JP2001501458A - ヒートショックタンパク質プロモーターと局部加熱との組合せを利用した遺伝子発現の場所的及び時期的制御 - Google Patents

ヒートショックタンパク質プロモーターと局部加熱との組合せを利用した遺伝子発現の場所的及び時期的制御

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Publication number
JP2001501458A
JP2001501458A JP10510126A JP51012698A JP2001501458A JP 2001501458 A JP2001501458 A JP 2001501458A JP 10510126 A JP10510126 A JP 10510126A JP 51012698 A JP51012698 A JP 51012698A JP 2001501458 A JP2001501458 A JP 2001501458A
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JP
Japan
Prior art keywords
gene
cells
cell
promoter
heat shock
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP10510126A
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English (en)
Japanese (ja)
Other versions
JP2001501458A5 (enExample
Inventor
モーネン，クリット
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Government of the United States of America
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Government of the United States of America
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Filing date
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Application filed by Government of the United States of America filed Critical Government of the United States of America
Publication of JP2001501458A publication Critical patent/JP2001501458A/ja
Publication of JP2001501458A5 publication Critical patent/JP2001501458A5/ja
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP10510126A 1996-08-15 1997-08-14 ヒートショックタンパク質プロモーターと局部加熱との組合せを利用した遺伝子発現の場所的及び時期的制御 Withdrawn JP2001501458A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2421396P 1996-08-15 1996-08-15
US60/024,213 1996-08-15
PCT/US1997/015270 WO1998006864A2 (en) 1996-08-15 1997-08-14 Spatial and temporal control of gene expression using a heat shock protein promoter in combination with local heat

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2008203353A Division JP2008291043A (ja) 1996-08-15 2008-08-06 ヒートショックタンパク質プロモーターと局部加熱との組合せを利用した遺伝子発現の場所的及び時期的制御

Publications (2)

Publication Number Publication Date
JP2001501458A true JP2001501458A (ja) 2001-02-06
JP2001501458A5 JP2001501458A5 (enExample) 2005-04-07

Family

ID=21819426

Family Applications (2)

Application Number Title Priority Date Filing Date
JP10510126A Withdrawn JP2001501458A (ja) 1996-08-15 1997-08-14 ヒートショックタンパク質プロモーターと局部加熱との組合せを利用した遺伝子発現の場所的及び時期的制御
JP2008203353A Ceased JP2008291043A (ja) 1996-08-15 2008-08-06 ヒートショックタンパク質プロモーターと局部加熱との組合せを利用した遺伝子発現の場所的及び時期的制御

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2008203353A Ceased JP2008291043A (ja) 1996-08-15 2008-08-06 ヒートショックタンパク質プロモーターと局部加熱との組合せを利用した遺伝子発現の場所的及び時期的制御

Country Status (8)

Country Link
US (2) US7186698B2 (enExample)
EP (1) EP0922110B1 (enExample)
JP (2) JP2001501458A (enExample)
AT (1) ATE392481T1 (enExample)
AU (1) AU732872C (enExample)
CA (1) CA2263706A1 (enExample)
DE (1) DE69738640T2 (enExample)
WO (1) WO1998006864A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008540347A (ja) * 2005-05-03 2008-11-20 フェテリネールメディツィニシュ ウニベルジテート ウィーン 浸透性カプセル
JP2017506884A (ja) * 2014-01-17 2017-03-16 ウェイク・フォレスト・ユニヴァーシティ・ヘルス・サイエンシズ 活性薬の送達を増強するための方法

