CA2250583C - Process for the preparation of n-methyl-d-phenylalanyl-n-[1-[3-[(aminoiminomethyl)amino]propyl]-3,3-difluoro-2-oxohexyl]-l-prolinamide - Google Patents
Process for the preparation of n-methyl-d-phenylalanyl-n-[1-[3-[(aminoiminomethyl)amino]propyl]-3,3-difluoro-2-oxohexyl]-l-prolinamide Download PDFInfo
- Publication number
- CA2250583C CA2250583C CA002250583A CA2250583A CA2250583C CA 2250583 C CA2250583 C CA 2250583C CA 002250583 A CA002250583 A CA 002250583A CA 2250583 A CA2250583 A CA 2250583A CA 2250583 C CA2250583 C CA 2250583C
- Authority
- CA
- Canada
- Prior art keywords
- amino
- bis
- hydroxy
- protected
- difluorononane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C277/08—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups of substituted guanidines
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62472196A | 1996-03-26 | 1996-03-26 | |
| US08/624,721 | 1996-03-26 | ||
| PCT/US1997/002869 WO1997035874A1 (en) | 1996-03-26 | 1997-02-25 | Process for the preparation of n-methyl-d-phenylalanyl-n-[1-[3-[(aminoiminomethyl)amino]propyl]-3,3-difluoro-2-oxohexyl]-l-prolinamide |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2250583A1 CA2250583A1 (en) | 1997-10-02 |
| CA2250583C true CA2250583C (en) | 2003-01-14 |
Family
ID=24503070
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002250583A Expired - Fee Related CA2250583C (en) | 1996-03-26 | 1997-02-25 | Process for the preparation of n-methyl-d-phenylalanyl-n-[1-[3-[(aminoiminomethyl)amino]propyl]-3,3-difluoro-2-oxohexyl]-l-prolinamide |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP1012165A1 (xx) |
| JP (1) | JP2000507267A (xx) |
| KR (1) | KR20000004991A (xx) |
| CN (1) | CN1121410C (xx) |
| AR (1) | AR006366A1 (xx) |
| AU (1) | AU710040B2 (xx) |
| BR (1) | BR9708369A (xx) |
| CA (1) | CA2250583C (xx) |
| IL (1) | IL126071A (xx) |
| NO (1) | NO984490L (xx) |
| NZ (1) | NZ331432A (xx) |
| WO (1) | WO1997035874A1 (xx) |
| ZA (1) | ZA972506B (xx) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0503203A1 (en) * | 1991-03-15 | 1992-09-16 | Merrell Dow Pharmaceuticals Inc. | Novel thrombin inhibitors |
-
1997
- 1997-02-25 IL IL12607197A patent/IL126071A/xx not_active IP Right Cessation
- 1997-02-25 WO PCT/US1997/002869 patent/WO1997035874A1/en not_active Application Discontinuation
- 1997-02-25 KR KR1019980707603A patent/KR20000004991A/ko not_active Application Discontinuation
- 1997-02-25 JP JP9534396A patent/JP2000507267A/ja active Pending
- 1997-02-25 CN CN97193317A patent/CN1121410C/zh not_active Expired - Fee Related
- 1997-02-25 BR BR9708369A patent/BR9708369A/pt not_active Application Discontinuation
- 1997-02-25 NZ NZ331432A patent/NZ331432A/xx unknown
- 1997-02-25 EP EP97908712A patent/EP1012165A1/en not_active Withdrawn
- 1997-02-25 CA CA002250583A patent/CA2250583C/en not_active Expired - Fee Related
- 1997-02-25 AU AU20550/97A patent/AU710040B2/en not_active Ceased
- 1997-03-24 AR ARP970101169A patent/AR006366A1/es not_active Application Discontinuation
- 1997-03-24 ZA ZA9702506A patent/ZA972506B/xx unknown
-
1998
- 1998-09-25 NO NO984490A patent/NO984490L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2055097A (en) | 1997-10-17 |
| CN1214691A (zh) | 1999-04-21 |
| JP2000507267A (ja) | 2000-06-13 |
| EP1012165A1 (en) | 2000-06-28 |
| WO1997035874A1 (en) | 1997-10-02 |
| NO984490D0 (no) | 1998-09-25 |
| NO984490L (no) | 1998-09-25 |
| AU710040B2 (en) | 1999-09-09 |
| IL126071A (en) | 2003-06-24 |
| ZA972506B (en) | 1997-09-26 |
| CN1121410C (zh) | 2003-09-17 |
| NZ331432A (en) | 2000-03-27 |
| AR006366A1 (es) | 1999-08-25 |
| CA2250583A1 (en) | 1997-10-02 |
| IL126071A0 (en) | 1999-05-09 |
| KR20000004991A (ko) | 2000-01-25 |
| BR9708369A (pt) | 1999-08-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed | ||
| MKLA | Lapsed |
Effective date: 20050225 |