ATE392481T1 - Räumliche und temporäre kontrolle der genexpression mittels eines hitzeschockproteinpromotors in kombination mit lokaler hitze - Google Patents

Räumliche und temporäre kontrolle der genexpression mittels eines hitzeschockproteinpromotors in kombination mit lokaler hitze

Info

Publication number
ATE392481T1
ATE392481T1 AT97940696T AT97940696T ATE392481T1 AT E392481 T1 ATE392481 T1 AT E392481T1 AT 97940696 T AT97940696 T AT 97940696T AT 97940696 T AT97940696 T AT 97940696T AT E392481 T1 ATE392481 T1 AT E392481T1
Authority
AT
Austria
Prior art keywords
heat
gene expression
shock protein
spatial
combination
Prior art date
Application number
AT97940696T
Other languages
German (de)
English (en)
Inventor
Chrit Moonen
Original Assignee
Us Gov Health & Human Serv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Gov Health & Human Serv filed Critical Us Gov Health & Human Serv
Application granted granted Critical
Publication of ATE392481T1 publication Critical patent/ATE392481T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT97940696T 1996-08-15 1997-08-14 Räumliche und temporäre kontrolle der genexpression mittels eines hitzeschockproteinpromotors in kombination mit lokaler hitze ATE392481T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2421396P 1996-08-15 1996-08-15

Publications (1)

Publication Number Publication Date
ATE392481T1 true ATE392481T1 (de) 2008-05-15

Family

ID=21819426

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97940696T ATE392481T1 (de) 1996-08-15 1997-08-14 Räumliche und temporäre kontrolle der genexpression mittels eines hitzeschockproteinpromotors in kombination mit lokaler hitze

Country Status (8)

