CA2285457A1 - Procede d'administration de proteines par voie orale - Google Patents

Procede d'administration de proteines par voie orale Download PDF

Info

Publication number
CA2285457A1
CA2285457A1 CA002285457A CA2285457A CA2285457A1 CA 2285457 A1 CA2285457 A1 CA 2285457A1 CA 002285457 A CA002285457 A CA 002285457A CA 2285457 A CA2285457 A CA 2285457A CA 2285457 A1 CA2285457 A1 CA 2285457A1
Authority
CA
Canada
Prior art keywords
composition
insulin
hydrogels
maa
hydrogel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002285457A
Other languages
English (en)
Inventor
Mariko Morishita
Tsuneji Nagai
Nicholas A. Peppas
Anthony M. Lowman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Purdue Research Foundation
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2285457A1 publication Critical patent/CA2285457A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne une composition et un procédé d'administration par voie orale de constituants bioactifs à des vertébrés. Le procédé comprend l'étape d'administration par voie orale aux vertébrés d'une composition comprenant une matrice d'hydrogel dilatable et une composition bioactive contenue à l'intérieur de la matrice d'hydrogel.
CA002285457A 1997-04-02 1998-04-02 Procede d'administration de proteines par voie orale Abandoned CA2285457A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US4228097P 1997-04-02 1997-04-02
US60/042,280 1997-04-02
US6136797P 1997-10-08 1997-10-08
US60/061,367 1997-10-08
PCT/US1998/006563 WO1998043615A1 (fr) 1997-04-02 1998-04-02 Procede d'administration de proteines par voie orale

Publications (1)

Publication Number Publication Date
CA2285457A1 true CA2285457A1 (fr) 1998-10-08

Family

ID=26719055

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002285457A Abandoned CA2285457A1 (fr) 1997-04-02 1998-04-02 Procede d'administration de proteines par voie orale

Country Status (14)

Country Link
EP (1) EP0975328A1 (fr)
JP (1) JP2002512607A (fr)
KR (1) KR20010005952A (fr)
CN (1) CN1259045A (fr)
AU (1) AU727053B2 (fr)
BR (1) BR9808466A (fr)
CA (1) CA2285457A1 (fr)
IL (1) IL132176A0 (fr)
NO (1) NO994757L (fr)
NZ (1) NZ500075A (fr)
PL (1) PL335974A1 (fr)
TR (1) TR199903240T2 (fr)
WO (1) WO1998043615A1 (fr)
YU (1) YU49699A (fr)

