CA2263706A1 - Spatial and temporal control of gene expression using a heat shock protein promoter in combination with local heat - Google Patents
Spatial and temporal control of gene expression using a heat shock protein promoter in combination with local heat Download PDFInfo
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- CA2263706A1 CA2263706A1 CA002263706A CA2263706A CA2263706A1 CA 2263706 A1 CA2263706 A1 CA 2263706A1 CA 002263706 A CA002263706 A CA 002263706A CA 2263706 A CA2263706 A CA 2263706A CA 2263706 A1 CA2263706 A1 CA 2263706A1
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- BPICBUSOMSTKRF-UHFFFAOYSA-N xylazine Chemical compound CC1=CC=CC(C)=C1NC1=NCCCS1 BPICBUSOMSTKRF-UHFFFAOYSA-N 0.000 description 1
- 229960001600 xylazine Drugs 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
- C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Toxicology (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Saccharide Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2421396P | 1996-08-15 | 1996-08-15 | |
| US60/024,213 | 1996-08-15 | ||
| PCT/US1997/015270 WO1998006864A2 (en) | 1996-08-15 | 1997-08-14 | Spatial and temporal control of gene expression using a heat shock protein promoter in combination with local heat |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2263706A1 true CA2263706A1 (en) | 1998-02-19 |
Family
ID=21819426
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002263706A Abandoned CA2263706A1 (en) | 1996-08-15 | 1997-08-14 | Spatial and temporal control of gene expression using a heat shock protein promoter in combination with local heat |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US7186698B2 (enExample) |
| EP (1) | EP0922110B1 (enExample) |
| JP (2) | JP2001501458A (enExample) |
| AT (1) | ATE392481T1 (enExample) |
| AU (1) | AU732872C (enExample) |
| CA (1) | CA2263706A1 (enExample) |
| DE (1) | DE69738640T2 (enExample) |
| WO (1) | WO1998006864A2 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US6342596B1 (en) | 1998-05-05 | 2002-01-29 | Hsf Pharmaceuticals S.A. | Molecular regulatory circuits to achieve sustained activation of genes of interest by a single stress |
| KR20020013463A (ko) * | 1998-08-18 | 2002-02-20 | 와일러 제임스 에프. | 유전자의 발현을 증강시키고 제한하는 방법 |
| US6900049B2 (en) * | 1998-09-10 | 2005-05-31 | Cell Genesys, Inc. | Adenovirus vectors containing cell status-specific response elements and methods of use thereof |
| US6684097B1 (en) | 1999-04-22 | 2004-01-27 | University Of Miami | Intraoperative monitoring of temperature-induced tissue changes with a high-resolution digital x-ray system during thermotherapy |
| US7115391B1 (en) | 1999-10-01 | 2006-10-03 | Genovo, Inc. | Production of recombinant AAV using adenovirus comprising AAV rep/cap genes |
| EP1222299A1 (en) * | 1999-10-01 | 2002-07-17 | Genovo, Incorporated | Production of recombinant aav using adenovirus comprising aav rep/cap genes |
| US6953659B2 (en) * | 2000-07-14 | 2005-10-11 | Massachusetts Institute Of Technology | Direct, externally imposed control of nucleic acids |
| CA2349506C (en) | 2001-06-14 | 2009-12-08 | Duke University | A method for selective expression of therapeutic genes by hyperthermia |
| WO2003006608A2 (en) | 2001-07-10 | 2003-01-23 | Davidson Michael N | Enhancement of transfection of dna into the liver |
| CA2369985A1 (en) * | 2002-01-18 | 2003-07-18 | Duke University | Generation of recombinant adeno-associated viral vectors by a complete adenovirus-mediated approach |
