CA2284665C - Recombinant antibodies and immunoconjugates targeted to cd-22 bearing cells and tumors - Google Patents

Recombinant antibodies and immunoconjugates targeted to cd-22 bearing cells and tumors Download PDF

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Publication number
CA2284665C
CA2284665C CA2284665A CA2284665A CA2284665C CA 2284665 C CA2284665 C CA 2284665C CA 2284665 A CA2284665 A CA 2284665A CA 2284665 A CA2284665 A CA 2284665A CA 2284665 C CA2284665 C CA 2284665C
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CA
Canada
Prior art keywords
antibody
chain
rfb4
seq
cell
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2284665A
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English (en)
French (fr)
Other versions
CA2284665A1 (en
Inventor
David Fitzgerald
Ira Pastan
Elizabeth Mansfield
Robert Kreitman
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US Department of Health and Human Services
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US Department of Health and Human Services
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Application filed by US Department of Health and Human Services filed Critical US Department of Health and Human Services
Publication of CA2284665A1 publication Critical patent/CA2284665A1/en
Application granted granted Critical
Publication of CA2284665C publication Critical patent/CA2284665C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA2284665A 1997-03-20 1998-03-19 Recombinant antibodies and immunoconjugates targeted to cd-22 bearing cells and tumors Expired - Lifetime CA2284665C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4143797P 1997-03-20 1997-03-20
US60/041,437 1997-03-20
PCT/US1998/005453 WO1998041641A1 (en) 1997-03-20 1998-03-19 Recombinant antibodies and immunoconjugates targeted to cd-22 bearing cells and tumors

Publications (2)

Publication Number Publication Date
CA2284665A1 CA2284665A1 (en) 1998-09-24
CA2284665C true CA2284665C (en) 2010-08-17

Family

ID=21916511

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2284665A Expired - Lifetime CA2284665C (en) 1997-03-20 1998-03-19 Recombinant antibodies and immunoconjugates targeted to cd-22 bearing cells and tumors

Country Status (9)

Country Link
US (2) US7541034B1 (enExample)
EP (1) EP0970227B1 (enExample)
JP (3) JP2002501488A (enExample)
AT (1) ATE383430T1 (enExample)
AU (1) AU740904B2 (enExample)
CA (1) CA2284665C (enExample)
DE (1) DE69838979T2 (enExample)
ES (1) ES2300122T3 (enExample)
WO (1) WO1998041641A1 (enExample)

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Also Published As

Publication number Publication date
US7541034B1 (en) 2009-06-02
JP2008208131A (ja) 2008-09-11
DE69838979D1 (de) 2008-02-21
US20090305411A1 (en) 2009-12-10
JP2002501488A (ja) 2002-01-15
US9592304B2 (en) 2017-03-14
EP0970227A1 (en) 2000-01-12
AU6764698A (en) 1998-10-12
JP2010200752A (ja) 2010-09-16
DE69838979T2 (de) 2008-12-24
EP0970227B1 (en) 2008-01-09
ATE383430T1 (de) 2008-01-15
ES2300122T3 (es) 2008-06-01
WO1998041641A1 (en) 1998-09-24
AU740904B2 (en) 2001-11-15
CA2284665A1 (en) 1998-09-24

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