Country Link
US (2) US7186698B2 (enExample)
EP (1) EP0922110B1 (enExample)
JP (2) JP2001501458A (enExample)
AT (1) ATE392481T1 (enExample)
AU (1) AU732872C (enExample)
CA (1) CA2263706A1 (enExample)
DE (1) DE69738640T2 (enExample)
WO (1) WO1998006864A2 (enExample)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6342596B1 (en) 1998-05-05 2002-01-29 Hsf Pharmaceuticals S.A. Molecular regulatory circuits to achieve sustained activation of genes of interest by a single stress
KR20020013463A (ko) * 1998-08-18 2002-02-20 와일러 제임스 에프. 유전자의 발현을 증강시키고 제한하는 방법
US6900049B2 (en) * 1998-09-10 2005-05-31 Cell Genesys, Inc. Adenovirus vectors containing cell status-specific response elements and methods of use thereof
US6684097B1 (en) 1999-04-22 2004-01-27 University Of Miami Intraoperative monitoring of temperature-induced tissue changes with a high-resolution digital x-ray system during thermotherapy
US7115391B1 (en) 1999-10-01 2006-10-03 Genovo, Inc. Production of recombinant AAV using adenovirus comprising AAV rep/cap genes
EP1222299A1 (en) * 1999-10-01 2002-07-17 Genovo, Incorporated Production of recombinant aav using adenovirus comprising aav rep/cap genes
US6953659B2 (en) * 2000-07-14 2005-10-11 Massachusetts Institute Of Technology Direct, externally imposed control of nucleic acids
CA2349506C (en) 2001-06-14 2009-12-08 Duke University A method for selective expression of therapeutic genes by hyperthermia
WO2003006608A2 (en) 2001-07-10 2003-01-23 Davidson Michael N Enhancement of transfection of dna into the liver
CA2369985A1 (en) * 2002-01-18 2003-07-18 Duke University Generation of recombinant adeno-associated viral vectors by a complete adenovirus-mediated approach
CN1809641A (zh) * 2003-06-19 2006-07-26 彼得·布罗姆利 蛋白质生产系统
US7840263B2 (en) 2004-02-27 2010-11-23 Cardiac Pacemakers, Inc. Method and apparatus for device controlled gene expression
AT500838B1 (de) * 2004-04-20 2007-11-15 Veterinaermedizinische Uni Wie Multiple hse
WO2006116789A2 (en) * 2005-05-03 2006-11-09 Veterinärmedizinische Universität Wien Permeable capsules
CA2617594C (en) 2005-08-03 2016-08-02 Grains Research & Development Corporation Polysaccharide synthases
US7774057B2 (en) * 2005-09-06 2010-08-10 Cardiac Pacemakers, Inc. Method and apparatus for device controlled gene expression for cardiac protection
US20070190028A1 (en) * 2006-02-13 2007-08-16 Jihong Qu Method and apparatus for heat or electromagnetic control of gene expression
US7871406B2 (en) * 2006-08-04 2011-01-18 INTIO, Inc. Methods for planning and performing thermal ablation
CN101505654B (zh) * 2006-08-22 2012-08-29 皇家飞利浦电子股份有限公司 用于获取哺乳动物身体信息的方法和装置
WO2009125332A1 (en) * 2008-04-07 2009-10-15 Peter Bromley New and safe procedure for immunization against infectious diseases agents
WO2010060162A1 (en) 2008-11-28 2010-06-03 Empresa Brasileira De Pesquisa Agropecuária - Embrapa Use of at(n) insertions in promoter elements for controlling the expression levels of coding sequences in plants
US20110127254A1 (en) * 2009-11-30 2011-06-02 Cypress Technology Llc Electric Heating Systems and Associated Methods
US9848950B2 (en) 2012-04-27 2017-12-26 Medtronic Ardian Luxembourg S.A.R.L. Methods and devices for localized disease treatment by ablation
US9101745B2 (en) 2013-03-14 2015-08-11 Sonogene Llc Sonochemical induction of ABCA1 expression and compositions therefor
JP2017506884A (ja) * 2014-01-17 2017-03-16 ウェイク・フォレスト・ユニヴァーシティ・ヘルス・サイエンシズ 活性薬の送達を増強するための方法
WO2018098315A1 (en) * 2016-11-22 2018-05-31 The Regents Of The University Of California Acoustic and ultrasound-based mechanogenetics and thermogenetics for immunotherapy
US11318330B2 (en) * 2018-09-26 2022-05-03 General Electric Company Neuromodulation techniques
US20220241337A1 (en) * 2019-02-22 2022-08-04 The Trustees Of Columbia University In The City Of Newyork Preparing tissues for delivery of therapeutic and diagnostic agents and delivering the agents
US20220298515A1 (en) * 2019-09-10 2022-09-22 The Regents Of The University Of California Ultrasound-based thermogenetics for immunotherapy
US11176717B2 (en) * 2019-09-26 2021-11-16 Siemens Healthcare Gmbh Guiding protocol development for magnetic resonance thermometry
US20210222128A1 (en) 2020-01-22 2021-07-22 Massachusetts Institute Of Technology Inducible tissue constructs and uses thereof
CN115768890A (zh) * 2020-04-15 2023-03-07 加州理工学院 通过分子和物理启动对t细胞免疫疗法的热控制

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE56720B1 (en) 1983-02-07 1991-11-20 Battelle Memorial Institute Methods and compositions for expression of competent eukaryotic gene products
AU604214B2 (en) 1985-07-31 1990-12-13 Battelle Memorial Institute An improved heat-shock control method and system for the production of competent eukaryotic gene products
AU606049B2 (en) * 1986-02-06 1991-01-31 General Hospital Corporation, The Inducible heat shock and amplification system
WO1987005935A1 (en) * 1986-04-04 1987-10-08 Battelle Memorial Institute At Columbus, Ohio Gene Methods and compositions for expression of competent eukaryotic gene products
ATE67787T1 (de) * 1986-10-15 1991-10-15 Battelle Memorial Institute Verfahren zur herstellung von proteinen mittels induzierbarer expressionssysteme in in-vivovermehrten, genetisch modifizierten eukaryotischen wirtszellen.
US5591632A (en) * 1987-03-02 1997-01-07 Beth Israel Hospital Recombinant BCG
EP0299127A1 (en) * 1987-07-16 1989-01-18 IntraCel Corporation A method for the expression of recombinant genes under stimulation from an inducively expressed activator protein
ZA892518B (en) 1988-04-08 1989-12-27 Intracel Corp Method for the in-vivo production and testing of proteins by recombinant gene expression in selected host-cells
EP0386185A1 (fr) * 1988-07-29 1990-09-12 IntraCel Corporation Procede d'expression genetique de proteines heterologues par des cellules transfectees in vivo
DE69034168T3 (de) * 1989-03-21 2013-04-11 Vical, Inc. Expression von exogenen Polynukleotidsequenzen in Wirbeltieren
US5521084A (en) 1992-11-10 1996-05-28 Biostar, Inc. Bovine heat shock promoter and uses thereof
WO1995000178A1 (en) * 1993-06-25 1995-01-05 Board Of Regents, The University Of Texas System Pore-forming and superantigen encoding toxin cassettes for gene therapy
US5979454A (en) * 1995-05-15 1999-11-09 The Regents Of The University Of California Method and apparatus for causing rapid and deep spatially selective coagulation during thermally mediated therapeutic procedures
US5490840A (en) * 1994-09-26 1996-02-13 General Electric Company Targeted thermal release of drug-polymer conjugates

