AU714258B2 - Non-ulcerogenic analgesic/antiinflammatory clonixin derivative - Google Patents
Non-ulcerogenic analgesic/antiinflammatory clonixin derivative Download PDFInfo
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- AU714258B2 AU714258B2 AU69249/96A AU6924996A AU714258B2 AU 714258 B2 AU714258 B2 AU 714258B2 AU 69249/96 A AU69249/96 A AU 69249/96A AU 6924996 A AU6924996 A AU 6924996A AU 714258 B2 AU714258 B2 AU 714258B2
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- clonixate
- analgesic
- antiinflammatory
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
WO 98/07701 PCT/EP96/03610 1 Non-ulcerogenic analgesic/antiinflammator clonixin derivative This invention refers to a novel product which is useful in human and animal therapeutics, particularly in the treatment of pain and/or inflammation with non-steroidal analgesic/antiinflammatory agents and with low ulcerogenic effect.
BACKGROUND ART The treatment of pain and/or inflammation in mammals with concomitant absence of adverse side-effect has been a goal long sought. In general steroids having cortisonelike activity suffer from the drawback of the side effects induced by the corticoid, such as electrolyte imbalance, water retention, etc. Thus, the treatment with non-steroidal analgesic/antiinflammatory agents has emerged as a whole field in modern therapeutics.
Relatively active analgesic/antiinflammatory products are already known in the art, and many of them are on the market. However, virtually all of them present ulceration of the gastrointestinal track as an adverse side-effect.
Thus, the provision of new analgesic-antiinflammatory products that have a better balance between high analgesic/antiinflammatory activities and low ulcerogenic adverse effects, is an important problem of modern therapeutics. This problem has not been solved satisfactorily yet, despite the existence of abundant research in the field.
From the chemical point of view, most commercial nonsteroidal analgesic/antiinflammatory active principles are carboxylic acids, often used in the form of salts.
WO 98/07701 PCT/EP96/03610 2 One group of these products includes derivatives of salicylic acid, such as diflunisal. Another group includes 2-aryl-substituted propionic acids, such as ibuprofen, ketoprofen, naproxen, suprofen, tiaprofenic acid, flurbiprofen, and -in a broad sense- indobufen and ketorolac. Another group includes aryl-substituted acetic acids, such as diclofenac, etodolac, fentiazac, sulindac and indomethacin. Another group includes substituted 2anilinobenzoic acids, such as mefenamic and meclofenamic acids. Finally, another group includes substituted 2anilinonicotinic acids such as clonixin or clonixic acid the carboxylic acid which is structurally closest to the product of the present invention.
0
O-H
N N-H
CH,
N
Cl
(IV)
Most of the attempts to ameliorate the balance between high analgesic/antiinflammatory activities and low ulcerogenic adverse effects of the above-mentioned carboxylic acids have involved the preparation of esters, such as those illustrated below.
US 5.508.301 discloses the 2-(1-pyrrolidinyl)ethyl ester of ketorolac. US 4.548.952 discloses the carboxymethyl ester of diclofenac, which is being used under the name aceclofenac. Nitroxy-(C1-C10)-alkyl esters of several WO 98/07701 PCT/EP96/03610 3 analgesic/antiinflammatory carboxylic acids, such as ketorolac, flurbiprofen, ketoprofen, naproxen, indomethacin and diclofenac, are claimed in WO 95/09831, WO 94/12463 or WO 94/04484.
In respect of clonixic acid the carboxylic acid which is structurally closest to the product of the present invention, attempts have been made to ameliorate the balance between high analgesic/antiinflammatory activities and low ulcerogenic adverse effects that have led to the preparation of several esters. Thus, US 4.273.777 discloses pivaloyloxymethyl clonixate (III) and phznalidyl clonixate, and provides some pharmacological comparative data. US 3.689.653 discloses some lower-alkyl clonixates (methyl, ethyl, heptyl), but does not provide pharmacological data.