| CN1809641A (zh) * | 2003-06-19 | 2006-07-26 | 彼得·布罗姆利 | 蛋白质生产系统 |
| US7840263B2 (en) | 2004-02-27 | 2010-11-23 | Cardiac Pacemakers, Inc. | Method and apparatus for device controlled gene expression |
| AT500838B1 (de) * | 2004-04-20 | 2007-11-15 | Veterinaermedizinische Uni Wie | Multiple hse |
| WO2006116789A2 (en) * | 2005-05-03 | 2006-11-09 | Veterinärmedizinische Universität Wien | Permeable capsules |
| CA2617594C (en) | 2005-08-03 | 2016-08-02 | Grains Research & Development Corporation | Polysaccharide synthases |
| US7774057B2 (en) * | 2005-09-06 | 2010-08-10 | Cardiac Pacemakers, Inc. | Method and apparatus for device controlled gene expression for cardiac protection |
| US20070190028A1 (en) * | 2006-02-13 | 2007-08-16 | Jihong Qu | Method and apparatus for heat or electromagnetic control of gene expression |
| US7871406B2 (en) * | 2006-08-04 | 2011-01-18 | INTIO, Inc. | Methods for planning and performing thermal ablation |
| CN101505654B (zh) * | 2006-08-22 | 2012-08-29 | 皇家飞利浦电子股份有限公司 | 用于获取哺乳动物身体信息的方法和装置 |
| WO2009125332A1 (en) * | 2008-04-07 | 2009-10-15 | Peter Bromley | New and safe procedure for immunization against infectious diseases agents |
| WO2010060162A1 (en) | 2008-11-28 | 2010-06-03 | Empresa Brasileira De Pesquisa Agropecuária - Embrapa | Use of at(n) insertions in promoter elements for controlling the expression levels of coding sequences in plants |
| US20110127254A1 (en) * | 2009-11-30 | 2011-06-02 | Cypress Technology Llc | Electric Heating Systems and Associated Methods |
| US9848950B2 (en) | 2012-04-27 | 2017-12-26 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and devices for localized disease treatment by ablation |
| US9101745B2 (en) | 2013-03-14 | 2015-08-11 | Sonogene Llc | Sonochemical induction of ABCA1 expression and compositions therefor |
| JP2017506884A (ja) * | 2014-01-17 | 2017-03-16 | ウェイク・フォレスト・ユニヴァーシティ・ヘルス・サイエンシズ | 活性薬の送達を増強するための方法 |
| WO2018098315A1 (en) * | 2016-11-22 | 2018-05-31 | The Regents Of The University Of California | Acoustic and ultrasound-based mechanogenetics and thermogenetics for immunotherapy |
| US11318330B2 (en) * | 2018-09-26 | 2022-05-03 | General Electric Company | Neuromodulation techniques |
| US20220241337A1 (en) * | 2019-02-22 | 2022-08-04 | The Trustees Of Columbia University In The City Of Newyork | Preparing tissues for delivery of therapeutic and diagnostic agents and delivering the agents |
| US20220298515A1 (en) * | 2019-09-10 | 2022-09-22 | The Regents Of The University Of California | Ultrasound-based thermogenetics for immunotherapy |
| US11176717B2 (en) * | 2019-09-26 | 2021-11-16 | Siemens Healthcare Gmbh | Guiding protocol development for magnetic resonance thermometry |
| US20210222128A1 (en) | 2020-01-22 | 2021-07-22 | Massachusetts Institute Of Technology | Inducible tissue constructs and uses thereof |
| CN115768890A (zh) * | 2020-04-15 | 2023-03-07 | 加州理工学院 | 通过分子和物理启动对t细胞免疫疗法的热控制 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE56720B1 (en) | 1983-02-07 | 1991-11-20 | Battelle Memorial Institute | Methods and compositions for expression of competent eukaryotic gene products |
| AU604214B2 (en) | 1985-07-31 | 1990-12-13 | Battelle Memorial Institute | An improved heat-shock control method and system for the production of competent eukaryotic gene products |
| AU606049B2 (en) * | 1986-02-06 | 1991-01-31 | General Hospital Corporation, The | Inducible heat shock and amplification system |
