BR9712436A - Polìmeros polianiÈnicos como adjuvantes para imunização da mucosa - Google Patents
Polìmeros polianiÈnicos como adjuvantes para imunização da mucosaInfo
- Publication number
- BR9712436A BR9712436A BR9712436-2A BR9712436A BR9712436A BR 9712436 A BR9712436 A BR 9712436A BR 9712436 A BR9712436 A BR 9712436A BR 9712436 A BR9712436 A BR 9712436A
- Authority
- BR
- Brazil
- Prior art keywords
- acid
- polyanionic polymers
- adjuvants
- salts
- mucosal
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Abstract
Patente de Invenção: <B>"POLìMEROS POLIANIÈNICOS COMO ADJUVANTES PARA IMUNIZAçãO DA MUCOSA"<D>. São divulgados adjuvantes mucosais para vacinas compreendidos de polímeros polianiónicos solúveis em água que têm unidades constitucionais aniónicas obtidas a partir de ácidos tais como ácido acrílico, ácido metacrílico, ácido maléico, ácido fumárico, ácido etilsulfónico, ácido vinilsulfúrico, ácido vinilsulfónico, ácido estirenossulfónico, ácido vinilfenilsulfúrico, ácido 2-metacriloiloxietano sulfónico, ácido 3-metacriloilóxi-2-hidroxipropanossulfónico, ácido 3-metacril amido-3-metilbutanóico, ácido acrilamidometilpropanossulfónico, ácido vinilfosfórico, ácido 4-vinilbenzóico, ácido 3-vinil oxipropano-1-sulfónico, ácido N-vinilsuccinimídico e sais dos anteriores. Os polímeros polianiónicos podem ainda ter unidades de repetição constitucionais hidrófobas tais como alquilésteres, cicloalquilésteres, hidroxialquilésteres, éteres, glicóis, grupos aromáticos e sais dos mesmos. Também são divulgados aqui o uso de polímeros polianiónicos da presente invenção para e indução ou para a melhoria de respostas inunológicas mucosais, assim como de vacinas não parenterais que contenham o polímero polianiónico da presente invenção.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9622159.3A GB9622159D0 (en) | 1996-10-24 | 1996-10-24 | Polyanionic polymers as adjuvants for mucosal immunization |
| PCT/EP1997/005861 WO1998017310A2 (en) | 1996-10-24 | 1997-10-23 | Polyanionic polymers as adjuvants for mucosal immunization |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9712436A true BR9712436A (pt) | 2000-10-24 |
Family
ID=10801896
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9712436-2A BR9712436A (pt) | 1996-10-24 | 1997-10-23 | Polìmeros polianiÈnicos como adjuvantes para imunização da mucosa |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6610310B2 (pt) |
| EP (1) | EP0934077B1 (pt) |
| JP (1) | JP4344014B2 (pt) |
| AT (1) | ATE360440T1 (pt) |
| AU (1) | AU717349B2 (pt) |
| BR (1) | BR9712436A (pt) |
| CA (1) | CA2269780C (pt) |
| DE (1) | DE69737658T2 (pt) |
| ES (1) | ES2285741T3 (pt) |
| GB (1) | GB9622159D0 (pt) |
| WO (1) | WO1998017310A2 (pt) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040116350A1 (en) * | 2001-09-17 | 2004-06-17 | Paul Wentworth Jr | Methods and compositions relating to hydrogen peroxide and superoxide production by antibodies |
| US20040157280A1 (en) * | 2001-09-17 | 2004-08-12 | Paul Wentworth | Antibody mediated ozone generation |
| US20050129680A1 (en) * | 2001-09-17 | 2005-06-16 | Paul Wentworth | Antimicrobial activity of antibodies |
| MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
| CA2505923A1 (en) * | 2002-11-14 | 2004-05-27 | Novartis Ag | Antibody-or neutrophil-mediated ozone generation |
| GB0313916D0 (en) | 2003-06-16 | 2003-07-23 | Glaxosmithkline Biolog Sa | Vaccine composition |
| JP4860109B2 (ja) * | 2003-12-26 | 2012-01-25 | バイオリーダース・コーポレイション | ポリガンマグルタミン酸を含む免疫増強用組成物 |
| DE102006047617B4 (de) * | 2006-10-09 | 2008-11-27 | Clariant International Limited | Verfahren zur Herstellung basischer (Meth)acrylamide |
| US20090017064A1 (en) * | 2007-07-10 | 2009-01-15 | Wyeth | Methods and Compositions for Immunizing Pigs Against Porcine Circovirus |
