EP0954320A4 - Inositol polyphosphate derivatives and methods of using same - Google Patents

Inositol polyphosphate derivatives and methods of using same

Info

Publication number
EP0954320A4
EP0954320A4 EP97942600A EP97942600A EP0954320A4 EP 0954320 A4 EP0954320 A4 EP 0954320A4 EP 97942600 A EP97942600 A EP 97942600A EP 97942600 A EP97942600 A EP 97942600A EP 0954320 A4 EP0954320 A4 EP 0954320A4
Authority
EP
European Patent Office
Prior art keywords
methods
same
inositol polyphosphate
polyphosphate derivatives
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97942600A
Other languages
German (de)
French (fr)
Other versions
EP0954320A1 (en
Inventor
Alexis Traynor-Kaplan
Carsten Schultz
Stefan Roemer
Christoph Stadler
Marco Rudolf
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Inologic Inc
University of California San Diego UCSD
Original Assignee
University of California
Inologic Inc
University of California San Diego UCSD
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/926,831 external-priority patent/US5880099A/en
Application filed by University of California, Inologic Inc, University of California San Diego UCSD filed Critical University of California
Publication of EP0954320A1 publication Critical patent/EP0954320A1/en
Publication of EP0954320A4 publication Critical patent/EP0954320A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A61K31/6615—Compounds having two or more esterified phosphorus acid groups, e.g. inositol triphosphate, phytic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A61K31/015—Hydrocarbons carbocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/117—Esters of phosphoric acids with cycloaliphatic alcohols

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
EP97942600A 1996-09-20 1997-09-19 Inositol polyphosphate derivatives and methods of using same Withdrawn EP0954320A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US717122 1985-03-28
US71712296A 1996-09-20 1996-09-20
US926831 1997-09-10
US08/926,831 US5880099A (en) 1996-09-20 1997-09-10 Inositol polyphosphates and methods of using same
PCT/US1997/016679 WO1998011901A1 (en) 1996-09-20 1997-09-19 Inositol polyphosphate derivatives and methods of using same

Publications (2)

Publication Number Publication Date
EP0954320A1 EP0954320A1 (en) 1999-11-10
EP0954320A4 true EP0954320A4 (en) 2001-04-04

Family

ID=27109658

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97942600A Withdrawn EP0954320A4 (en) 1996-09-20 1997-09-19 Inositol polyphosphate derivatives and methods of using same

Country Status (7)

Country Link
EP (1) EP0954320A4 (en)
JP (1) JP2002524016A (en)
KR (1) KR20060028630A (en)
CN (2) CN1478783A (en)
AU (1) AU721150B2 (en)
CA (1) CA2267348A1 (en)
WO (1) WO1998011901A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6221856B1 (en) 1999-02-03 2001-04-24 Inologic, Inc. Inositol derivatives for inhibiting superoxide anion production
EP1097713A1 (en) 1999-11-03 2001-05-09 Euroscreen S.A. Inhibitors of the inositol polyphosphate 5-phosphatase ship-2 molecule
US7453006B2 (en) 2000-11-21 2008-11-18 Inologic, Inc. Inositol derivatives for increasing chloride secretion and inhibiting inflammation
AU2002327006A1 (en) * 2001-09-20 2003-04-01 Inologic, Inc. Method of modulating sodium ion absorption in epithelial cells
AR050866A1 (en) * 2004-09-09 2006-11-29 Dow Agrosciences Llc INOSITOL GENES 2-KINASE POLYPHOSPHATE AND USES OF THE SAME
DK1863495T3 (en) * 2005-03-18 2015-04-20 Normoxys Inc CALCIUM AND SODIUM SALT OF MYO-INOSITOL 1.6: 2,3: 4,5 TRIPYROPHOSPHATE FOR CANCER TREATMENT
US9162205B2 (en) * 2012-12-31 2015-10-20 Uop Llc Apparatuses for distributing fluids in fluidized bed reactors
JP2023104168A (en) 2022-01-17 2023-07-28 国立研究開発法人産業技術総合研究所 Conductive member and method for manufacturing the conductive member

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0262227A1 (en) * 1986-03-11 1988-04-06 MITSUI TOATSU CHEMICALS, Inc. Process for the preparation of myoinositol derivatives
WO1994023724A1 (en) * 1993-04-09 1994-10-27 The Regents Of The University Of California Membrane-permeant second messengers

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0262227A1 (en) * 1986-03-11 1988-04-06 MITSUI TOATSU CHEMICALS, Inc. Process for the preparation of myoinositol derivatives
WO1994023724A1 (en) * 1993-04-09 1994-10-27 The Regents Of The University Of California Membrane-permeant second messengers

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
ISMAILOV I. ET AL: "A BIOLOGIC FUNCTION FOR AN "ORPHAN" MESSENGER: D-MYO-INOSITOL 3,4,5,6-TETRAKISPHOSPHATE SELECTIVELY BLOCKS EPITHELIAL CALCIUM-ACTIVATED CHLORIDE CHANNELS.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 93, no. 19, 1996 - 17 September 1996 (1996-09-17), pages 10505 - 9, XP000919161 *
LU, PEI-JUNG ET AL: "MOLECULAR INTERACTIONS OF ENDOGENOUS D-MYO-INOSITOL PHOSPHATES WITH THE INTRACELLULAR D-MYO-INOSITOL 1,4,5-TRISPHOSPHATE RECOGNITION SITE.", BIOCHEMISTRY, vol. 33, no. 38, 1994, USA, pages 11586 - 97, XP000916576 *
ROEMER ET AL: "SYNTHESIS OF D MYO INOSITOL 3,4,5,6 AND 1,4,5,6 TETRAKISPHOSPHATE ANALOGUES AND THEIR MEMBRANE PERMEANT DERIVATIVES", J. CHEM. SOC. CHEM. COMMUN., 1995, pages 411 - 412, XP000916568 *
SAWADA T ET AL: "Synthesis of 1-O-Alkyl- and 1-O-Acyl-myo-inositol 3, 4, 5-trisphosphates as Novel Analogues of Phosphatidyl-myo-inositol 3, 4, 5-trisphosphate", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,GB,OXFORD, vol. 5, no. 19, 5 October 1995 (1995-10-05), pages 2263 - 2266, XP004135296, ISSN: 0960-894X *
See also references of WO9811901A1 *
STAUB ET AL.: "Treatment of vasogenic brain edema with the novel Cl transport inhibitor Torasemide.", JOURNAL OF NEUROTRAUMA, vol. 11, no. 6, 1994, pages 679 - 690, XP000916577 *
TRAYNOR-KAPLAN ET AL: "Protein Kinase C activity does not mediate the inhibitory effect of Carbachol on chloride secretion by T84 cells.", AMERICAN JOURNAL OF PHYSIOLOGY, vol. 5, no. 1, 1994, pages C1224 - C1230, XP000916572 *
XIE W. ET AL: "INOSITOL 3,4,5,6-TETRAKISPHOSPHATE INHIBITS THE CALMODULIN-DEPENDENT PROTEIN KINASE II-ACTIVATED CHLORIDE CONDUCTANCE IN T84 COLONIC EPITHELIAL CELLS.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 24, 1996 - 14 June 1996 (1996-06-14), pages 14092 - 97, XP000919198 *

Also Published As

Publication number Publication date
CN1478783A (en) 2004-03-03
JP2002524016A (en) 2002-07-30
CN1145489C (en) 2004-04-14
KR20060028630A (en) 2006-03-30
WO1998011901A1 (en) 1998-03-26
CN1239894A (en) 1999-12-29
EP0954320A1 (en) 1999-11-10
AU4426697A (en) 1998-04-14
AU721150B2 (en) 2000-06-22
CA2267348A1 (en) 1998-03-26

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