CA2283798A1 - Nucleic acid-containing polymerizable complex - Google Patents

Nucleic acid-containing polymerizable complex Download PDF

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Publication number
CA2283798A1
CA2283798A1 CA002283798A CA2283798A CA2283798A1 CA 2283798 A1 CA2283798 A1 CA 2283798A1 CA 002283798 A CA002283798 A CA 002283798A CA 2283798 A CA2283798 A CA 2283798A CA 2283798 A1 CA2283798 A1 CA 2283798A1
Authority
CA
Canada
Prior art keywords
polymerizable
nucleic acid
containing monomer
monomer unit
ethylene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002283798A
Other languages
English (en)
French (fr)
Inventor
T. Christian Boles
Stephen J. Kron
Christopher P. Adams
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Matrix Technologies LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2283798A1 publication Critical patent/CA2283798A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
CA002283798A 1997-03-05 1998-02-20 Nucleic acid-containing polymerizable complex Abandoned CA2283798A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/812,105 US5932711A (en) 1997-03-05 1997-03-05 Nucleic acid-containing polymerizable complex
US08/812,105 1997-03-05
PCT/US1998/003246 WO1998039351A1 (en) 1997-03-05 1998-02-20 Nucleic acid-containing polymerizable complex

Publications (1)

Publication Number Publication Date
CA2283798A1 true CA2283798A1 (en) 1998-09-11

Family

ID=25208519

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002283798A Abandoned CA2283798A1 (en) 1997-03-05 1998-02-20 Nucleic acid-containing polymerizable complex

Country Status (8)

