CA2269780C - Polyanionic polymers as adjuvants for mucosal immunization - Google Patents

Polyanionic polymers as adjuvants for mucosal immunization Download PDF

Info

Publication number
CA2269780C
CA2269780C CA002269780A CA2269780A CA2269780C CA 2269780 C CA2269780 C CA 2269780C CA 002269780 A CA002269780 A CA 002269780A CA 2269780 A CA2269780 A CA 2269780A CA 2269780 C CA2269780 C CA 2269780C
Authority
CA
Canada
Prior art keywords
adjuvant
acid
paa
specimens
antigen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002269780A
Other languages
English (en)
French (fr)
Other versions
CA2269780A1 (en
Inventor
Luuk Hilgers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zoetis Schweiz GmbH
Original Assignee
Dimminaco AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dimminaco AG filed Critical Dimminaco AG
Publication of CA2269780A1 publication Critical patent/CA2269780A1/en
Application granted granted Critical
Publication of CA2269780C publication Critical patent/CA2269780C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
CA002269780A 1996-10-24 1997-10-23 Polyanionic polymers as adjuvants for mucosal immunization Expired - Lifetime CA2269780C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9622159.3A GB9622159D0 (en) 1996-10-24 1996-10-24 Polyanionic polymers as adjuvants for mucosal immunization
GB9622159.3 1996-10-24
PCT/EP1997/005861 WO1998017310A2 (en) 1996-10-24 1997-10-23 Polyanionic polymers as adjuvants for mucosal immunization

Publications (2)

Publication Number Publication Date
CA2269780A1 CA2269780A1 (en) 1998-04-30
CA2269780C true CA2269780C (en) 2008-12-02

Family

ID=10801896

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002269780A Expired - Lifetime CA2269780C (en) 1996-10-24 1997-10-23 Polyanionic polymers as adjuvants for mucosal immunization

Country Status (11)

Country Link
US (1) US6610310B2 (https=)
EP (1) EP0934077B1 (https=)
JP (1) JP4344014B2 (https=)
AT (1) ATE360440T1 (https=)
AU (1) AU717349B2 (https=)
BR (1) BR9712436A (https=)
CA (1) CA2269780C (https=)
DE (1) DE69737658T2 (https=)
ES (1) ES2285741T3 (https=)
GB (1) GB9622159D0 (https=)
WO (1) WO1998017310A2 (https=)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050129680A1 (en) * 2001-09-17 2005-06-16 Paul Wentworth Antimicrobial activity of antibodies
US20040157280A1 (en) * 2001-09-17 2004-08-12 Paul Wentworth Antibody mediated ozone generation
US20040116350A1 (en) * 2001-09-17 2004-06-17 Paul Wentworth Jr Methods and compositions relating to hydrogen peroxide and superoxide production by antibodies
MX339524B (es) 2001-10-11 2016-05-30 Wyeth Corp Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica.
CN100570365C (zh) * 2002-11-14 2009-12-16 斯克里普斯研究所 抗体或嗜中性粒细胞介导的臭氧产生
GB0313916D0 (en) 2003-06-16 2003-07-23 Glaxosmithkline Biolog Sa Vaccine composition
JP4860109B2 (ja) * 2003-12-26 2012-01-25 バイオリーダース・コーポレイション ポリガンマグルタミン酸を含む免疫増強用組成物
DE102006047617B4 (de) * 2006-10-09 2008-11-27 Clariant International Limited Verfahren zur Herstellung basischer (Meth)acrylamide
US20090017064A1 (en) * 2007-07-10 2009-01-15 Wyeth Methods and Compositions for Immunizing Pigs Against Porcine Circovirus
FR2922767B1 (fr) * 2007-10-24 2009-12-18 Seppic Sa Procede de preparation d'une composition vaccinale comprenant au moins un antigene et au moins un adjuvant.
EP2217271B1 (en) 2007-11-06 2016-05-04 Zoetis Services LLC Mycoplasma hyopneumoniae avirulent -adjuvanted live vaccine
EP2062594A1 (en) * 2007-11-21 2009-05-27 Wyeth Farma, S.A. Bluetongue virus vaccine and immunogenic compositions, methods of use and methods of producing same
DE102008017216B4 (de) * 2008-04-04 2013-08-14 Clariant International Ltd. Kontinuierliches Verfahren zur Herstellung von Fettsäureamiden
TW201010719A (en) * 2008-08-19 2010-03-16 Wyeth Corp Immunological composition
GB0907989D0 (en) 2009-05-08 2009-06-24 Hybrid Systems Ltd Multivalent adjuvant display
BRPI1011753B8 (pt) 2009-06-22 2021-05-25 Wyeth Llc conjugados imunogênicos de polissacarídeo capsular de staphylococcus aureus de sorotipos 5 e 8, seu uso e composições que os compreendem
HUE036372T2 (hu) 2009-06-22 2018-07-30 Wyeth Llc Staphylococcus aureus antigének immunogén készítményei
DE102009031059A1 (de) 2009-06-30 2011-01-05 Clariant International Ltd. Vorrichtung zur kontinuierlichen Durchführung chemischer Reaktionen bei hohen Temperaturen
US20110110980A1 (en) 2009-09-02 2011-05-12 Wyeth Llc Heterlogous prime-boost immunization regimen
DE102009042523B4 (de) 2009-09-22 2012-02-16 Clariant International Ltd. Vorrichtung und Verfahren zur kontinuierlichen Durchführung heterogen katalysierter chemischer Reaktionen bei hohen Temperaturen
DE102009042522A1 (de) 2009-09-22 2011-04-07 Clariant International Ltd. Kontinuierliches Umesterungsverfahren
CN103153293B (zh) 2010-08-04 2016-08-24 体恤医药公司 用于组织维护和修复的多阴离子聚合物和亚精胺的超分子复合物
KR101594228B1 (ko) 2010-08-23 2016-02-15 와이어쓰 엘엘씨 네이세리아 메닌기티디스 ｒＬＰ２０８６ 항원의 안정한 제제
NZ607224A (en) 2010-09-10 2014-11-28 Wyeth Llc Non-lipidated variants of neisseria meningitidis orf2086 antigens
DK2654784T3 (en) 2010-12-22 2017-02-13 Wyeth Llc STABLE IMMUNOGENIC COMPOSITIONS OF STAPHYLOCOCCUS AUREUS ANTIGENES
DE102010056565A1 (de) 2010-12-30 2012-07-05 Clariant International Ltd. Verfahren zur Modifizierung Hydroxylgruppen tragender Polymere
DE102010056566A1 (de) * 2010-12-30 2012-07-05 Clariant International Ltd. Kontinuierliches Verfahren zur Veresterung Säuregruppen tragender Polymere
DE102010056564A1 (de) 2010-12-30 2012-07-05 Clariant International Limited Hydroxylgruppen und Estergruppen tragende Polymere und Verfahren zu ihrer Herstellung
SA115360586B1 (ar) 2012-03-09 2017-04-12 فايزر انك تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها
MX359256B (es) 2012-03-09 2018-09-19 Pfizer Composiciones de neisseria meningitidis y metodos de las mismas.
UA114503C2 (uk) 2012-04-04 2017-06-26 Зоетіс Сервісіз Ллс Комбінована вакцина pcv та mycoplasma hyopneumoniae
US9120859B2 (en) 2012-04-04 2015-09-01 Zoetis Services Llc Mycoplasma hyopneumoniae vaccine
UA114504C2 (uk) 2012-04-04 2017-06-26 Зоетіс Сервісіз Ллс Комбінована вакцина pcv, mycoplasma hyopneumoniae та prrs
EP3363806B1 (en) 2012-12-20 2022-11-16 Pfizer Inc. Glycoconjugation process
US9802987B2 (en) 2013-03-08 2017-10-31 Pfizer Inc. Immunogenic fusion polypeptides
RU2662968C2 (ru) 2013-09-08 2018-07-31 Пфайзер Инк. Иммуногенная композиция против neisseria meningitidis (варианты)
CN105579060B (zh) 2013-09-25 2021-03-16 硕腾服务有限责任公司 Pcv2b趋异株疫苗组合物以及使用方法
AU2016221318B2 (en) 2015-02-19 2020-06-25 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
PE20220774A1 (es) 2015-05-04 2022-05-16 Pfizer Conjugados proteina-polisacarido de estreptococo grupo b, metodos para producir conjugados, composiciones inmunogenas que comprenden conjugados y sus usos
FI3471760T3 (fi) * 2016-06-17 2025-01-27 Boehringer Ingelheim Vetmedica Gmbh Lineaarisia tai haaroittuneita polyakryylihappopolymeeriadjuvantteja käsittäviä uusia immunogeenisiä formulaatioita
US10751402B2 (en) 2016-11-09 2020-08-25 Pfizer Inc. Immunogenic compositions and uses thereof
AU2018215585B2 (en) 2017-01-31 2022-03-17 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
AU2019236328B2 (en) 2018-03-16 2025-10-09 Zoetis Services Llc Peptide vaccines against Interleukin-31
CN109134724A (zh) * 2018-07-24 2019-01-04 石家庄哈顿生物技术有限公司 一种动物疫苗用聚丙烯酸类聚合物佐剂的研制方法
EP4034157A1 (en) 2019-09-27 2022-08-03 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
KR20230056727A (ko) 2020-08-26 2023-04-27 화이자 인코포레이티드 B군 스트렙토코쿠스 폴리사카라이드-단백질 접합체, 접합체를 생산하는 방법, 접합체를 포함하는 면역원성 조성물, 및 그의 용도
WO2026038177A1 (en) 2024-08-16 2026-02-19 Pfizer Inc. Immunogenic compositions and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4567042A (en) * 1983-06-15 1986-01-28 American Home Products Corporation Inactivated canine coronavirus vaccine
EP0283085B1 (en) * 1987-03-17 1992-11-11 Akzo N.V. Adjuvant mixture
US5242686A (en) * 1990-11-07 1993-09-07 American Home Products Corporation Feline vaccine compositions and method for preventing chlamydia infections or diseases using the same
EP0532833A1 (en) * 1991-05-28 1993-03-24 Miles Inc. Vaccine for equine rhinopneumonitis
BE1008977A5 (fr) * 1994-12-27 1996-10-01 Solvay Adjuvants pour vaccins.

