CA2262788A1 - Derive de clonixine anti-inflammatoire/analgesique non ulcerigene - Google Patents

Derive de clonixine anti-inflammatoire/analgesique non ulcerigene Download PDF

Info

Publication number
CA2262788A1
CA2262788A1 CA002262788A CA2262788A CA2262788A1 CA 2262788 A1 CA2262788 A1 CA 2262788A1 CA 002262788 A CA002262788 A CA 002262788A CA 2262788 A CA2262788 A CA 2262788A CA 2262788 A1 CA2262788 A1 CA 2262788A1
Authority
CA
Canada
Prior art keywords
clonixate
analgesic
nitroxybutyl
compound
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002262788A
Other languages
English (en)
Inventor
Gustavo Enrique Aldoma
Susana Elida Piatti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Handforth Investments Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2262788A1 publication Critical patent/CA2262788A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Le dérivé de la clonixine présentant la formule (I), ou le 4-nitroxybutyle clonixate est un nouveau produit anti-inflammatoire analgésique non stéroïde qui présente un équilibre extraordinaire entre de fortes activités analgésiques/anti-inflammatoires et de faibles effets défavorables ulcérigènes, grâce à une activité anti-inflammatoire très puissante (deux fois celle de l'acide clonixique). Le composé (I) est préparé en faisant réagir du 4-chlorobutyle clonixate avec du nitrate d'argent dans de l'acétonitrile. Le 4-chlorobutyle clonixate est préparé en faisant réagir un clonixate alcalin avec du 1-bromo-4-chlorobutane dans de l'acétonitrile. Le 4-nitroxybutyle cloxinate (I) est particulièrement utile comme principe actif dans le traitement des douleurs et/ou des inflammations chez le mammifère.
CA002262788A 1996-08-16 1996-08-16 Derive de clonixine anti-inflammatoire/analgesique non ulcerigene Abandoned CA2262788A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP1996/003610 WO1998007701A1 (fr) 1996-08-16 1996-08-16 Derive de clonixine anti-inflammatoire/analgesique non ulcerigene

Publications (1)

Publication Number Publication Date
CA2262788A1 true CA2262788A1 (fr) 1998-02-26

Family

ID=8166287

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002262788A Abandoned CA2262788A1 (fr) 1996-08-16 1996-08-16 Derive de clonixine anti-inflammatoire/analgesique non ulcerigene

Country Status (9)

Country Link
JP (1) JP2000516235A (fr)
AU (1) AU714258B2 (fr)
BR (1) BR9612730A (fr)
CA (1) CA2262788A1 (fr)
CO (1) CO4900065A1 (fr)
PE (1) PE99398A1 (fr)
TW (1) TW337521B (fr)
UY (1) UY24666A1 (fr)
WO (1) WO1998007701A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20030042935A (ko) * 2001-11-26 2003-06-02 알앤피코리아 주식회사 클로닉신리신 제제
ITMI20021861A1 (it) 2002-08-29 2004-02-29 Nicox Sa Procedimento di sintesi di nitrossialchilesteri di acidi carbossilici, intermedi impiegabili in detto procedimento e loro preparazione.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4273777A (en) * 1979-06-04 1981-06-16 Laboratorios Bago S.A. Methods of treating mammals suffering from inflammation and pain
IT1256345B (it) * 1992-08-20 1995-12-01 Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazione

Also Published As

Publication number Publication date
BR9612730A (pt) 1999-08-24
JP2000516235A (ja) 2000-12-05
AU6924996A (en) 1998-03-06
UY24666A1 (es) 1998-02-03
CO4900065A1 (es) 2000-03-27
PE99398A1 (es) 1999-01-25
AU714258B2 (en) 1999-12-23
TW337521B (en) 1998-08-01
WO1998007701A1 (fr) 1998-02-26

Similar Documents

Publication Publication Date Title
US5621000A (en) Nitric esters having a pharmacological activity and process for their preparation
KR100343243B1 (ko) 항-염증성및/또는진통성활성을가지는니트릭에스테르들과그제조방법
RU2109009C1 (ru) Производные 2-(2,6-дигалофениламино)фенилуксусной кислоты и способ их получения
EP0586490B1 (fr) Derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent
EP0429366A1 (fr) Nouveaux dérivés de l'isoindolone, leur préparation et les compositions pharmaceutiques qui les contiennent
CH651561A5 (fr) Derives des nor-tropane et granatane et leur procede de preparation.
FR2466465A1 (fr) Derives de d-6-n-propylergolines, leur procede de preparation et compositions pharmaceutiques en contenant
PL84190B1 (en) 3-aroyl-alkenyleneimines[us3835149a]
CA1240332A (fr) Derives de pyridine, et leur preparation
AU714258B2 (en) Non-ulcerogenic analgesic/antiinflammatory clonixin derivative
RU2125990C1 (ru) Производные замещенной гетероциклом фенил-циклогексан-карбоновой кислоты, смесь их изомеров или отдельные изомеры и их соли
CA2089349C (fr) Nouveaux derives de pyrrolidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CA2105683C (fr) Acides n-¬(4,5-dihydroxy-et 4,5,8-trihydroxy-9,10-dihydro-9, 10-dioxo-2-anthracene-yl)carbonyl|amines utiles pour les therapies d'affectations osteoarticulaires
US5519043A (en) Fluorenyl derivatives
EP0922033A1 (fr) Derive de clonixine anti-inflammatoire/analgesique non ulcerigene
US4116972A (en) Anti-inflammatory 1-oxo-isoindoline derivatives and processes for their preparation
CS216206B2 (en) Method of making the derivatives of the diphenylpyrazole
MXPA99001358A (en) Non-ulcerogenic analgesic/anti-inflammatory clonixin derivative
EP3390360A1 (fr) Procédé de préparation d'un agent pharmaceutique
JPH0662547B2 (ja) グリシン誘導体
US4568690A (en) 1-Methyl-5-p-methylbenzoylpyrrole-2-acetamidoacetanilides with antiinflammatory, analgesic, antipyretic and anti-platelet aggregant activity
JPH04334358A (ja) 縮合ベンゼンオキシ酢酸誘導体
US4432991A (en) Therapeutically active 3-amino-1-phenyl(and substituted phenyl)-2-pyrazolines
CA2111169C (fr) Derives de l'acide phenylacetique, procede pour leur preparation et utilisation correspondante
EP0101633B1 (fr) Esters pyridinecarboxyliques de dopamine et de ses dérivés N-alkylés

Legal Events

Date Code Title Description
FZDE Dead