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US6342596B1 (en) 1998-05-05 2002-01-29 Hsf Pharmaceuticals S.A. Molecular regulatory circuits to achieve sustained activation of genes of interest by a single stress
AU763183B2 (en) * 1998-08-18 2003-07-17 Research Development Foundation Methods to enhance and confine expression of genes
US6900049B2 (en) 1998-09-10 2005-05-31 Cell Genesys, Inc. Adenovirus vectors containing cell status-specific response elements and methods of use thereof
US6684097B1 (en) 1999-04-22 2004-01-27 University Of Miami Intraoperative monitoring of temperature-induced tissue changes with a high-resolution digital x-ray system during thermotherapy
EP1222299A1 (en) * 1999-10-01 2002-07-17 Genovo, Incorporated Production of recombinant aav using adenovirus comprising aav rep/cap genes
US7115391B1 (en) 1999-10-01 2006-10-03 Genovo, Inc. Production of recombinant AAV using adenovirus comprising AAV rep/cap genes
US6953659B2 (en) * 2000-07-14 2005-10-11 Massachusetts Institute Of Technology Direct, externally imposed control of nucleic acids
CA2349506C (en) 2001-06-14 2009-12-08 Duke University A method for selective expression of therapeutic genes by hyperthermia
JP4426288B2 (ja) 2001-07-10 2010-03-03 ソノジーン，リミテッド ライアビリティー カンパニー 肝臓へのｄｎａのトランスフェクションの増強
CA2369985A1 (en) * 2002-01-18 2003-07-18 Duke University Generation of recombinant adeno-associated viral vectors by a complete adenovirus-mediated approach
WO2004111246A1 (en) * 2003-06-19 2004-12-23 Peter Bromley Protein production system
US7840263B2 (en) 2004-02-27 2010-11-23 Cardiac Pacemakers, Inc. Method and apparatus for device controlled gene expression
AT500838B1 (de) * 2004-04-20 2007-11-15 Veterinaermedizinische Uni Wie Multiple hse
EP1920057A4 (en) 2005-08-03 2009-03-18 Grains Res & Dev Corp POLYSACCHARIDE synthases
US7774057B2 (en) * 2005-09-06 2010-08-10 Cardiac Pacemakers, Inc. Method and apparatus for device controlled gene expression for cardiac protection
US20070190028A1 (en) * 2006-02-13 2007-08-16 Jihong Qu Method and apparatus for heat or electromagnetic control of gene expression
US7871406B2 (en) * 2006-08-04 2011-01-18 INTIO, Inc. Methods for planning and performing thermal ablation
ATE499970T1 (de) * 2006-08-22 2011-03-15 Koninkl Philips Electronics Nv Vorrichtung zum erhalten von informationen über einen säugetierkörper
WO2009125332A1 (en) * 2008-04-07 2009-10-15 Peter Bromley New and safe procedure for immunization against infectious diseases agents
EP2370583B1 (en) 2008-11-28 2020-07-15 Empresa Brasileira de Pesquisa Agropecuária - EMBRAPA Use of at(n) insertions in promoter elements for controlling the expression levels of coding sequences in plants
US20110127254A1 (en) * 2009-11-30 2011-06-02 Cypress Technology Llc Electric Heating Systems and Associated Methods
US9848950B2 (en) 2012-04-27 2017-12-26 Medtronic Ardian Luxembourg S.A.R.L. Methods and devices for localized disease treatment by ablation
US9101745B2 (en) 2013-03-14 2015-08-11 Sonogene Llc Sonochemical induction of ABCA1 expression and compositions therefor
WO2018098315A1 (en) * 2016-11-22 2018-05-31 The Regents Of The University Of California Acoustic and ultrasound-based mechanogenetics and thermogenetics for immunotherapy
US11318330B2 (en) * 2018-09-26 2022-05-03 General Electric Company Neuromodulation techniques
US20220241337A1 (en) * 2019-02-22 2022-08-04 The Trustees Of Columbia University In The City Of Newyork Preparing tissues for delivery of therapeutic and diagnostic agents and delivering the agents
WO2021050658A1 (en) * 2019-09-10 2021-03-18 The Regents Of The University Of California Ultrasound-based thermogenetics for immunotherapy
US11176717B2 (en) * 2019-09-26 2021-11-16 Siemens Healthcare Gmbh Guiding protocol development for magnetic resonance thermometry
US20210222128A1 (en) 2020-01-22 2021-07-22 Massachusetts Institute Of Technology Inducible tissue constructs and uses thereof
US12359208B2 (en) 2020-04-15 2025-07-15 California Institute Of Technology Thermal control of T-cell immunotherapy through molecular and physical actuation

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DK172882B1 (da) 1983-02-07 1999-09-06 Rothwell Property Ltd DNA indeholdende udtrykkelseskontrolregion fra et eukaryot varmechokproteingen, vektor og eukaryot celle indeholdende DNA'e
EP0231368A1 (en) 1985-07-31 1987-08-12 Battelle Memorial Institute An improved heat-shock control method and system for the production of competent eukaryotic gene products
AU606049B2 (en) * 1986-02-06 1991-01-31 General Hospital Corporation, The Inducible heat shock and amplification system
WO1987005935A1 (en) * 1986-04-04 1987-10-08 Battelle Memorial Institute At Columbus, Ohio Gene Methods and compositions for expression of competent eukaryotic gene products
ES2038602T3 (es) * 1986-10-15 1993-08-01 Battelle Memorial Institute Metodo para la produccion de proteinas por medio de sistemas de expresion inducible en celulas-huesped en carioticas geneticamente modificadas multiplicadas in-vivo.
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EP0299127A1 (en) * 1987-07-16 1989-01-18 IntraCel Corporation A method for the expression of recombinant genes under stimulation from an inducively expressed activator protein
ZA892518B (en) 1988-04-08 1989-12-27 Intracel Corp Method for the in-vivo production and testing of proteins by recombinant gene expression in selected host-cells
EP0386185A1 (fr) * 1988-07-29 1990-09-12 IntraCel Corporation Procede d'expression genetique de proteines heterologues par des cellules transfectees in vivo
DE69034078T2 (de) * 1989-03-21 2004-04-01 Vical, Inc., San Diego Expression von exogenen Polynukleotidsequenzen in Wirbeltieren
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US5979454A (en) * 1995-05-15 1999-11-09 The Regents Of The University Of California Method and apparatus for causing rapid and deep spatially selective coagulation during thermally mediated therapeutic procedures
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008540347A (ja) * 2005-05-03 2008-11-20 フェテリネールメディツィニシュ ウニベルジテート ウィーン 浸透性カプセル
JP2017506884A (ja) * 2014-01-17 2017-03-16 ウェイク・フォレスト・ユニヴァーシティ・ヘルス・サイエンシズ 活性薬の送達を増強するための方法

Also Published As

Publication number Publication date
DE69738640T2 (de) 2009-07-16
EP0922110A2 (en) 1999-06-16
WO1998006864A2 (en) 1998-02-19
US20050059623A1 (en) 2005-03-17
US7186698B2 (en) 2007-03-06
AU732872C (en) 2002-02-21
JP2008291043A (ja) 2008-12-04
AU4241697A (en) 1998-03-06
ATE392481T1 (de) 2008-05-15
DE69738640D1 (de) 2008-05-29
WO1998006864A3 (en) 1998-05-14
CA2263706A1 (en) 1998-02-19
AU732872B2 (en) 2001-05-03
US20020165191A1 (en) 2002-11-07
EP0922110B1 (en) 2008-04-16

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