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US6878384B2 (en) 2001-03-13 2005-04-12 Microvention, Inc. Hydrogels that undergo volumetric expansion in response to changes in their environment and their methods of manufacture and use
ATE385193T1 (de) 2002-03-20 2008-02-15 Mannkind Corp Inhalationsgerät
CN101010305B (zh) 2004-08-20 2010-08-11 曼金德公司 二酮哌嗪合成的催化反应
DK1791542T3 (en) 2004-08-23 2015-06-15 Mannkind Corp Diketopiperazinsalte for pharmaceutical delivery
US8110212B2 (en) 2005-04-07 2012-02-07 Drexel University Bioactive thermogelling polymer systems and methods of their use
EP1916995B2 (fr) 2005-07-29 2022-06-29 Stichting Groningen Centre for Drug Research Système de distribution pulsatile commandé par le ph, procédés de préparation et utilisation
DK1915171T3 (da) * 2005-08-01 2013-12-09 Mannkind Corp Fremgangsmåde til bevarelse af funktionen af insulin-producerende celler
MX358592B (es) 2005-09-14 2018-08-27 Mannkind Corp Método para formulación de fármaco basado en el aumento de la afinidad de superficies de micropartículas cristalinas hacia agentes activos.
RU2403059C2 (ru) 2006-02-22 2010-11-10 Маннкайнд Корпорейшн Способ улучшения фармацевтических свойств микрочастиц, содержащих дикетопиперазин и активный агент
JP2010500917A (ja) 2006-06-15 2010-01-14 マイクロベンション， インコーポレイテッド 膨張性ポリマーで構成される塞栓形成デバイス
BRPI0821070B1 (pt) 2007-12-21 2018-10-23 Microvention Inc dispositivo para implantação e método para a preparação de um filamento de hidrogel para implantação em um animal
KR101548092B1 (ko) 2008-06-13 2015-08-27 맨카인드 코포레이션 건조 분말 흡입기 및 약물 투여 시스템
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
ES2421385T3 (es) 2008-06-20 2013-09-02 Mannkind Corp Aparato interactivo y procedimiento para establecer el perfil, en tiempo real, de esfuerzos de inhalación
TWI532497B (zh) 2008-08-11 2016-05-11 曼凱公司 超快起作用胰島素之用途
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
EP2676695A3 (fr) 2009-03-11 2017-03-01 MannKind Corporation Appareil, système et procédé de mesure de résistance d'un inhalateur
US10639396B2 (en) 2015-06-11 2020-05-05 Microvention, Inc. Polymers
WO2010144789A2 (fr) 2009-06-12 2010-12-16 Mannkind Corporation Microparticules de dicétopipérazine avec des surfaces spécifiques définies
HUP0900482A2 (en) 2009-08-03 2011-03-28 Cera Med Kft Pharmaceutical formulation for oral administration
JP2013505791A (ja) 2009-09-24 2013-02-21 マイクロベンション インコーポレイテッド 医学的使用のための注射用ヒドロゲル繊維
US9993252B2 (en) 2009-10-26 2018-06-12 Microvention, Inc. Embolization device constructed from expansile polymer
JP5784622B2 (ja) 2009-11-03 2015-09-24 マンカインド コーポレ−ション 吸入活動をシミュレートするための装置及び方法
CN102985125A (zh) 2010-06-21 2013-03-20 曼金德公司 干粉药物输送系统和方法
JP6133270B2 (ja) 2011-04-01 2017-05-24 マンカインド コーポレイション 薬剤カートリッジのためのブリスター包装
WO2012145431A2 (fr) 2011-04-18 2012-10-26 Microvention, Inc. Dispositifs d'embolisation
WO2012174472A1 (fr) 2011-06-17 2012-12-20 Mannkind Corporation Microparticules de dicétopipérazine de capacité élevée
JP6018640B2 (ja) 2011-10-24 2016-11-02 マンカインド コーポレイション 疼痛を緩和するのに有効な鎮痛組成物並びに当該組成物を含む乾燥粉末及び乾燥粉末薬剤輸送システム
US9011884B2 (en) 2012-04-18 2015-04-21 Microvention, Inc. Embolic devices
RU2650035C2 (ru) 2012-07-12 2018-04-06 Маннкайнд Корпорейшн Системы и способы доставки сухих порошковых лекарств
EP2911690A1 (fr) 2012-10-26 2015-09-02 MannKind Corporation Compositions et procédés de vaccin antigrippal inhalable
EP3587404B1 (fr) 2013-03-15 2022-07-13 MannKind Corporation Compositions de dicétopipérazine microcristallines, procédés de préparation et leur utilisation
MX2020009878A (es) 2013-07-18 2022-07-27 Mannkind Corp Composiciones farmaceuticas en polvo seco estables al calor y metodos.
EP3030294B1 (fr) 2013-08-05 2020-10-07 MannKind Corporation Appareil d'insufflation
WO2015021044A1 (fr) * 2013-08-05 2015-02-12 University Of Rochester Compositions et procédés pour la libération en réponse à des stimuli d'un agent thérapeutique
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
WO2015153996A1 (fr) 2014-04-03 2015-10-08 Micro Vention, Inc. Dispositifs d'embolisation
US10092663B2 (en) 2014-04-29 2018-10-09 Terumo Corporation Polymers
WO2015167752A1 (fr) 2014-04-29 2015-11-05 Microvention, Inc. Polymères comprenant des agents actifs
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
US10265405B2 (en) 2014-11-18 2019-04-23 Board Of Regents, The University Of Texas System Polymers for delivery of factor VIII and/or factor IX

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US2976576A (en) * 1956-04-24 1961-03-28 Wichterle Otto Process for producing shaped articles from three-dimensional hydrophilic high polymers
US3220960A (en) * 1960-12-21 1965-11-30 Wichterle Otto Cross-linked hydrophilic polymers and articles made therefrom
DE1617393C2 (de) * 1966-01-06 1982-11-11 Československá akademie věd, Praha Verfahren zur Herstellung von biologisch aktive Stoffe enthaltenden hydrophilen vernetzten Copolymeren
US3607848A (en) * 1967-08-07 1971-09-21 Ceskoslovenska Akademie Ved Method for preparing insoluble,cross-linked organic hydrogels comprising copolymers of glycol monoesters with diesters
US3885078A (en) * 1968-03-06 1975-05-20 Ceskoslovenska Akademie Ved Hydrogel laminates and method of manufacturing thereof
US4071508A (en) * 1975-02-11 1978-01-31 Plastomedical Sciences, Inc. Anionic hydrogels based on hydroxyalkyl acrylates and methacrylates
FR2601026B1 (fr) * 1986-04-15 1988-09-16 Rhone Poulenc Chimie Matiere seche hydratable en un gel aqueux contenant des particules de polymeres dispersees, procede pour sa preparation et son application en biologie

Also Published As

Publication number Publication date
YU49699A (sh) 2002-12-10
AU6880998A (en) 1998-10-22
BR9808466A (pt) 2001-08-07
TR199903240T2 (xx) 2000-05-22
PL335974A1 (en) 2000-06-05
IL132176A0 (en) 2001-03-19
NZ500075A (en) 2001-03-30
JP2002512607A (ja) 2002-04-23
KR20010005952A (ko) 2001-01-15
NO994757D0 (no) 1999-09-30
WO1998043615A1 (fr) 1998-10-08
EP0975328A1 (fr) 2000-02-02
CN1259045A (zh) 2000-07-05
AU727053B2 (en) 2000-11-30
NO994757L (no) 1999-11-29

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Legal Events

Date Code Title Description
FZDE Discontinued