O 0 rOCH 2
OCOC(CH
3 3 N N-H
CH,
CI
(III)
The method of estimating the analgesic and antiinflammatory activities of these carboxylic acids and their esters, differ from one document to another; therefore, significant comparisons between published activities are often difficult to make. In any case, it is generally observed that analgesic and antiinflammatory activities of esters are not substantially higher than those of the corresponding acids. Thus, for instance, US WO 98/07701 PCT/EP96/03610 4 4.273.777 shows that pivaloyloxymethyl clonixate (III) and phthalidyl clonixate have analgesic and antiinflammatory activities similar to those of clonixic acid.
Methods of estimating ulcerogenicity also differ from one document to another. In any case, it is generally observed that ulcerogenic adverse effects of esters, although smaller than those of the corresponding acids, still have a substantial value. Thus, for instance, in WO 95/09831 gastrointestinal damages of the 4 -nitroxybutyl esters of ketorolac and indomethacin are estimated as of those of the acids. In WO 94/12463 the relative ulcerogenicity of 4-nitroxybutyl esters of ketoprofen, flurbiprofen, suprofen, indobufen and etodolac are estimated as 20-35 of those of the acids. WO 94/04484 mention the low ulcerogenicity of the 4-nitroxybutyl ester of diclofenac, but it does not include data. In US 4.273.777 the ulcerogenic index of pivaloyloxymethyl and phthalidyl clonixate were evaluated as 3.0 and 3.6, values that are smaller than the one of clonixic acid but that still are substantial.
Therefore, it is clear that, despite the numerous attempts to prepare esters of non-steroidal analgesic/antiinflammatory carboxylic acids with a better balance between high analgesic/antiinflammatory activities and low ulcerogenic adverse effects, a completely satisfactory solution has not been reached yet. In particular, this is true for the case of esters of clonixic acid.
DESCRIPTION OF THE INVENTION The present invention solves the above-mentioned problem WO 98/07701 PCT/EP96/03610 by providing 4-nitroxybutyl clonixate, a novel product of formula and its pharmaceutically acceptable solvates hydrates) and addition salts hydrochloride) O
O
O,(CH,),CH
2 0NO 2 O,(HCH2CH 2
X
O CH 3
CH
C CI
(V)
The subject matter of the present invention also includes the 4-halobutyl clonixates of formula where X Cl, Br, or I, which are novel intermediates for the preparation of Specially preferred is 4-chlorobutyl clonixate, i.e. intermediate where X Cl.
The subject matter of the present invention includes pharmaceutical compositions comprising a therapeutically effective amount of 4-nitroxybutyl clonixate or a pharmaceutically acceptable solvate or addition salt thereof, and appropriate amounts of pharmaceutically acceptable excipients or carriers, preferably for oral administration. In a particular embodiment, the pharmaceutical compositions of the present invention are used for the treatment of pain and/or inflammation in mammals.
Another aspect of the present invention is the use of 4nitroxybutyl clonixate or a pharmaceutically acceptable solvate or addition salt thereof, for the preparation of a medicine for the treatment of pain WO 98/07701 PCT/EP96/03610 6 and/or inflammation in mammals. In other words, the present invention refers to a method of treatment of a mammal suffering from pain and/or inflammation, comprising the administration of a therapeutically effective amount of 4 -nitroxybutyl clonixate or a pharmaceutically acceptable solvate or addition salt thereof, together with appropriate amounts of pharmaceutically acceptable excipients or carriers. Oral administration is the preferred way.
A further embodiment of the present invention is a preparation process of 4-nitroxybutyl clonixate or a pharmaceutically acceptable solvate or addition salt thereof, that comprises the reaction, in an appropriate solvent, of a 4-halobutyl clonixate of formula where X is Cl, Br or I, with a nitrate selected between silver nitrate and mercurous nitrate, optionally adding the necessary reagent to obtain the desired solvate or addition salt. Thus, for example, when the addition salt is the hydrochloride, the necessary reagent is HCl or HC1 In a preferred embodiment of the process, X is Cl, and the nitrate is silver nitrate.
In a particular embodiment of the process the 4-halobutyl clonixates of formula are prepared by a reaction between an alkaline salt of clonixic acid, and the compound Y-(CH 2 4 where X is as defined above, and Y is a leaving group better than X. Specially preferred is the process where the alkaline salt is the potassium one, X is Cl and Y is Br.
The reaction steps of the processes of the present invention can be carried out in any appropriate solvent known in the art for reactions of the same type. In a particular embodiment the solvent is acetonitrile.
WO 98/07701 PCT/EP96/03610 7 Compared with the non-steroidal analgesicantiinflammatory products known in the art, the product of the present invention, 4-nitroxybutyl clonixate unexpectedly presents an excellent balance between high analgesic/antiinflammatory activities and low ulcerogenic adverse effects. This is so as a consequence of a surprisingly high antiinflammatory activity, simultaneous to an acceptable good analgesic activity and very low ulcerogenic adverse effects. Actually, the ulcerogenicity is so low that it appears as negligible (index 0) in the comparative pharmacological tests of the accompanying examples.
In order to make significant comparison of analgesic activity, antiinflammatory activity and ulcerogenicity, products have been tested under comparable conditions in the accompanying Examples 3-5. The identity and origin of tested products in Table 1 is as follows: 4-Nitroxybutyl clonixate, subject matter of the present invention, prepared here for the first time (cf.
Example 1).
Butyl clonixate, prepared here for the first time, for comparison (cf. Example 2).
(III): Pivaloyloxymethyl clonixate, proposed as analgesic-antiinflammatory product with low ulcerogenic adverse effects; disclosed in US 4.273.777.
Clonixic acid, commercially available analgesicantiinflammatory agent, also known as clonixin.
WO 98/07701 PCT/EP96/03610 8 Table 1: Comparative tests of analgesic activities, antiinflammatory activities, and ulcerogenic adverse effects of clonixic acid and some of their esters.
Compound ANL,% ANT,% ULC 4-nitroxybutyl clonixate 27 58 0 (II) butyl clonixate 26 21 8 (III) pivaloyloxymethyl clonixate 27 27 8 (IV) clonixic acid 25 28 333 ANL analgesic activity as percentage of pain reduction in a writhing test (0 no activity); ANT antiinflammatory activity as percentage of edema inhibition (0 no activity); ULC ulcerogenic index (0 no adverse effects none of the animals has any haemorrhage at all). ULC is the result of the sum of the ulceration scorer of each animal (with scorers above zero) multiplied by the percentage frequency of animals, divided by the total number of animals.
Table 1 summarizes the results of comparative tests of analgesic activities, antiinflammatory activities and ulcerogenic adverse effects of clonixic acid (IV) and clonixates Parameters ANL, ANT and ULC are defined in the footnote of the table, and they are fully explained in Examples 3, 4 and 5, respectively. For the desired purposes, the higher ANL value, the higher ANT value, and the lower ULC value, the better.
Concerning the analgesic activities (ANL) in the table, tested clonixates are roughly as active as WO 98/07701 PCT/EP96/03610 9 clonixic acid (IV).
Concerning the antiinflammatory activities (ANT) in the table, butyl clonixate (II) and pivaloyloxymethyl clonixate (III) are roughly as active as clonixic acid as it was expected. However, unexpectedly, 4nitroxybutyl clonixate the product of the present invention, has an antiinflammatory activity that is surprisingly high. Actually, this activity is two times the one of clonixic acid (IV).
The table also shows remarkable differences in ulcerogenicity. It is not surprising that all tested esters are less ulcerogenic than the corresponding acids.
However, nothing in the art allowed to predict that 4nitroxybutyl clonixate has such a low ulcerogenic adverse effect. Actually, it is so low that it appears as negligible (value 0) in the test, what means that none of the treated animals showed any haemorrhage at all.