Also Published As

Publication number Publication date
EP0922110A2 (en) 1999-06-16
AU732872C (en) 2002-02-21
WO1998006864A2 (en) 1998-02-19
JP2001501458A (ja) 2001-02-06
JP2008291043A (ja) 2008-12-04
US7186698B2 (en) 2007-03-06
CA2263706A1 (en) 1998-02-19
DE69738640T2 (de) 2009-07-16
DE69738640D1 (de) 2008-05-29
AU4241697A (en) 1998-03-06
EP0922110B1 (en) 2008-04-16
US20020165191A1 (en) 2002-11-07
AU732872B2 (en) 2001-05-03
WO1998006864A3 (en) 1998-05-14
US20050059623A1 (en) 2005-03-17

Similar Documents

Publication Publication Date Title
ATE392481T1 (de) Räumliche und temporäre kontrolle der genexpression mittels eines hitzeschockproteinpromotors in kombination mit lokaler hitze
ATE309360T1 (de) Vaskularer endothelialer wachstumsfaktor 2
ATE205254T1 (de) Transformierender wachstumsfaktor alpha h1
NO972373L (no) Vektorer for vevs-spesifikk replikasjon
DE69835085D1 (de) Regulation der transcription in säugetierzellen und viraler replikation durch eine tetracyclinrepressor
BG49941A3 (bg) Метод за получаване на рекомбинантен колонии стимулиращ фактор-1
ATE304058T1 (de) Rekombinante mva viren und deren verwendung
ATE330019T1 (de) Vektor zur gewebespezifischen replikation und expression
NO965627D0 (no) Nytt cytokin betegnet lerk-5
ATE520713T1 (de) Identifizierung und veränderung von immundominanten polypeptidepitopen
ATE294236T1 (de) Promotor der tie rezeptor protein kinase
NO960309L (no) Agonister og antagonister for humaninterleukin-10
DE69434926D1 (de) Menschlicher gewebsinhibitor von metalloproteinase-4
DK251890D0 (da) Polypeptid og dets anvendelse samt ekspressionssystem til dets eksprimering
BR0009170A (pt) ácidos nucléicos akt, polipeptìdeos e uso dos mesmos
NO965431L (no) Höy-affinitet melatoninreseptorer og anvendelser derav
NO892029L (no) Fremgangsmaate ved spesifikk genetisk manipulering av mikroorganisme.
ATE378056T1 (de) Medizinische verwendung von stammzellen, die vegfr-1 exprimieren
AU6987696A (en) The use of the wap of mmtv regulatory sequences for targeted expression of linked heterologous genes in human mammary cells, including human mammary carcinoma cells
ATE239076T1 (de) Zielspezifische abgabe zum nukleus mittels protein h von streptococcus
WO2000053785A3 (en) Method to improve translation of polypeptides by using untranslated regions from heat-shock proteins
ATE362531T1 (de) Interne ribosom eintrittstelle (ires), vektor der diesen enthaltet und dessen therapeutische verwendung
DK0887404T3 (da) Gen, som bibringer selektiv proliferationsaktivitet

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties