CA2264943A1 - Novel methods - Google Patents

Novel methods Download PDF

Info

Publication number
CA2264943A1
CA2264943A1 CA002264943A CA2264943A CA2264943A1 CA 2264943 A1 CA2264943 A1 CA 2264943A1 CA 002264943 A CA002264943 A CA 002264943A CA 2264943 A CA2264943 A CA 2264943A CA 2264943 A1 CA2264943 A1 CA 2264943A1
Authority
CA
Canada
Prior art keywords
cardiovascular disease
formula
compound
effects
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002264943A
Other languages
English (en)
French (fr)
Inventor
Maxine Gowen
Jeremy N. Bradbeer (Deceased)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of CA2264943A1 publication Critical patent/CA2264943A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30Oestrogens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Pyridine Compounds (AREA)
CA002264943A 1996-09-06 1997-09-03 Novel methods Abandoned CA2264943A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US2543996P 1996-09-06 1996-09-06
US60/025,439 1996-09-06
US5066697P 1997-06-24 1997-06-24
US60/050,666 1997-06-24
PCT/US1997/015475 WO1998009619A1 (en) 1996-09-06 1997-09-03 Novel methods

Publications (1)

Publication Number Publication Date
CA2264943A1 true CA2264943A1 (en) 1998-03-12

Family

ID=26699738

Family Applications (2)

Application Number Title Priority Date Filing Date
CA002264943A Abandoned CA2264943A1 (en) 1996-09-06 1997-09-03 Novel methods
CA002264775A Abandoned CA2264775A1 (en) 1996-09-06 1997-09-03 Method of treating post menopausal diseases, including osteoporosis

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA002264775A Abandoned CA2264775A1 (en) 1996-09-06 1997-09-03 Method of treating post menopausal diseases, including osteoporosis

Country Status (16)

Country Link
EP (2) EP0927029A4 (de)
JP (2) JP2002515046A (de)
KR (2) KR20000068473A (de)
CN (2) CN1236313A (de)
AR (1) AR008155A1 (de)
AU (2) AU4409797A (de)
BR (2) BR9711676A (de)
CA (2) CA2264943A1 (de)
CO (2) CO5070658A1 (de)
CZ (1) CZ76699A3 (de)
IL (1) IL128645A0 (de)
NO (2) NO991097D0 (de)
PL (2) PL332278A1 (de)
TR (2) TR199900506T2 (de)
TW (1) TW411273B (de)
WO (2) WO1998009619A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5749998A (en) * 1997-02-11 1998-08-26 Novo Nordisk A/S Methods for treatment or prophylaxis of menopausal symptoms
GB9827121D0 (en) * 1998-12-09 1999-02-03 Orion Corp Agent for lowering endothelin levels
DE19905961A1 (de) * 1999-02-12 2000-08-17 Stefan Neubauer Verwendung von Östrogenen zur Behandlung der Herzinsuffizienz
US6528681B2 (en) * 2000-04-05 2003-03-04 Bristol-Meyers Squibb Pharma Company Halogenated triphenylethylene derivatives as selective estrogen receptor modulators
TWI303990B (en) 2000-10-17 2008-12-11 Pfizer Prod Inc New use of estrogen agonists/antagonists for improving vascular health

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2196003A (en) * 1986-09-11 1988-04-20 Nat Res Dev Iodo-and bromo-tamoxifen derivatives
ES2112994T3 (es) * 1992-09-15 1998-04-16 Merrell Pharma Inc Analogos de clomifeno no metabolizables utilizados en el tratamiento de tumores resistentes al tamoxifeno.
US6197789B1 (en) * 1995-06-07 2001-03-06 Neorx Corporation Prevention and treatment of cardiovascular pathologies with tamoxifen analogues
US5681835A (en) * 1994-04-25 1997-10-28 Glaxo Wellcome Inc. Non-steroidal ligands for the estrogen receptor
US5604248A (en) * 1994-05-05 1997-02-18 Eli Lilly And Company Method for minimizing the uterotrophic effect of tamoxifen and tamoxifen analogs
US5470883A (en) * 1994-05-23 1995-11-28 Stromberg; Brent V. Method of treating peripheral vasoconstriction with tamoxifen citrate
HN1996000101A (es) * 1996-02-28 1997-06-26 Inc Pfizer Terapia combinada para la osteoporosis
US6069175A (en) * 1996-11-15 2000-05-30 Pfizer Inc. Estrogen agonist/antagonists treatment of atherosclerosis

Also Published As

Publication number Publication date
TW411273B (en) 2000-11-11
WO1998009619A1 (en) 1998-03-12
AR008155A1 (es) 1999-12-09
PL332278A1 (en) 1999-08-30
JP2002515047A (ja) 2002-05-21
TR199900504T2 (xx) 1999-06-21
WO1998009519A1 (en) 1998-03-12
KR20000068473A (ko) 2000-11-25
JP2002515046A (ja) 2002-05-21
CO4920218A1 (es) 2000-05-29
CO5070658A1 (es) 2001-08-28
NO991097L (no) 1999-03-05
CN1236299A (zh) 1999-11-24
NO991097D0 (no) 1999-03-05
AU4247397A (en) 1998-03-26
NO991096D0 (no) 1999-03-05
BR9711676A (pt) 1999-08-24
EP0927029A4 (de) 2001-06-13
NO991096L (no) 1999-03-05
EP0929216A4 (de) 2001-04-04
CN1236313A (zh) 1999-11-24
EP0927029A1 (de) 1999-07-07
EP0929216A1 (de) 1999-07-21
CZ76699A3 (cs) 1999-08-11
CA2264775A1 (en) 1998-03-12
IL128645A0 (en) 2000-01-31
PL332038A1 (en) 1999-08-16
AU4409797A (en) 1998-03-26
BR9711681A (pt) 1999-08-24
KR20000068472A (ko) 2000-11-25
TR199900506T2 (xx) 1999-07-21

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Legal Events

Date Code Title Description
FZDE Discontinued