Country Link
US (2) US5932711A (https=)
EP (1) EP0971943B1 (https=)
JP (1) JP2001513109A (https=)
AT (1) ATE449781T1 (https=)
AU (1) AU6436498A (https=)
CA (1) CA2283798A1 (https=)
DE (1) DE69841304D1 (https=)
WO (1) WO1998039351A1 (https=)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020150921A1 (en) * 1996-02-09 2002-10-17 Francis Barany Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
US6852487B1 (en) * 1996-02-09 2005-02-08 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
EP1736554B1 (en) 1996-05-29 2013-10-09 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions
WO1998051823A1 (en) * 1997-05-16 1998-11-19 Mosaic Technologies Electrophoretic analysis of molecules using immobilized probes
CA2331767A1 (en) 1998-06-18 1999-12-23 Mosaic Technologies Denaturing gradient affinity electrophoresis and methods of use thereof
EP1088105A4 (en) * 1998-06-19 2003-06-25 Exact Sciences Corp DETECTION OF NON-VIRAL ORGANISMS HAVING SRP RNA
AU6412799A (en) * 1998-10-05 2000-04-26 Mosaic Technologies Reverse displacement assay for detection of nucleic acid sequences
WO2000029619A2 (en) * 1998-11-13 2000-05-25 Mosaic Technologies Multielement analytical device for assay of nucleic acid sequences and uses therefore
CA2353596A1 (en) * 1998-12-04 2000-06-15 Mosaic Technologies, Inc. Method for the immobilization of oligonucleotides
US20050153926A1 (en) * 1998-12-04 2005-07-14 Adams Christopher P. Method for the immobilization of oligonucleotides
WO2000034521A1 (en) * 1998-12-08 2000-06-15 Boston Probes, Inc. Methods, kits and compositions for the identification of nucleic acids electrostatically bound to matrices
WO2000050870A1 (en) * 1999-02-26 2000-08-31 Mosaic Technologies Biochemical purification devices with immobilized capture probes and their uses
EP1235930A2 (en) * 1999-04-02 2002-09-04 Mosaic Technologies Electrophoretic analysis of target molecules using adapter molecules
US6372813B1 (en) 1999-06-25 2002-04-16 Motorola Methods and compositions for attachment of biomolecules to solid supports, hydrogels, and hydrogel arrays
US6664061B2 (en) 1999-06-25 2003-12-16 Amersham Biosciences Ab Use and evaluation of a [2+2] photoaddition in immobilization of oligonucleotides on a three-dimensional hydrogel matrix
US6921638B2 (en) * 1999-06-25 2005-07-26 Amersham Biosciences Ab Hydrogel-based microarray signal amplification methods and devices therefor
WO2001002452A1 (en) * 1999-07-02 2001-01-11 Symyx Technologies, Inc. Polymer brushes for immobilizing molecules to a surface or substrate, where the polymers have water-soluble or water-dispersible segments and probes bonded thereto
RU2157385C1 (ru) * 1999-07-19 2000-10-10 Институт молекулярной биологии им. В.А. Энгельгардта РАН Способ изготовления микрочипов на основе олигонуклеотидов
EP1208238B1 (en) * 1999-08-27 2008-11-12 Matrix Technologies Corporation Methods of immobilizing ligands on solid supports
US6376177B1 (en) * 1999-10-06 2002-04-23 Virtual Pro, Inc. Apparatus and method for the analysis of nucleic acids hybridization on high density NA chips
US7109024B2 (en) * 1999-11-15 2006-09-19 Dr. Chip Biotechnology Inc. Biomolecule-bound substrates
RU2175972C2 (ru) * 1999-12-28 2001-11-20 Институт молекулярной биологии им. В.А. Энгельгардта РАН Способ иммобилизации олигонуклеотидов, содержащих непредельные группы, в полимерных гидрогелях при формировании микрочипа
US20030138774A1 (en) * 2000-01-19 2003-07-24 Jones Chris L. Methods and apparatus for separating and detecting nucleic acid
EP1130121A3 (en) * 2000-01-26 2003-04-16 Nisshinbo Industries Inc. Immobilized nucleic acid and method for detecting nucleic acid
US20040014644A1 (en) * 2000-03-14 2004-01-22 Vladimir Efimov Oligonucleotide analogues and methods of use for modulating gene expression
US6962906B2 (en) * 2000-03-14 2005-11-08 Active Motif Oligonucleotide analogues, methods of synthesis and methods of use
US7115738B2 (en) 2000-03-14 2006-10-03 Active Motif Hydroxyproline/phosphono oligonucleotide analogues, methods of synthesis and methods of use
EP1303639A2 (en) 2000-04-14 2003-04-23 Cornell Research Foundation, Inc. Method of designing addressable array for detection of nucleic acid sequence differences using ligase detection reaction
RU2278612C2 (ru) * 2000-07-14 2006-06-27 Лайфскен, Инк. Иммуносенсор
DE10049074A1 (de) * 2000-10-02 2002-04-18 Andreas Kage Verfahren zur Selektion hochaffin an ein Target bindender Nukleinsäuren
AU2002246978A1 (en) * 2001-01-10 2002-07-24 Symyx Technologies, Inc. Polymer brushes for immobilizing molecules to a surface
US20020142304A1 (en) * 2001-03-09 2002-10-03 Anderson Daniel G. Uses and methods of making microarrays of polymeric biomaterials
WO2002095840A1 (en) * 2001-05-24 2002-11-28 University Of Saskatchewan Technologies Inc. Nucleic acid circuit elements and methods
US20050261486A1 (en) * 2001-05-31 2005-11-24 Q-Rna Compositions and methods for binding agglomeration proteins
US20040005543A1 (en) * 2002-01-18 2004-01-08 Abraham Grossman Compositions and methods for binding agglomeration proteins
US6656725B2 (en) * 2001-08-15 2003-12-02 The University Of Chicago Method of fabrication of microarray of gel-immobilized compounds on a chip by copolymerization
EP1437368B8 (en) * 2001-10-16 2014-01-08 Federalnoe Gosudarstvennoe Byudzhetnoe Uchrezhdenie Nauki Institut Molekulyarnoi Biologi Im. V.A. Engelgardta Rossiiskoi Akademii Nauk Composition for polymerising immobilisation of biological molecules and method for producing said composition
JP3888947B2 (ja) * 2002-02-01 2007-03-07 日清紡績株式会社 生体分子の担体への固定法
US20060134713A1 (en) 2002-03-21 2006-06-22 Lifescan, Inc. Biosensor apparatus and methods of use
US20030180814A1 (en) * 2002-03-21 2003-09-25 Alastair Hodges Direct immunosensor assay
US20040028804A1 (en) * 2002-08-07 2004-02-12 Anderson Daniel G. Production of polymeric microarrays
WO2004020659A1 (de) * 2002-08-08 2004-03-11 Siemens Aktiengesellschaft Erkennungsschichten aus hydrogel auf der basis von polyacrylamid für die biosensorik
AU2002368411A1 (en) 2002-11-29 2004-06-23 Marcella Chiari Method for immobilizing biologic molecules on solid surfaces
US20040248162A1 (en) * 2002-12-17 2004-12-09 Affymetrix, Inc. Releasable polymer arrays
US20040185473A1 (en) * 2002-12-17 2004-09-23 Affymetrix, Inc. Releasable polymer arrays
DE10323685A1 (de) * 2003-05-22 2004-12-09 Rühe, Jürgen, Prof. Dr. Verfahren zur kovalenten Immobilisierung von Sonden-Biomolekülen an organischen Oberflächen
US7785769B2 (en) * 2003-07-25 2010-08-31 The United States of America as reprsented by the Secretary of the Navy Immobilization of oligonucleotides and proteins in sugar-containing hydrogels
US20050136536A1 (en) * 2003-09-15 2005-06-23 Anderson Daniel G. Embryonic epithelial cells
WO2005027962A1 (en) * 2003-09-18 2005-03-31 Isis Pharmaceuticals, Inc. 4’-thionucleosides and oligomeric compounds
CA2586515A1 (en) * 2003-11-05 2005-05-26 Exact Sciences Corporation Repetitive reversed-field affinity electrophoresis and uses therefor
CA2494571C (en) 2003-12-02 2010-02-09 F.Hoffmann-La Roche Ag Oligonucleotides containing molecular rods
DE102004062281A1 (de) * 2003-12-29 2005-07-28 Siemens Ag Verfahren und Spotting-Lösung zum Herstellen von Microarrays
EP1701785A1 (en) 2004-01-07 2006-09-20 Solexa Ltd. Modified molecular arrays
US7547775B2 (en) * 2004-12-31 2009-06-16 Affymetrix, Inc. Parallel preparation of high fidelity probes in an array format
US7749701B2 (en) * 2005-08-11 2010-07-06 Agilent Technologies, Inc. Controlling use of oligonucleotide sequences released from arrays
US8658608B2 (en) * 2005-11-23 2014-02-25 Yale University Modified triple-helix forming oligonucleotides for targeted mutagenesis
RU2394915C2 (ru) * 2006-03-24 2010-07-20 Александр Борисович Четверин Бесконтактные способы обнаружения молекулярных колоний, наборы реагентов и устройство для их осуществления
JP2010515464A (ja) * 2007-01-11 2010-05-13 イエール・ユニバーシテイ Ｈｉｖ細胞表面受容体の標的化不活性化のための組成物および方法
WO2008130263A1 (fr) 2007-04-20 2008-10-30 Institut Molekulyarnoi Biologii Im V.A. Engeldardta Rossiskoi Akademii Nauk Monomère et composition destinés à la réception d'hydrogel à faible pourcentage et/ou de l'hydrogel possédant une faible quantité de réticulations transversales, hydrogel et la biopuce basés sur cet hydrogel
EP3301104B1 (en) 2009-05-29 2019-10-30 Life Technologies Corporation Scaffolded nucleic acid polymer particles and methods of making and using
WO2013006824A2 (en) 2011-07-07 2013-01-10 Life Technologies Corporation Polymer particles, nucleic acid polymer particles and methods of making and using the same
WO2013123409A1 (en) 2012-02-17 2013-08-22 NVS Technologies, Inc. Polymer scaffolds for assay applications
CA2888132A1 (en) 2012-10-12 2014-04-17 NVS Technologies, Inc. Polymers having orthogonal reactive groups and uses thereof
WO2014152921A2 (en) 2013-03-14 2014-09-25 NVS Technologies, Inc. Surface oxidation for sequestering biomolecules and related methods
EP3044329B1 (en) 2013-09-13 2020-04-22 Life Technologies Corporation Device preparation using condensed nucleic acid particles
US11136597B2 (en) 2016-02-16 2021-10-05 Yale University Compositions for enhancing targeted gene editing and methods of use thereof
WO2018187493A1 (en) 2017-04-04 2018-10-11 Yale University Compositions and methods for in utero delivery

