CA2288184C - Method for treating a lactic raw material containing gmp - Google Patents
Method for treating a lactic raw material containing gmp Download PDFInfo
- Publication number
- CA2288184C CA2288184C CA002288184A CA2288184A CA2288184C CA 2288184 C CA2288184 C CA 2288184C CA 002288184 A CA002288184 A CA 002288184A CA 2288184 A CA2288184 A CA 2288184A CA 2288184 C CA2288184 C CA 2288184C
- Authority
- CA
- Canada
- Prior art keywords
- raw material
- gmp
- resin
- lactic raw
- lactic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000002994 raw material Substances 0.000 title claims abstract description 65
- 238000000034 method Methods 0.000 title claims description 44
- 239000011347 resin Substances 0.000 claims abstract description 85
- 229920005989 resin Polymers 0.000 claims abstract description 85
- 239000007788 liquid Substances 0.000 claims abstract description 29
- 125000000129 anionic group Chemical group 0.000 claims abstract description 25
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 14
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 14
- 108010067454 caseinomacropeptide Proteins 0.000 claims abstract description 10
- 238000005342 ion exchange Methods 0.000 claims abstract description 7
- 238000004519 manufacturing process Methods 0.000 claims abstract description 7
- 108010046377 Whey Proteins Proteins 0.000 claims description 42
- 102000007544 Whey Proteins Human genes 0.000 claims description 33
- 239000005862 Whey Substances 0.000 claims description 30
- 235000009508 confectionery Nutrition 0.000 claims description 26
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 25
- 239000011159 matrix material Substances 0.000 claims description 16
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 15
- 239000012141 concentrate Substances 0.000 claims description 15
- 230000002209 hydrophobic effect Effects 0.000 claims description 14
- 238000000108 ultra-filtration Methods 0.000 claims description 14
- 235000018102 proteins Nutrition 0.000 claims description 13
- 239000007864 aqueous solution Substances 0.000 claims description 12
- 235000021119 whey protein Nutrition 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 10
- 239000000047 product Substances 0.000 claims description 10
- 108010076119 Caseins Proteins 0.000 claims description 9
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 9
- 239000008101 lactose Substances 0.000 claims description 9
- 239000005018 casein Substances 0.000 claims description 8
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims description 8
- 235000021240 caseins Nutrition 0.000 claims description 8
- 108010028463 kappa-casein glycomacropeptide Proteins 0.000 claims description 8
- 239000012465 retentate Substances 0.000 claims description 8
- 238000001035 drying Methods 0.000 claims description 7
- 238000005406 washing Methods 0.000 claims description 7
- 238000000909 electrodialysis Methods 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 238000000926 separation method Methods 0.000 claims description 6
- 108091005804 Peptidases Proteins 0.000 claims description 5
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 5
- 239000004365 Protease Substances 0.000 claims description 5
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims description 5
- 238000001704 evaporation Methods 0.000 claims description 5
- 230000008020 evaporation Effects 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 5
- 239000012466 permeate Substances 0.000 claims description 5
- 238000001223 reverse osmosis Methods 0.000 claims description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 4
- 239000003146 anticoagulant agent Substances 0.000 claims description 4
- 238000009296 electrodeionization Methods 0.000 claims description 4
- 230000007062 hydrolysis Effects 0.000 claims description 4
- 238000006460 hydrolysis reaction Methods 0.000 claims description 4
