CA2264571A1 - Polypeptides fused with alfalfa mosaic virus or ilarvirus capsid - Google Patents
Polypeptides fused with alfalfa mosaic virus or ilarvirus capsid Download PDFInfo
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- CA2264571A1 CA2264571A1 CA002264571A CA2264571A CA2264571A1 CA 2264571 A1 CA2264571 A1 CA 2264571A1 CA 002264571 A CA002264571 A CA 002264571A CA 2264571 A CA2264571 A CA 2264571A CA 2264571 A1 CA2264571 A1 CA 2264571A1
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- plant
- capsid protein
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- 235000012015 potatoes Nutrition 0.000 description 1
- 235000008476 powdered milk Nutrition 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/20011—Rhabdoviridae
- C12N2760/20111—Lyssavirus, e.g. rabies virus
- C12N2760/20122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/14011—Bromoviridae
- C12N2770/14022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/704,856 US6042832A (en) | 1996-08-28 | 1996-08-28 | Polypeptides fused with alfalfa mosaic virus or ilarvirus capsid proteins |
| US08/704,856 | 1996-08-28 | ||
| PCT/US1997/015200 WO1998008375A1 (en) | 1996-08-28 | 1997-08-28 | Polypeptides fused with alfalfa mosaic virus or ilarvirus capsid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2264571A1 true CA2264571A1 (en) | 1998-03-05 |
Family
ID=24831131
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002264571A Abandoned CA2264571A1 (en) | 1996-08-28 | 1997-08-28 | Polypeptides fused with alfalfa mosaic virus or ilarvirus capsid |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US6042832A (enExample) |
| EP (1) | EP1006782B1 (enExample) |
| JP (1) | JP2001500487A (enExample) |
| AT (1) | ATE325882T1 (enExample) |
| CA (1) | CA2264571A1 (enExample) |
| DE (1) | DE69735854D1 (enExample) |
| WO (1) | WO1998008375A1 (enExample) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6660500B2 (en) * | 1988-02-26 | 2003-12-09 | Large Scale Biology Corporation | Production of peptides in plants as viral coat protein fusions |
| US6846968B1 (en) * | 1988-02-26 | 2005-01-25 | Large Scale Biology Corporation | Production of lysosomal enzymes in plants by transient expression |
| US6544769B1 (en) * | 1996-12-13 | 2003-04-08 | Schering Corporation | Compostions comprising viruses and methods for concentrating virus preparations |
| WO2000025574A1 (en) * | 1998-10-30 | 2000-05-11 | Thomas Jefferson University | Production of biomedical peptides and proteins in plants using plant virus vectors |
| JP2003517280A (ja) * | 1999-02-05 | 2003-05-27 | トーマス・ジェファーソン・ユニバーシティ | トランス相補性システムを用いての植物における生物医学用ペプチド及びタンパク質の生成 |
| US6984486B1 (en) * | 1999-02-19 | 2006-01-10 | J. David Gladstone Institutes | Synthetic peptide of regulatory virus protein R (VPR) of human immunodeficiency virus type 1 (HIV-1) and the utilization thereof |
| US20020061309A1 (en) * | 2000-03-08 | 2002-05-23 | Garger Stephen J. | Production of peptides in plants as N-terminal viral coat protein fusions |
| US6730306B1 (en) * | 2000-03-08 | 2004-05-04 | Large Scale Biology Corporation | Parvovirus vaccine as viral coat protein fusions |
| US8101189B2 (en) * | 2002-07-05 | 2012-01-24 | Folia Biotech Inc. | Vaccines and immunopotentiating compositions and methods for making and using them |