Also Published As

Publication number Publication date
CA2269780A1 (en) 1998-04-30
GB9622159D0 (en) 1996-12-18
JP4344014B2 (ja) 2009-10-14
ES2285741T3 (es) 2007-11-16
JP2001507336A (ja) 2001-06-05
DE69737658T2 (de) 2008-01-31
AU717349B2 (en) 2000-03-23
US20030021793A1 (en) 2003-01-30
WO1998017310A2 (en) 1998-04-30
EP0934077B1 (en) 2007-04-25
US6610310B2 (en) 2003-08-26
WO1998017310A3 (en) 1998-06-18
ATE360440T1 (de) 2007-05-15
DE69737658D1 (de) 2007-06-06
AU5313398A (en) 1998-05-15
EP0934077A2 (en) 1999-08-11
BR9712436A (pt) 2000-10-24

Similar Documents

Publication Publication Date Title
CA2269780C (en) Polyanionic polymers as adjuvants for mucosal immunization
US6511677B1 (en) Polymerizable fatty acids, phospholipids and polymerized liposomes therefrom
CA2275033C (en) Biodegradable targetable microparticle delivery system
EP0762875B1 (en) Microparticle delivery system
JP2001526640A (ja) モノホスホリルリピドａの水性免疫アジュバント組成物
JP3365635B2 (ja) キトサン誘導性免疫強化
JPH09500132A (ja) ヒドロゲルマイクロカプセル化ワクチン
US6340464B1 (en) Adjuvants for vaccines
MXPA99003830A (en) Polyanionic polymers as adjuvants for mucosal immunization
JP2002504521A (ja) 粘膜の微粒子共役ワクチン
JP4095696B2 (ja) 鳥類腸管リンパ組織への取込目的物搬送用の微粒子及び搬送方法
WO2000076476A1 (en) Adjuvant-containing polymerized liposomes for oral, mucosal or intranasal vaccination
KR100664466B1 (ko) 경구용 백신 운반을 위한 미세입자 및 이들의 제조방법
CN121287898A (zh) 一种mpl复合佐剂及其制备方法
CN115920027A (zh) 纳米疫苗佐剂及其在制备提高石斛多糖释放力药物上的应用
Liao et al. Carbopol Dispersed U@ PAA with High Colloidal Stability as a Combination Nano-Adjuvant Boosts Immune Responses and Protection Against Pseudorabies Virus in Mice and Pigs
Kumar VETERINARY IMMUNOLOGY
Danilovtseva et al. Synthetic water-soluble polymers in self-organizing nanosystems for immynology
MXPA00006531A (en) Novel polymerizable fatty acids, phospholipids and polymerized liposomes therefrom
MXPA97004823A (en) Adjuvants for vacu

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20171023