- 229940108461 rennet Drugs 0.000 claims description 4
- 108010058314 rennet Proteins 0.000 claims description 4
- 235000020183 skimmed milk Nutrition 0.000 claims description 4
- 230000002785 anti-thrombosis Effects 0.000 claims description 3
- 229940071162 caseinate Drugs 0.000 claims description 3
- 208000002925 dental caries Diseases 0.000 claims description 3
- 239000006185 dispersion Substances 0.000 claims description 3
- 238000001728 nano-filtration Methods 0.000 claims description 3
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims description 2
- 238000003916 acid precipitation Methods 0.000 claims description 2
- 230000002378 acidificating effect Effects 0.000 claims description 2
- 230000001142 anti-diarrhea Effects 0.000 claims description 2
- 229940124537 antidiarrhoeal agent Drugs 0.000 claims description 2
- 229910001424 calcium ion Inorganic materials 0.000 claims description 2
- 238000002425 crystallisation Methods 0.000 claims description 2
- 230000008025 crystallization Effects 0.000 claims description 2
- 230000002328 demineralizing effect Effects 0.000 claims description 2
- 238000001914 filtration Methods 0.000 claims description 2
- 238000004108 freeze drying Methods 0.000 claims description 2
- 238000001471 micro-filtration Methods 0.000 claims description 2
- 150000007522 mineralic acids Chemical class 0.000 claims description 2
- 230000020477 pH reduction Effects 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 239000011780 sodium chloride Substances 0.000 claims description 2
- 238000001694 spray drying Methods 0.000 claims description 2
- 239000011344 liquid material Substances 0.000 claims 18
- 239000003937 drug carrier Substances 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 230000000844 anti-bacterial effect Effects 0.000 claims 1
- 229960004676 antithrombotic agent Drugs 0.000 claims 1
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 claims 1
- 239000000920 calcium hydroxide Substances 0.000 claims 1
- 229910001861 calcium hydroxide Inorganic materials 0.000 claims 1
- 235000011116 calcium hydroxide Nutrition 0.000 claims 1
- 238000005119 centrifugation Methods 0.000 claims 1
- 238000000605 extraction Methods 0.000 claims 1
- 239000000706 filtrate Substances 0.000 claims 1
- 235000013305 food Nutrition 0.000 abstract description 2
- 239000008367 deionised water Substances 0.000 description 12
- 229910021641 deionized water Inorganic materials 0.000 description 12
- 239000000843 powder Substances 0.000 description 8
- 239000000243 solution Substances 0.000 description 8
- 239000004793 Polystyrene Substances 0.000 description 7
- 150000001768 cations Chemical class 0.000 description 7
- 229920002223 polystyrene Polymers 0.000 description 7
- 102000011632 Caseins Human genes 0.000 description 6
- 238000006243 chemical reaction Methods 0.000 description 6
- 239000012508 resin bead Substances 0.000 description 6
- 238000003756 stirring Methods 0.000 description 6
- 238000004458 analytical method Methods 0.000 description 5
- 125000002091 cationic group Chemical group 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 102100021935 C-C motif chemokine 26 Human genes 0.000 description 4
- 101000897493 Homo sapiens C-C motif chemokine 26 Proteins 0.000 description 4
- 238000004128 high performance liquid chromatography Methods 0.000 description 4
- 241000283690 Bos taurus Species 0.000 description 3
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 3
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 3
- 239000004473 Threonine Substances 0.000 description 3
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 239000007789 gas Substances 0.000 description 3
- 235000013336 milk Nutrition 0.000 description 3
- 239000008267 milk Substances 0.000 description 3
- 210000004080 milk Anatomy 0.000 description 3
- 230000006641 stabilisation Effects 0.000 description 3
- 238000011105 stabilization Methods 0.000 description 3