The low ulcerogenicity, together with the acceptable good analgesic activity and the surprisingly high antiinflammatory activity, gives to product an extraordinary good balance between high analgesic/antiinflammatory activities and low ulcerogenic adverse effects. This unexpected technical feature of the product of the invention cannot be attributed to a mere esterification of clonixic acid. It can neither be attributed to the presence of the four carbon atoms of the butyl group. It can neither be attributed to the presence of the nitroxy substituent at the end of the butyl chain.
Thus, 4-nitroxybutyl clonixate is a very useful analgesic-antiinflammatory active principle which WO 98/07701 PCT/EP96/03610 represents a technical advantage in the treatment of pain and/or inflammation, over the non-steroidal analgesicantiinflammatory products known in the art, and particularly over the known esters of'clonixic acid.
EXAMPLES
Example 1. Preparation of 4-nitroxybutyl clonixate (la) 4-Chlorobutvl clonixate. Clonixic acid (10 g, 83 mmol) was suspended in 300 mL acetonitrile. Potassium carbonate (10.5 g 76 mmol) was added, and the mixture was stirred for 10 min under nitrogen. l-Bromo-4chlorobutane (8.8 mL 76 mmol) was added dropwise and slowly, and the mixture was stirred at 80 oC for 2 h.
Solids were filtered off. Solvent evaporation from filtrate, at 45 °C under vacuum, yielded an oil residue.
Washing with ethanol:water 70:30, followed by solvent evaporation under vacuum, washing with hexane, and filtration, yielded 12.5 g of the title compound as a solid melting at 69-70 which was used in the following step without further purification.
(Ib) 4-Nitroxybutyl clonixate A solution of silver nitrate (5.8 g, 34 mmol) in 10 mL acetonitrile was added dropwise onto a suspension of 4-chlorobutyl clonixate (6 g 17 mmol) in 300 mL acetonitrile. The reaction mixture was refluxed for 90 h; then it was filtered. Solvent evaporation under vacuum from the filtrate yielded a solid residue that was dissolved with dichloromethane; the obtained solution was washed with abundant water. The organic phase was separated from the aqueous one, it was dried with anhydrous magnesium sulfate, and the solvent was evaporated under vacuum. Column chromatography of the solid residue, in silicagel with isopropyl ether:hexane WO 98/07701 PCT/EP96/03610 11 1:1, allowed the collection of a fraction that, after solvent evaporation under vacuum, yielded the title compound (5.28 g 82 as a solid melting at 55-7 oC, with the following spectroscopic properties: IR cm1): 1700 1620 (asymmetrical
NO
2 1280 (symmetrical
NO
2 880 (NO stretching). NMR ppm): 1.95 4H); 2.40 3H); 4.4 2H); 4.54 2H); 6.7-8.5 (aromatic); 9.9 1H). Mass spectrum 20 eV): 379 Example 2. Preparation of butyl clonixate (II).
Clonixic acid (3.0 g 11.4 mmol) was suspended in 80 mL acetonitrile. Potassium carbonate (3.15 g 22.8 mmol) was added, and the mixture was stirred for 10 min under nitrogen. A solution of 1-bromobutane (2.5 mL 22.8 mmol) in acetonitrile (5 mL) was added dropwise, and the mixture was stirred at 80 oC for 4 h. Solids were filtered off. From filtrate, solvent evaporation at 45 °C under vacuum yielded a solid residue. Washing of the residue with ethanol:water 70:30, followed by solvent evaporation under vacuum, washing with hexane, solvent evaporation and recrystallization from acetonitrile, yielded 3.2 g (88 of the title compound as a solid melting at 65-8 with the following mass spectrum 70 eV) 318/20 35 303/5 (100 261/63 89 (17 Example 3: Comparison of analgesic activities.
Analgesic activities were assessed in mice using a writhing test according to R. K6ster et al. Fed.