| WO1987005935A1 (en) * | 1986-04-04 | 1987-10-08 | Battelle Memorial Institute At Columbus, Ohio Gene | Methods and compositions for expression of competent eukaryotic gene products |
| ATE67787T1 (de) * | 1986-10-15 | 1991-10-15 | Battelle Memorial Institute | Verfahren zur herstellung von proteinen mittels induzierbarer expressionssysteme in in-vivovermehrten, genetisch modifizierten eukaryotischen wirtszellen. |
| US5591632A (en) * | 1987-03-02 | 1997-01-07 | Beth Israel Hospital | Recombinant BCG |
| EP0299127A1 (en) * | 1987-07-16 | 1989-01-18 | IntraCel Corporation | A method for the expression of recombinant genes under stimulation from an inducively expressed activator protein |
| ZA892518B (en) | 1988-04-08 | 1989-12-27 | Intracel Corp | Method for the in-vivo production and testing of proteins by recombinant gene expression in selected host-cells |
| EP0386185A1 (fr) * | 1988-07-29 | 1990-09-12 | IntraCel Corporation | Procede d'expression genetique de proteines heterologues par des cellules transfectees in vivo |
| DE69034168T3 (de) * | 1989-03-21 | 2013-04-11 | Vical, Inc. | Expression von exogenen Polynukleotidsequenzen in Wirbeltieren |
| US5521084A (en) | 1992-11-10 | 1996-05-28 | Biostar, Inc. | Bovine heat shock promoter and uses thereof |
| WO1995000178A1 (en) * | 1993-06-25 | 1995-01-05 | Board Of Regents, The University Of Texas System | Pore-forming and superantigen encoding toxin cassettes for gene therapy |
| US5979454A (en) * | 1995-05-15 | 1999-11-09 | The Regents Of The University Of California | Method and apparatus for causing rapid and deep spatially selective coagulation during thermally mediated therapeutic procedures |
| US5490840A (en) * | 1994-09-26 | 1996-02-13 | General Electric Company | Targeted thermal release of drug-polymer conjugates |
-
1997
- 1997-08-14 AT AT97940696T patent/ATE392481T1/de not_active IP Right Cessation
- 1997-08-14 CA CA002263706A patent/CA2263706A1/en not_active Abandoned
- 1997-08-14 DE DE69738640T patent/DE69738640T2/de not_active Expired - Fee Related
- 1997-08-14 JP JP10510126A patent/JP2001501458A/ja not_active Withdrawn
- 1997-08-14 WO PCT/US1997/015270 patent/WO1998006864A2/en not_active Ceased
- 1997-08-14 AU AU42416/97A patent/AU732872C/en not_active Ceased
- 1997-08-14 EP EP97940696A patent/EP0922110B1/en not_active Expired - Lifetime
-
2002
- 2002-03-11 US US10/096,549 patent/US7186698B2/en not_active Expired - Fee Related
-
2004
- 2004-06-09 US US10/864,102 patent/US20050059623A1/en not_active Abandoned
-
2008
- 2008-08-06 JP JP2008203353A patent/JP2008291043A/ja not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP0922110A2 (en) | 1999-06-16 |
| AU732872C (en) | 2002-02-21 |
| WO1998006864A2 (en) | 1998-02-19 |
| JP2001501458A (ja) | 2001-02-06 |
| JP2008291043A (ja) | 2008-12-04 |
| US7186698B2 (en) | 2007-03-06 |
| DE69738640T2 (de) | 2009-07-16 |
| DE69738640D1 (de) | 2008-05-29 |
| AU4241697A (en) | 1998-03-06 |
| ATE392481T1 (de) | 2008-05-15 |
| EP0922110B1 (en) | 2008-04-16 |
| US20020165191A1 (en) | 2002-11-07 |
| AU732872B2 (en) | 2001-05-03 |
| WO1998006864A3 (en) | 1998-05-14 |
| US20050059623A1 (en) | 2005-03-17 |
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Legal Events
| Date | Code | Title | Description |
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| EEER | Examination request | ||
| FZDE | Discontinued |