- 239000007858 starting material Substances 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 2
- 150000001450 anions Chemical class 0.000 description 2
- 230000005587 bubbling Effects 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 238000003795 desorption Methods 0.000 description 2
- 238000011026 diafiltration Methods 0.000 description 2
- 238000010828 elution Methods 0.000 description 2
- 238000005243 fluidization Methods 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 230000008929 regeneration Effects 0.000 description 2
- 238000011069 regeneration method Methods 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- 241000195940 Bryophyta Species 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 241000282849 Ruminantia Species 0.000 description 1
- 239000003929 acidic solution Substances 0.000 description 1
- 239000012670 alkaline solution Substances 0.000 description 1
- 239000003957 anion exchange resin Substances 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 239000003793 antidiarrheal agent Substances 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- -1 aromatic amino acids Chemical class 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 235000013351 cheese Nutrition 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 238000010908 decantation Methods 0.000 description 1
- 235000021185 dessert Nutrition 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- MYRTYDVEIRVNKP-UHFFFAOYSA-N divinylbenzene Substances C=CC1=CC=CC=C1C=C MYRTYDVEIRVNKP-UHFFFAOYSA-N 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000004088 foaming agent Substances 0.000 description 1
- 239000003349 gelling agent Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 239000003456 ion exchange resin Substances 0.000 description 1
- 229920003303 ion-exchange polymer Polymers 0.000 description 1
- 239000012263 liquid product Substances 0.000 description 1
- 235000020166 milkshake Nutrition 0.000 description 1
- 235000011929 mousse Nutrition 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 235000021246 κ-casein Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING OR TREATMENT THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/14—Milk preparations; Milk powder or milk powder preparations in which the chemical composition of the milk is modified by non-chemical treatment
- A23C9/146—Milk preparations; Milk powder or milk powder preparations in which the chemical composition of the milk is modified by non-chemical treatment by ion-exchange
- A23C9/1465—Chromatographic separation of protein or lactose fraction; Adsorption of protein or lactose fraction followed by elution
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
- A23J1/20—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from milk, e.g. casein; from whey
- A23J1/205—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from milk, e.g. casein; from whey from whey, e.g. lactalbumine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4732—Casein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Birds (AREA)
- Zoology (AREA)
- Analytical Chemistry (AREA)
- Dairy Products (AREA)
- Peptides Or Proteins (AREA)
- Confectionery (AREA)
- Cosmetics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97201607A EP0880902A1 (fr) | 1997-05-27 | 1997-05-27 | Procédé de traitement d'une matiére première lactosérique |
| EP97201607.5 | 1997-05-27 | ||
| PCT/EP1998/003176 WO1998053702A1 (fr) | 1997-05-27 | 1998-05-22 | Procede de traitement d'une matiere premiere lactique contenant du gmp |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2288184A1 CA2288184A1 (en) | 1998-12-03 |
| CA2288184C true CA2288184C (en) | 2009-10-27 |
Family
ID=8228378
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002288184A Expired - Fee Related CA2288184C (en) | 1997-05-27 | 1998-05-22 | Method for treating a lactic raw material containing gmp |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6787158B1 (enExample) |
