pharmaceuticals, Inc. Inhibitors of factor Xa
US6844367B1 (en) 1999-09-17 2005-01-18 Millennium Pharmaceuticals, Inc. Benzamides and related inhibitors of factor Xa
US6720317B1 (en) 1999-09-17 2004-04-13 Millennium Pharmaceuticals, Inc. Inhibitors of factor Xa
EP1216228B1 (fr) * 1999-09-17 2008-10-29 Millennium Pharmaceuticals, Inc. BENZAMIDES ET INHIBITEURS CORRESPONDANTS DU FACTEUR Xa
KR20020070385A (ko) * 2000-01-29 2002-09-06 주식회사 엘지씨아이 아릴-아미딘을 가진 팩터 Ｘａ 억제제와 그의 유도체, 및그의 프로드럭
EP1259485B1 (fr) 2000-02-29 2005-11-30 Millennium Pharmaceuticals, Inc. Benzamides et inhibiteurs associes du facteur xa
SE0001803D0 (sv) 2000-05-16 2000-05-16 Astrazeneca Ab New compounds i
EP1296982B1 (fr) 2000-06-23 2007-09-19 Bristol-Myers Squibb Pharma Company Derives de pyrazole condenses par 1 - (heteroaryl-phenyl) utilises comme inhibiteurs du facteur xa
US6599926B2 (en) 2000-06-23 2003-07-29 Bristol-Myers Squibb Company Heteroaryl-phenyl substituted factor Xa inhibitors
DE10036852A1 (de) * 2000-07-28 2002-02-07 Merck Patent Gmbh Urethanderivate
US6670362B2 (en) 2000-09-20 2003-12-30 Pfizer Inc. Pyridazine endothelin antagonists
US6710061B2 (en) 2001-03-09 2004-03-23 Ortho-Mcneil Pharamceutical, Inc. Aminopyrrolidine sulfonamides as serine protease inhibitors
JP2004520438A (ja) 2001-03-09 2004-07-08 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド セリンプロテアーゼインヒビターとしてのアミノピロリジンスルホンアミド
CH1427415H1 (de) 2001-09-21 2023-12-21 Bristol Myers Squibb Holdings Ireland Lactamhaltige verbindungen und ihre derivate als faktor-xa-hemmer
TWI331526B (en) 2001-09-21 2010-10-11 Bristol Myers Squibb Pharma Co Lactam-containing compounds and derivatives thereof as factor xa inhibitors
GB0124931D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124939D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124941D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124934D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124936D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124933D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124938D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
TW200302225A (en) 2001-12-04 2003-08-01 Bristol Myers Squibb Co Substituted amino methyl factor Xa inhibitors
WO2003048081A2 (fr) 2001-12-04 2003-06-12 Bristol-Myers Squibb Company Glycinamides en tant qu'inhibiteurs du facteur xa
BRPI0307351B8 (pt) 2002-02-12 2021-05-25 Smithkline Beecham Corp composto, composição farmacêutica, uso de um composto, e, processo para preparar um composto
AU2003273179A1 (en) 2002-05-10 2003-12-12 Bristol-Myers Squibb Company 1,1-disubstituted cycloalkyl derivatives as factor xa inhibitors
US7479502B2 (en) 2002-12-03 2009-01-20 Pharmacyclics, Inc. 2-(2-hydroxybiphenyl-3-yl)-1H-benzoimidazole-5-carboxamidine derivatives as factor VIIA inhibitors
US7122557B2 (en) 2003-03-18 2006-10-17 Bristol-Myers Squibb Company Sulfonyl-amidino-containing and tetrahydropyrimidino-containing compounds as factor Xa inhibitors
GB0308185D0 (en) 2003-04-09 2003-05-14 Smithkline Beecham Corp Novel compounds
CN1826121B (zh) * 2003-07-23 2013-05-29 幸讬制药公司 苯基与吡啶基衍生物用于制备调控钙离子释放活化钙离子通道的药物的用途
EP1846372B1 (fr) 2005-01-07 2014-04-16 Synta Pharmaceuticals Corp. Composes utilises pour des etats inflammatoires et immunitaires
CN101595092B (zh) 2006-11-02 2012-02-01 米伦纽姆医药公司 合成因子xa抑制剂的医药盐的方法
JP2010509392A (ja) 2006-11-13 2010-03-25 ファイザー・プロダクツ・インク ジアリール、ジピリジニルおよびアリール−ピリジニル誘導体ならびにその使用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5563158A (en) * 1993-12-28 1996-10-08 The Dupont Merck Pharmaceutical Company Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists
ES2193202T3 (es) * 1994-12-02 2003-11-01 Yamanouchi Pharma Co Ltd Nuevo derivado de amidinonaftilo o sal de este.
DK0813525T3 (da) * 1995-03-10 2004-02-16 Berlex Lab Benzamidinderivater, deres fremstilling og anvendelse som antikoagulanter
EP0874629B1 (fr) * 1995-12-21 2004-05-19 Bristol-Myers Squibb Pharma Company ISOXAZOLINE, ISOTHIAZOLINE ET PYRAZOLINE INHIBITEURS DU FACTEUR Xa
ES2218677T3 (es) * 1996-04-17 2004-11-16 Bristol-Myers Squibb Pharma Company Derivados de n-(amidinofenil)-n'-(subst.)-3h-2,4-benzodiazepin-3-ona como inhibidores del factor xa.
ATE230392T1 (de) * 1996-08-16 2003-01-15 Bristol Myers Squibb Pharma Co Amidinophenyl-pyrrolidine, -pyrroline und - isoxazolidine und ihre derivate
PT929547E (pt) * 1996-09-12 2003-03-31 Schering Ag Derivados da benzamidina substituidos por derivados de aminoacidos ciclicos e de hidroxiacidos ciclicos e seu uso como anticoagulantes
EA003056B1 (ru) * 1996-12-23 2002-12-26 Дюпон Фармасьютикалз Компани АЗОТСОДЕРЖАЩИЕ ГЕТЕРОАРОМАТИЧЕСКИЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ ФАКТОРА Ха, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И СПОСОБ ЛЕЧЕНИЯ
WO1998028282A2 (fr) * 1996-12-23 1998-07-02 Du Pont Pharmaceuticals Company OXYGENE OU SOUFRE CONTANANT DES HETERO-AROMATIQUES UTILISES COMME INHIBITEURS DU FACTEUR Xa

Also Published As

Publication number Publication date
WO1998057934A1 (fr) 1998-12-23
EP0993448A1 (fr) 2000-04-19
AU7976998A (en) 1999-01-04

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued