CA2256413C - Anti-endoglin monoclonal antibodies and their use in antiangiogenic therapy - Google Patents
Anti-endoglin monoclonal antibodies and their use in antiangiogenic therapy Download PDFInfo
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- CA2256413C CA2256413C CA002256413A CA2256413A CA2256413C CA 2256413 C CA2256413 C CA 2256413C CA 002256413 A CA002256413 A CA 002256413A CA 2256413 A CA2256413 A CA 2256413A CA 2256413 C CA2256413 C CA 2256413C
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- endoglin
- therapeutic treatment
- angiogenesis
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6817—Toxins
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K—PEPTIDES
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
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Landscapes
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- Chemical & Material Sciences (AREA)
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- Heart & Thoracic Surgery (AREA)
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US655,953 | 1984-09-28 | ||
| US65595396A | 1996-05-31 | 1996-05-31 | |
| PCT/US1997/009610 WO1997045450A1 (en) | 1996-05-31 | 1997-05-30 | Anti-endoglin monoclonal antibodies and their use in antiangiogenic therapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2256413A1 CA2256413A1 (en) | 1997-12-04 |
| CA2256413C true CA2256413C (en) | 2007-07-03 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002256413A Expired - Lifetime CA2256413C (en) | 1996-05-31 | 1997-05-30 | Anti-endoglin monoclonal antibodies and their use in antiangiogenic therapy |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US5928641A (enExample) |
| EP (1) | EP0938505B1 (enExample) |
| JP (1) | JP4318752B2 (enExample) |
| AT (1) | ATE214075T1 (enExample) |
| CA (1) | CA2256413C (enExample) |
| DE (1) | DE69710911T2 (enExample) |
| ES (1) | ES2169864T3 (enExample) |
| WO (1) | WO1997045450A1 (enExample) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6749853B1 (en) | 1992-03-05 | 2004-06-15 | Board Of Regents, The University Of Texas System | Combined methods and compositions for coagulation and tumor treatment |
| US5965132A (en) | 1992-03-05 | 1999-10-12 | Board Of Regents, The University Of Texas System | Methods and compositions for targeting the vasculature of solid tumors |
| DE19845798A1 (de) * | 1998-09-29 | 2000-04-13 | Schering Ag | Verwendung von Neoangiogenese-Markern für Diagnose und Therapie von Tumoren, diese enthaltende Mittel, sowie Verfahren zu deren Herstellung |
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| RU2607029C1 (ru) * | 2015-10-20 | 2017-01-10 | ФЕДЕРАЛЬНОЕ ГОСУДАРСТВЕННОЕ БЮДЖЕТНОЕ УЧРЕЖДЕНИЕ "РОССИЙСКИЙ НАУЧНЫЙ ЦЕНТР РАДИОЛОГИИ И ХИРУРГИЧЕСКИХ ТЕХНОЛОГИЙ" МИНИСТЕРСТВА ЗДРАВООХРАНЕНИЯ РОССИЙСКОЙ ФЕДЕРАЦИИ / ФГБУ "РНЦРХТ" Минздрава России | ШТАММ ГИБРИДНЫХ КУЛЬТИВИРУЕМЫХ КЛЕТОК ЖИВОТНЫХ Mus musculus L. - EN-4C9 - ПРОДУЦЕНТ МОНОКЛОНАЛЬНЫХ АНТИТЕЛ ПРОТИВ ЭНДОГЛИНА (CD105) ЧЕЛОВЕКА |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL94389A0 (en) * | 1989-06-01 | 1991-03-10 | Health Research Inc | Monoclonal antibody reactive to a unique antigen widely present on various human leukemia and lymphoma cells and method of using same for diagnosis and treatment |
| US5660827A (en) * | 1992-03-05 | 1997-08-26 | Board Of Regents, The University Of Texas System | Antibodies that bind to endoglin |
-
1997
- 1997-05-30 JP JP54307197A patent/JP4318752B2/ja not_active Expired - Lifetime
- 1997-05-30 ES ES97926889T patent/ES2169864T3/es not_active Expired - Lifetime
- 1997-05-30 CA CA002256413A patent/CA2256413C/en not_active Expired - Lifetime
- 1997-05-30 DE DE69710911T patent/DE69710911T2/de not_active Expired - Lifetime
- 1997-05-30 WO PCT/US1997/009610 patent/WO1997045450A1/en not_active Ceased
- 1997-05-30 AT AT97926889T patent/ATE214075T1/de active
- 1997-05-30 EP EP97926889A patent/EP0938505B1/en not_active Expired - Lifetime
- 1997-08-29 US US08/920,537 patent/US5928641A/en not_active Expired - Lifetime
-
1999
- 1999-05-14 US US09/312,382 patent/US6200566B1/en not_active Expired - Lifetime
Also Published As
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|---|---|
| US5928641A (en) | 1999-07-27 |
| DE69710911T2 (de) | 2002-09-19 |
| WO1997045450A1 (en) | 1997-12-04 |
| ATE214075T1 (de) | 2002-03-15 |
| EP0938505A1 (en) | 1999-09-01 |
| DE69710911D1 (de) | 2002-04-11 |
| ES2169864T3 (es) | 2002-07-16 |
| JP2000511425A (ja) | 2000-09-05 |
| JP4318752B2 (ja) | 2009-08-26 |
| CA2256413A1 (en) | 1997-12-04 |
| US6200566B1 (en) | 2001-03-13 |
| EP0938505B1 (en) | 2002-03-06 |
| EP0938505A4 (en) | 2000-07-19 |
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