| EP (2) | EP0880902A1 (enExample) |
| JP (1) | JP4286325B2 (enExample) |
| AU (1) | AU746520B2 (enExample) |
| BR (1) | BR9809171B1 (enExample) |
| CA (1) | CA2288184C (enExample) |
| DE (1) | DE69836909T2 (enExample) |
| NZ (1) | NZ500848A (enExample) |
| WO (1) | WO1998053702A1 (enExample) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2275041C2 (ru) * | 1999-04-29 | 2006-04-27 | Сосьете Де Продюи Нестле С.А. | Состав молочной смеси, способ его получения и молочная смесь, содержащая его (варианты) |
| GB9923048D0 (en) * | 1999-09-29 | 1999-12-01 | Nestle Sa | Composition comprising casein protein and whey protein |
| EP1048226B1 (en) * | 1999-04-29 | 2005-08-31 | Société des Produits Nestlé S.A. | Infant formula containing sweet whey protein |
| WO2002030210A1 (en) * | 2000-10-10 | 2002-04-18 | Bopa Ireland Limited | A dairy product |
| AU2002345773A1 (en) * | 2001-06-08 | 2002-12-23 | Societe Des Produits Nestle S.A. | Sugar-based composition containing caseinoglycomacropeptide |
| ATE433674T1 (de) * | 2003-06-23 | 2009-07-15 | Nestec Sa | Säuglingsnährpräparat oder folgemilch |
| DE602004030567D1 (de) * | 2003-06-23 | 2011-01-27 | Nestec Sa | Säuglingsnährpräparat oder folgemilch |
| US8377430B2 (en) | 2005-04-13 | 2013-02-19 | Nestec S.A. | Infant formula with probiotics |
| EP1870649A1 (en) | 2006-06-20 | 2007-12-26 | Octapharma AG | Lyophilisation targetting defined residual moisture by limited desorption energy levels |
| EP1932437A1 (en) | 2006-12-15 | 2008-06-18 | Nestec S.A. | Infant formula |
| FI120953B (fi) * | 2007-06-26 | 2010-05-31 | Valio Oy | Menetelmä hyvin säilyvän vähälaktoosisen tai laktoosittoman maitotuotteen valmistamiseksi |
| EP2044851A1 (en) | 2007-09-26 | 2009-04-08 | Nestec S.A. | Prevention of allergy at weaning |
| US20110048219A1 (en) * | 2007-11-13 | 2011-03-03 | Pyles Robert A | Blast-resistant barrier |
| EP2224826B1 (en) | 2007-11-26 | 2018-12-26 | Nestec S.A. | Age-tailored nutrition system for infants |
| EP2096115A1 (en) | 2008-02-26 | 2009-09-02 | Nestec S.A. | Oligosaccharide ingredient |
| EP2116140A1 (en) * | 2008-05-08 | 2009-11-11 | Nestec S.A. | Sialic acid to support the immune system in the elderly |
| EP2346352A1 (en) * | 2008-10-20 | 2011-07-27 | Nestec S.A. | Nutritional composition with anti-regurgitation properties |
| US9055752B2 (en) | 2008-11-06 | 2015-06-16 | Intercontinental Great Brands Llc | Shelf-stable concentrated dairy liquids and methods of forming thereof |
| RU2540538C2 (ru) | 2009-01-19 | 2015-02-10 | Нестек С.А. | Питательная композиция для младенцев |
| SG173914A1 (en) | 2009-04-01 | 2011-10-28 | Nestec Sa | Reduction of risk of obesity |
| KR101739326B1 (ko) | 2009-04-02 | 2017-05-24 | 노보자임스 에이/에스 | 젖-기반 단백질 가수분해물의 제조 방법 |
| CA2755860A1 (en) | 2009-04-03 | 2010-10-07 | Nestec S.A. | Improvement in promotion of healthy catch-up growth |
| EP2251029A1 (en) | 2009-05-12 | 2010-11-17 | Nestec S.A. | Lactoferrin and gut neuronal health in adults and/or elderly |
| EP2251032A1 (en) | 2009-05-12 | 2010-11-17 | Nestec S.A. | Lactoferrin and brain health and protection in adults |
| EP2251031A1 (en) | 2009-05-12 | 2010-11-17 | Nestec S.A. | Lactoferrin and neuronal health and development in the infant gut |
| EP2251030A1 (en) | 2009-05-12 | 2010-11-17 | Nestec S.A. | Lactoferrin and brain health and development in infants |
| JP2013510799A (ja) * | 2009-11-11 | 2013-03-28 | オーラル ヘルス オーストラリア ピーティーワイ リミテッド | 抗バイオフィルム糖ペプチド |
| PH12012501050A1 (en) | 2009-12-08 | 2013-02-04 | Nestec Sa | Infant formula with probiotics and milk fat globule membrane components |
| WO2012004585A1 (en) * | 2010-07-09 | 2012-01-12 | Abdulla Badawy | Ingestible formulation comprising glycomacropeptide and at least one of tryptophan, tyrosine and phenylalanine and uses thereof |
| UA112972C2 (uk) | 2010-09-08 | 2016-11-25 | Інтерконтінентал Грейт Брендс ЛЛС | Рідкий молочний концентрат з високим вмістом сухих речовин |
| EP2436389A1 (en) | 2010-10-01 | 2012-04-04 | Nestec S.A. | Milk-based protein hydrolysates and infant formulae and nutritional compositions made thereof |
| BR112013031086A2 (pt) | 2011-06-08 | 2016-11-29 | Nestec Sa | composições nutricionais tendo componentes de membrana de glóbulo de gordura de leite exógenos |
| EP2811840A2 (en) | 2012-02-06 | 2014-12-17 | Arla Foods Amba | Low-protein frozen confectionery product |
| US20160193302A1 (en) | 2013-09-02 | 2016-07-07 | Nestec S.A. | Lactoferrin and memory and learning speed in children |
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| CN116261398A (zh) | 2020-10-16 | 2023-06-13 | 雀巢产品有限公司 | 包含人乳低聚糖的营养组合物 |
| AU2021376858A1 (en) | 2020-11-10 | 2023-04-13 | Société des Produits Nestlé S.A. | Nutritional composition |
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| WO2025008277A1 (en) | 2023-07-06 | 2025-01-09 | Societe Des Produits Nestle S.A. | Combination for dietary management of gut health |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1442298A (en) * | 1972-09-01 | 1976-07-14 | Ici Ltd | Replenishment of fluidised beds |
| GB2188526B (en) * | 1986-02-19 | 1990-10-10 | Agricultural & Food Res | A proteinaceous material obtainable from milk or casein-containing milk products ,process for its production and its use in food and drink |
| JP2622686B2 (ja) * | 1987-05-15 | 1997-06-18 | 雪印乳業株式会社 | ｋ−カゼイングリコマクロペプチドの製造法 |
| FR2646775A1 (fr) | 1989-05-11 | 1990-11-16 | Centre Nat Rech Scient | Utilisation du caseinoglycopeptide k, notamment de lait de vache, pour la fabrication d'une composition, notamment d'un medicament, pour la prevention et le traitement des thromboses |
| JP2961625B2 (ja) * | 1991-01-21 | 1999-10-12 | 雪印乳業株式会社 | α−ラクトアルブミン含有量の高い組成物の製造方法 |
| JP2920427B2 (ja) * | 1991-01-21 | 1999-07-19 | 雪印乳業株式会社 | κ−カゼイングリコマクロペプチドの製造法 |
| JP3035833B2 (ja) * | 1991-01-21 | 2000-04-24 | 雪印乳業株式会社 | シアル酸類含有組成物の製造方法 |
| JP3123618B2 (ja) * | 1992-03-18 | 2001-01-15 | 雪印乳業株式会社 | 新規ペプチド、該ペプチドを有効成分とする胃酸分泌抑制−抗潰瘍剤及び飲食品 |
| JP3161846B2 (ja) * | 1992-11-11 | 2001-04-25 | 明治乳業株式会社 | 牛乳ホエ−中のシアル酸結合ペプタイドの分離法 |
| DE4344342C2 (de) * | 1993-12-23 | 1996-08-08 | Milupa Ag | Molkenprotein-dominante Säuglingsnahrung |
| US6168823B1 (en) * | 1997-10-09 | 2001-01-02 | Wisconsin Alumni Research Foundation | Production of substantially pure kappa casein macropeptide |
| US5968586A (en) * | 1997-10-09 | 1999-10-19 | Wisconsin Alumni Research Foundation | Production of κ-casein macropeptide for nutraceutical uses |
-
1997
- 1997-05-27 EP EP97201607A patent/EP0880902A1/fr not_active Withdrawn
-
1998
- 1998-05-22 EP EP98930751A patent/EP0986312B1/fr not_active Expired - Lifetime
- 1998-05-22 WO PCT/EP1998/003176 patent/WO1998053702A1/fr not_active Ceased
- 1998-05-22 AU AU81077/98A patent/AU746520B2/en not_active Expired
- 1998-05-22 BR BRPI9809171-9A patent/BR9809171B1/pt not_active IP Right Cessation
- 1998-05-22 DE DE69836909T patent/DE69836909T2/de not_active Expired - Lifetime
- 1998-05-22 CA CA002288184A patent/CA2288184C/en not_active Expired - Fee Related
- 1998-05-22 JP JP50025199A patent/JP4286325B2/ja not_active Expired - Fee Related
- 1998-05-22 NZ NZ500848A patent/NZ500848A/en not_active IP Right Cessation
-
1999
- 1999-11-29 US US09/450,217 patent/US6787158B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US6787158B1 (en) | 2004-09-07 |
| DE69836909T2 (de) | 2007-09-06 |
| AU8107798A (en) | 1998-12-30 |
| AU746520B2 (en) | 2002-05-02 |
| BR9809171B1 (pt) | 2011-01-11 |
| WO1998053702A1 (fr) | 1998-12-03 |
| EP0986312B1 (fr) | 2007-01-17 |
| EP0986312A1 (fr) | 2000-03-22 |
| BR9809171A (pt) | 2000-08-01 |
| CA2288184A1 (en) | 1998-12-03 |
| NZ500848A (en) | 2001-12-21 |
| JP2002514085A (ja) | 2002-05-14 |
| JP4286325B2 (ja) | 2009-06-24 |
| EP0880902A1 (fr) | 1998-12-02 |
| DE69836909D1 (de) | 2007-03-08 |
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