CA2288307A1 - Recepteur activateur nouveau entrant en jeu dans la cytoxicite naturelle induite par les cellules nk humaines et anticorps revelant sa presence - Google Patents
Recepteur activateur nouveau entrant en jeu dans la cytoxicite naturelle induite par les cellules nk humaines et anticorps revelant sa presence Download PDFInfo
- Publication number
- CA2288307A1 CA2288307A1 CA002288307A CA2288307A CA2288307A1 CA 2288307 A1 CA2288307 A1 CA 2288307A1 CA 002288307 A CA002288307 A CA 002288307A CA 2288307 A CA2288307 A CA 2288307A CA 2288307 A1 CA2288307 A1 CA 2288307A1
- Authority
- CA
- Canada
- Prior art keywords
- isolated
- seq
- group
- chosen
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000003013 cytotoxicity Effects 0.000 title claims abstract 8
- 231100000135 cytotoxicity Toxicity 0.000 title claims abstract 8
- 210000000822 natural killer cell Anatomy 0.000 title claims 16
- 230000001404 mediated effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 17
- 108010004222 Natural Cytotoxicity Triggering Receptor 3 Proteins 0.000 claims abstract 3
- 102100032852 Natural cytotoxicity triggering receptor 3 Human genes 0.000 claims abstract 3
- 238000000034 method Methods 0.000 claims 11
- 239000012472 biological sample Substances 0.000 claims 9
- 239000000203 mixture Substances 0.000 claims 9
- 239000007787 solid Substances 0.000 claims 9
- 239000012634 fragment Substances 0.000 claims 8
- 125000003275 alpha amino acid group Chemical group 0.000 claims 5
- 210000004408 hybridoma Anatomy 0.000 claims 5
- 210000004027 cell Anatomy 0.000 claims 3
- 102000040430 polynucleotide Human genes 0.000 claims 3
- 108091033319 polynucleotide Proteins 0.000 claims 3
- 239000002157 polynucleotide Substances 0.000 claims 3
- 230000002163 immunogen Effects 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 230000004962 physiological condition Effects 0.000 claims 2
- 230000004936 stimulating effect Effects 0.000 claims 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 206010053614 Type III immune complex mediated reaction Diseases 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 239000003623 enhancer Substances 0.000 claims 1
- 230000002068 genetic effect Effects 0.000 claims 1
- 230000016178 immune complex formation Effects 0.000 claims 1
- 230000003053 immunization Effects 0.000 claims 1
- 230000005847 immunogenicity Effects 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 230000001960 triggered effect Effects 0.000 claims 1
- 210000001939 mature NK cell Anatomy 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2288307A CA2288307C (fr) | 1999-11-15 | 1999-11-15 | Recepteur activateur nouveau entrant en jeu dans la cytoxicite naturelle induite par les cellules nk humaines et anticorps revelant sa presence |
AU26677/01A AU783899B2 (en) | 1999-11-15 | 2000-11-15 | Novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells, and antibodies that identify the same |
JP2001538509A JP4776845B2 (ja) | 1999-11-15 | 2000-11-15 | ヒトナチュラルキラー細胞によって媒介される天然細胞毒性に関連した新規トリガリングレセプターおよび同一の性質を有する抗体 |
DK00989877T DK1240326T3 (da) | 1999-11-15 | 2000-11-15 | Udlösende receptor der er involveret i naturlig cytotoxicitet medieret af humane naturlige dræberceller og antistoffer som identificerer denne receptor |
DE60041655T DE60041655D1 (de) | 1999-11-15 | 2000-11-15 | Auslösender rezeptor der an der natürlichen cytotoxizität der menschlichen natürlichen killerzellen (natural killer cells) beteiligt ist und antikörper die diesen rezeptor identifizieren |
AT00989877T ATE423848T1 (de) | 1999-11-15 | 2000-11-15 | Auslösender rezeptor der an der natürlichen cytotoxizität der menschlichen natürlichen killerzellen (natural killer cells) beteiligt ist und antikörper die diesen rezeptor identifizieren |
EP00989877A EP1240326B1 (fr) | 1999-11-15 | 2000-11-15 | Recepteur de declenchement implique dans la cytotoxicite naturelle induite par les lymphocytes tueurs naturels (natural killer cells) d'origine humaine et anticorps permettant d'identifier ce recepteur |
PCT/EP2000/011697 WO2001036630A2 (fr) | 1999-11-15 | 2000-11-15 | Nouveau recepteur de declenchement implique dans la cytotoxicite naturelle induite par les lymphocytes tueurs naturels (nk) et anticorps permettant de l'identifier |
ES00989877T ES2321687T3 (es) | 1999-11-15 | 2000-11-15 | Receptor activador implicado en la citotoxicidad natural mediada por las celulas destructoras naturales humanas y anticuerpos que identifican dicho receptor. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2288307A CA2288307C (fr) | 1999-11-15 | 1999-11-15 | Recepteur activateur nouveau entrant en jeu dans la cytoxicite naturelle induite par les cellules nk humaines et anticorps revelant sa presence |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2288307A1 true CA2288307A1 (fr) | 2001-05-15 |
CA2288307C CA2288307C (fr) | 2012-05-15 |
Family
ID=4164540
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2288307A Expired - Fee Related CA2288307C (fr) | 1999-11-15 | 1999-11-15 | Recepteur activateur nouveau entrant en jeu dans la cytoxicite naturelle induite par les cellules nk humaines et anticorps revelant sa presence |
Country Status (1)
Country | Link |
---|---|
CA (1) | CA2288307C (fr) |
-
1999
- 1999-11-15 CA CA2288307A patent/CA2288307C/fr not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2288307C (fr) | 2012-05-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |
Effective date: 20161115 |