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2003266A1 (de) * 1970-01-26 1971-08-05 Waldhof Zellstoff Fab Verfahren zur Herstellung von Gelen
JPH06502667A (ja) * 1990-10-26 1994-03-24 ジンタ・インコーポレイテッド オリゴマーの固相合成用非芳香族有機ポリマー試薬
DK51092D0 (da) * 1991-05-24 1992-04-15 Ole Buchardt Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf
FR2679255B1 (fr) * 1991-07-17 1993-10-22 Bio Merieux Procede d'immobilisation d'un fragment nucleique par fixation passive sur un support solide, support solide ainsi obtenu et son utilisation.
US5495006A (en) * 1991-09-27 1996-02-27 Allelix Biopharmaceuticals, Inc. Antiviral polynucleotide conjugates
DE4322884A1 (de) * 1992-10-09 1994-04-14 Bayer Ag Biologisch aktive Polymere
JPH06121698A (ja) * 1992-10-12 1994-05-06 Canon Inc Ｄｎａプローブ用モノマー、ｄｎａプローブ、及びその製造方法

Also Published As

Publication number Publication date
EP0971943A1 (en) 2000-01-19
ATE449781T1 (de) 2009-12-15
US6180770B1 (en) 2001-01-30
DE69841304D1 (de) 2010-01-07
WO1998039351A1 (en) 1998-09-11
AU6436498A (en) 1998-09-22
EP0971943B1 (en) 2009-11-25
US5932711A (en) 1999-08-03
JP2001513109A (ja) 2001-08-28
EP0971943A4 (en) 2001-03-14

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued