CA2276312C - Microporation of tissue for delivery of bioactive agents - Google Patents
Microporation of tissue for delivery of bioactive agents Download PDFInfo
- Publication number
- CA2276312C CA2276312C CA2276312A CA2276312A CA2276312C CA 2276312 C CA2276312 C CA 2276312C CA 2276312 A CA2276312 A CA 2276312A CA 2276312 A CA2276312 A CA 2276312A CA 2276312 C CA2276312 C CA 2276312C
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- 239000011734 sodium Substances 0.000 description 1
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- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 description 1
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- RGYLYUZOGHTBRF-BIHRQFPBSA-N tetragastrin Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C2=CC=CC=C2NC=1)CCSC)C(N)=O)C1=CC=CC=C1 RGYLYUZOGHTBRF-BIHRQFPBSA-N 0.000 description 1
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- 231100000419 toxicity Toxicity 0.000 description 1
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- 230000008733 trauma Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
- A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
- A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0047—Sonopheresis, i.e. ultrasonically-enhanced transdermal delivery, electroporation of a pharmacologically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B2017/00017—Electrical control of surgical instruments
- A61B2017/00137—Details of operation mode
- A61B2017/00154—Details of operation mode pulsed
- A61B2017/00172—Pulse trains, bursts, intermittent continuous operation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Dermatology (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Medical Informatics (AREA)
- Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Pathology (AREA)
- Optics & Photonics (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Medicinal Preparation (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Electrotherapy Devices (AREA)
- Radiation-Therapy Devices (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Surgical Instruments (AREA)
- Laser Surgery Devices (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thermotherapy And Cooling Therapy Devices (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2789115A CA2789115C (en) | 1996-12-31 | 1997-12-30 | Microporation of tissue for delivery of bioactive agents |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77841596A | 1996-12-31 | 1996-12-31 | |
| US08/778,415 | 1996-12-31 | ||
| PCT/US1997/011670 WO1998000193A1 (en) | 1996-07-03 | 1997-07-03 | Multiple mechanical microporation of skin or mucosa |
| WOPCT/US97/11670 | 1997-07-03 | ||
| PCT/US1997/024127 WO1998029134A2 (en) | 1996-12-31 | 1997-12-30 | Microporation of tissue for delivery of bioactive agents |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2789115A Division CA2789115C (en) | 1996-12-31 | 1997-12-30 | Microporation of tissue for delivery of bioactive agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2276312A1 CA2276312A1 (en) | 1998-07-09 |
| CA2276312C true CA2276312C (en) | 2012-11-27 |
Family
ID=25113276
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2276312A Expired - Lifetime CA2276312C (en) | 1996-12-31 | 1997-12-30 | Microporation of tissue for delivery of bioactive agents |
| CA2789115A Expired - Lifetime CA2789115C (en) | 1996-12-31 | 1997-12-30 | Microporation of tissue for delivery of bioactive agents |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2789115A Expired - Lifetime CA2789115C (en) | 1996-12-31 | 1997-12-30 | Microporation of tissue for delivery of bioactive agents |
Country Status (9)
| Country | Link |
|---|---|
| EP (2) | EP0952850A2 (https=) |
| JP (5) | JP2001512329A (https=) |
| AT (1) | ATE365026T1 (https=) |
| AU (1) | AU5623298A (https=) |
| CA (2) | CA2276312C (https=) |
| DE (1) | DE69737836T2 (https=) |
| DK (1) | DK1314400T3 (https=) |
| ES (1) | ES2289192T3 (https=) |
| WO (1) | WO1998029134A2 (https=) |
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| US5980898A (en) | 1996-11-14 | 1999-11-09 | The United States Of America As Represented By The U.S. Army Medical Research & Material Command | Adjuvant for transcutaneous immunization |
| US20060002949A1 (en) | 1996-11-14 | 2006-01-05 | Army Govt. Of The Usa, As Rep. By Secretary Of The Office Of The Command Judge Advocate, Hq Usamrmc. | Transcutaneous immunization without heterologous adjuvant |
| US6797276B1 (en) | 1996-11-14 | 2004-09-28 | The United States Of America As Represented By The Secretary Of The Army | Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response |
| US6517532B1 (en) | 1997-05-15 | 2003-02-11 | Palomar Medical Technologies, Inc. | Light energy delivery head |
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| CA2330211A1 (en) * | 1998-06-08 | 1999-12-16 | Karel Petrak | Formulations for electroporation |
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-
1997
- 1997-12-30 EP EP97952676A patent/EP0952850A2/en not_active Ceased
- 1997-12-30 EP EP03002035A patent/EP1314400B1/en not_active Expired - Lifetime
- 1997-12-30 WO PCT/US1997/024127 patent/WO1998029134A2/en not_active Ceased
- 1997-12-30 CA CA2276312A patent/CA2276312C/en not_active Expired - Lifetime
- 1997-12-30 DE DE69737836T patent/DE69737836T2/de not_active Expired - Lifetime
- 1997-12-30 CA CA2789115A patent/CA2789115C/en not_active Expired - Lifetime
- 1997-12-30 AT AT03002035T patent/ATE365026T1/de active
- 1997-12-30 JP JP53029898A patent/JP2001512329A/ja not_active Withdrawn
- 1997-12-30 DK DK03002035T patent/DK1314400T3/da active
- 1997-12-30 AU AU56232/98A patent/AU5623298A/en not_active Abandoned
- 1997-12-30 ES ES03002035T patent/ES2289192T3/es not_active Expired - Lifetime
-
2008
- 2008-06-16 JP JP2008157298A patent/JP2008307391A/ja not_active Withdrawn
-
2009
- 2009-09-02 JP JP2009203124A patent/JP2010005425A/ja not_active Withdrawn
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2013
- 2013-01-31 JP JP2013016445A patent/JP5657040B2/ja not_active Expired - Fee Related
- 2013-03-08 JP JP2013046499A patent/JP5680685B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP5657040B2 (ja) | 2015-01-21 |
| EP1314400B1 (en) | 2007-06-20 |
| EP0952850A2 (en) | 1999-11-03 |
| ES2289192T3 (es) | 2008-02-01 |
| ATE365026T1 (de) | 2007-07-15 |
| WO1998029134A3 (en) | 1998-10-15 |
| CA2789115C (en) | 2014-04-29 |
| JP2013165967A (ja) | 2013-08-29 |
| JP2010005425A (ja) | 2010-01-14 |
| JP5680685B2 (ja) | 2015-03-04 |
| EP1314400A3 (en) | 2003-10-15 |
| JP2001512329A (ja) | 2001-08-21 |
| DE69737836D1 (de) | 2007-08-02 |
| CA2789115A1 (en) | 1998-07-09 |
| EP1314400A2 (en) | 2003-05-28 |
| JP2008307391A (ja) | 2008-12-25 |
| DE69737836T2 (de) | 2008-03-06 |
| DK1314400T3 (da) | 2007-10-15 |
| WO1998029134A2 (en) | 1998-07-09 |
| AU5623298A (en) | 1998-07-31 |
| JP2013099586A (ja) | 2013-05-23 |
| CA2276312A1 (en) | 1998-07-09 |
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