CA2267348A1 - Inositol polyphosphate derivatives and methods of using same - Google Patents

Inositol polyphosphate derivatives and methods of using same Download PDF

Info

Publication number
CA2267348A1
CA2267348A1 CA002267348A CA2267348A CA2267348A1 CA 2267348 A1 CA2267348 A1 CA 2267348A1 CA 002267348 A CA002267348 A CA 002267348A CA 2267348 A CA2267348 A CA 2267348A CA 2267348 A1 CA2267348 A1 CA 2267348A1
Authority
CA
Canada
Prior art keywords
derivative
inositol
myo
acetoxymethyl
ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002267348A
Other languages
English (en)
French (fr)
Inventor
Alexis Traynor-Kaplan
Carsten Schultz
Stefan Roemer
Christoph Stadler
Marco Rudolf
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Inologic Inc
University of California San Diego UCSD
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/926,831 external-priority patent/US5880099A/en
Application filed by Individual filed Critical Individual
Publication of CA2267348A1 publication Critical patent/CA2267348A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A61K31/6615—Compounds having two or more esterified phosphorus acid groups, e.g. inositol triphosphate, phytic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A61K31/015—Hydrocarbons carbocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/117—Esters of phosphoric acids with cycloaliphatic alcohols
CA002267348A 1996-09-20 1997-09-19 Inositol polyphosphate derivatives and methods of using same Abandoned CA2267348A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US71712296A 1996-09-20 1996-09-20
US08/717,122 1996-09-20
US08/926,831 US5880099A (en) 1996-09-20 1997-09-10 Inositol polyphosphates and methods of using same
US08/926,831 1997-09-10
PCT/US1997/016679 WO1998011901A1 (en) 1996-09-20 1997-09-19 Inositol polyphosphate derivatives and methods of using same

Publications (1)

Publication Number Publication Date
CA2267348A1 true CA2267348A1 (en) 1998-03-26

Family

ID=27109658

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002267348A Abandoned CA2267348A1 (en) 1996-09-20 1997-09-19 Inositol polyphosphate derivatives and methods of using same

Country Status (7)

Country Link
EP (1) EP0954320A4 (ja)
JP (1) JP2002524016A (ja)
KR (1) KR20060028630A (ja)
CN (2) CN1478783A (ja)
AU (1) AU721150B2 (ja)
CA (1) CA2267348A1 (ja)
WO (1) WO1998011901A1 (ja)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6221856B1 (en) * 1999-02-03 2001-04-24 Inologic, Inc. Inositol derivatives for inhibiting superoxide anion production
EP1097713A1 (en) 1999-11-03 2001-05-09 Euroscreen S.A. Inhibitors of the inositol polyphosphate 5-phosphatase ship-2 molecule
US7453006B2 (en) 2000-11-21 2008-11-18 Inologic, Inc. Inositol derivatives for increasing chloride secretion and inhibiting inflammation
WO2003024189A2 (en) * 2001-09-20 2003-03-27 Inologic, Inc. Method of modulating sodium ion absorption in epithelial cells
AR050866A1 (es) * 2004-09-09 2006-11-29 Dow Agrosciences Llc Genes de inositol polifosfato 2-quinasa y usos de los mismos
CA2601641A1 (en) * 2005-03-18 2006-09-28 Oxyplus, Inc. Calcium salt of myo-inositol 1,6:2,3:4,5 tripyrophosphate as an allosteric effector of hemoglobin
US9162205B2 (en) * 2012-12-31 2015-10-20 Uop Llc Apparatuses for distributing fluids in fluidized bed reactors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4952717A (en) * 1986-03-11 1990-08-28 Mitsui Toatsu Chemicals, Incorporated Myoinositol derivatives and preparation process thereof
US5693521A (en) * 1993-04-09 1997-12-02 The Regents Of The University Of California Membrane-permeant second messengers

Also Published As

Publication number Publication date
CN1478783A (zh) 2004-03-03
EP0954320A4 (en) 2001-04-04
KR20060028630A (ko) 2006-03-30
CN1239894A (zh) 1999-12-29
CN1145489C (zh) 2004-04-14
JP2002524016A (ja) 2002-07-30
AU4426697A (en) 1998-04-14
WO1998011901A1 (en) 1998-03-26
EP0954320A1 (en) 1999-11-10
AU721150B2 (en) 2000-06-22

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued