CA2250707A1 - Peptides contenant de la cysteine ou de la methionine et possedant des effets immunomodulateurs - Google Patents

Peptides contenant de la cysteine ou de la methionine et possedant des effets immunomodulateurs Download PDF

Info

Publication number
CA2250707A1
CA2250707A1 CA002250707A CA2250707A CA2250707A1 CA 2250707 A1 CA2250707 A1 CA 2250707A1 CA 002250707 A CA002250707 A CA 002250707A CA 2250707 A CA2250707 A CA 2250707A CA 2250707 A1 CA2250707 A1 CA 2250707A1
Authority
CA
Canada
Prior art keywords
leu
pro
cys
seq
gly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002250707A
Other languages
English (en)
Inventor
Hakan Bergstrand
Tomas Eriksson
Magnus Lindvall
Bengt Sarnstrand
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9601422A external-priority patent/SE9601422D0/xx
Priority claimed from SE9603469A external-priority patent/SE9603469D0/xx
Application filed by Individual filed Critical Individual
Publication of CA2250707A1 publication Critical patent/CA2250707A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Transplantation (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

On décrit des molécules d'acide nucléique qui codent des peptides contenant de la cystéine ou de la méthionine et ont pour fonction de stimuler ou de supprimer la réponse immune chez un mammifère. De manière classique, ces peptides ne contiennent pas plus de 30 restes d'acides aminés et ils peuvent, le cas échéant, être liés à un peptide signal sécrétoire mammifère au niveau de leur extrémité terminale amino.
CA002250707A 1996-04-12 1997-04-04 Peptides contenant de la cysteine ou de la methionine et possedant des effets immunomodulateurs Abandoned CA2250707A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
SE9601422A SE9601422D0 (sv) 1996-04-12 1996-04-12 Synthetic genes
SE9603469A SE9603469D0 (sv) 1996-09-23 1996-09-23 Synthetic genes
SE9603469-9 1996-09-23
SE9601422-0 1996-09-23

Publications (1)

Publication Number Publication Date
CA2250707A1 true CA2250707A1 (fr) 1997-10-23

Family

ID=26662584

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002250707A Abandoned CA2250707A1 (fr) 1996-04-12 1997-04-04 Peptides contenant de la cysteine ou de la methionine et possedant des effets immunomodulateurs

Country Status (7)

Country Link
EP (1) EP0923604A1 (fr)
JP (1) JP2000508898A (fr)
AR (1) AR006641A1 (fr)
AU (1) AU2417597A (fr)
CA (1) CA2250707A1 (fr)
ID (1) ID16421A (fr)
WO (1) WO1997039023A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9603463D0 (sv) * 1996-09-23 1996-09-23 Astra Ab New compounds
SE9603466D0 (sv) * 1996-09-23 1996-09-23 Astra Ab New compounds
SE9603468D0 (sv) * 1996-09-23 1996-09-23 Astra Ab New compounds
WO1999019347A1 (fr) * 1997-10-10 1999-04-22 Astrazeneca Ab Genes synthetiques a action immunoregulatrice
GB0524884D0 (en) 2005-12-06 2006-01-11 Syngenta Ltd Improvements in or relating to organic compounds
CN115636870B (zh) * 2022-11-24 2024-04-30 安徽农业大学 具有肝癌细胞毒性和α-葡萄糖苷酶抑制活性的环色-苏-缬-亮-亮肽及制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4971952A (en) * 1986-03-06 1990-11-20 Collagen Corporation Method of treating inflammation with cartilage inducing factor
US4822606A (en) * 1986-04-07 1989-04-18 Duke University Immunosuppressive synthetic peptides and analogs thereof based on retroviral envelope sequences
WO1988005783A1 (fr) * 1987-01-28 1988-08-11 Ortho Pharmaceutical Corporation Peptides immunodepresseurs et leurs procedes d'utilisation
GB8714802D0 (en) * 1987-06-24 1987-07-29 Proteus Biotech Ltd Synthetic polypeptides
JPH02240020A (ja) * 1989-01-26 1990-09-25 Childrens Medical Center Corp:The 外科的切除後の腫瘍再発阻止剤
WO1990014360A1 (fr) * 1989-05-17 1990-11-29 Oncogene Science, Inc. Inhibiteurs de la croissance de tumeurs derivees de tissus, procedes de preparation et leurs utilisations
JP3188457B2 (ja) * 1992-03-07 2001-07-16 森永乳業株式会社 免疫促進剤
US6696061B1 (en) * 1992-08-11 2004-02-24 President And Fellows Of Harvard College Immunomodulatory peptides
JPH08502244A (ja) * 1992-08-11 1996-03-12 プレジデント アンド フェローズ オブ ハーバード カレッジ 免疫調節ペプチド
JPH08503694A (ja) * 1992-09-08 1996-04-23 セントコー・インコーポレーテッド ペプチド系の細胞接着阻害物質
US5510332A (en) * 1994-07-07 1996-04-23 Texas Biotechnology Corporation Process to inhibit binding of the integrin α4 62 1 to VCAM-1 or fibronectin and linear peptides therefor
SE9403526D0 (sv) * 1994-10-14 1994-10-14 Astra Ab New Peptides
SE9501067D0 (sv) * 1995-03-24 1995-03-24 Astra Ab New peptides

Also Published As

Publication number Publication date
EP0923604A1 (fr) 1999-06-23
WO1997039023A1 (fr) 1997-10-23
ID16421A (id) 1997-09-25
AR006641A1 (es) 1999-09-08
AU2417597A (en) 1997-11-07
JP2000508898A (ja) 2000-07-18

Similar Documents

Publication Publication Date Title
JP4422903B2 (ja) 癌抑制遺伝子ｗｔ１の産物に基づく癌抗原
JP5490343B2 (ja) Ｊｎｋシグナル導入経路の細胞透過性ペプチドインヒビター
JPH08505878A (ja) 免疫原のリソソーム標的
CA2715484C (fr) Suppression des reponses immunitaires aux vecteurs viraux
ES2353637T3 (es) Moléculas denominadas ldcam.
JP2003520606A (ja) 癌抗原ｎｙｅｓｏ−１由来の新規ｍｈｃクラスｉｉ拘束ｔ細胞エピトープ
JPH09502086A (ja) 完全ｍａｇｅ１遺伝子のクローニング及び特性決定
JPH06508025A (ja) 癌胎児性抗原を発現する組換えウイルスとその使用方法
WO1999048923A1 (fr) Ligands polyvalents modulant l'angiogenese
PT758383E (pt) Fracções polipeptídicas solúveis da ptroteína lag-3; processo de produção; composição terapêutica; anticorpos anti-idiotipo
CN101389760A (zh) 有效治疗肿瘤或其他需要除去或破坏细胞的病症的肽
US8303957B2 (en) Mutated immunogenic peptides derived from R9M, polynucleotides coding for same and therapeutic uses thereof
ES2347645T3 (es) Motivo de transduccion biomolecular mph-1-btm y utilizacion del mismo.
KR20140069222A (ko) 교차 제시 수지상 세포를 표적으로 하는 백시바디
WO1999019347A1 (fr) Genes synthetiques a action immunoregulatrice
CA2250707A1 (fr) Peptides contenant de la cysteine ou de la methionine et possedant des effets immunomodulateurs
KR100978344B1 (ko) 생체분자 전달 모티브 Sim-2-BTM 및 이것의 이용 방법
JP2000511417A (ja) Ｄ異性体のアミノ酸を含む免疫調節化合物
US20100173840A1 (en) Pharmaceutical Composition for Treating Autoimmune, Allergic and Inflammatory Diseases and Delivery Method Thereof
WO1999048924A1 (fr) Peptides derives de l'endostatine avec activite antiangiogenique et anticancereuse
JP2008505846A (ja) 悪性哺乳動物細胞および形質転換哺乳動物細胞に対して選択的に致死性を有するペプチド

Legal Events

Date Code Title Description
FZDE Discontinued