CO4910158A1 - Derivados de n-(imidazolilbutilo) bencenosulfonamida, su preparacion y su aplicacion en terapeutica - Google Patents

Derivados de n-(imidazolilbutilo) bencenosulfonamida, su preparacion y su aplicacion en terapeutica

Info

Publication number
CO4910158A1
CO4910158A1 CO97067574A CO97067574A CO4910158A1 CO 4910158 A1 CO4910158 A1 CO 4910158A1 CO 97067574 A CO97067574 A CO 97067574A CO 97067574 A CO97067574 A CO 97067574A CO 4910158 A1 CO4910158 A1 CO 4910158A1
Authority
CO
Colombia
Prior art keywords
group
alkyl
optionally substituted
halogen atoms
derivatives
Prior art date
Application number
CO97067574A
Other languages
English (en)
Inventor
Jean Michel Altenburger
Gilbert Lassalle
Valerie Martin
Daniel Galtier
Original Assignee
Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo filed Critical Synthelabo
Publication of CO4910158A1 publication Critical patent/CO4910158A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/68—Halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

Derivados de N-(imidazolil-butilo)bencenosulfonamida de fórmula:en la cual:R1 y R´1 representan cada uno independientemente del otro, o bien un átomo de hidrógeno o bien un átomo de halógeno, o bien un grupo (C1 -C4 )alquilo, R2 representa o bien un grupo piperidin-1-ilo eventualmente substituido en posición 4 por uno o varios grupos elegidos entre los grupos hidroxi, (C1 -C4 ) alquilo lineal o ramificado, hidroxi (C1 -C4 )alquilo, (C1 -C4 )alcoxi (C1 -C4 )alquilo, (C1 -C4 )alcoxi, (C1 -C4 )alquiltio, nitrilo, monofluorometilo, difluorometilo, trifluorometilo, 2-fluoroetoxi, 2,2,2-trifluoroetoxi, (C3 -C6 ) cicloalquilo, -COOR´ y -CONR´R´´ (siendo R´ un grupo (C1 -C4 ) alquilo y R´´ un átomo de hidrógeno o un grupo (C1 -C4 )alquilo) o por un grupo =CYZ [siendo elegidos Y y Z independientemente uno de otro entre los átomos de hidrógeno y de halógeno y los grupos (C1 -C4 )alquilo (eventualmente substituido por uno o varios átomos de halógeno), ciano y- COOR´), siendo R´ tal como se lo ha definido un grupo =NOCH3 , o bien un grupo espiro [(C3 -C6 )cicloalcano-1,4´ -piperidin]-1-ilo, o bien un grupo 1,2,3,6-tetrahidropiridin-1-ilo eventualmente substituido en posición 4 por un grupo (C1 -C4 ) alquilo lineal o ramificado (eventualmente substituido por uno o varios átomos de halógeno)o (C3 -C6 )cicloalquilo o bien un grupo hexahidro-1-H-azepin-1-ilo eventualmente substituido en posición 4 por un grupo trifluorometilo o =CF2 , o bien un grupo heptahidroazocin-1-ilo, o bien un grupo octahidro-1H-azonin-1-ilo,...
CO97067574A 1996-11-22 1997-11-19 Derivados de n-(imidazolilbutilo) bencenosulfonamida, su preparacion y su aplicacion en terapeutica CO4910158A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9614309A FR2756285B1 (fr) 1996-11-22 1996-11-22 Derives de n-(imidazolylbutyle)benzenesulfonamide, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
CO4910158A1 true CO4910158A1 (es) 2000-04-24

Family

ID=9497920

Family Applications (1)

Application Number Title Priority Date Filing Date
CO97067574A CO4910158A1 (es) 1996-11-22 1997-11-19 Derivados de n-(imidazolilbutilo) bencenosulfonamida, su preparacion y su aplicacion en terapeutica

Country Status (20)

Country Link
EP (1) EP0946517A1 (es)
JP (1) JP2001504128A (es)
KR (1) KR20000069063A (es)
CN (1) CN1238765A (es)
AR (1) AR009627A1 (es)
AU (1) AU5226498A (es)
BG (1) BG103414A (es)
BR (1) BR9713291A (es)
CA (1) CA2270478A1 (es)
CO (1) CO4910158A1 (es)
CZ (1) CZ178299A3 (es)
EE (1) EE9900201A (es)
FR (1) FR2756285B1 (es)
HU (1) HUP9904599A2 (es)
IL (1) IL129546A0 (es)
NO (1) NO992436L (es)
SK (1) SK66799A3 (es)
TR (1) TR199901143T2 (es)
WO (1) WO1998022443A1 (es)
ZA (1) ZA9710515B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2783521B1 (fr) * 1998-09-18 2002-04-26 Synthelabo Derives de n-(arginyl) benzenesulfonamide, leur preparation et leur application en therapeutique
FR2806722B1 (fr) * 2000-03-23 2002-05-17 Sanofi Synthelabo Derives de n-(heterocyclylbutyl) benzene-ou pyridine sulfonamide, leur preparation et leur application en therapeutique
ES2799309T3 (es) 2014-09-29 2020-12-16 Cellix Bio Private Ltd Compuestos y composiciones para el tratamiento de esclerosis múltiple

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2689130B1 (fr) * 1992-03-30 1994-05-27 Synthelabo Derives de 1-[2 (arylsulfonylamino)ethyl-1-oxo] piperidine, leur preparation et leur application en therapeutique.
FR2710066B1 (fr) * 1993-09-14 1995-10-20 Synthelabo Dérivés de 1-[2-amino-5-[1-(triphénylméthyl-1H-imidazol-4-yl]-1-oxopentyl]piperidine, leur préparation et leur utilisation comme intermédiaires de synthèse.
FR2727410B1 (fr) * 1994-11-25 1996-12-20 Synthelabo Chlorures de sulfonyles, leur preparation et leur utilisation comme intermediaires de synthese
FR2728570B1 (fr) * 1994-12-23 1997-04-11 Synthelabo Derives de 1-oxo-2-(phenylsulfonylamino)pentylpiperidine, leur preparation et leur application en therapeutique
DE19548797A1 (de) * 1995-12-27 1997-07-03 Thomae Gmbh Dr K Substituierte 2-Amino-imidazole, ihre Herstellung und ihre Verwendung als Arzneimittel

Also Published As

Publication number Publication date
CZ178299A3 (cs) 1999-08-11
WO1998022443A1 (fr) 1998-05-28
HUP9904599A2 (hu) 2000-06-28
FR2756285A1 (fr) 1998-05-29
EE9900201A (et) 1999-12-15
AR009627A1 (es) 2000-04-26
FR2756285B1 (fr) 1998-12-18
SK66799A3 (en) 2000-02-14
CN1238765A (zh) 1999-12-15
KR20000069063A (ko) 2000-11-25
TR199901143T2 (xx) 1999-08-23
BG103414A (en) 2000-01-31
IL129546A0 (en) 2000-02-29
EP0946517A1 (fr) 1999-10-06
NO992436D0 (no) 1999-05-20
AU5226498A (en) 1998-06-10
NO992436L (no) 1999-07-22
JP2001504128A (ja) 2001-03-27
CA2270478A1 (en) 1998-05-28
BR9713291A (pt) 1999-10-26
ZA9710515B (en) 1998-06-10

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