| FR2922767B1 (fr) | 2007-10-24 | 2009-12-18 | Seppic Sa | Procede de preparation d'une composition vaccinale comprenant au moins un antigene et au moins un adjuvant. |
| MX2010005014A (es) | 2007-11-06 | 2010-06-30 | Wyeth Llc | Vacuna viva avirulenta de mycoplasma hyopneumoniae con adyuvante. |
| EP2062594A1 (en) * | 2007-11-21 | 2009-05-27 | Wyeth Farma, S.A. | Bluetongue virus vaccine and immunogenic compositions, methods of use and methods of producing same |
| DE102008017216B4 (de) * | 2008-04-04 | 2013-08-14 | Clariant International Ltd. | Kontinuierliches Verfahren zur Herstellung von Fettsäureamiden |
| TW201010719A (en) * | 2008-08-19 | 2010-03-16 | Wyeth Corp | Immunological composition |
| GB0907989D0 (en) | 2009-05-08 | 2009-06-24 | Hybrid Systems Ltd | Multivalent adjuvant display |
| RU2531234C2 (ru) | 2009-06-22 | 2014-10-20 | ВАЙЕТ ЭлЭлСи | КОНЪЮГАТ ПОЛИСАХАРИД-БЕЛОК ДЛЯ ИНДУЦИРОВАНИЯ ИММУННОГО ОТВЕТА И ЗАЩИТЫ ПРОТИВ ИНФЕКЦИИ Staphylococcus aureus, СПОСОБЫ ПОЛУЧЕНИЯ КОНЪЮГАТА (ВАРИАНТЫ), КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ КОНЪЮГАТ И СПОСОБЫ ИНДУЦИРОВАНИЯ ИММУННОГО ОТВЕТА И ПРЕДОТВРАЩЕНИЯ ИНФЕКЦИИ Staphylococcus aureus |
| TWI469789B (zh) | 2009-06-22 | 2015-01-21 | Wyeth Llc | 金黃色葡萄球菌抗原之免疫原性組合物 |
| DE102009031059A1 (de) | 2009-06-30 | 2011-01-05 | Clariant International Ltd. | Vorrichtung zur kontinuierlichen Durchführung chemischer Reaktionen bei hohen Temperaturen |
| US20110110980A1 (en) | 2009-09-02 | 2011-05-12 | Wyeth Llc | Heterlogous prime-boost immunization regimen |
| DE102009042522A1 (de) | 2009-09-22 | 2011-04-07 | Clariant International Ltd. | Kontinuierliches Umesterungsverfahren |
| DE102009042523B4 (de) | 2009-09-22 | 2012-02-16 | Clariant International Ltd. | Vorrichtung und Verfahren zur kontinuierlichen Durchführung heterogen katalysierter chemischer Reaktionen bei hohen Temperaturen |
| EP2600858A4 (en) | 2010-08-04 | 2014-03-05 | Tixupharma | SUPRAMOLECULAR COMPLEXES OF POLYANIONIC POLYMERS AND SPERMIDINE FOR WOVEN CARE AND REPAIR |
| SI3246044T2 (sl) | 2010-08-23 | 2024-06-28 | Wyeth Llc | Stabilne formulacije antigenov neisseria meningitidis RLP2086 |
| ES2585328T5 (es) | 2010-09-10 | 2022-12-14 | Wyeth Llc | Variantes no lipidadas de antígenos ORF2086 de Neisseria meningitidis |
| EP2654784B1 (en) | 2010-12-22 | 2016-12-07 | Wyeth LLC | Stable immunogenic compositions of staphylococcus aureus antigens |
| DE102010056564A1 (de) | 2010-12-30 | 2012-07-05 | Clariant International Limited | Hydroxylgruppen und Estergruppen tragende Polymere und Verfahren zu ihrer Herstellung |
| DE102010056566A1 (de) * | 2010-12-30 | 2012-07-05 | Clariant International Ltd. | Kontinuierliches Verfahren zur Veresterung Säuregruppen tragender Polymere |
| DE102010056565A1 (de) | 2010-12-30 | 2012-07-05 | Clariant International Ltd. | Verfahren zur Modifizierung Hydroxylgruppen tragender Polymere |
| SA115360586B1 (ar) | 2012-03-09 | 2017-04-12 | فايزر انك | تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها |
| RU2665841C2 (ru) | 2012-03-09 | 2018-09-04 | Пфайзер Инк. | Композиции neisseria meningitidis и способы их применения |
| US9120859B2 (en) | 2012-04-04 | 2015-09-01 | Zoetis Services Llc | Mycoplasma hyopneumoniae vaccine |
| UA114504C2 (uk) | 2012-04-04 | 2017-06-26 | Зоетіс Сервісіз Ллс | Комбінована вакцина pcv, mycoplasma hyopneumoniae та prrs |
| UA114503C2 (uk) | 2012-04-04 | 2017-06-26 | Зоетіс Сервісіз Ллс | Комбінована вакцина pcv та mycoplasma hyopneumoniae |
| EP4169929A1 (en) | 2012-12-20 | 2023-04-26 | Pfizer Inc. | Immunogenic compositions comprising pn-serotype 12f |
| JP6446377B2 (ja) | 2013-03-08 | 2018-12-26 | ファイザー・インク | 免疫原性融合ポリペプチド |
| EP3041502A2 (en) | 2013-09-08 | 2016-07-13 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| MX2016003855A (es) | 2013-09-25 | 2016-08-04 | Zoetis Services Llc | Composicion de vacuna de circovirus porcino tipo 2b divergente y procedimientos de uso. |
| RU2723045C2 (ru) | 2015-02-19 | 2020-06-08 | Пфайзер Инк. | Композиции neisseria meningitidis и способы их получения |
| IL297740A (en) | 2015-05-04 | 2022-12-01 | Pfizer | Protein-polysaccharide conjugates of group b streptococcus, methods for preparing the conjugates, immunogenic preparations containing conjugates and their uses |
| CA3027877A1 (en) * | 2016-06-17 | 2017-12-21 | Merial, Inc. | Novel immunogenic formulations comprising linear or branched polyacrylic acid polymer adjuvants |
| US10751402B2 (en) | 2016-11-09 | 2020-08-25 | Pfizer Inc. | Immunogenic compositions and uses thereof |
| IL267733B2 (en) | 2017-01-31 | 2023-10-01 | Pfizer | NEISSERIA MENINGITIDIS preparations and methods therefor |
| BR112020017715A2 (pt) | 2018-03-16 | 2020-12-29 | Zoetis Services Llc | Vacinas de peptídeo contra interleucina-31 |
| CN109134724A (zh) * | 2018-07-24 | 2019-01-04 | 石家庄哈顿生物技术有限公司 | 一种动物疫苗用聚丙烯酸类聚合物佐剂的研制方法 |
| CA3192786A1 (en) | 2020-08-26 | 2022-03-03 | Pfizer Inc. | Group b streptococcus polysaccharide-protein conjugates, methods for producing conjugates, immunogenic compositions comprising conjugates, and uses thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4567042A (en) * | 1983-06-15 | 1986-01-28 | American Home Products Corporation | Inactivated canine coronavirus vaccine |
| ZA881694B (en) * | 1987-03-17 | 1988-09-06 | Akzo N.V. | Adjuvant mixture |
| US5242686A (en) * | 1990-11-07 | 1993-09-07 | American Home Products Corporation | Feline vaccine compositions and method for preventing chlamydia infections or diseases using the same |
| EP0532833A1 (en) * | 1991-05-28 | 1993-03-24 | Miles Inc. | Vaccine for equine rhinopneumonitis |
| BE1008977A5 (fr) * | 1994-12-27 | 1996-10-01 | Solvay | Adjuvants pour vaccins. |
-
1996
- 1996-10-24 GB GBGB9622159.3A patent/GB9622159D0/en active Pending
-
1997
- 1997-10-23 CA CA002269780A patent/CA2269780C/en not_active Expired - Lifetime
- 1997-10-23 JP JP51897598A patent/JP4344014B2/ja not_active Expired - Lifetime
- 1997-10-23 AU AU53133/98A patent/AU717349B2/en not_active Expired
- 1997-10-23 BR BR9712436-2A patent/BR9712436A/pt not_active Application Discontinuation
- 1997-10-23 DE DE69737658T patent/DE69737658T2/de not_active Expired - Lifetime
- 1997-10-23 AT AT97950021T patent/ATE360440T1/de not_active IP Right Cessation
- 1997-10-23 WO PCT/EP1997/005861 patent/WO1998017310A2/en active IP Right Grant
- 1997-10-23 US US09/297,214 patent/US6610310B2/en not_active Expired - Lifetime
- 1997-10-23 ES ES97950021T patent/ES2285741T3/es not_active Expired - Lifetime
- 1997-10-23 EP EP97950021A patent/EP0934077B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP2001507336A (ja) | 2001-06-05 |
| DE69737658D1 (de) | 2007-06-06 |
| EP0934077B1 (en) | 2007-04-25 |
| DE69737658T2 (de) | 2008-01-31 |
| JP4344014B2 (ja) | 2009-10-14 |
| CA2269780C (en) | 2008-12-02 |
| CA2269780A1 (en) | 1998-04-30 |
| GB9622159D0 (en) | 1996-12-18 |
| AU717349B2 (en) | 2000-03-23 |
| WO1998017310A3 (en) | 1998-06-18 |
| WO1998017310A2 (en) | 1998-04-30 |
| ES2285741T3 (es) | 2007-11-16 |
| AU5313398A (en) | 1998-05-15 |
| US6610310B2 (en) | 2003-08-26 |
| EP0934077A2 (en) | 1999-08-11 |
| US20030021793A1 (en) | 2003-01-30 |
| ATE360440T1 (de) | 2007-05-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: DE ACORDO COM O ART. 37, PUBLIQUE-SE O INDEFERIMENTO DO PRESENTE PEDIDO, TENDO POR BASE O ART. 8O COMBINADO COM OS ARTS. 11 E 13 DA LEI NO 9.279/96. |