Proc. 1959, vol. 18, p. 412). Writhes were induced by acetic acid in sets of albino mice, of both sexes, from the CWF strain, each weighing 25-8 g. Mice had no food WO 98/07701 PCT/EP96/03610 12 (but water ad libitum) for 12 h before treatment. Every mouse, 30 min before receiving 0.25 mL of 3 aqueous acetic acid was treated p.o. with the following doses of the tested compounds: 8.5 mg/kg of clonixic acid (IV) or clonixates Immediately after receiving the acetic acid, the number of writhes was counted for min. The average values were compared with the control (29.5 writhes), and the results -shown in Table 1 were obtained, expressed as percentages of reduction in the number of writhes. The higher the number in the ANL column in Table 1, the better analgesic activity (0 no activity).
Example 4. Comparison of antiinflammatory activities.
Antiinflammatory activities were assessed in Sprague Dawley rats, using a carrageenin induced paw edema test according to C.A. Winter et al. (Proc. Soc. Exp. Biol.
Med. 1962, vol. 111, pp. 544-7). Rats of both sexes, approximately weighing 150 g each, received 0.1 mL of 1 carrageenin saline suspension by injection in the subplantar region of one paw. 30 min before the injection of carrageenin, the following doses of tested compound were administered 22.5 mg/kg of clonixic acid (IV) or clonixates Paw volumes were measured 3 h after the injection. The results shown in Table 1 were obtained, expressed as percentages of edema inhibition (volume reduction) of treated animals, compared with the untreated (control) set. The higher the number in the ANT column of Table 1, the better antiinflammatory activity (0 no activity).
Example 5. Comparison of ulceroqenic adverse effects.
Ulcerogenic effects were evaluated by a macroscopic WO 98/07701 PCT/EP96/03610 13 examination of the ulceration of gastric epithelium, according to M. Chaumontet et al. (Arzneim. Forsch. Drug Res. 1978, vol. 28 pp. 2119-21). Sets of Sprague Dawley rats, approximately weighing 150 g each, received p.o. the following doses of the tested compounds: 125 mg/kg of clonixic acid (IV) or clonixates After 4 h of the administration, animals were sacrificed, the stomach was removed, open and examined for macroscopic damage. For every compound an ulcerogenic index was calculated according to the following evaluation: 0 no haemorrhage; 1 small haemorrhage; 2 large haemorrhage; 3 small ulcers (less than 2 mm diameter); 4 large ulcers (more than 2 mm diameter); perforated ulcer. The obtained ulcerogenic indexes are shown in the column ULC of Table 1. A value ULC 0 means no adverse effects, that none of the animals had any haemorrhage at all.
Claims (12)
1. The compound 4-nitroxybutyl clonixate, of formula and pharmaceutically acceptable solvates and addition salts thereof. O o/(CH) 3 CH 2 0NO, SN N-H CH 3 CI (I)
2. The compound 4-nitroxybutyl clonixate, of formula
3. A pharmaceutical composition comprising a therapeutically effective amount of a compound according to claim 1 or 2, and appropriate amounts of pharmaceutically acceptable excipients or carriers.
4. A pharmaceutical composition for the treatment of pain and/or inflammation in mammals, comprising a compound according to claim 1 or 2 as active ingredient.
Use of a compound according to claim 1 or 2, for the preparation of an medicament for the treatment of pain and/or inflammation in mammals.
6. Method of treatment of a mammal suffering from pain and/or inflammation, comprising the administration to said mammal of a therapeutically effective amount of a compound according to claim 1 or 2, together with _C1 i; r WO 98/07701 PCT/EP96/03610 appropriate amounts of pharmaceutically acceptable excipients or carriers.
