HUP9904599A2 - N-(Imidazolil-butil)-benzolszulfanomid-származékok, eljárás előállításukra és alkalmazásuk a gyógyászatban - Google Patents
N-(Imidazolil-butil)-benzolszulfanomid-származékok, eljárás előállításukra és alkalmazásuk a gyógyászatbanInfo
- Publication number
- HUP9904599A2 HUP9904599A2 HU9904599A HUP9904599A HUP9904599A2 HU P9904599 A2 HUP9904599 A2 HU P9904599A2 HU 9904599 A HU9904599 A HU 9904599A HU P9904599 A HUP9904599 A HU P9904599A HU P9904599 A2 HUP9904599 A2 HU P9904599A2
- Authority
- HU
- Hungary
- Prior art keywords
- general formula
- pipe powder
- carbon
- alkyl
- imidazolylbutyl
- Prior art date
Links
- LRQVXUYWQZZCJD-UHFFFAOYSA-N n-[4-(1h-imidazol-2-yl)butyl]benzenesulfonamide Chemical class C=1C=CC=CC=1S(=O)(=O)NCCCCC1=NC=CN1 LRQVXUYWQZZCJD-UHFFFAOYSA-N 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 239000000843 powder Substances 0.000 abstract 5
- 229910052799 carbon Inorganic materials 0.000 abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- -1 1,2,3,6-tetrahydropyridin-1-yl Chemical group 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 101100134922 Gallus gallus COR5 gene Proteins 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000002785 anti-thrombosis Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 229910052757 nitrogen Chemical group 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/68—Halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Az (I) általánős képletű vegyületek, ahől R1 és R1' jelentése többekközött hidrőgén, halőgénatőm vagy 1-4 szénatőmős alkilcsőpőrt, R2jelentése piperidin-1-il, adőtt esetben szűbsztitűált 1,2,3,6-tetra-hidrőpiridin-1-il, hexahidrő-1H-azepin-1-il, heptahidrő-azőcin-1-il,őktahidrő-1H-azőnin-1-il-csőpőrt, (b) általánős képletű csőpőrt, ahőla-B =CON'' csőpőrt, m értéke 1 vagy 2, és értéke 1 vagy 2, vagy (c)általánős képletű csőpőrt, ahől Q jelentése szén- vagy nitrőgénatőm, Djelentése 1-4 szénatőmős alkil- vagy -CH2CF3 csőpőrt és R értéke 1-3;R3 jelentése 1-5 szénatőmős alkilcsőpőrt vagy COR5 általánős képletűcsőpőrt, ahől R5 jelentése 1-4 szénatőmős alkil-, -(CH2)nOCH3, -CH2O(C2H4O)nCH3, -(CH2)nCF3, -(CH2)nOH általánős képletű csőpőrt, ahőln értéke 1-4 vagy SO2R6, -CONHR6, -SO2N(R6)2 általánős képletűcsőpőrt, ahől R6 jelentése 1-4 szénatőmős alkilcsőpőrt, R4 jelentésehidrőgén- vagy halőgénatőm és A jelentése fenilcsőpőrt, vagy adőttesetben szűbsztitűált heterőciklűsős csőpőrt, vagy 5-8 szénatőmősciklőalkilcsőpőrt gyógyszerhatóanyagként használhatók. A találmányvegyületek trőmbózisellenes hatással rendelkeznek. (c) ŕ
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9614309A FR2756285B1 (fr) | 1996-11-22 | 1996-11-22 | Derives de n-(imidazolylbutyle)benzenesulfonamide, leur preparation et leur application en therapeutique |
PCT/FR1997/002079 WO1998022443A1 (fr) | 1996-11-22 | 1997-11-19 | Derives de n-(imidazolylbutyle) benzenesulfonamide ayant une activite antithrombotique |
Publications (1)
Publication Number | Publication Date |
---|---|
HUP9904599A2 true HUP9904599A2 (hu) | 2000-06-28 |
Family
ID=9497920
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9904599A HUP9904599A2 (hu) | 1996-11-22 | 1997-11-19 | N-(Imidazolil-butil)-benzolszulfanomid-származékok, eljárás előállításukra és alkalmazásuk a gyógyászatban |
Country Status (20)
Country | Link |
---|---|
EP (1) | EP0946517A1 (hu) |
JP (1) | JP2001504128A (hu) |
KR (1) | KR20000069063A (hu) |
CN (1) | CN1238765A (hu) |
AR (1) | AR009627A1 (hu) |
AU (1) | AU5226498A (hu) |
BG (1) | BG103414A (hu) |
BR (1) | BR9713291A (hu) |
CA (1) | CA2270478A1 (hu) |
CO (1) | CO4910158A1 (hu) |
CZ (1) | CZ178299A3 (hu) |
EE (1) | EE9900201A (hu) |
FR (1) | FR2756285B1 (hu) |
HU (1) | HUP9904599A2 (hu) |
IL (1) | IL129546A0 (hu) |
NO (1) | NO992436L (hu) |
SK (1) | SK66799A3 (hu) |
TR (1) | TR199901143T2 (hu) |
WO (1) | WO1998022443A1 (hu) |
ZA (1) | ZA9710515B (hu) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2783521B1 (fr) * | 1998-09-18 | 2002-04-26 | Synthelabo | Derives de n-(arginyl) benzenesulfonamide, leur preparation et leur application en therapeutique |
FR2806722B1 (fr) * | 2000-03-23 | 2002-05-17 | Sanofi Synthelabo | Derives de n-(heterocyclylbutyl) benzene-ou pyridine sulfonamide, leur preparation et leur application en therapeutique |
ES2799309T3 (es) | 2014-09-29 | 2020-12-16 | Cellix Bio Private Ltd | Compuestos y composiciones para el tratamiento de esclerosis múltiple |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2689130B1 (fr) * | 1992-03-30 | 1994-05-27 | Synthelabo | Derives de 1-[2 (arylsulfonylamino)ethyl-1-oxo] piperidine, leur preparation et leur application en therapeutique. |
FR2710066B1 (fr) * | 1993-09-14 | 1995-10-20 | Synthelabo | Dérivés de 1-[2-amino-5-[1-(triphénylméthyl-1H-imidazol-4-yl]-1-oxopentyl]piperidine, leur préparation et leur utilisation comme intermédiaires de synthèse. |
FR2727410B1 (fr) * | 1994-11-25 | 1996-12-20 | Synthelabo | Chlorures de sulfonyles, leur preparation et leur utilisation comme intermediaires de synthese |
FR2728570B1 (fr) * | 1994-12-23 | 1997-04-11 | Synthelabo | Derives de 1-oxo-2-(phenylsulfonylamino)pentylpiperidine, leur preparation et leur application en therapeutique |
DE19548797A1 (de) * | 1995-12-27 | 1997-07-03 | Thomae Gmbh Dr K | Substituierte 2-Amino-imidazole, ihre Herstellung und ihre Verwendung als Arzneimittel |
-
1996
- 1996-11-22 FR FR9614309A patent/FR2756285B1/fr not_active Expired - Fee Related
-
1997
- 1997-11-19 KR KR1019997004485A patent/KR20000069063A/ko not_active Application Discontinuation
- 1997-11-19 EP EP97947089A patent/EP0946517A1/fr not_active Ceased
- 1997-11-19 HU HU9904599A patent/HUP9904599A2/hu unknown
- 1997-11-19 CN CN97199986A patent/CN1238765A/zh active Pending
- 1997-11-19 WO PCT/FR1997/002079 patent/WO1998022443A1/fr not_active Application Discontinuation
- 1997-11-19 JP JP52328498A patent/JP2001504128A/ja active Pending
- 1997-11-19 TR TR1999/01143T patent/TR199901143T2/xx unknown
- 1997-11-19 SK SK667-99A patent/SK66799A3/sk unknown
- 1997-11-19 CZ CZ991782A patent/CZ178299A3/cs unknown
- 1997-11-19 IL IL12954697A patent/IL129546A0/xx unknown
- 1997-11-19 BR BR9713291-8A patent/BR9713291A/pt not_active Application Discontinuation
- 1997-11-19 CA CA002270478A patent/CA2270478A1/en not_active Abandoned
- 1997-11-19 CO CO97067574A patent/CO4910158A1/es unknown
- 1997-11-19 AU AU52264/98A patent/AU5226498A/en not_active Abandoned
- 1997-11-19 EE EEP199900201A patent/EE9900201A/xx unknown
- 1997-11-21 ZA ZA9710515A patent/ZA9710515B/xx unknown
- 1997-11-21 AR ARP970105455A patent/AR009627A1/es unknown
-
1999
- 1999-05-19 BG BG103414A patent/BG103414A/xx unknown
- 1999-05-20 NO NO992436A patent/NO992436L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CZ178299A3 (cs) | 1999-08-11 |
WO1998022443A1 (fr) | 1998-05-28 |
FR2756285A1 (fr) | 1998-05-29 |
EE9900201A (et) | 1999-12-15 |
AR009627A1 (es) | 2000-04-26 |
FR2756285B1 (fr) | 1998-12-18 |
SK66799A3 (en) | 2000-02-14 |
CN1238765A (zh) | 1999-12-15 |
KR20000069063A (ko) | 2000-11-25 |
TR199901143T2 (xx) | 1999-08-23 |
BG103414A (en) | 2000-01-31 |
IL129546A0 (en) | 2000-02-29 |
EP0946517A1 (fr) | 1999-10-06 |
NO992436D0 (no) | 1999-05-20 |
AU5226498A (en) | 1998-06-10 |
NO992436L (no) | 1999-07-22 |
CO4910158A1 (es) | 2000-04-24 |
JP2001504128A (ja) | 2001-03-27 |
CA2270478A1 (en) | 1998-05-28 |
BR9713291A (pt) | 1999-10-26 |
ZA9710515B (en) | 1998-06-10 |
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