| MXPA05000287A (es) * | 2002-07-05 | 2005-09-08 | Leclerc Denis | Particula viral adyuvante. |
| AU2003287622A1 (en) * | 2002-11-06 | 2004-06-03 | Fraunhofer Usa | Expression of foreign sequences in plants using trans-activation system |
| US7692063B2 (en) * | 2002-11-12 | 2010-04-06 | Ibio, Inc. | Production of foreign nucleic acids and polypeptides in sprout systems |
| US7683238B2 (en) * | 2002-11-12 | 2010-03-23 | iBio, Inc. and Fraunhofer USA, Inc. | Production of pharmaceutically active proteins in sprouted seedlings |
| EP1594956A4 (en) * | 2003-02-03 | 2007-08-01 | Fraunhofer Usa Inc | SYSTEM FOR EXPRESSION OF GENES IN PLANTS |
| CA2526720C (en) | 2003-05-22 | 2013-10-22 | Fraunhofer Usa, Inc. | Recombinant carrier molecule for expression, delivery and purification of target polypeptides |
| WO2005056578A2 (en) * | 2003-12-09 | 2005-06-23 | Ventria Bioscience | High-level expression of fusion polypeptides in plant seeds utilizing seed-storage proteins as fusion carriers |
| WO2005066204A2 (en) * | 2003-12-31 | 2005-07-21 | Schering-Plough Ltd. | Neutralizing epitope-based growth enhancing vaccine |
| ES2532609T3 (es) | 2004-02-20 | 2015-03-30 | Ibio, Inc. | Sistemas y métodos para expresión clonales en plantas |
| AU2005220734A1 (en) * | 2004-02-27 | 2005-09-22 | Dow Global Technologies Inc. | High efficiency peptide production in plant cells |
| JP2008522628A (ja) * | 2004-12-11 | 2008-07-03 | サイトジェニックス， インコーポレイテッド | 高品質核酸のセルフリー生合成及びその使用 |
| MY144766A (en) * | 2004-12-30 | 2011-10-31 | Schering Plough Ltd | Plant virus coat fusion proteins with gdf8 epitopes and vaccines thereof |
| EP1885394A4 (en) * | 2005-06-01 | 2009-10-21 | Dow Global Technologies Inc | PRODUCTION OF MULTIVALENT PARTICLES LIKE VIRUSES |
| CA2616859C (en) * | 2005-08-03 | 2015-04-14 | Fraunhofer Usa, Inc. | Compositions and methods for production of immunoglobulins |
| EP1989326A4 (en) | 2006-01-17 | 2009-09-30 | Health Research Inc | BIO-HETERODUPLEX TRACKING TEST |
| AU2007215080A1 (en) * | 2006-02-13 | 2007-08-23 | Fraunhofer Usa, Inc. | Influenza antigens, vaccine compositions, and related methods |
| BRPI0707779B8 (pt) * | 2006-02-13 | 2021-05-25 | Fraunhofer Usa Inc | antígeno isolado, composição de vacina e método para produção de uma proteína antígeno |
| WO2008048344A2 (en) * | 2006-02-13 | 2008-04-24 | Fraunhofer Usa, Inc. | Bacillus anthracis antigens, vaccine compositions, and related methods |
| CN105769931B (zh) | 2006-09-15 | 2021-04-27 | 渥太华医院研究机构 | 溶瘤弹状病毒 |
| WO2008058396A1 (en) * | 2006-11-15 | 2008-05-22 | Folia Biotech Inc. | Papaya mosaic virus-based vaccines for influenza |
| JP2010508857A (ja) | 2006-11-15 | 2010-03-25 | フォリア バイオテック インコーポレイテッド | パパイヤモザイクウイルスに基づく免疫原性の親和性で複合体化された抗原系及びその使用 |
| BRPI0810865A2 (pt) * | 2007-04-28 | 2017-05-09 | Fraunhofer Usa Inc | antígenos de tripanossoma, composições vacinais, e métodos relacionados |
| US8404252B2 (en) * | 2007-07-11 | 2013-03-26 | Fraunhofer Usa, Inc. | Yersinia pestis antigens, vaccine compositions, and related methods |
| CA2615372A1 (en) | 2007-07-13 | 2009-01-13 | Marc-Andre D'aoust | Influenza virus-like particles (vlps) comprising hemagglutinin |
| WO2009033276A1 (en) * | 2007-09-11 | 2009-03-19 | UNIVERSITé LAVAL | Malva mosaic virus and virus-like particles and uses thereof |
| CN103122354B (zh) | 2007-11-27 | 2018-03-23 | 麦迪卡格公司 | 表达血凝素之转基因植物中生产的重组流感病毒样颗粒(vlp) |
| AU2009270404B2 (en) * | 2008-07-18 | 2015-01-29 | Medicago Inc. | New influenza virus immunizing epitope |
| WO2010037046A1 (en) | 2008-09-28 | 2010-04-01 | Fraunhofer Usa, Inc. | Humanized neuraminidase antibody and methods of use thereof |
| CA2762042C (en) | 2009-06-24 | 2012-11-20 | Medicago Inc. | Chimeric influenza virus-like particles comprising hemagglutinin |
| HRP20171564T1 (hr) | 2009-09-22 | 2017-11-17 | Medicago Inc. | Postupak za pripremu biljnih čestica sličnih virusu (vlp) |
| US8784819B2 (en) | 2009-09-29 | 2014-07-22 | Ibio Inc. | Influenza hemagglutinin antibodies, compositions and related methods |
| EP3092309B1 (en) | 2014-01-10 | 2021-02-24 | Medicago Inc. | Cpmv enhancer elements |
| KR102696265B1 (ko) * | 2021-02-25 | 2024-08-21 | 주식회사 바이오앱 | 식물 발현 시스템을 이용한 알팔파 모자이크 바이러스 유사 입자 제조 방법 및 이의 활용 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8421282D0 (en) * | 1984-08-22 | 1984-09-26 | Connaught Lab | Multispecific antigenic proteins |
| US5466788A (en) | 1985-03-07 | 1995-11-14 | Mycogen Plant Science, Inc. | Subgenomic promoter |
| CA1288073C (en) | 1985-03-07 | 1991-08-27 | Paul G. Ahlquist | Rna transformation vector |
| US4956282A (en) * | 1985-07-29 | 1990-09-11 | Calgene, Inc. | Mammalian peptide expression in plant cells |
| US5041385A (en) * | 1986-11-01 | 1991-08-20 | Oxford Gene Systems Limited | Vector expressing fusion proteins and particles |
| US5977438A (en) * | 1988-02-26 | 1999-11-02 | Biosource Technologies, Inc. | Production of peptides in plants as viral coat protein fusions |
| US5316931A (en) * | 1988-02-26 | 1994-05-31 | Biosource Genetics Corp. | Plant viral vectors having heterologous subgenomic promoters for systemic expression of foreign genes |
| GB9108386D0 (en) * | 1991-04-19 | 1991-06-05 | Agricultural Genetics Co | Modified plant viruses as vectors |
| US5612487A (en) * | 1991-08-26 | 1997-03-18 | Edible Vaccines, Inc. | Anti-viral vaccines expressed in plants |
| WO1995021248A1 (en) * | 1994-02-03 | 1995-08-10 | The Scripps Research Institute | Method for using tobacco mosaic virus to overproduce peptides and proteins |
| US5862541A (en) * | 1997-10-06 | 1999-01-26 | Mailhot; Louis | Swimming pool skimmer well frog rescue device |
-
1996
- 1996-08-28 US US08/704,856 patent/US6042832A/en not_active Expired - Lifetime
-
1997
- 1997-08-28 DE DE69735854T patent/DE69735854D1/de not_active Expired - Lifetime
- 1997-08-28 WO PCT/US1997/015200 patent/WO1998008375A1/en not_active Ceased
- 1997-08-28 JP JP10511934A patent/JP2001500487A/ja not_active Ceased
- 1997-08-28 US US09/242,881 patent/US6448070B1/en not_active Expired - Lifetime
- 1997-08-28 CA CA002264571A patent/CA2264571A1/en not_active Abandoned
- 1997-08-28 AT AT97941378T patent/ATE325882T1/de not_active IP Right Cessation
- 1997-08-28 EP EP97941378A patent/EP1006782B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ATE325882T1 (de) | 2006-06-15 |
| JP2001500487A (ja) | 2001-01-16 |
| DE69735854D1 (de) | 2006-06-14 |
| EP1006782B1 (en) | 2006-05-10 |
| EP1006782A1 (en) | 2000-06-14 |
| US6448070B1 (en) | 2002-09-10 |
| WO1998008375A1 (en) | 1998-03-05 |
| EP1006782A4 (en) | 2004-03-03 |
| US6042832A (en) | 2000-03-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |