CA2270478A1 - Derives de n-(imidazolylbutyle) benzenesulfonamide ayant une activite antithrombotique - Google Patents
Derives de n-(imidazolylbutyle) benzenesulfonamide ayant une activite antithrombotique Download PDFInfo
- Publication number
- CA2270478A1 CA2270478A1 CA002270478A CA2270478A CA2270478A1 CA 2270478 A1 CA2270478 A1 CA 2270478A1 CA 002270478 A CA002270478 A CA 002270478A CA 2270478 A CA2270478 A CA 2270478A CA 2270478 A1 CA2270478 A1 CA 2270478A1
- Authority
- CA
- Canada
- Prior art keywords
- group
- formula
- alkyl
- compound
- branched
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/68—Halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Composés de formule (I) dans laquelle R¿1? et R'¿1? représentent hydrogène, halogène ou (C¿1?-C¿4?)alkyle, R¿2? représente un groupe pipéridin-1-yle, 1,2,3,6-tétrahydropyridin-1-yle éventuellement substitués, hexahydro-1H-azépin-1-yle, heptahydroazocin-1-yle, octahydro-1H-azonin-1-yle, (a) (A-B = -CONR", m = 1 à 2 et p = 1 à 2), (b) (Q = carbone ou azote, D = (C¿1?-C¿4?)alkyle ou -CH¿2?CF¿3?, et r = 1 à 3), R¿3? représente (C¿1?-C¿5?)alkyle, -COR¿5? [R¿5? étant (C¿1?-C¿4?) alkyle, -(CH¿2?)¿n?OCH¿3?, -CH¿2?O(C¿2?H¿4?O)¿n?CH¿3?, -(CH¿2?)¿n?CF¿3?, -(CH¿2?)¿n?OH (n égal 1 à 4)], -SO¿2?R¿6?, -CONHR¿6?, -SO¿2?N(R¿6?)¿2? (R¿6? étant (C¿1?-C¿4?) alkyle), R¿4? représente hydrogène ou halogène et A représente phényle ou hétérocycle éventuellement substitués ou cyclo(C¿5?-C¿8?)alkyle. Application en thérapeutique.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR96/14309 | 1996-11-22 | ||
FR9614309A FR2756285B1 (fr) | 1996-11-22 | 1996-11-22 | Derives de n-(imidazolylbutyle)benzenesulfonamide, leur preparation et leur application en therapeutique |
PCT/FR1997/002079 WO1998022443A1 (fr) | 1996-11-22 | 1997-11-19 | Derives de n-(imidazolylbutyle) benzenesulfonamide ayant une activite antithrombotique |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2270478A1 true CA2270478A1 (fr) | 1998-05-28 |
Family
ID=9497920
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002270478A Abandoned CA2270478A1 (fr) | 1996-11-22 | 1997-11-19 | Derives de n-(imidazolylbutyle) benzenesulfonamide ayant une activite antithrombotique |
Country Status (20)
Country | Link |
---|---|
EP (1) | EP0946517A1 (fr) |
JP (1) | JP2001504128A (fr) |
KR (1) | KR20000069063A (fr) |
CN (1) | CN1238765A (fr) |
AR (1) | AR009627A1 (fr) |
AU (1) | AU5226498A (fr) |
BG (1) | BG103414A (fr) |
BR (1) | BR9713291A (fr) |
CA (1) | CA2270478A1 (fr) |
CO (1) | CO4910158A1 (fr) |
CZ (1) | CZ178299A3 (fr) |
EE (1) | EE9900201A (fr) |
FR (1) | FR2756285B1 (fr) |
HU (1) | HUP9904599A2 (fr) |
IL (1) | IL129546A0 (fr) |
NO (1) | NO992436L (fr) |
SK (1) | SK66799A3 (fr) |
TR (1) | TR199901143T2 (fr) |
WO (1) | WO1998022443A1 (fr) |
ZA (1) | ZA9710515B (fr) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2783521B1 (fr) * | 1998-09-18 | 2002-04-26 | Synthelabo | Derives de n-(arginyl) benzenesulfonamide, leur preparation et leur application en therapeutique |
FR2806722B1 (fr) * | 2000-03-23 | 2002-05-17 | Sanofi Synthelabo | Derives de n-(heterocyclylbutyl) benzene-ou pyridine sulfonamide, leur preparation et leur application en therapeutique |
WO2016051420A1 (fr) | 2014-09-29 | 2016-04-07 | Cellix Bio Private Limited | Compositions et méthodes pour le traitement de la sclérose en plaques |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2689130B1 (fr) * | 1992-03-30 | 1994-05-27 | Synthelabo | Derives de 1-[2 (arylsulfonylamino)ethyl-1-oxo] piperidine, leur preparation et leur application en therapeutique. |
FR2710066B1 (fr) * | 1993-09-14 | 1995-10-20 | Synthelabo | Dérivés de 1-[2-amino-5-[1-(triphénylméthyl-1H-imidazol-4-yl]-1-oxopentyl]piperidine, leur préparation et leur utilisation comme intermédiaires de synthèse. |
FR2727410B1 (fr) * | 1994-11-25 | 1996-12-20 | Synthelabo | Chlorures de sulfonyles, leur preparation et leur utilisation comme intermediaires de synthese |
FR2728570B1 (fr) * | 1994-12-23 | 1997-04-11 | Synthelabo | Derives de 1-oxo-2-(phenylsulfonylamino)pentylpiperidine, leur preparation et leur application en therapeutique |
DE19548797A1 (de) * | 1995-12-27 | 1997-07-03 | Thomae Gmbh Dr K | Substituierte 2-Amino-imidazole, ihre Herstellung und ihre Verwendung als Arzneimittel |
-
1996
- 1996-11-22 FR FR9614309A patent/FR2756285B1/fr not_active Expired - Fee Related
-
1997
- 1997-11-19 CO CO97067574A patent/CO4910158A1/es unknown
- 1997-11-19 WO PCT/FR1997/002079 patent/WO1998022443A1/fr not_active Application Discontinuation
- 1997-11-19 KR KR1019997004485A patent/KR20000069063A/ko not_active Application Discontinuation
- 1997-11-19 CA CA002270478A patent/CA2270478A1/fr not_active Abandoned
- 1997-11-19 JP JP52328498A patent/JP2001504128A/ja active Pending
- 1997-11-19 TR TR1999/01143T patent/TR199901143T2/xx unknown
- 1997-11-19 HU HU9904599A patent/HUP9904599A2/hu unknown
- 1997-11-19 IL IL12954697A patent/IL129546A0/xx unknown
- 1997-11-19 CZ CZ991782A patent/CZ178299A3/cs unknown
- 1997-11-19 AU AU52264/98A patent/AU5226498A/en not_active Abandoned
- 1997-11-19 EE EEP199900201A patent/EE9900201A/xx unknown
- 1997-11-19 EP EP97947089A patent/EP0946517A1/fr not_active Ceased
- 1997-11-19 BR BR9713291-8A patent/BR9713291A/pt not_active Application Discontinuation
- 1997-11-19 CN CN97199986A patent/CN1238765A/zh active Pending
- 1997-11-19 SK SK667-99A patent/SK66799A3/sk unknown
- 1997-11-21 ZA ZA9710515A patent/ZA9710515B/xx unknown
- 1997-11-21 AR ARP970105455A patent/AR009627A1/es unknown
-
1999
- 1999-05-19 BG BG103414A patent/BG103414A/xx unknown
- 1999-05-20 NO NO992436A patent/NO992436L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO1998022443A1 (fr) | 1998-05-28 |
EE9900201A (et) | 1999-12-15 |
CO4910158A1 (es) | 2000-04-24 |
KR20000069063A (ko) | 2000-11-25 |
FR2756285B1 (fr) | 1998-12-18 |
HUP9904599A2 (hu) | 2000-06-28 |
JP2001504128A (ja) | 2001-03-27 |
ZA9710515B (en) | 1998-06-10 |
TR199901143T2 (xx) | 1999-08-23 |
AU5226498A (en) | 1998-06-10 |
FR2756285A1 (fr) | 1998-05-29 |
CN1238765A (zh) | 1999-12-15 |
IL129546A0 (en) | 2000-02-29 |
BG103414A (en) | 2000-01-31 |
BR9713291A (pt) | 1999-10-26 |
NO992436L (no) | 1999-07-22 |
EP0946517A1 (fr) | 1999-10-06 |
SK66799A3 (en) | 2000-02-14 |
CZ178299A3 (cs) | 1999-08-11 |
NO992436D0 (no) | 1999-05-20 |
AR009627A1 (es) | 2000-04-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US8614321B2 (en) | Benzoimidazolyl-pyrazine compounds for inflammation and immune-related uses | |
EP1024138B1 (fr) | Derives de pyrazole | |
US8314134B2 (en) | Compounds for inflammation and immune-related uses | |
CA2722811C (fr) | Composes de pyrazole comme antagonistes de ccr1 | |
US20110052643A1 (en) | Compounds for inflammation and immune-related uses | |
MX2015003918A (es) | Piridinonas anti-fibroticas. | |
US8324219B2 (en) | Substituted benzoimidazolyl-pyrazine compounds for inflammation and immune-related uses | |
US20110118262A1 (en) | Pyrrolidinyl and Piperidinyl Compounds Useful as NHE-1 Inhibitiors | |
CA2777762A1 (fr) | Composes d'amino-pyrimidine en tant qu'inhibiteurs de tbkl et ou d'ikk epsilon | |
AU2008282737A1 (en) | Vinyl-aryl derivatives for inflammation and immune-related uses | |
MX2008016557A (es) | Analogos de piridina nuevos. | |
KR20090031605A (ko) | 신규한 피리딘 유사체 | |
JPH10511375A (ja) | フィブリノゲン拮抗剤として有用なピペリジン酢酸誘導体 | |
CA2270478A1 (fr) | Derives de n-(imidazolylbutyle) benzenesulfonamide ayant une activite antithrombotique | |
US7705029B2 (en) | Acrylonitrile derivatives for inflammation and immune-related uses | |
US5602149A (en) | 1-OXO-2-(phenylsulphonylamino)pentypiperidine derivatives, their preparation and their therapeutic application | |
KR20100017964A (ko) | 1-벤질피라졸 유도체, 그의 제법 및 그의 치료학적 용도 | |
EP0661273B1 (fr) | Dérivés d'indane et procédés pour leur préparation | |
MXPA99004741A (en) | N-(imidazolylbutyl) benzenesulphonamide derivatives, their preparation and therapeutic application | |
JPH10130240A (ja) | Icam−1産生阻害剤 | |
NZ314407A (en) | 2-amino-benzenesulphonic acid derivatives |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Discontinued |