7. An intermediate compound of formula where X is Cl, Br or I. O,(CH 2 3 CH 2 X N N-H CH, CI (V)
8. The intermediate compound according to claim 7, where X is Cl.
9. A preparation process of a compound according to claim 1 or 2, comprising the reaction, in an appropriate solvent, of an intermediate compound of formula where X is Cl, Br or I, with a nitrate selected between silver nitrate and mercurous nitrate, optionally adding the necessary reagent to obtain the desired solvate or addition salt.
A process according to claim 9, where X is Cl and the nitrate is silver nitrate.
11. A process according to claim 9 or 10, where the intermediate compound of formula is prepared by a reaction between an alkaline salt of clonixic acid and Y- (CH 2 4 where X is as defined above and Y is a leaving group better than X. WO 98/07701 PCT/EP96/03610
12. A process according to any of the claims 9 to 11, where the reactions are carried out in acetonitrile as solvent.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP1996/003610 WO1998007701A1 (en) | 1996-08-16 | 1996-08-16 | Non-ulcerogenic analgesic/anti-inflammatory clonixin derivative |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU6924996A AU6924996A (en) | 1998-03-06 |
| AU714258B2 true AU714258B2 (en) | 1999-12-23 |
Family
ID=8166287
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU69249/96A Ceased AU714258B2 (en) | 1996-08-16 | 1996-08-16 | Non-ulcerogenic analgesic/antiinflammatory clonixin derivative |
Country Status (9)
| Country | Link |
|---|---|
| JP (1) | JP2000516235A (en) |
| AU (1) | AU714258B2 (en) |
| BR (1) | BR9612730A (en) |
| CA (1) | CA2262788A1 (en) |
| CO (1) | CO4900065A1 (en) |
| PE (1) | PE99398A1 (en) |
| TW (1) | TW337521B (en) |
| UY (1) | UY24666A1 (en) |
| WO (1) | WO1998007701A1 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20030042935A (en) * | 2001-11-26 | 2003-06-02 | 알앤피코리아 주식회사 | Clonixin lysinate formulation |
| ITMI20021861A1 (en) * | 2002-08-29 | 2004-02-29 | Nicox Sa | NITROXIALKYL ESTER SYNTHESIS PROCESS OF CARBOXYLIC ACIDS, INTERMEDIATES THAT CAN BE USED IN THAT PROCEDURE AND THEIR PREPARATION. |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4273777A (en) * | 1979-06-04 | 1981-06-16 | Laboratorios Bago S.A. | Methods of treating mammals suffering from inflammation and pain |
| IT1256345B (en) * | 1992-08-20 | 1995-12-01 | NITRIC ESTERS OF PHENYLACETIC 2- (2,6-DI-HALO-PHENYLAMIN) DERIVATIVES AND PROCEDURE FOR THEIR PREPARATION |
-
1996
- 1996-08-16 WO PCT/EP1996/003610 patent/WO1998007701A1/en not_active Application Discontinuation
- 1996-08-16 JP JP10510291A patent/JP2000516235A/en active Pending
- 1996-08-16 AU AU69249/96A patent/AU714258B2/en not_active Ceased
- 1996-08-16 BR BR9612730A patent/BR9612730A/en not_active Application Discontinuation
- 1996-08-16 CA CA002262788A patent/CA2262788A1/en not_active Abandoned
- 1996-09-03 TW TW085110724A patent/TW337521B/en active
-
1997
- 1997-08-12 UY UY24666A patent/UY24666A1/en unknown
- 1997-08-14 PE PE1997000716A patent/PE99398A1/en not_active Application Discontinuation
- 1997-08-15 CO CO97046964A patent/CO4900065A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2262788A1 (en) | 1998-02-26 |
| PE99398A1 (en) | 1999-01-25 |
| AU6924996A (en) | 1998-03-06 |
| BR9612730A (en) | 1999-08-24 |
| TW337521B (en) | 1998-08-01 |
| CO4900065A1 (en) | 2000-03-27 |
| WO1998007701A1 (en) | 1998-02-26 |
| JP2000516235A (en) | 2000-12-05 |
| UY24666A1 (en) | 1998-02-03 |
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