CA2267348A1 - Derives de polyphosphates d'inositol et leurs procedes d'utilisation - Google Patents
Derives de polyphosphates d'inositol et leurs procedes d'utilisation Download PDFInfo
- Publication number
- CA2267348A1 CA2267348A1 CA002267348A CA2267348A CA2267348A1 CA 2267348 A1 CA2267348 A1 CA 2267348A1 CA 002267348 A CA002267348 A CA 002267348A CA 2267348 A CA2267348 A CA 2267348A CA 2267348 A1 CA2267348 A1 CA 2267348A1
- Authority
- CA
- Canada
- Prior art keywords
- derivative
- inositol
- myo
- acetoxymethyl
- ester
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000000034 method Methods 0.000 title claims abstract description 187
- 235000002949 phytic acid Nutrition 0.000 title claims abstract description 95
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims abstract description 203
- 230000028327 secretion Effects 0.000 claims abstract description 197
- 239000005557 antagonist Substances 0.000 claims abstract description 92
- 239000000556 agonist Substances 0.000 claims abstract description 84
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- 230000002708 enhancing effect Effects 0.000 claims abstract description 16
- 206010012735 Diarrhoea Diseases 0.000 claims abstract description 15
- 201000009881 secretory diarrhea Diseases 0.000 claims abstract description 15
- 229960000367 inositol Drugs 0.000 claims description 233
- CDAISMWEOUEBRE-UHFFFAOYSA-N inositol Chemical compound OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 claims description 179
- 150000002148 esters Chemical class 0.000 claims description 112
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 109
- 125000000217 alkyl group Chemical group 0.000 claims description 60
- MRVYFOANPDTYBY-UZAAGFTCSA-N 1D-myo-inositol 3,4,5,6-tetrakisphosphate Chemical group O[C@H]1[C@@H](O)[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H]1OP(O)(O)=O MRVYFOANPDTYBY-UZAAGFTCSA-N 0.000 claims description 55
- -1 acetoxymethyl Chemical group 0.000 claims description 43
- 125000004063 butyryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 39
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 23
- RQQIRMLGKSPXSE-WIPMOJCBSA-N [1-acetyloxy-2-[[(2s,3r,5s,6s)-2,6-dihydroxy-3,4,5-triphosphonooxycyclohexyl]oxy-hydroxyphosphoryl]oxyethyl] acetate Chemical compound CC(=O)OC(OC(C)=O)COP(O)(=O)OC1[C@H](O)[C@H](OP(O)(O)=O)C(OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H]1O RQQIRMLGKSPXSE-WIPMOJCBSA-N 0.000 claims description 15
- HOXINJBQVZWYGZ-UHFFFAOYSA-N fenbutatin oxide Chemical compound C=1C=CC=CC=1C(C)(C)C[Sn](O[Sn](CC(C)(C)C=1C=CC=CC=1)(CC(C)(C)C=1C=CC=CC=1)CC(C)(C)C=1C=CC=CC=1)(CC(C)(C)C=1C=CC=CC=1)CC(C)(C)C1=CC=CC=C1 HOXINJBQVZWYGZ-UHFFFAOYSA-N 0.000 claims description 12
- 125000001118 alkylidene group Chemical group 0.000 claims description 10
- MMWCIQZXVOZEGG-MLQGYMEPSA-N 1D-myo-inositol 1,3,4-trisphosphate Chemical group O[C@@H]1[C@@H](O)[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@@H](O)[C@H]1OP(O)(O)=O MMWCIQZXVOZEGG-MLQGYMEPSA-N 0.000 claims description 7
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- MRVYFOANPDTYBY-YORTWTKJSA-F 1D-myo-inositol 1,4,5,6-tetrakisphosphate(8-) Chemical class O[C@H]1[C@@H](O)[C@@H](OP([O-])([O-])=O)[C@H](OP([O-])([O-])=O)[C@@H](OP([O-])([O-])=O)[C@@H]1OP([O-])([O-])=O MRVYFOANPDTYBY-YORTWTKJSA-F 0.000 description 19
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- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
L'invention concerne des compositions qui sont des antagonistes de polyphosphates d'inositol, pénétrant dans les cellules. De plus, elle se rapporte à des procédés pour augmenter la sécrétion d'ions chlorure par une cellule, qui consiste à mettre les cellules en contact avec des antagonistes de polyphosphates d'inositol, pénétrant dans les cellules. Elle porte encore sur des procédés pour augmenter la sécrétion d'ions chlorure chez un individu, qui consiste à administrer à ce dernier des antagonistes de polyphosphates d'inositol, pénétrant dans les cellules. L'invention concerne aussi des procédés pour atténuer un symptôme ou un signe associé à la mucovicidose chez un individu, qui consistent à administrer à ce dernier un antagoniste de polyphosphates d'inositol, pénétrant dans les cellules. Elle porte, par ailleurs, sur des compositions qui sont des agonistes de polyphosphates d'inositol, pénétrant dans les cellules. Des procédés pour réduire la sécrétion d'ions chlorure par une cellules, par la mise en contact de la cellule avec des agonistes de polyphosphates d'inositol, pénétrant dans les cellules, sont décrits, ainsi que des procédés pour réduire la sécrétion d'ions chlorures chez un individu par l'administration à ce dernier d'agonistes de polyphosphates d'inositol, pénétrant dans les cellules. L'invention porte, de plus, sur des procédés pour atténuer un symptôme ou un signe associé à la diarrhée sécrétoire chez un individu, par l'administration à ce dernier d'agonistes de polyphosphates d'inositol, pénétrant dans les cellules,.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71712296A | 1996-09-20 | 1996-09-20 | |
US08/717,122 | 1996-09-20 | ||
US08/926,831 US5880099A (en) | 1996-09-20 | 1997-09-10 | Inositol polyphosphates and methods of using same |
US08/926,831 | 1997-09-10 | ||
PCT/US1997/016679 WO1998011901A1 (fr) | 1996-09-20 | 1997-09-19 | Derives de polyphosphates d'inositol et leurs procedes d'utilisation |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2267348A1 true CA2267348A1 (fr) | 1998-03-26 |
Family
ID=27109658
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002267348A Abandoned CA2267348A1 (fr) | 1996-09-20 | 1997-09-19 | Derives de polyphosphates d'inositol et leurs procedes d'utilisation |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0954320A4 (fr) |
JP (1) | JP2002524016A (fr) |
KR (1) | KR20060028630A (fr) |
CN (2) | CN1478783A (fr) |
AU (1) | AU721150B2 (fr) |
CA (1) | CA2267348A1 (fr) |
WO (1) | WO1998011901A1 (fr) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6221856B1 (en) * | 1999-02-03 | 2001-04-24 | Inologic, Inc. | Inositol derivatives for inhibiting superoxide anion production |
EP1097713A1 (fr) | 1999-11-03 | 2001-05-09 | Euroscreen S.A. | Inhibiteur de la inositol-phosphatase ship-2 |
US7453006B2 (en) | 2000-11-21 | 2008-11-18 | Inologic, Inc. | Inositol derivatives for increasing chloride secretion and inhibiting inflammation |
WO2003024189A2 (fr) * | 2001-09-20 | 2003-03-27 | Inologic, Inc. | Procede de modulation de l'absorption des ions sodium dans les cellules epitheliales |
AR050866A1 (es) * | 2004-09-09 | 2006-11-29 | Dow Agrosciences Llc | Genes de inositol polifosfato 2-quinasa y usos de los mismos |
DK1863495T3 (en) * | 2005-03-18 | 2015-04-20 | Normoxys Inc | CALCIUM AND SODIUM SALT OF MYO-INOSITOL 1.6: 2,3: 4,5 TRIPYROPHOSPHATE FOR CANCER TREATMENT |
US9162205B2 (en) * | 2012-12-31 | 2015-10-20 | Uop Llc | Apparatuses for distributing fluids in fluidized bed reactors |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1987005598A1 (fr) * | 1986-03-11 | 1987-09-24 | Mitsui Toatsu Chemicals, Incorporated | Derives de myoinositol et procede de preparation |
US5693521A (en) * | 1993-04-09 | 1997-12-02 | The Regents Of The University Of California | Membrane-permeant second messengers |
-
1997
- 1997-09-19 CA CA002267348A patent/CA2267348A1/fr not_active Abandoned
- 1997-09-19 CN CNA031495788A patent/CN1478783A/zh active Pending
- 1997-09-19 KR KR1020057013708A patent/KR20060028630A/ko active IP Right Grant
- 1997-09-19 WO PCT/US1997/016679 patent/WO1998011901A1/fr not_active Application Discontinuation
- 1997-09-19 CN CNB971989893A patent/CN1145489C/zh not_active Expired - Fee Related
- 1997-09-19 AU AU44266/97A patent/AU721150B2/en not_active Ceased
- 1997-09-19 EP EP97942600A patent/EP0954320A4/fr not_active Withdrawn
- 1997-09-19 JP JP51490898A patent/JP2002524016A/ja not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
EP0954320A1 (fr) | 1999-11-10 |
KR20060028630A (ko) | 2006-03-30 |
CN1239894A (zh) | 1999-12-29 |
CN1478783A (zh) | 2004-03-03 |
JP2002524016A (ja) | 2002-07-30 |
EP0954320A4 (fr) | 2001-04-04 |
CN1145489C (zh) | 2004-04-14 |
WO1998011901A1 (fr) | 1998-03-26 |
AU721150B2 (en) | 2000-06-22 |
AU4426697A (en) | 1998-04-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
FZDE | Discontinued |